CR20180143A - Nuevos compuestos biciclicos como inhibidores duales de atx/ca - Google Patents

Nuevos compuestos biciclicos como inhibidores duales de atx/ca

Info

Publication number
CR20180143A
CR20180143A CR20180143A CR20180143A CR20180143A CR 20180143 A CR20180143 A CR 20180143A CR 20180143 A CR20180143 A CR 20180143A CR 20180143 A CR20180143 A CR 20180143A CR 20180143 A CR20180143 A CR 20180143A
Authority
CR
Costa Rica
Prior art keywords
atx
compounds
dual inhibitors
new bicycle
bicycle compounds
Prior art date
Application number
CR20180143A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Hunziker
Jérôme Hert
Petra Schmitz
Patrizio Mattei
Markus Rudolph
Christoph; Ullmer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20180143A publication Critical patent/CR20180143A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CR20180143A 2015-09-24 2016-09-20 Nuevos compuestos biciclicos como inhibidores duales de atx/ca CR20180143A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186642 2015-09-24
PCT/EP2016/072277 WO2017050747A1 (en) 2015-09-24 2016-09-20 New bicyclic compounds as dual atx/ca inhibitors

Publications (1)

Publication Number Publication Date
CR20180143A true CR20180143A (es) 2018-05-03

Family

ID=54199040

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20180143A CR20180143A (es) 2015-09-24 2016-09-20 Nuevos compuestos biciclicos como inhibidores duales de atx/ca

Country Status (19)

Country Link
US (2) US10738053B2 (enExample)
EP (1) EP3353181B1 (enExample)
JP (1) JP6845230B2 (enExample)
KR (1) KR20180053408A (enExample)
CN (1) CN107614505B (enExample)
AR (1) AR106100A1 (enExample)
AU (1) AU2016328365B2 (enExample)
BR (1) BR112017026682A2 (enExample)
CA (1) CA2984585A1 (enExample)
CL (1) CL2018000649A1 (enExample)
CO (1) CO2017011152A2 (enExample)
CR (1) CR20180143A (enExample)
IL (1) IL255511B (enExample)
MX (1) MX2017015034A (enExample)
PE (1) PE20180233A1 (enExample)
PH (1) PH12018500409A1 (enExample)
RU (1) RU2725138C2 (enExample)
TW (1) TW201725206A (enExample)
WO (1) WO2017050747A1 (enExample)

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UA123362C2 (uk) 2015-09-04 2021-03-24 Ф. Хоффманн-Ля Рош Аг Феноксиметильні похідні
CR20180057A (es) 2015-09-24 2018-04-02 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores duales de atx/ca.
AU2016328535A1 (en) * 2015-09-24 2017-11-09 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
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CR20180072A (es) 2015-09-24 2018-02-26 Hoffmann La Roche Nuevos compuestos biciclicos como inhibidores de atx
SG11201908560SA (en) * 2017-03-16 2019-10-30 Hoffmann La Roche Heterocyclic compounds useful as dual atx/ca inhibitors
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
CN114127054B (zh) 2019-07-22 2024-04-09 勃林格殷格翰国际有限公司 作为用于治疗炎性气道或纤维化疾病的自分泌运动因子(atx)调节剂的n-甲基、n-(6-(甲氧基)哒嗪-3-基)胺衍生物
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