TW201725206A - 作為雙重atx/ca抑制劑之新穎雙環化合物 - Google Patents
作為雙重atx/ca抑制劑之新穎雙環化合物 Download PDFInfo
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- TW201725206A TW201725206A TW105130903A TW105130903A TW201725206A TW 201725206 A TW201725206 A TW 201725206A TW 105130903 A TW105130903 A TW 105130903A TW 105130903 A TW105130903 A TW 105130903A TW 201725206 A TW201725206 A TW 201725206A
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- substituted
- alkyl
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- pyrrole
- alkoxy
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- CQRUZVNAXCQQSP-CPJLOUKISA-N [3-(2,2-dimethylpropanoylamino)-5-(trifluoromethyl)pyridin-2-yl]methyl (3aS,6aR)-3a-methoxy-2-(5-sulfamoylpyridine-2-carbonyl)-3,4,6,6a-tetrahydro-1H-pyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound CC(C(=O)NC=1C(=NC=C(C=1)C(F)(F)F)COC(=O)N1C[C@H]2CN(C[C@@]2(C1)OC)C(=O)C1=NC=C(C=C1)S(N)(=O)=O)(C)C CQRUZVNAXCQQSP-CPJLOUKISA-N 0.000 claims description 2
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- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- ZLORJBFLGIFKCT-UHFFFAOYSA-N tert-butyl 6H-pyrrolo[3,4-c]pyrrole-5-carboxylate Chemical compound C(C)(C)(C)OC(=O)N1CC2=CN=CC2=C1 ZLORJBFLGIFKCT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| HRP20191937T1 (hr) | 2012-09-25 | 2020-01-10 | F. Hoffmann - La Roche Ag | Derivati heksahidropirolo [3,4-c]pirola i srodni spojevi kao inhibitori autotaksina (atx) i kao inhibitori proizvodnje lizofosfatidne kiseline (lpa) za liječenje npr. bubrežnih bolesti |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| RS56776B1 (sr) | 2013-11-26 | 2018-04-30 | Hoffmann La Roche | Derivati oktahidro-ciklobuta [1,2-c;3,4-c']dipirola kao inhibitori autotaksina |
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| UA118582C2 (uk) | 2014-03-26 | 2019-02-11 | Ф. Хоффманн-Ля Рош Аг | Біциклічні сполуки як інгібітори продукції аутотаксину (atx) і лізофосфатидилової кислоти (lpa) |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| CR20180058A (es) | 2015-09-04 | 2018-02-26 | Hoffmann La Roche | Nuevos derivados de fenoximetilo |
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| PE20180552A1 (es) | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
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2016
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- 2016-09-20 MX MX2017015034A patent/MX2017015034A/es unknown
- 2016-09-20 KR KR1020187011566A patent/KR20180053408A/ko not_active Withdrawn
- 2016-09-20 JP JP2018515621A patent/JP6845230B2/ja active Active
- 2016-09-20 CA CA2984585A patent/CA2984585A1/en not_active Abandoned
- 2016-09-20 CN CN201680032856.4A patent/CN107614505B/zh active Active
- 2016-09-20 EP EP16788029.3A patent/EP3353181B1/en active Active
- 2016-09-20 RU RU2018114518A patent/RU2725138C2/ru active
- 2016-09-20 CR CR20180143A patent/CR20180143A/es unknown
- 2016-09-20 WO PCT/EP2016/072277 patent/WO2017050747A1/en not_active Ceased
- 2016-09-20 PE PE2017002424A patent/PE20180233A1/es unknown
- 2016-09-20 AU AU2016328365A patent/AU2016328365B2/en not_active Ceased
- 2016-09-22 AR ARP160102880A patent/AR106100A1/es unknown
- 2016-09-23 TW TW105130903A patent/TW201725206A/zh unknown
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2017
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2018
- 2018-02-23 PH PH12018500409A patent/PH12018500409A1/en unknown
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| EP3353181B1 (en) | 2021-08-11 |
| JP2018528244A (ja) | 2018-09-27 |
| US10738053B2 (en) | 2020-08-11 |
| AU2016328365A1 (en) | 2017-11-09 |
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| JP6845230B2 (ja) | 2021-03-17 |
| RU2725138C2 (ru) | 2020-06-30 |
| MX2017015034A (es) | 2018-04-13 |
| BR112017026682A2 (pt) | 2018-08-14 |
| RU2018114518A3 (enExample) | 2020-01-09 |
| CR20180143A (es) | 2018-05-03 |
| HK1246788A1 (zh) | 2018-09-14 |
| KR20180053408A (ko) | 2018-05-21 |
| CN107614505B (zh) | 2021-05-07 |
| CL2018000649A1 (es) | 2018-08-17 |
| AR106100A1 (es) | 2017-12-13 |
| CN107614505A (zh) | 2018-01-19 |
| PH12018500409A1 (en) | 2018-08-29 |
| EP3353181A1 (en) | 2018-08-01 |
| US20200291038A1 (en) | 2020-09-17 |
| CO2017011152A2 (es) | 2018-03-28 |
| PE20180233A1 (es) | 2018-01-31 |
| US10889588B2 (en) | 2021-01-12 |
| WO2017050747A1 (en) | 2017-03-30 |
| IL255511B (en) | 2020-01-30 |
| IL255511A (en) | 2018-01-31 |
| CA2984585A1 (en) | 2017-03-30 |
| AU2016328365B2 (en) | 2020-04-23 |
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