AR106118A1 - Compuestos bicíclicos como inhibidores de atx - Google Patents
Compuestos bicíclicos como inhibidores de atxInfo
- Publication number
- AR106118A1 AR106118A1 ARP160102899A ARP160102899A AR106118A1 AR 106118 A1 AR106118 A1 AR 106118A1 AR P160102899 A ARP160102899 A AR P160102899A AR P160102899 A ARP160102899 A AR P160102899A AR 106118 A1 AR106118 A1 AR 106118A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- cycloalkyl
- pyridinyl
- alkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones que contienen los compuestos y métodos de uso de dichos compuestos. Reivindicación 1: Compuestos de la fórmula (1) en la que: R¹ es fenilo sustituido, fenil-alquilo C₁₋₆ sustituido, fenoxi-alquilo C₁₋₆ sustituido, fenil-alquenilo C₂₋₆ sustituido, fenil-alquinilo C₂₋₆ sustituido, piridinilo sustituido, piridinil-alquilo C₁₋₆ sustituido, piridinil-alquenilo C₂₋₆ sustituido, piridinil-alquinilo C₂₋₆ sustituido, tiofenilo sustituido, tiofenil-alquilo C₁₋₆ sustituido, tiofenil-alquenilo C₂₋₆ sustituido o tiofenil-alquinilo C₂₋₆ sustituido, dichos fenilo sustituido, fenil-alquilo C₁₋₆ sustituido, fenoxi-alquilo C₁₋₆ sustituido, fenil-alquenilo C₂₋₆ sustituido, fenil-alquinilo C₂₋₆ sustituido, piridinilo sustituido, piridinil-alquilo C₁₋₆ sustituido, piridinil-alquenilo C₂₋₆ sustituido, piridinil-alquinilo C₂₋₆ sustituido, tiofenilo sustituido, tiofenil-alquilo C₁₋₆ sustituido, tiofenil-alquenilo C₂₋₆ sustituido y tiofenil-alquinilo C₂₋₆ sustituido están sustituidos por R³, R⁴ y R⁵; Y es un -OC(O)- o -C(O)-; W es -C(O)-, -S(O)₂ o -CR⁶R⁷-; R² se elige entre los sistemas de anillo B, F, L, M, O, Z, AF, AG, AH, AJ, AN, AO, AP, AQ, AR, AS, AT, AU, AV, AW, AX, AY, AZ, BA, BC y BD seleccionados del grupo de fórmulas (2); R³ es halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, hidroxialquilo C₁₋₆, cicloalquilo C₃₋₈, (cicloalquil C₃₋₈)-alquilo C₁₋₆, (cicloalquil C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈, (cicloalcoxi C₃₋₈)-alquilo C₁₋₆, alquilamino C₁₋₆, (alquil C₁₋₆)-carbonilamino, (cicloalquil C₃₋₈)-carbonil-amino, (alquil C₁₋₆)-tetrazolilo, (alquil C₁₋₆)-tetrazolil-alquilo C₁₋₆ o heterocicloalquil-alcoxi C₁₋₆; R⁴ y R⁵ se eligen con independencia entre H, halógeno, hidroxi, ciano, alquilo C₁₋₆, alcoxi C₁₋₆, (alcoxi C₁₋₆)-alquilo C₁₋₆, haloalcoxi C₁₋₆, haloalquilo C₁₋₆, hidroxi-alquilo C₁₋₆, cicloalquilo C₃₋₈, (cicloalquil C₃₋₈)-alquilo C₁₋₆, (cicloalquil C₃₋₈)-alcoxi C₁₋₆, cicloalcoxi C₃₋₈, (cicloalcoxi C₃₋₈)-alquilo C₁₋₆, (alquil C₁₋₆)-carbonil-amino, (cicloalquil C₃₋₈)-carbonilamino, (alquil C₁₋₆)-tetrazolilo, (alquil C₁₋₆)-tetrazolil-alquilo C₁₋₆ y heterocicloalquil-alcoxi C₁₋₆; R⁶ es H o alquilo C₁₋₆; R⁷ es H, alquilo C₁₋₆, halógeno, haloalquilo C₁₋₆ o alcoxi C₁₋₆; m, n, p y q se eligen con independencia entre 1 y 2; r es el número 1, 2 ó 3; y las sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15186684 | 2015-09-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR106118A1 true AR106118A1 (es) | 2017-12-13 |
Family
ID=54199050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP160102899A AR106118A1 (es) | 2015-09-24 | 2016-09-23 | Compuestos bicíclicos como inhibidores de atx |
Country Status (21)
Country | Link |
---|---|
US (2) | US20180312515A1 (es) |
EP (1) | EP3353176B1 (es) |
JP (1) | JP6876685B2 (es) |
KR (1) | KR20180054635A (es) |
CN (1) | CN107922412B (es) |
AR (1) | AR106118A1 (es) |
AU (1) | AU2016328437A1 (es) |
BR (1) | BR112018006034A2 (es) |
CA (1) | CA2991615A1 (es) |
CL (1) | CL2018000687A1 (es) |
CO (1) | CO2018000631A2 (es) |
CR (1) | CR20180072A (es) |
HK (1) | HK1251876A1 (es) |
IL (1) | IL256661A (es) |
MA (1) | MA42919A (es) |
MX (1) | MX2018001890A (es) |
PE (1) | PE20180451A1 (es) |
RU (1) | RU2018112230A (es) |
TW (1) | TW201722947A (es) |
WO (1) | WO2017050792A1 (es) |
ZA (1) | ZA201801032B (es) |
Families Citing this family (18)
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CN104364239B (zh) | 2012-06-13 | 2017-08-25 | 霍夫曼-拉罗奇有限公司 | 二氮杂螺环烷烃和氮杂螺环烷烃 |
AR092645A1 (es) | 2012-09-25 | 2015-04-29 | Hoffmann La Roche | Derivados biciclicos inhibidores de autotaxina (atx) |
AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
CN105764905B (zh) | 2013-11-26 | 2019-06-07 | 豪夫迈·罗氏有限公司 | 新的八氢-环丁二烯并[1,2-c;3,4-c’]二吡咯-2基 |
EA032357B1 (ru) | 2014-03-26 | 2019-05-31 | Ф. Хоффманн-Ля Рош Аг | Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa) |
PL3122750T3 (pl) | 2014-03-26 | 2020-03-31 | F.Hoffmann-La Roche Ag | Związki bicykliczne jako inhibitory wytwarzania autotaksyny (ATX) i kwasu lizofosfatydowego (LPA) |
MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
MX2018000511A (es) | 2015-09-04 | 2018-04-24 | Hoffmann La Roche | Derivados de fenoximetilo. |
EP3353180B1 (en) | 2015-09-24 | 2022-03-16 | F. Hoffmann-La Roche AG | Bicyclic compounds as atx inhibitors |
AU2016328437A1 (en) | 2015-09-24 | 2018-01-25 | F. Hoffmann-La Roche Ag | Bicyclic compounds as ATX inhibitors |
MA42923A (fr) | 2015-09-24 | 2021-04-28 | Hoffmann La Roche | Composés bicycliques comme inhibiteurs mixtes de atx/ca |
CR20180143A (es) | 2015-09-24 | 2018-05-03 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca |
JP7090099B2 (ja) | 2017-03-16 | 2022-06-23 | エフ.ホフマン-ラ ロシュ アーゲー | Atxインヒビターとしての新規二環式化合物 |
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- 2016-09-21 AU AU2016328437A patent/AU2016328437A1/en not_active Abandoned
- 2016-09-21 KR KR1020187008127A patent/KR20180054635A/ko unknown
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- 2016-09-21 RU RU2018112230A patent/RU2018112230A/ru not_active Application Discontinuation
- 2016-09-21 CN CN201680047765.8A patent/CN107922412B/zh active Active
- 2016-09-21 PE PE2018000089A patent/PE20180451A1/es unknown
- 2016-09-21 WO PCT/EP2016/072349 patent/WO2017050792A1/en active Application Filing
- 2016-09-21 BR BR112018006034A patent/BR112018006034A2/pt not_active Application Discontinuation
- 2016-09-21 CA CA2991615A patent/CA2991615A1/en not_active Abandoned
- 2016-09-21 MA MA042919A patent/MA42919A/fr unknown
- 2016-09-23 TW TW105130908A patent/TW201722947A/zh unknown
- 2016-09-23 AR ARP160102899A patent/AR106118A1/es unknown
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2017
- 2017-12-31 IL IL256661A patent/IL256661A/en unknown
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2018
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- 2018-03-15 CL CL2018000687A patent/CL2018000687A1/es unknown
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- 2018-08-31 HK HK18111205.8A patent/HK1251876A1/zh unknown
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CL2018000687A1 (es) | 2018-08-03 |
BR112018006034A2 (pt) | 2018-10-09 |
CA2991615A1 (en) | 2017-03-30 |
US20200087307A1 (en) | 2020-03-19 |
US20180312515A1 (en) | 2018-11-01 |
CR20180072A (es) | 2018-02-26 |
IL256661A (en) | 2018-02-28 |
CN107922412B (zh) | 2021-02-23 |
WO2017050792A1 (en) | 2017-03-30 |
KR20180054635A (ko) | 2018-05-24 |
RU2018112230A (ru) | 2019-10-30 |
EP3353176A1 (en) | 2018-08-01 |
CN107922412A (zh) | 2018-04-17 |
AU2016328437A1 (en) | 2018-01-25 |
JP2018528245A (ja) | 2018-09-27 |
MX2018001890A (es) | 2018-06-20 |
EP3353176B1 (en) | 2022-01-19 |
CO2018000631A2 (es) | 2018-04-19 |
HK1251876A1 (zh) | 2019-04-26 |
MA42919A (fr) | 2018-08-01 |
ZA201801032B (en) | 2018-12-19 |
PE20180451A1 (es) | 2018-03-05 |
US10800786B2 (en) | 2020-10-13 |
JP6876685B2 (ja) | 2021-05-26 |
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