CL2013003344A1 - Compuestos derivados de piridin-2(1h)-ona sustituidos, inhibidores de quinasas jak; composicion farmaceutica que los comprende; combinacion farmaceutica; utiles en el tratamiento de enfermedades mieloproliferatavas, leucemia, rechazo de trasplantes, enfermedades mediadas por el sistema inmune, entre otras. - Google Patents
Compuestos derivados de piridin-2(1h)-ona sustituidos, inhibidores de quinasas jak; composicion farmaceutica que los comprende; combinacion farmaceutica; utiles en el tratamiento de enfermedades mieloproliferatavas, leucemia, rechazo de trasplantes, enfermedades mediadas por el sistema inmune, entre otras.Info
- Publication number
- CL2013003344A1 CL2013003344A1 CL2013003344A CL2013003344A CL2013003344A1 CL 2013003344 A1 CL2013003344 A1 CL 2013003344A1 CL 2013003344 A CL2013003344 A CL 2013003344A CL 2013003344 A CL2013003344 A CL 2013003344A CL 2013003344 A1 CL2013003344 A1 CL 2013003344A1
- Authority
- CL
- Chile
- Prior art keywords
- diseases
- myeloproliferatavas
- pyridin
- leukemia
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11382170A EP2527344A1 (en) | 2011-05-25 | 2011-05-25 | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
US201161511636P | 2011-07-26 | 2011-07-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2013003344A1 true CL2013003344A1 (es) | 2014-05-30 |
Family
ID=44736146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2013003344A CL2013003344A1 (es) | 2011-05-25 | 2013-11-21 | Compuestos derivados de piridin-2(1h)-ona sustituidos, inhibidores de quinasas jak; composicion farmaceutica que los comprende; combinacion farmaceutica; utiles en el tratamiento de enfermedades mieloproliferatavas, leucemia, rechazo de trasplantes, enfermedades mediadas por el sistema inmune, entre otras. |
Country Status (20)
Country | Link |
---|---|
US (1) | US20140170110A1 (es) |
EP (2) | EP2527344A1 (es) |
JP (1) | JP2014515362A (es) |
KR (1) | KR20140027318A (es) |
CN (1) | CN103649085A (es) |
AR (1) | AR086546A1 (es) |
AU (1) | AU2012260979A1 (es) |
BR (1) | BR112013029862A2 (es) |
CA (1) | CA2833203A1 (es) |
CL (1) | CL2013003344A1 (es) |
CO (1) | CO6821946A2 (es) |
CR (1) | CR20130617A (es) |
EA (1) | EA201301319A1 (es) |
GT (1) | GT201300291A (es) |
IL (1) | IL229193A0 (es) |
PE (1) | PE20141010A1 (es) |
SG (1) | SG194903A1 (es) |
UY (1) | UY34092A (es) |
WO (1) | WO2012160030A1 (es) |
ZA (1) | ZA201307547B (es) |
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BR112012018865A2 (pt) | 2010-01-29 | 2016-04-12 | Boehringer Ingelheim Int | naftiridinas substituídas e seu uso como inibidores de quinase syk |
UY33213A (es) | 2010-02-18 | 2011-09-30 | Almirall Sa | Derivados de pirazol como inhibidores de jak |
EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
CN103827090B (zh) | 2011-07-26 | 2016-04-20 | 勃林格殷格翰国际有限公司 | 取代的喹啉及其作为药物的用途 |
EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
WO2013170671A1 (zh) * | 2012-05-14 | 2013-11-21 | 华东理工大学 | 蝶啶酮衍生物及其作为egfr、blk、flt3抑制剂的应用 |
WO2014146246A1 (en) * | 2013-03-19 | 2014-09-25 | Merck Sharp & Dohme Corp. | Cycloalkyl nitrile pyrazolo pyridones as janus kinase inhibitors |
GB201321737D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
US10273237B2 (en) * | 2013-12-10 | 2019-04-30 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN-α responses |
EP3124487A1 (en) * | 2014-03-24 | 2017-02-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
EA032315B1 (ru) | 2015-03-18 | 2019-05-31 | Бристол-Маерс Сквибб Компани | Замещенные трициклические гетероциклические соединения |
BR112017019605A2 (pt) | 2015-03-18 | 2018-05-08 | Bristol-Myers Squibb Company | compostos heterocíclicos úteis como inibidores de tnf |
AU2016233289A1 (en) | 2015-03-18 | 2017-11-09 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds useful as inhibitors of TNF |
EP3303348B1 (en) * | 2015-05-28 | 2019-08-07 | Theravance Biopharma R&D IP, LLC | Naphthyridine compounds as jak kinase inhibitors |
EP3118621A1 (en) * | 2015-07-14 | 2017-01-18 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Methods and compositions for the diagnosis and for the treatment of adrenoleukodystrophy |
EA201890421A1 (ru) | 2015-08-03 | 2018-07-31 | Бристол-Маерс Сквибб Компани | Циклические соединения, пригодные в качестве модуляторов tnf-альфа |
CN107365312B (zh) * | 2016-05-13 | 2021-10-01 | 瑞博(杭州)医药科技有限公司 | 一种制备Oclacitinib的新方法 |
JP6883653B2 (ja) | 2016-12-20 | 2021-06-09 | アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag | アミノ−トリアゾロピリジン化合物および癌の治療におけるその使用 |
JP7009504B2 (ja) * | 2017-01-11 | 2022-01-25 | レオ ファーマ アクティーゼルスカブ | ヤヌスキナーゼ阻害剤としての新規アミノイミダゾピリジン誘導体及びそれらの医薬としての使用 |
CN107089929A (zh) * | 2017-06-22 | 2017-08-25 | 广西科技大学 | 反式‑(4‑氰甲基)环己基氨基甲酸叔丁酯的制备方法 |
TWI820146B (zh) | 2018-06-15 | 2023-11-01 | 瑞典商阿斯特捷利康公司 | 嘌呤酮化合物及其在治療癌症中之用途 |
US20210269447A1 (en) * | 2018-07-06 | 2021-09-02 | Leo Pharma A/S | Novel amino-imidazopyrimidine derivatives as janus kinase inhibitors and pharmaceutical use thereof |
CN113613640A (zh) * | 2018-09-08 | 2021-11-05 | 谭文 | 肾上腺素能β2受体激动剂R-对映体在治疗炎症性肠病及其肠外疾病的新应用 |
MX2022006439A (es) | 2019-12-19 | 2022-07-19 | Active Biotech Ab | Compuestos para el tratamiento de enfermedades oculares asociadas con la vascularizacion excesiva. |
CN113121538B (zh) * | 2019-12-31 | 2023-04-21 | 成都百裕制药股份有限公司 | 呋喃衍生物及其在医药上的应用 |
CN113493471B (zh) * | 2020-04-03 | 2024-06-11 | 山东轩竹医药科技有限公司 | 杂芳环类激酶抑制剂 |
KR20230004697A (ko) * | 2020-04-17 | 2023-01-06 | 청두 바이위 파머수티컬 씨오., 엘티디 | 이미다졸리디논 유도체 및 그 의학적 용도 |
US20240051957A1 (en) * | 2021-03-16 | 2024-02-15 | Hk Inno.N Corporation | Crystalline form of heterocyclic compound as protein kinase inhibitor |
JP2024511349A (ja) * | 2021-03-16 | 2024-03-13 | エイチケー イノ.エヌ コーポレーション | タンパク質キナーゼ阻害剤としてのヘテロ環化合物の新規塩およびこれらの用途 |
WO2022199547A1 (zh) * | 2021-03-22 | 2022-09-29 | 成都赜灵生物医药科技有限公司 | 一种7,9-二氢嘌呤衍生物及其制药用途 |
WO2023025160A1 (zh) * | 2021-08-23 | 2023-03-02 | 成都百裕制药股份有限公司 | 一种咪唑啉酮衍生物的制备工艺及其中间体 |
WO2024017220A1 (zh) * | 2022-07-20 | 2024-01-25 | 成都百裕制药股份有限公司 | 咪唑啉酮衍生物联合多柔比星在治疗肿瘤中的应用 |
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GB9015522D0 (en) | 1990-07-13 | 1990-08-29 | Braithwaite Philip W | Inhaler |
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DE4027391A1 (de) | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
DE69132850T2 (de) | 1990-09-26 | 2002-05-29 | Pharmachemie Bv | Wirbelkammer-Pulverinhalator |
GB9026025D0 (en) | 1990-11-29 | 1991-01-16 | Boehringer Ingelheim Kg | Inhalation device |
AU650953B2 (en) | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
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-
2011
- 2011-05-25 EP EP11382170A patent/EP2527344A1/en not_active Withdrawn
-
2012
- 2012-05-21 BR BR112013029862A patent/BR112013029862A2/pt not_active IP Right Cessation
- 2012-05-21 EP EP12722152.1A patent/EP2714686A1/en not_active Withdrawn
- 2012-05-21 KR KR1020137031136A patent/KR20140027318A/ko not_active Application Discontinuation
- 2012-05-21 CA CA2833203A patent/CA2833203A1/en not_active Abandoned
- 2012-05-21 JP JP2014511833A patent/JP2014515362A/ja active Pending
- 2012-05-21 CN CN201280031591.8A patent/CN103649085A/zh active Pending
- 2012-05-21 US US14/119,920 patent/US20140170110A1/en not_active Abandoned
- 2012-05-21 SG SG2013083506A patent/SG194903A1/en unknown
- 2012-05-21 WO PCT/EP2012/059394 patent/WO2012160030A1/en active Application Filing
- 2012-05-21 PE PE2013002502A patent/PE20141010A1/es not_active Application Discontinuation
- 2012-05-21 EA EA201301319A patent/EA201301319A1/ru unknown
- 2012-05-21 AU AU2012260979A patent/AU2012260979A1/en not_active Abandoned
- 2012-05-23 UY UY0001034092A patent/UY34092A/es unknown
- 2012-05-24 AR ARP120101834A patent/AR086546A1/es unknown
-
2013
- 2013-10-10 ZA ZA2013/07547A patent/ZA201307547B/en unknown
- 2013-10-31 IL IL229193A patent/IL229193A0/en unknown
- 2013-11-15 CO CO13269468A patent/CO6821946A2/es active IP Right Grant
- 2013-11-21 CL CL2013003344A patent/CL2013003344A1/es unknown
- 2013-11-22 CR CR20130617A patent/CR20130617A/es unknown
- 2013-11-22 GT GT201300291A patent/GT201300291A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ZA201307547B (en) | 2014-07-30 |
EP2527344A1 (en) | 2012-11-28 |
UY34092A (es) | 2013-01-03 |
CR20130617A (es) | 2014-03-04 |
KR20140027318A (ko) | 2014-03-06 |
EA201301319A1 (ru) | 2014-04-30 |
JP2014515362A (ja) | 2014-06-30 |
SG194903A1 (en) | 2013-12-30 |
WO2012160030A1 (en) | 2012-11-29 |
CO6821946A2 (es) | 2013-12-31 |
AR086546A1 (es) | 2014-01-08 |
IL229193A0 (en) | 2013-12-31 |
PE20141010A1 (es) | 2014-08-17 |
EP2714686A1 (en) | 2014-04-09 |
BR112013029862A2 (pt) | 2016-12-20 |
CN103649085A (zh) | 2014-03-19 |
US20140170110A1 (en) | 2014-06-19 |
AU2012260979A1 (en) | 2013-12-12 |
CA2833203A1 (en) | 2012-11-29 |
GT201300291A (es) | 2014-11-13 |
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