AR098398A1 - Proceso para fluorar compuestos - Google Patents
Proceso para fluorar compuestosInfo
- Publication number
- AR098398A1 AR098398A1 ARP140104259A ARP140104259A AR098398A1 AR 098398 A1 AR098398 A1 AR 098398A1 AR P140104259 A ARP140104259 A AR P140104259A AR P140104259 A ARP140104259 A AR P140104259A AR 098398 A1 AR098398 A1 AR 098398A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- unsubstituted
- substrate
- fluorinated
- so2r3
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/127—Preparation from compounds containing pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Se describen métodos de preparación de un sustrato fluorado mediante la combinación de fluoruro de potasio, una sal de amonio cuaternario y un sustrato sustituido con al menos un grupo de cloro, bromo, sulfonilo o nitro, para proveer de ese modo el sustrato fluorado. Reivindicación 1: Un método de preparación de un sustrato fluorado que comprende: combinar fluoruro de potasio, una o más sales de amonio cuaternario y un sustrato sustituido con al menos un grupo de cloro, bromo, sulfonilo o nitro, para proveer de ese modo el sustrato fluorado. Reivindicación 2: El método de la reivindicación 1, donde la sal de amonio cuaternario comprende un catión de tetraalquilamonio de fórmula ⁺N(R²⁰)(R²¹)(R²²)(R²³), donde R²⁰ - R²³ son, independientes entre sí, alquilos C₁₋₄₀ sustituidos o no sustituidos, alquenilos C₂₋₄₀ sustituidos o no sustituidos, alquinilos C₂₋₄₀ sustituidos o no sustituidos, cicloalquilos C₃₋₈ sustituidos o no sustituidos, o cicloalquenilos C₃₋₈ sustituidos o no sustituidos. Reivindicación 18: El método de la reivindicación 1, donde el sustrato tiene la fórmula (1) ó (2) donde A es Cl, Br, SO₂R³ o NO₂; B es H, Cl, Br, SO₂R³ o NO₂; C es H, Cl, Br, SO₂R³ o NO₂; R¹ es H, CN o CO₂R³, donde cada R³ es, independiente de cualquier otro, alquilo C₁₋₁₂, alquenilo C₂₋₁₂, alquinilo C₂₋₁₂, heterocicloalquilo, heteroarilo, cicloalquilo o arilo opcionalmente sustituidos; y R² es H, arilo sustituido o no sustituido, o heteroarilo sustituido o no sustituido; y donde el producto fluorado tiene la fórmula (3) ó (4) donde D es B o F; y G es B o F.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361902989P | 2013-11-12 | 2013-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR098398A1 true AR098398A1 (es) | 2016-05-26 |
Family
ID=51999557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140104259A AR098398A1 (es) | 2013-11-12 | 2014-11-12 | Proceso para fluorar compuestos |
Country Status (14)
Country | Link |
---|---|
US (1) | US9493415B2 (es) |
EP (1) | EP3068764B1 (es) |
JP (1) | JP6563391B2 (es) |
CN (1) | CN105899488B (es) |
AR (1) | AR098398A1 (es) |
BR (1) | BR102014028162A2 (es) |
CA (1) | CA2929940A1 (es) |
ES (1) | ES2720234T3 (es) |
HU (1) | HUE043300T2 (es) |
IL (1) | IL245542B (es) |
PL (1) | PL3068764T3 (es) |
TW (1) | TW201609652A (es) |
UY (1) | UY35831A (es) |
WO (1) | WO2015073525A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR102014028164A2 (pt) * | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | processo para fluoração de compostos |
TW201609651A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程(一) |
TWI726900B (zh) | 2015-08-04 | 2021-05-11 | 美商陶氏農業科學公司 | 用於氟化化合物之過程 |
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CA1292746C (en) | 1983-12-23 | 1991-12-03 | Charles A. Wilson | Preparation of difluoropyridine compounds |
GB8504268D0 (en) * | 1985-02-19 | 1985-03-20 | Shell Int Research | Preparation of fluorinated pyridines |
DE3827436A1 (de) * | 1988-08-12 | 1990-02-15 | Bayer Ag | Verfahren zum einfuehren von fluoratomen an aromatische kerne durch nucleophilen austausch |
JP2501723B2 (ja) * | 1991-07-17 | 1996-05-29 | ヘキスト・アクチェンゲゼルシャフト | クロロフルオロニトロベンゼンの製造方法 |
CA2232728C (en) * | 1995-09-22 | 2003-11-04 | Wakunaga Pharmaceutical Co., Ltd. | Novel pyridonecarboxylic acid derivatives or their salts, and antibacterial agents containing the same as their effective components |
DE19817264A1 (de) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue Dihydropyrimidine |
CN100545133C (zh) | 2001-05-17 | 2009-09-30 | 罗狄亚化学公司 | 离子性质的组合物作为取代试剂的用途,由氟化试剂构成的组合物及其使用方法 |
CN1357530A (zh) * | 2001-07-23 | 2002-07-10 | 昆山双鹤药业有限责任公司 | 用邻氯硝基苯制备2,3,4-三氟硝基苯的生产工艺 |
KR100441153B1 (ko) | 2002-03-14 | 2004-07-21 | 주식회사 씨트리 | 유기 불소화합물의 제조방법 |
DE10227223A1 (de) | 2002-06-18 | 2004-01-08 | Kühlein, Klaus, Prof.Dr. | Verfahren zur Herstellung substituierter organischer Verbindungen und Verwendung von Katalysatoren für Substitutionsreaktionen |
KR20050084010A (ko) | 2002-11-28 | 2005-08-26 | 아스트라제네카 아베 | 항균제로서의 옥사졸리디논 |
WO2005063661A1 (ja) | 2003-12-25 | 2005-07-14 | Sumitomo Chemical Company, Limited | フッ素化剤およびそれを用いる含フッ素化合物の製造方法 |
DE102004033525A1 (de) | 2004-07-08 | 2006-02-02 | Lanxess Deutschland Gmbh | Verbessertes Verfahren zur Herstellung kernfluorierter Aromaten |
US7592486B2 (en) | 2004-09-16 | 2009-09-22 | Board Of Regents Of The University Of Nebraska | Anhydrous fluoride salts and reagents and methods for their production |
EA200701073A1 (ru) | 2004-11-17 | 2007-12-28 | Минрад Инк. | Способ получения севофлурана |
CN100344605C (zh) * | 2006-06-30 | 2007-10-24 | 上海万溯化学有限公司 | 一种3-氟-5-硝基三氟甲苯的制备方法 |
AR068509A1 (es) * | 2007-09-19 | 2009-11-18 | Jerini Ag | Antagosnistas del receptor de bradiquinina b1 |
CN101591211B (zh) * | 2008-05-30 | 2012-10-03 | 南京理工大学 | 微波卤素交换氟化制备氟代化合物的方法 |
CN101519373B (zh) * | 2008-12-30 | 2011-10-05 | 凯莱英医药化学(天津)有限公司 | 一种2,6-二氟吡啶的合成方法 |
CN101602712B (zh) * | 2009-07-21 | 2011-04-06 | 南京第一农药集团有限公司 | 一种合成2-氟-3-氯-5-三氟甲基吡啶的方法 |
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CN102531962A (zh) * | 2010-12-30 | 2012-07-04 | 上海恩氟佳科技有限公司 | 2-氟-5-氯苯腈的制备方法 |
TWI592401B (zh) | 2011-01-25 | 2017-07-21 | 陶氏農業科學公司 | 用於製備4-胺基-3-氯-5-氟-6-(經取代的)吡啶甲酸酯的方法(一) |
TWI529163B (zh) | 2011-01-25 | 2016-04-11 | 陶氏農業科學公司 | 用於製備4-胺基-5-氟-3-鹵素-6-(經取代之)吡啶甲酸酯的方法 |
TWI537252B (zh) | 2011-01-25 | 2016-06-11 | 陶氏農業科學公司 | 用於製備4-胺基-5-氟-3-鹵素-6-(經取代之)吡啶甲酸酯的方法(一) |
TWI520943B (zh) | 2011-01-25 | 2016-02-11 | 陶氏農業科學公司 | 用於製備4-胺基-3-氯-5-氟-6-(經取代的)吡啶甲酸酯的方法(二) |
FR2975990B1 (fr) | 2011-06-01 | 2013-05-24 | Rhodia Operations | Procede de preparation d'un compose organique fluore |
CN102617360B (zh) * | 2012-03-01 | 2013-11-06 | 江西吉翔医药化工有限公司 | 3,5-二氯-2,4-二氟苯胺的合成方法 |
AR091856A1 (es) | 2012-07-24 | 2015-03-04 | Dow Agrosciences Llc | Proceso para la preparacion de 4-amino-5-fluor-3-halo-6-(substituido) picolinatos |
AR092355A1 (es) | 2012-07-24 | 2015-04-15 | Dow Agrosciences Llc | Fluoruros de fluoropicolinoilo y procesos para su preparacion |
CN103012279B (zh) * | 2012-11-27 | 2015-01-28 | 浙江工业大学 | 一种4,5,6-三氟嘧啶化合物的制备方法 |
WO2014093580A1 (en) | 2012-12-13 | 2014-06-19 | Dow Agrosciences Llc | Process for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates |
CN104994733B (zh) | 2012-12-13 | 2017-03-15 | 美国陶氏益农公司 | 制备4‑氨基‑5‑氟‑3‑氯‑6‑(取代的)吡啶甲酸酯的方法 |
EP2931044B1 (en) | 2012-12-13 | 2017-07-05 | Dow AgroSciences LLC | Processes for the preparation of 4-amino-3-halo-6- (substituted)picolinates and 4-amino-5-fluoro-3-halo-6- (substituted)picolinates |
BR102014028164A2 (pt) | 2013-11-12 | 2015-09-08 | Dow Agrosciences Llc | processo para fluoração de compostos |
TW201609651A (zh) | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程(一) |
-
2014
- 2014-11-11 BR BR102014028162A patent/BR102014028162A2/pt not_active Application Discontinuation
- 2014-11-11 TW TW103139039A patent/TW201609652A/zh unknown
- 2014-11-12 JP JP2016529877A patent/JP6563391B2/ja not_active Expired - Fee Related
- 2014-11-12 CA CA2929940A patent/CA2929940A1/en not_active Abandoned
- 2014-11-12 EP EP14805449.7A patent/EP3068764B1/en not_active Not-in-force
- 2014-11-12 HU HUE14805449A patent/HUE043300T2/hu unknown
- 2014-11-12 UY UY0001035831A patent/UY35831A/es not_active Application Discontinuation
- 2014-11-12 CN CN201480061492.3A patent/CN105899488B/zh not_active Expired - Fee Related
- 2014-11-12 ES ES14805449T patent/ES2720234T3/es active Active
- 2014-11-12 WO PCT/US2014/065199 patent/WO2015073525A1/en active Application Filing
- 2014-11-12 PL PL14805449T patent/PL3068764T3/pl unknown
- 2014-11-12 AR ARP140104259A patent/AR098398A1/es unknown
- 2014-11-12 US US14/539,696 patent/US9493415B2/en not_active Expired - Fee Related
-
2016
- 2016-05-08 IL IL245542A patent/IL245542B/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL245542A0 (en) | 2016-06-30 |
EP3068764B1 (en) | 2019-02-20 |
BR102014028162A2 (pt) | 2015-09-08 |
WO2015073525A1 (en) | 2015-05-21 |
US9493415B2 (en) | 2016-11-15 |
IL245542B (en) | 2019-01-31 |
UY35831A (es) | 2015-06-30 |
ES2720234T3 (es) | 2019-07-18 |
PL3068764T3 (pl) | 2019-08-30 |
CN105899488A (zh) | 2016-08-24 |
CN105899488B (zh) | 2019-09-03 |
CA2929940A1 (en) | 2015-05-21 |
JP6563391B2 (ja) | 2019-08-21 |
TW201609652A (zh) | 2016-03-16 |
US20150141654A1 (en) | 2015-05-21 |
EP3068764A1 (en) | 2016-09-21 |
HUE043300T2 (hu) | 2019-08-28 |
JP2016538278A (ja) | 2016-12-08 |
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