CN102617360B - 3,5-二氯-2,4-二氟苯胺的合成方法 - Google Patents
3,5-二氯-2,4-二氟苯胺的合成方法 Download PDFInfo
- Publication number
- CN102617360B CN102617360B CN 201210050792 CN201210050792A CN102617360B CN 102617360 B CN102617360 B CN 102617360B CN 201210050792 CN201210050792 CN 201210050792 CN 201210050792 A CN201210050792 A CN 201210050792A CN 102617360 B CN102617360 B CN 102617360B
- Authority
- CN
- China
- Prior art keywords
- chloro
- difluoroaniline
- dichloro
- raw material
- synthetic method
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000010189 synthetic method Methods 0.000 title claims abstract description 10
- KLECNQGLBJHVSH-UHFFFAOYSA-N 3,5-dichloro-2,4-difluoroaniline Chemical compound NC1=CC(Cl)=C(F)C(Cl)=C1F KLECNQGLBJHVSH-UHFFFAOYSA-N 0.000 title abstract 5
- 238000004821 distillation Methods 0.000 claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 15
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims abstract description 12
- KQOOFMWRLDRDAX-UHFFFAOYSA-N 2-chloro-4-fluoro-1-nitrobenzene Chemical class [O-][N+](=O)C1=CC=C(F)C=C1Cl KQOOFMWRLDRDAX-UHFFFAOYSA-N 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 18
- NJZSQTMICFLABM-UHFFFAOYSA-N 2-chloro-1-fluoro-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC(F)=C1Cl NJZSQTMICFLABM-UHFFFAOYSA-N 0.000 claims description 17
- -1 chloro-2,4 difluorobenzene amine Chemical class 0.000 claims description 15
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000005660 chlorination reaction Methods 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 7
- 230000009467 reduction Effects 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 4
- 238000004334 fluoridation Methods 0.000 claims description 4
- HXJUTPCZVOIRIF-UHFFFAOYSA-N sulfolane Chemical group O=S1(=O)CCCC1 HXJUTPCZVOIRIF-UHFFFAOYSA-N 0.000 claims description 4
- 239000003444 phase transfer catalyst Substances 0.000 claims description 3
- 229920000137 polyphosphoric acid Polymers 0.000 claims description 3
- AVQQQNCBBIEMEU-UHFFFAOYSA-N 1,1,3,3-tetramethylurea Chemical compound CN(C)C(=O)N(C)C AVQQQNCBBIEMEU-UHFFFAOYSA-N 0.000 claims description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
- 239000008118 PEG 6000 Substances 0.000 claims description 2
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 2
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 2
- 239000003880 polar aprotic solvent Substances 0.000 claims description 2
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract description 16
- 239000000047 product Substances 0.000 abstract description 9
- 239000011698 potassium fluoride Substances 0.000 abstract description 4
- 235000003270 potassium fluoride Nutrition 0.000 abstract description 4
- 239000006227 byproduct Substances 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- OWALCRQILZGQDH-UHFFFAOYSA-N 1,3-dichloro-2,4-difluoro-5-nitrobenzene Chemical compound [O-][N+](=O)C1=CC(Cl)=C(F)C(Cl)=C1F OWALCRQILZGQDH-UHFFFAOYSA-N 0.000 abstract 2
- JSEVUBOYVADSHX-UHFFFAOYSA-N 1,3-dichloro-2-fluoro-4-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C(F)=C1Cl JSEVUBOYVADSHX-UHFFFAOYSA-N 0.000 abstract 1
- JORVCRLRRRRLFI-UHFFFAOYSA-N 1,3-dichloro-2-fluorobenzene Chemical compound FC1=C(Cl)C=CC=C1Cl JORVCRLRRRRLFI-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 238000007796 conventional method Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 8
- 239000000460 chlorine Substances 0.000 description 8
- 229910052801 chlorine Inorganic materials 0.000 description 8
- UTMYBNIUMQLFSK-UHFFFAOYSA-N 1,5-dichloro-2-fluoro-3-nitrobenzene Chemical compound [O-][N+](=O)C1=CC(Cl)=CC(Cl)=C1F UTMYBNIUMQLFSK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000006722 reduction reaction Methods 0.000 description 6
- 0 CC(*F)=C(*)C(*)O Chemical compound CC(*F)=C(*)C(*)O 0.000 description 5
- 238000010792 warming Methods 0.000 description 5
- 239000002699 waste material Substances 0.000 description 5
- PBKONEOXTCPAFI-UHFFFAOYSA-N 1,2,4-trichlorobenzene Chemical compound ClC1=CC=C(Cl)C(Cl)=C1 PBKONEOXTCPAFI-UHFFFAOYSA-N 0.000 description 3
- 241000238631 Hexapoda Species 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 239000005938 Teflubenzuron Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CJDWRQLODFKPEL-UHFFFAOYSA-N teflubenzuron Chemical compound FC1=CC=CC(F)=C1C(=O)NC(=O)NC1=CC(Cl)=C(F)C(Cl)=C1F CJDWRQLODFKPEL-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- GBDZXPJXOMHESU-UHFFFAOYSA-N 1,2,3,4-tetrachlorobenzene Chemical compound ClC1=CC=C(Cl)C(Cl)=C1Cl GBDZXPJXOMHESU-UHFFFAOYSA-N 0.000 description 2
- QUIMTLZDMCNYGY-UHFFFAOYSA-N 2,4-dichloro-1-nitrobenzene Chemical compound [O-][N+](=O)C1=CC=C(Cl)C=C1Cl QUIMTLZDMCNYGY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- HRYILSDLIGTCOP-UHFFFAOYSA-N N-benzoylurea Chemical class NC(=O)NC(=O)C1=CC=CC=C1 HRYILSDLIGTCOP-UHFFFAOYSA-N 0.000 description 2
- OJGOGIGPIAKXKF-UHFFFAOYSA-N N-chloro-2,4-difluoroaniline Chemical compound ClNC1=C(C=C(C=C1)F)F OJGOGIGPIAKXKF-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- ZPQOPVIELGIULI-UHFFFAOYSA-N 1,3-dichlorobenzene Chemical compound ClC1=CC=CC(Cl)=C1 ZPQOPVIELGIULI-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000008359 benzonitriles Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000003842 bromide salts Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000006356 dehydrogenation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- XTHPWXDJESJLNJ-UHFFFAOYSA-N sulfurochloridic acid Chemical class OS(Cl)(=O)=O XTHPWXDJESJLNJ-UHFFFAOYSA-N 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000009901 transfer hydrogenation reaction Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210050792 CN102617360B (zh) | 2012-03-01 | 2012-03-01 | 3,5-二氯-2,4-二氟苯胺的合成方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201210050792 CN102617360B (zh) | 2012-03-01 | 2012-03-01 | 3,5-二氯-2,4-二氟苯胺的合成方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102617360A CN102617360A (zh) | 2012-08-01 |
CN102617360B true CN102617360B (zh) | 2013-11-06 |
Family
ID=46557628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201210050792 Active CN102617360B (zh) | 2012-03-01 | 2012-03-01 | 3,5-二氯-2,4-二氟苯胺的合成方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102617360B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102911080B (zh) * | 2012-09-12 | 2015-01-21 | 衢州学院 | 一种制备2,6-二氯-α-(4-氯苯基)-4-硝基苯乙腈的方法 |
TW201609652A (zh) * | 2013-11-12 | 2016-03-16 | 陶氏農業科學公司 | 用於氟化化合物之過程(三) |
CN105801429B (zh) * | 2014-12-31 | 2019-09-24 | 安徽新北卡化学有限公司 | 一种3,5-二氯-2,4-二氟苯胺的制备方法 |
CN109369414B (zh) * | 2018-11-15 | 2020-04-10 | 江苏中旗科技股份有限公司 | 一种制备伏虫隆中间体3,5-二氯-2,4-二氟苯胺的方法 |
CN110498730B (zh) * | 2019-08-13 | 2021-12-03 | 浙江吉泰新材料股份有限公司 | 一种1,2,4-三氟苯的合成方法 |
CN110642720B (zh) * | 2019-10-12 | 2022-09-27 | 浙江吉泰新材料股份有限公司 | 一种2,4-二氟-3,5-二氯硝基苯的制备方法 |
CN114920661B (zh) * | 2022-04-29 | 2024-01-02 | 浙江沙星科技股份有限公司 | 一种2-氟-3-氨基苯甲酸的合成方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0052833B1 (de) * | 1980-11-22 | 1983-12-14 | CELAMERCK GmbH & Co. KG | Harnstoffderivate, ihre Herstellung und Verwendung |
ES2059184T3 (es) * | 1991-10-11 | 1994-11-01 | Hoechst Ag | Procedimiento para la preparacion de 2,4-diclorofluorobenceno. |
CN1267402C (zh) * | 2005-03-11 | 2006-08-02 | 浙江工业大学 | 3,5-二氯-2,4-二氟硝基苯和伏虫隆的合成方法 |
CN101177379A (zh) * | 2006-11-10 | 2008-05-14 | 浙江富盛控股集团有限公司 | 一种2,4,6-三氯氟苯的制备方法 |
-
2012
- 2012-03-01 CN CN 201210050792 patent/CN102617360B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN102617360A (zh) | 2012-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102617360B (zh) | 3,5-二氯-2,4-二氟苯胺的合成方法 | |
CN105801429B (zh) | 一种3,5-二氯-2,4-二氟苯胺的制备方法 | |
CN101302190B (zh) | 一种制备2,3-二氯吡啶的方法 | |
EP0562435B1 (de) | Verfahren zur Herstellung von 3,5-Difluoranilin | |
CN103172571A (zh) | 一种驱虫药阿苯达唑的制备新方法 | |
CN103130657B (zh) | 一种2-氯-4-氨基苯酚的合成方法 | |
CN101613286A (zh) | 硝基苯氯化物的分离及综合利用方法 | |
CN106748801A (zh) | 一种3,5‑二氯苯胺的合成方法 | |
CN106866426B (zh) | 一种生产3,4,5-三氯三氟甲苯的副产物2,4,5-三氯三氟甲苯的综合利用方法 | |
CN101353328A (zh) | 2-氯-4-氨基-6,7-二甲氧基喹唑啉的制备方法 | |
CN105037172B (zh) | 一种2‑(4’‑氯苯基)苯胺的制备方法 | |
CN100427458C (zh) | 除草剂中间体3-氯-2-甲基苯胺的生产工艺 | |
CN103709071B (zh) | 3,4-二氟苯腈的制备方法 | |
CN102898358A (zh) | 含氟吡啶类化合物的制备方法 | |
CN102491901B (zh) | 4-溴-2-硝基三氟甲苯的制备方法 | |
CN103910639A (zh) | 一种制备2,6-二氯-4-三氟甲基苯胺的方法 | |
CN103508901A (zh) | 一种合成3,5-二氯苯胺的方法 | |
CN101265224A (zh) | 一种制备4-三氟甲硫基苯胺的方法 | |
CN109721496A (zh) | 一种3-硝基邻二甲苯的合成方法 | |
CN107915659B (zh) | 一种3,4-二氯苯腈的合成方法 | |
CN111004128A (zh) | 一种3,5-二氯苯胺的生产工艺 | |
JP5027572B2 (ja) | 3,4’−ジアミノジフェニルエーテルの製造方法 | |
CN105315127B (zh) | 一种4‑叔丁基溴苄的制备方法 | |
EP0460639A1 (en) | Process for producing 3,5-difluoroaniline and derivative thereof | |
JPH04178355A (ja) | 3,5―ジフルオロアニリンの製造方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Zheng Tucai Inventor after: Nie Xiaowen Inventor after: Kuang Qinglei Inventor after: Zheng Jianlin Inventor after: Wei Yuan Inventor after: Chen Feng Inventor after: Wang Ji Inventor before: Zheng Shicai Inventor before: Nie Xiaowen Inventor before: Kuang Qinglei Inventor before: Zheng Jianlin Inventor before: Wei Yuan Inventor before: Chen Feng Inventor before: Wang Ji |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHENG SHICAI NIE XIAOWEN KUANG QINGLEI ZHENG JIANLIN WEI YUAN CHEN FENG WANG JI TO: ZHENG TUCAI NIE XIAOWEN KUANG QINGLEI ZHENG JIANLIN WEI YUAN CHEN FENG WANG JI |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Synthesis of 3,5-dichloro-2,4-difluoroaniline Effective date of registration: 20210728 Granted publication date: 20131106 Pledgee: Bank of China Limited Leping sub branch Pledgor: JIANGXI JIXIANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2021980007008 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220413 Granted publication date: 20131106 Pledgee: Bank of China Limited Leping sub branch Pledgor: JIANGXI JIXIANG PHARMACEUTICAL CO.,LTD. Registration number: Y2021980007008 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Synthesis of 3,5-dichloro-2,4-difluoroaniline Effective date of registration: 20220516 Granted publication date: 20131106 Pledgee: Bank of China Limited Leping sub branch Pledgor: JIANGXI JIXIANG PHARMACEUTICAL CO.,LTD. Registration number: Y2022980005710 |
|
PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230710 Granted publication date: 20131106 Pledgee: Bank of China Limited Leping sub branch Pledgor: JIANGXI JIXIANG PHARMACEUTICAL CO.,LTD. Registration number: Y2022980005710 |