AR090371A1 - Forma cristalina - Google Patents

Forma cristalina

Info

Publication number
AR090371A1
AR090371A1 ARP130100880A ARP130100880A AR090371A1 AR 090371 A1 AR090371 A1 AR 090371A1 AR P130100880 A ARP130100880 A AR P130100880A AR P130100880 A ARP130100880 A AR P130100880A AR 090371 A1 AR090371 A1 AR 090371A1
Authority
AR
Argentina
Prior art keywords
crystalline form
carbonylimino
benzenesulfonylamino
pyrazine
diamino
Prior art date
Application number
ARP130100880A
Other languages
English (en)
Inventor
Howsham Catherine
Lindenberg Christian
Perlberg Anett
Tufilli Nicola
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48237169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR090371(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR090371A1 publication Critical patent/AR090371A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente se relaciona con una forma cristalina de la sal de succinato del bloqueador de canales de sodio epitelial (ENaC), el éster dipropilcarbamoilmetilo del ácido 3-(3-{2-[(E)-3,5-diamino-6-cloro-pirazina-2-carbonilimino]-1,3,8-triaza-espiro[4.5]decano-8-carbonil}-bencenosulfonilamino)-propiónico, composiciones farmacéuticas que comprenden dicha forma cristalina, usos de dicha forma cristalina y composiciones farmacéuticas, y métodos para preparar dicha forma cristalina. Reivindicación 1: Una forma cristalina de succinato de éster dipropilcarbamoilmetilo del ácido 3-(3-{2-[(E)-3,5-diamino-6-cloro-pirazina-2-carbonilimino]-1,3,8-triaza-espiro[4.5]decano-8-carbonil}-bencenosulfonilamino)-propiónico de fórmula (1) que comprende la forma C.
ARP130100880A 2012-03-19 2013-03-19 Forma cristalina AR090371A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261612727P 2012-03-19 2012-03-19

Publications (1)

Publication Number Publication Date
AR090371A1 true AR090371A1 (es) 2014-11-05

Family

ID=48237169

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130100880A AR090371A1 (es) 2012-03-19 2013-03-19 Forma cristalina

Country Status (35)

Country Link
US (1) US8809340B2 (es)
EP (1) EP2828261B1 (es)
JP (1) JP6134378B2 (es)
KR (1) KR101686311B1 (es)
CN (1) CN104302648B (es)
AR (1) AR090371A1 (es)
AU (1) AU2013237073B2 (es)
CA (1) CA2865536C (es)
CL (1) CL2014002339A1 (es)
CO (1) CO7071138A2 (es)
CY (1) CY1117410T1 (es)
DK (1) DK2828261T3 (es)
EA (1) EA023716B1 (es)
EC (1) ECSP14023397A (es)
ES (1) ES2565811T3 (es)
GT (1) GT201400200A (es)
HK (1) HK1200454A1 (es)
HR (1) HRP20160420T1 (es)
HU (1) HUE028761T2 (es)
IN (1) IN2014DN07461A (es)
JO (1) JO3184B1 (es)
MA (1) MA37391B1 (es)
MX (1) MX352185B (es)
MY (1) MY165082A (es)
NZ (1) NZ629032A (es)
PE (1) PE20142352A1 (es)
PH (1) PH12014502064A1 (es)
PL (1) PL2828261T3 (es)
SG (1) SG11201405105TA (es)
SI (1) SI2828261T1 (es)
TN (1) TN2014000369A1 (es)
TW (1) TWI608006B (es)
UA (1) UA114904C2 (es)
WO (1) WO2013140319A1 (es)
ZA (1) ZA201406238B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
US9050339B2 (en) 2010-09-17 2015-06-09 Novartis Ag Pyrazine derivatives as ENaC blockers
RU2749213C2 (ru) 2014-10-07 2021-06-07 Вертекс Фармасьютикалз Инкорпорейтед Сокристаллы модуляторов регулятора трансмембранной проводимости при кистозном фиброзе

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CO7071138A2 (es) 2014-09-30
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AU2013237073A1 (en) 2014-09-25
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MA37391A1 (fr) 2016-07-29
KR20140122281A (ko) 2014-10-17
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