AR078863A1 - Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion. - Google Patents

Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion.

Info

Publication number
AR078863A1
AR078863A1 ARP100104035A ARP100104035A AR078863A1 AR 078863 A1 AR078863 A1 AR 078863A1 AR P100104035 A ARP100104035 A AR P100104035A AR P100104035 A ARP100104035 A AR P100104035A AR 078863 A1 AR078863 A1 AR 078863A1
Authority
AR
Argentina
Prior art keywords
ylmethyl
hydrogen
obesity
depression
treatment
Prior art date
Application number
ARP100104035A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR078863A1 publication Critical patent/AR078863A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP100104035A 2009-11-16 2010-11-02 Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion. AR078863A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09382246 2009-11-16
US29862910P 2010-01-27 2010-01-27

Publications (1)

Publication Number Publication Date
AR078863A1 true AR078863A1 (es) 2011-12-07

Family

ID=41728051

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104035A AR078863A1 (es) 2009-11-16 2010-11-02 Derivados de espiropiperidina antagonista de receptores orl-1, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de la migrana, obesidad y/o depresion.

Country Status (34)

Country Link
US (1) US8232289B2 (OSRAM)
EP (1) EP2501703B1 (OSRAM)
JP (1) JP5680101B2 (OSRAM)
KR (1) KR101363830B1 (OSRAM)
CN (1) CN102612520B (OSRAM)
AR (1) AR078863A1 (OSRAM)
AU (1) AU2010319581C1 (OSRAM)
CA (1) CA2796161C (OSRAM)
CO (1) CO6541545A2 (OSRAM)
CR (1) CR20130087A (OSRAM)
DK (1) DK2501703T3 (OSRAM)
DO (1) DOP2012000135A (OSRAM)
EA (1) EA020848B1 (OSRAM)
EC (1) ECSP12011902A (OSRAM)
ES (1) ES2435814T3 (OSRAM)
HN (1) HN2012001011A (OSRAM)
HR (1) HRP20130967T1 (OSRAM)
IL (1) IL219370A (OSRAM)
JO (1) JO2887B1 (OSRAM)
MA (1) MA33751B1 (OSRAM)
ME (1) ME01537B (OSRAM)
MX (1) MX2012005691A (OSRAM)
MY (1) MY160665A (OSRAM)
NZ (1) NZ600006A (OSRAM)
PE (1) PE20121430A1 (OSRAM)
PH (1) PH12012500969A1 (OSRAM)
PL (1) PL2501703T3 (OSRAM)
PT (1) PT2501703E (OSRAM)
RS (1) RS53018B (OSRAM)
SI (1) SI2501703T1 (OSRAM)
TW (1) TWI465453B (OSRAM)
UA (1) UA107943C2 (OSRAM)
WO (1) WO2011060035A1 (OSRAM)
ZA (1) ZA201202967B (OSRAM)

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SG10201401661RA (en) 2009-12-04 2014-07-30 Sunovion Pharmaceuticals Inc Multicycle compounds and pharmaceutical compositions useful for the treatment of neurological disorders
JP2013540145A (ja) * 2010-10-21 2013-10-31 ウニベルシテート デス ザールランデス コルチゾール依存性疾患の治療用の選択的ｃｙｐ１１ｂ１阻害剤
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之４',５'－二氫螺［哌啶－４,７'－噻吩并[２，３－c]哌喃］化合物
TW201416370A (zh) 2012-07-31 2014-05-01 Lilly Co Eli 用於治療焦慮之ｏｒｌ－１受體拮抗劑
NZ739834A (en) 2012-10-02 2018-11-30 Bayer Cropscience Ag Heterocyclic compounds as pesticides
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
JO3638B1 (ar) * 2015-09-09 2020-08-27 Lilly Co Eli مركبات مفيدة في تثبيط ror - جاما- t
CA3032302A1 (en) 2016-07-29 2018-02-01 Taleen G. Hanania Compounds and compositions and uses thereof
CN110087687A (zh) 2016-07-29 2019-08-02 赛诺维信制药公司 化合物、组合物及其用途
JP7146782B2 (ja) 2017-02-16 2022-10-04 サノビオン ファーマシューティカルズ インク 統合失調症を処置する方法
LT3589638T (lt) 2017-03-02 2021-06-10 Eli Lilly And Company Junginiai, naudingi ror-gama-t slopinimui
JP6766274B2 (ja) * 2017-03-02 2020-10-07 イーライ リリー アンド カンパニー Ｒｏｒ−ガンマ−ｔを阻害するのに有用な化合物
CN111183138A (zh) 2017-08-02 2020-05-19 赛诺维信制药公司 异色满化合物以及用途
KR102746817B1 (ko) 2018-02-16 2024-12-24 스미토모 파마 아메리카, 인크. 염, 결정 형태 및 이들의 제조 방법
CA3121910A1 (en) 2018-12-17 2020-06-25 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
AU2021257786A1 (en) 2020-04-14 2022-11-03 Sunovion Pharmaceuticals Inc. (S)-(4,5-dihydro-7H-thieno[2,3-c]pyran-7-yl)-N-methylmethanamine for treating neurological and psychiatric disorders
IL318169A (en) 2020-08-26 2025-03-01 Vertex Pharma Apol1 inhibitors and methods of use are the same
AU2023218994A1 (en) * 2022-02-08 2024-08-22 Vertex Pharmaceuticals Incorporated 2-methyl-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] derivatives as inhibitors of apol1 and methods of using same

Family Cites Families (15)

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IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
JP3989247B2 (ja) * 1999-12-06 2007-10-10 ユーロ−セルティーク エス．エイ． ノシセプチン受容体親和性を有するトリアゾスピロ化合物
NZ528978A (en) * 2001-04-18 2004-06-25 Euro Celtique S Spiropyrazole compounds
WO2002088089A1 (en) 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Spiropiperidine derivatives, nociceptin receptor antagonists containing the same as the active ingredient and medicinal compositions
ATE396995T1 (de) * 2001-07-23 2008-06-15 Banyu Pharma Co Ltd 4-oxoimidazolidin-2-spiro piperidin derivat
JP2005519921A (ja) * 2002-01-28 2005-07-07 ファイザー株式会社 Ｏｒｌ−１受容体リガンドとしてのｎ置換スピロピペリジン化合物
JPWO2003095427A1 (ja) 2002-05-10 2005-09-15 大正製薬株式会社 スピロ環化合物
US6995168B2 (en) * 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
KR20050043935A (ko) * 2002-09-09 2005-05-11 얀센 파마슈티카 엔.브이. Ｏｒｌ-1 수용체 매개 장애의 치료에 유용한 하이드록시 알킬 치환된 1,3,8-트리아자스피로[4.5]데칸-4-온 유도체
WO2005016913A1 (en) * 2003-08-19 2005-02-24 Pfizer Japan, Inc. Tetrahydroisoquinoline or isochroman compounds as orl-1 receptor ligands for the treatment of pain and cns disorders
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
CA2563164A1 (en) * 2004-03-29 2005-10-06 Pfizer Inc. Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as orl1-receptor antagonists
DE102004039382A1 (de) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP2020414A1 (en) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. spiro[piperidine-4,4'-thieno[3,2-c]pyran] derivatives and related compounds as inhibitors of the sigma receptor for the treatment of psychosis
CL2009000731A1 (es) * 2008-03-27 2009-05-15 Gruenenthal Gmbh Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea.

Also Published As

Publication number Publication date
WO2011060035A1 (en) 2011-05-19
JP5680101B2 (ja) 2015-03-04
CN102612520A (zh) 2012-07-25
KR101363830B1 (ko) 2014-02-14
TW201127841A (en) 2011-08-16
MA33751B1 (fr) 2012-11-01
PL2501703T3 (pl) 2014-02-28
IL219370A0 (en) 2012-06-28
CA2796161C (en) 2015-03-17
EA020848B1 (ru) 2015-02-27
PH12012500969A1 (en) 2013-01-07
EP2501703B1 (en) 2013-09-18
RS53018B (sr) 2014-04-30
IL219370A (en) 2015-01-29
DOP2012000135A (es) 2012-08-15
JP2013510859A (ja) 2013-03-28
EP2501703A1 (en) 2012-09-26
NZ600006A (en) 2014-05-30
AU2010319581C1 (en) 2014-05-15
AU2010319581B2 (en) 2013-12-19
MY160665A (en) 2017-03-15
CN102612520B (zh) 2015-04-08
DK2501703T3 (da) 2013-10-14
US8232289B2 (en) 2012-07-31
PE20121430A1 (es) 2012-10-26
HN2012001011A (es) 2015-08-31
ECSP12011902A (es) 2012-07-31
US20110118251A1 (en) 2011-05-19
TWI465453B (zh) 2014-12-21
MX2012005691A (es) 2012-06-13
CR20130087A (es) 2013-04-17
ES2435814T3 (es) 2013-12-23
KR20130026523A (ko) 2013-03-13
AU2010319581A1 (en) 2012-06-07
HK1169988A1 (en) 2013-02-15
CA2796161A1 (en) 2011-05-19
UA107943C2 (xx) 2015-03-10
PT2501703E (pt) 2013-11-26
EA201290352A1 (ru) 2012-10-30
HRP20130967T1 (hr) 2013-11-22
ME01537B (me) 2014-04-20
ZA201202967B (en) 2013-09-25
CO6541545A2 (es) 2012-10-16
SI2501703T1 (sl) 2013-11-29
JO2887B1 (en) 2015-03-15

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