EA201290352A1 - Спиропиперидиновые соединения в качестве антагонистов рецептора orl-1 - Google Patents

Спиропиперидиновые соединения в качестве антагонистов рецептора orl-1

Info

Publication number
EA201290352A1
EA201290352A1 EA201290352A EA201290352A EA201290352A1 EA 201290352 A1 EA201290352 A1 EA 201290352A1 EA 201290352 A EA201290352 A EA 201290352A EA 201290352 A EA201290352 A EA 201290352A EA 201290352 A1 EA201290352 A1 EA 201290352A1
Authority
EA
Eurasian Patent Office
Prior art keywords
orl
antagonists
receptor
spyropyperidine
connections
Prior art date
Application number
EA201290352A
Other languages
English (en)
Other versions
EA020848B1 (ru
Inventor
Ана Белен Бенито Колладо
Нурия Диас Буэсо
Альма Мария Хименес-Агуадо
Селия Лафуэнте Бланко
Мария Анхелес Мартинес-Грау
Консепсьон Педрегал-Терсеро
Мигель Анхель Толедо Эскрибано
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201290352A1 publication Critical patent/EA201290352A1/ru
Publication of EA020848B1 publication Critical patent/EA020848B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предложен антагонист рецептора ORL-1 формулыего применение и способы его получения. Антагонисты ORL-1, как полагают, пригодны для лечения избыточного веса, ожирения и/или поддержания веса после лечения избыточного веса или ожирения. Некоторые соединения также продемонстрировали на животных моделях, что соединения настоящего изробретения полезны для лечения мигрени.
EA201290352A 2009-11-16 2010-11-10 Спиропиперидиновые соединения в качестве антагонистов рецептора orl-1 EA020848B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09382246 2009-11-16
US29862910P 2010-01-27 2010-01-27
PCT/US2010/056180 WO2011060035A1 (en) 2009-11-16 2010-11-10 Spiropiperidine compounds as orl-1 receptor antagonists

Publications (2)

Publication Number Publication Date
EA201290352A1 true EA201290352A1 (ru) 2012-10-30
EA020848B1 EA020848B1 (ru) 2015-02-27

Family

ID=41728051

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290352A EA020848B1 (ru) 2009-11-16 2010-11-10 Спиропиперидиновые соединения в качестве антагонистов рецептора orl-1

Country Status (34)

Country Link
US (1) US8232289B2 (ru)
EP (1) EP2501703B1 (ru)
JP (1) JP5680101B2 (ru)
KR (1) KR101363830B1 (ru)
CN (1) CN102612520B (ru)
AR (1) AR078863A1 (ru)
AU (1) AU2010319581C1 (ru)
CA (1) CA2796161C (ru)
CO (1) CO6541545A2 (ru)
CR (1) CR20130087A (ru)
DK (1) DK2501703T3 (ru)
DO (1) DOP2012000135A (ru)
EA (1) EA020848B1 (ru)
EC (1) ECSP12011902A (ru)
ES (1) ES2435814T3 (ru)
HK (1) HK1169988A1 (ru)
HN (1) HN2012001011A (ru)
HR (1) HRP20130967T1 (ru)
IL (1) IL219370A (ru)
JO (1) JO2887B1 (ru)
MA (1) MA33751B1 (ru)
ME (1) ME01537B (ru)
MX (1) MX2012005691A (ru)
MY (1) MY160665A (ru)
NZ (1) NZ600006A (ru)
PE (1) PE20121430A1 (ru)
PL (1) PL2501703T3 (ru)
PT (1) PT2501703E (ru)
RS (1) RS53018B (ru)
SI (1) SI2501703T1 (ru)
TW (1) TWI465453B (ru)
UA (1) UA107943C2 (ru)
WO (1) WO2011060035A1 (ru)
ZA (1) ZA201202967B (ru)

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EP2630136A1 (en) * 2010-10-21 2013-08-28 Universität des Saarlandes Selective cyp11b1 inhibitors for the treatment of cortisol dependent diseases
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之４',５'－二氫螺［哌啶－４,７'－噻吩并[２，３－c]哌喃］化合物
TW201416370A (zh) 2012-07-31 2014-05-01 Lilly Co Eli 用於治療焦慮之ｏｒｌ－１受體拮抗劑
MX2015004275A (es) 2012-10-02 2015-08-14 Bayer Cropscience Ag Compuestos heterociclicos como plaguicidas.
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
AR105821A1 (es) * 2015-09-09 2017-11-15 Lilly Co Eli COMPUESTOS ÚTILES PARA INHIBIR ROR-g-T
EP3490607A4 (en) 2016-07-29 2020-04-08 Sunovion Pharmaceuticals Inc. COMPOUNDS AND COMPOSITIONS, AND USES THEREOF
MA45857A (fr) 2016-07-29 2021-05-19 Sunovion Pharmaceuticals Inc Composés et compositions, et utilisations associées
CN116808023A (zh) 2017-02-16 2023-09-29 桑诺维恩药品公司 治疗精神分裂症的方法
EP3589637B1 (en) * 2017-03-02 2021-04-14 Eli Lilly and Company Compounds useful for inhibiting ror-gamma-t
PL3589638T3 (pl) 2017-03-02 2021-09-27 Eli Lilly And Company Związki użyteczne do hamowania ror-gamma-t
JP7191085B2 (ja) 2017-08-02 2022-12-16 サノビオン ファーマシューティカルズ インク イソクロマン化合物およびその使用
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EP3938045A1 (en) 2019-03-14 2022-01-19 Sunovion Pharmaceuticals Inc. Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof
IL297248A (en) 2020-04-14 2022-12-01 Sunovion Pharmaceuticals Inc (s)-(5,4-dihydro-7h-thiano[3,2-c]pyran-7-yl)-n-methylmethanamine for the treatment of neurological and psychiatric disorders
CA3190609A1 (en) 2020-08-26 2022-03-03 Vertex Pharmaceuticals Incorporated Inhibitors of apol1 and methods of using same
WO2023154344A1 (en) * 2022-02-08 2023-08-17 Vertex Pharmaceuticals Incorporated 2-methyl-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] derivatives as inhibitors of apol1 and methods of using same

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Also Published As

Publication number Publication date
PL2501703T3 (pl) 2014-02-28
PT2501703E (pt) 2013-11-26
CA2796161A1 (en) 2011-05-19
CR20130087A (es) 2013-04-17
AU2010319581C1 (en) 2014-05-15
EP2501703A1 (en) 2012-09-26
ME01537B (me) 2014-04-20
JO2887B1 (en) 2015-03-15
JP2013510859A (ja) 2013-03-28
CN102612520A (zh) 2012-07-25
CO6541545A2 (es) 2012-10-16
MA33751B1 (fr) 2012-11-01
AU2010319581A1 (en) 2012-06-07
DK2501703T3 (da) 2013-10-14
HN2012001011A (es) 2015-08-31
DOP2012000135A (es) 2012-08-15
AR078863A1 (es) 2011-12-07
HRP20130967T1 (hr) 2013-11-22
ES2435814T3 (es) 2013-12-23
TW201127841A (en) 2011-08-16
CN102612520B (zh) 2015-04-08
HK1169988A1 (en) 2013-02-15
JP5680101B2 (ja) 2015-03-04
EA020848B1 (ru) 2015-02-27
IL219370A (en) 2015-01-29
MX2012005691A (es) 2012-06-13
KR101363830B1 (ko) 2014-02-14
AU2010319581B2 (en) 2013-12-19
US20110118251A1 (en) 2011-05-19
EP2501703B1 (en) 2013-09-18
TWI465453B (zh) 2014-12-21
ZA201202967B (en) 2013-09-25
US8232289B2 (en) 2012-07-31
SI2501703T1 (sl) 2013-11-29
UA107943C2 (en) 2015-03-10
CA2796161C (en) 2015-03-17
WO2011060035A1 (en) 2011-05-19
NZ600006A (en) 2014-05-30
KR20130026523A (ko) 2013-03-13
MY160665A (en) 2017-03-15
RS53018B (en) 2014-04-30
PE20121430A1 (es) 2012-10-26
IL219370A0 (en) 2012-06-28
ECSP12011902A (es) 2012-07-31

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM KZ RU