EA201100409A1 - Замещенные производные триазолопиридазина - Google Patents

Замещенные производные триазолопиридазина

Info

Publication number
EA201100409A1
EA201100409A1 EA201100409A EA201100409A EA201100409A1 EA 201100409 A1 EA201100409 A1 EA 201100409A1 EA 201100409 A EA201100409 A EA 201100409A EA 201100409 A EA201100409 A EA 201100409A EA 201100409 A1 EA201100409 A1 EA 201100409A1
Authority
EA
Eurasian Patent Office
Prior art keywords
present
triazolopiridazin
substituted derivatives
relates
gaba
Prior art date
Application number
EA201100409A
Other languages
English (en)
Other versions
EA020071B1 (ru
Inventor
Скотт Харбесон
Original Assignee
Консерт Фармасьютикалс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Консерт Фармасьютикалс Инк. filed Critical Консерт Фармасьютикалс Инк.
Publication of EA201100409A1 publication Critical patent/EA201100409A1/ru
Publication of EA020071B1 publication Critical patent/EA020071B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds

Abstract

Настоящее изобретение относится к новым замещенным триазолопиридазинам, к их производным и фармацевтически приемлемым солям. Настоящее изобретение также относится к композициям, содержащим соединение, соответствующее настоящему изобретению, и к применению таких композиций в способах лечения заболеваний или патологических состояний, которые эффективно лечить путем введения антагониста рецептора α1-GABA-A и/или агониста рецептора α2, α3 и α5 GABA-A.
EA201100409A 2008-08-29 2009-08-28 Замещенные производные триазолопиридазина EA020071B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9329308P 2008-08-29 2008-08-29
PCT/US2009/055427 WO2010025407A1 (en) 2008-08-29 2009-08-28 Substituted triazolo-pyridazine derivatives

Publications (2)

Publication Number Publication Date
EA201100409A1 true EA201100409A1 (ru) 2011-10-31
EA020071B1 EA020071B1 (ru) 2014-08-29

Family

ID=41721962

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201100409A EA020071B1 (ru) 2008-08-29 2009-08-28 Замещенные производные триазолопиридазина

Country Status (17)

Country Link
US (4) US8003646B2 (ru)
EP (2) EP2716158A1 (ru)
JP (3) JP5183808B2 (ru)
KR (1) KR20110063479A (ru)
CN (2) CN104098578A (ru)
AU (1) AU2009285533B2 (ru)
BR (1) BRPI0912928A2 (ru)
CA (1) CA2735549A1 (ru)
DK (1) DK2328414T3 (ru)
EA (1) EA020071B1 (ru)
ES (1) ES2451542T3 (ru)
HR (1) HRP20140195T1 (ru)
MX (1) MX2011002278A (ru)
PL (1) PL2328414T3 (ru)
PT (1) PT2328414E (ru)
WO (1) WO2010025407A1 (ru)
ZA (1) ZA201102123B (ru)

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PT2328414E (pt) 2008-08-29 2014-03-17 Concert Pharmaceuticals Inc Derivados de triazol-piridazina substituídos
WO2010037194A1 (pt) 2008-10-03 2010-04-08 Instituto Alberto Luiz De Coimbra De Pós Graduação E Pesquisa De Engenharia - Coppe/Ufrj Dispositivo para remoção de fragmentos metálicos e elementos metálicos do interior de canáis radiculares de dentes e processo para remoção dos mesmos
WO2011005520A1 (en) * 2009-06-23 2011-01-13 Concert Pharmaceuticals, Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
AU2012325909B2 (en) 2011-10-20 2016-06-09 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
JP2014530870A (ja) * 2011-10-20 2014-11-20 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
US9107414B2 (en) 2012-01-11 2015-08-18 Bayer Cropscience Ag Tetrazol-5-yl- and triazol-5-yl-aryl compounds and use thereof as herbicides
JP2015516440A (ja) 2012-05-11 2015-06-11 コンサート ファーマシューティカルズ インコーポレイテッド ７−（ｔｅｒｔ−ブチル−ｄ９）−３−（２，５−ジフルオロフェニル）−６−（（１−メチル−１Ｈ−１，２，４−トリアゾール−５−イル）メトキシ）−［１，２，４］トリアゾロ［４，３−ｂ］ピリダジンの２型多形
WO2013170241A1 (en) 2012-05-11 2013-11-14 Concert Pharmaceuticals, Inc. Polymorphs of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6-((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolol[4,3b]pyridazine
WO2013170243A1 (en) 2012-05-11 2013-11-14 Concert Pharmaceuticals, Inc. Form 5 polymorph of 7-(tert-butyl-d9)-3-(2,5-difluorophenyl)-6((1-methyl-1h-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine
WO2015052178A1 (en) 2013-10-10 2015-04-16 Basf Se 1,2,5-oxadiazole compounds and their use as herbicides
WO2015052173A1 (en) 2013-10-10 2015-04-16 Basf Se Tetrazole and triazole compounds and their use as herbicides
WO2015095549A1 (en) * 2013-12-18 2015-06-25 Concert Pharmaceuticals, Inc. Dosage regimen for gabaa receptor subtype selective drug
WO2015120110A2 (en) 2014-02-07 2015-08-13 Auspex Pharmaceuticals, Inc. Novel pharmaceutical formulations
CN104353078B (zh) * 2014-11-24 2017-10-24 王寿世 一种麻醉用药物组合物
CN104474549A (zh) * 2014-11-24 2015-04-01 王寿世 异丙酚和gabaa受体拮抗剂在制备麻醉药物中的用途
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WO2020191047A1 (en) * 2019-03-18 2020-09-24 Neurocycle Therapeutics, Inc. Use of gabaa receptor modulators for treatment of pain
WO2023205722A1 (en) * 2022-04-20 2023-10-26 Engrail Therapeutics, Inc. Gabaa receptor modulator salts, particles, and uses thereof

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Also Published As

Publication number Publication date
US20130225590A1 (en) 2013-08-29
BRPI0912928A2 (pt) 2015-08-04
JP5373982B2 (ja) 2013-12-18
US8921366B2 (en) 2014-12-30
MX2011002278A (es) 2011-04-14
JP2012501346A (ja) 2012-01-19
US20120004236A1 (en) 2012-01-05
ZA201102123B (en) 2011-12-28
CA2735549A1 (en) 2010-03-04
HRP20140195T1 (hr) 2014-04-11
US8003646B2 (en) 2011-08-23
EP2328414A1 (en) 2011-06-08
WO2010025407A1 (en) 2010-03-04
PL2328414T3 (pl) 2014-05-30
EP2328414B1 (en) 2013-12-11
CN104098578A (zh) 2014-10-15
CN102176826B (zh) 2014-08-20
EP2328414A4 (en) 2011-11-16
JP2014058518A (ja) 2014-04-03
AU2009285533A2 (en) 2011-04-21
US8399467B2 (en) 2013-03-19
AU2009285533B2 (en) 2014-02-13
US20100056529A1 (en) 2010-03-04
AU2009285533A1 (en) 2010-03-04
CN102176826A (zh) 2011-09-07
EA020071B1 (ru) 2014-08-29
EP2716158A1 (en) 2014-04-09
KR20110063479A (ko) 2011-06-10
JP2013100322A (ja) 2013-05-23
PT2328414E (pt) 2014-03-17
ES2451542T3 (es) 2014-03-27
JP5183808B2 (ja) 2013-04-17
DK2328414T3 (en) 2014-03-10
US20150111895A1 (en) 2015-04-23

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU