MA33751B1 - Composés de spiropipéridine en tant qu'antagonistes de récepteur orl-1 - Google Patents

Composés de spiropipéridine en tant qu'antagonistes de récepteur orl-1

Info

Publication number
MA33751B1
MA33751B1 MA34869A MA34869A MA33751B1 MA 33751 B1 MA33751 B1 MA 33751B1 MA 34869 A MA34869 A MA 34869A MA 34869 A MA34869 A MA 34869A MA 33751 B1 MA33751 B1 MA 33751B1
Authority
MA
Morocco
Prior art keywords
orl
compounds
treatment
spirobridine
receptor antagonists
Prior art date
Application number
MA34869A
Other languages
Arabic (ar)
English (en)
Inventor
Collado Ana Belen Benito
Buezo Nuria Diaz
Alma Maria Jimenez-Aguado
Blanco Celia Lafuente
Maria Angeles Martinez-Grau
Concepcion Pedregal-Tercero
Escribano Miguel Angel Toledo
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MA33751B1 publication Critical patent/MA33751B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un antagoniste de récepteur orl-1 de formule i, ses utilisations et procédés de préparation. Des antagonistes de orl-1 sont jugés utiles dans le traitement de la dépression et/ou le traitement du surpoids, de l'obésité, et/ou le maintien du poids après un traitement du surpoids ou de l'obésité. Certains composés ont également montré dans des modèles animaux que les composés de la présente invention sont utiles pour le traitement de migraines.
MA34869A 2009-11-16 2012-05-14 Composés de spiropipéridine en tant qu'antagonistes de récepteur orl-1 MA33751B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09382246 2009-11-16
US29862910P 2010-01-27 2010-01-27
PCT/US2010/056180 WO2011060035A1 (fr) 2009-11-16 2010-11-10 Composés de spiropipéridine en tant qu'antagonistes de récepteur orl-1

Publications (1)

Publication Number Publication Date
MA33751B1 true MA33751B1 (fr) 2012-11-01

Family

ID=41728051

Family Applications (1)

Application Number Title Priority Date Filing Date
MA34869A MA33751B1 (fr) 2009-11-16 2012-05-14 Composés de spiropipéridine en tant qu'antagonistes de récepteur orl-1

Country Status (34)

Country Link
US (1) US8232289B2 (fr)
EP (1) EP2501703B1 (fr)
JP (1) JP5680101B2 (fr)
KR (1) KR101363830B1 (fr)
CN (1) CN102612520B (fr)
AR (1) AR078863A1 (fr)
AU (1) AU2010319581C1 (fr)
CA (1) CA2796161C (fr)
CO (1) CO6541545A2 (fr)
CR (1) CR20130087A (fr)
DK (1) DK2501703T3 (fr)
DO (1) DOP2012000135A (fr)
EA (1) EA020848B1 (fr)
EC (1) ECSP12011902A (fr)
ES (1) ES2435814T3 (fr)
HN (1) HN2012001011A (fr)
HR (1) HRP20130967T1 (fr)
IL (1) IL219370A (fr)
JO (1) JO2887B1 (fr)
MA (1) MA33751B1 (fr)
ME (1) ME01537B (fr)
MX (1) MX2012005691A (fr)
MY (1) MY160665A (fr)
NZ (1) NZ600006A (fr)
PE (1) PE20121430A1 (fr)
PH (1) PH12012500969A1 (fr)
PL (1) PL2501703T3 (fr)
PT (1) PT2501703E (fr)
RS (1) RS53018B (fr)
SI (1) SI2501703T1 (fr)
TW (1) TWI465453B (fr)
UA (1) UA107943C2 (fr)
WO (1) WO2011060035A1 (fr)
ZA (1) ZA201202967B (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2781716A1 (fr) 2009-12-04 2011-06-09 Sunovion Pharmaceuticals Inc. Composes multicycliques de thienopyrimidone et methodes d'utilisation associeesle neurologique
US9394290B2 (en) * 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
TWI582096B (zh) * 2011-12-06 2017-05-11 美國禮來大藥廠 用於酒精依賴及濫用處理之４',５'－二氫螺［哌啶－４,７'－噻吩并[２，３－c]哌喃］化合物
TW201416370A (zh) 2012-07-31 2014-05-01 Lilly Co Eli 用於治療焦慮之ｏｒｌ－１受體拮抗劑
RU2641916C2 (ru) 2012-10-02 2018-01-23 Байер Кропсайенс Аг Гетероциклические соединения в качестве пестицидов
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
TW201607923A (zh) 2014-07-15 2016-03-01 歌林達有限公司 被取代之氮螺環（４．５）癸烷衍生物
JO3638B1 (ar) * 2015-09-09 2020-08-27 Lilly Co Eli مركبات مفيدة في تثبيط ror - جاما- t
AU2017301769B2 (en) 2016-07-29 2022-07-28 Pgi Drug Discovery Llc Compounds and compositions and uses thereof
SG10202100751YA (en) 2016-07-29 2021-03-30 Sunovion Pharmaceuticals Inc Compounds and compositions and uses thereof
AU2018220509B2 (en) 2017-02-16 2022-04-28 Sumitomo Pharma America, Inc. Methods of treating schizophrenia
EP3589637B1 (fr) * 2017-03-02 2021-04-14 Eli Lilly and Company Composés utiles pour l'inhibition du ror-gamma-t
HRP20210898T1 (hr) 2017-03-02 2021-08-20 Eli Lilly And Company SPOJEVI KORISNI ZA INHIBIRANJE ROR-γ-T
SG11202000669VA (en) 2017-08-02 2020-02-27 Sunovion Pharmaceuticals Inc Isochroman compounds and uses thereof
CA3091292A1 (fr) 2018-02-16 2019-08-22 Sunovion Pharmaceuticals Inc. Sels, formes cristallines et procedes de production associes
CN113453760B (zh) 2018-12-17 2024-05-24 弗特克斯药品有限公司 Apol1抑制剂及其使用方法
JP7703449B2 (ja) 2019-03-14 2025-07-07 スミトモ・ファーマ・アメリカ・インコーポレイテッド イソクロマニル化合物の塩およびその結晶体、ならびにそれらの製造方法、治療用途および医薬組成物
CN115734785A (zh) 2020-04-14 2023-03-03 桑诺维恩药品公司 (S)-(4,5-二氢-7H-噻吩并[2,3-c]吡喃-7-基)-N-甲基甲胺用于治疗神经和精神方面的病症
CA3183591A1 (fr) 2020-06-12 2021-12-16 Vertex Pharmaceuticals Incorporated Formes solides d'un inhibiteur d'apol1 et utilisation de celles-ci
IL300298B2 (en) 2020-08-26 2025-06-01 Vertex Pharma Inhibitors of apol1 and methods of using same
JP2025505647A (ja) * 2022-02-08 2025-02-28 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｐｏｌ１阻害剤としての２－メチル－４’，５’－ジヒドロピロ［ピペリジン－４，７’－チエノ［２，３－ｃ］ピラン］誘導体、およびそれを使用する方法

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IL96507A0 (en) 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
DE60033071T2 (de) * 1999-12-06 2007-08-23 Euro-Celtique S.A. Triazospiroverbindungen mit nociceptin-rezeptoraffinität
IL158485A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Spiropyrazole compounds
WO2002088089A1 (fr) 2001-04-19 2002-11-07 Banyu Pharmaceutical Co., Ltd. Derives de spiropiperidine, antagonistes du recepteur de nociceptine les contenant en tant qu'ingredient actif et compositions medicinales
JP4356453B2 (ja) * 2001-07-23 2009-11-04 萬有製薬株式会社 ４−オキソイミダゾリジン−２−スピロピペリジン誘導体
JP2005519921A (ja) * 2002-01-28 2005-07-07 ファイザー株式会社 Ｏｒｌ−１受容体リガンドとしてのｎ置換スピロピペリジン化合物
WO2003095427A1 (fr) 2002-05-10 2003-11-20 Taisho Pharmaceutical Co.,Ltd. Compose a noyau spiranique
US6995168B2 (en) * 2002-05-31 2006-02-07 Euro-Celtique S.A. Triazaspiro compounds useful for treating or preventing pain
US7081463B2 (en) * 2002-09-09 2006-07-25 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders
WO2005016913A1 (fr) * 2003-08-19 2005-02-24 Pfizer Japan, Inc. Composes de tetrahydroisoquinoline ou d'isochroman en tant que ligands du recepteur orl-1 pour le traitement de la douleur et des troubles du systeme nerveux central
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
WO2005092858A2 (fr) * 2004-03-29 2005-10-06 Pfizer Japan Inc. Composes alpha-aryle ou heteroaryle methyle beta piperidino propanamide en tant qu'antagoniste du recepteur orl1
DE102004039382A1 (de) * 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
EP2020414A1 (fr) 2007-06-20 2009-02-04 Laboratorios del Dr. Esteve S.A. Derivés spiro[piperidine-4,4'-thieno[3,2-c]pyran] et composés similaires en tant que inhibiteurs du recepteur sigma pour le traitement de pyschose
PL2260042T3 (pl) * 2008-03-27 2012-02-29 Gruenenthal Gmbh Podstawione spirocykliczne pochodne cykloheksanu

Also Published As

Publication number Publication date
CN102612520B (zh) 2015-04-08
EA020848B1 (ru) 2015-02-27
US20110118251A1 (en) 2011-05-19
HRP20130967T1 (hr) 2013-11-22
PE20121430A1 (es) 2012-10-26
CO6541545A2 (es) 2012-10-16
HN2012001011A (es) 2015-08-31
KR20130026523A (ko) 2013-03-13
NZ600006A (en) 2014-05-30
MY160665A (en) 2017-03-15
ECSP12011902A (es) 2012-07-31
ES2435814T3 (es) 2013-12-23
EP2501703B1 (fr) 2013-09-18
PH12012500969A1 (en) 2013-01-07
PT2501703E (pt) 2013-11-26
DK2501703T3 (da) 2013-10-14
DOP2012000135A (es) 2012-08-15
CA2796161C (fr) 2015-03-17
AU2010319581B2 (en) 2013-12-19
US8232289B2 (en) 2012-07-31
CN102612520A (zh) 2012-07-25
EP2501703A1 (fr) 2012-09-26
SI2501703T1 (sl) 2013-11-29
HK1169988A1 (en) 2013-02-15
KR101363830B1 (ko) 2014-02-14
MX2012005691A (es) 2012-06-13
JO2887B1 (en) 2015-03-15
AU2010319581A1 (en) 2012-06-07
TW201127841A (en) 2011-08-16
CA2796161A1 (fr) 2011-05-19
AU2010319581C1 (en) 2014-05-15
EA201290352A1 (ru) 2012-10-30
JP2013510859A (ja) 2013-03-28
ME01537B (me) 2014-04-20
AR078863A1 (es) 2011-12-07
IL219370A0 (en) 2012-06-28
PL2501703T3 (pl) 2014-02-28
CR20130087A (es) 2013-04-17
TWI465453B (zh) 2014-12-21
ZA201202967B (en) 2013-09-25
JP5680101B2 (ja) 2015-03-04
IL219370A (en) 2015-01-29
UA107943C2 (xx) 2015-03-10
RS53018B (sr) 2014-04-30
WO2011060035A1 (fr) 2011-05-19

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