ATE525370T1 - Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten - Google Patents

Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten

Info

Publication number
ATE525370T1
ATE525370T1 AT08805231T AT08805231T ATE525370T1 AT E525370 T1 ATE525370 T1 AT E525370T1 AT 08805231 T AT08805231 T AT 08805231T AT 08805231 T AT08805231 T AT 08805231T AT E525370 T1 ATE525370 T1 AT E525370T1
Authority
AT
Austria
Prior art keywords
compounds
pyridoä3
düpyridazine
phthalazine
receptor antagonists
Prior art date
Application number
AT08805231T
Other languages
English (en)
Inventor
Paul Gore
Brian Looker
Panayiotis Procopiou
Sadie Vile
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE525370T1 publication Critical patent/ATE525370T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08805231T 2007-10-11 2008-10-10 Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten ATE525370T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97910507P 2007-10-11 2007-10-11
PCT/EP2008/063642 WO2009047336A1 (en) 2007-10-11 2008-10-10 Phthalazine and pyrido [3,4-d] pyridaz ine compounds as h1 receptor antagonists

Publications (1)

Publication Number Publication Date
ATE525370T1 true ATE525370T1 (de) 2011-10-15

Family

ID=40104668

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08805231T ATE525370T1 (de) 2007-10-11 2008-10-10 Phthalazin- und pyridoä3,4- düpyridazinverbindungen als h1-rezeptor- antagonisten

Country Status (6)

Country Link
US (1) US20100216799A1 (de)
EP (1) EP2215082B1 (de)
JP (1) JP2011500537A (de)
AT (1) ATE525370T1 (de)
ES (1) ES2369320T3 (de)
WO (1) WO2009047336A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20080000642A (ko) * 2005-04-21 2008-01-02 니뽄 신야쿠 가부시키가이샤 프탈라지논 유도체 및 그 의약
DK2120579T3 (da) * 2006-12-28 2014-02-03 Abbvie Inc Inhibitorer af poly(ADP-ripose)polymerase
WO2008137084A2 (en) * 2007-05-04 2008-11-13 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
US11702418B2 (en) * 2019-12-20 2023-07-18 Mirati Therapeutics, Inc. SOS1 inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
EP0174464B1 (de) * 1984-09-14 1990-01-03 ASTA Pharma AG Substituierte Benzylphthalazinon-Derivate
EP0222191B1 (de) * 1985-11-11 1991-01-30 ASTA Pharma AG 4-Benzyl-1-(2H)-phthalazinon-Derivate
DE3634942A1 (de) * 1985-11-11 1987-05-14 Asta Werke Ag Chem Fab Neue 4-benzyl-1-(2h)-phthalazinon-derivate
EP0289939A1 (de) * 1987-05-08 1988-11-09 ASTA Pharma AG Neue 4-Benzyl-1-(2H)-phthalazinon-Derivate mit einem Aminosäurerest
CZ199593A3 (en) * 1992-10-02 1994-04-13 Asta Medica Ag Phthalazinone derivatives exhibiting anti-arrhythmic and analgesic activity and eliminating resistance to a plurality of medicaments (mdr)
DE69912379T2 (de) * 1998-08-14 2004-05-06 Pfizer Inc. Antithrombosemittel
US6180629B1 (en) * 1998-08-14 2001-01-30 Cell Pathways, Inc. [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
US20030073692A1 (en) * 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
CN1787818A (zh) * 2003-03-18 2006-06-14 麦克公司 趋化因子受体活性的氨基环丁基酰胺调节剂
CN1812981A (zh) * 2003-06-27 2006-08-02 万有制药株式会社 杂芳氧基含氮饱和杂环衍生物
WO2008074803A2 (en) * 2006-12-20 2008-06-26 Glaxo Group Limited 4-benzyl-l ( 2h) -phthalazinones as h1 receptor antagonists

Also Published As

Publication number Publication date
EP2215082A1 (de) 2010-08-11
EP2215082B1 (de) 2011-09-21
WO2009047336A1 (en) 2009-04-16
US20100216799A1 (en) 2010-08-26
JP2011500537A (ja) 2011-01-06
ES2369320T3 (es) 2011-11-29

Similar Documents

Publication Publication Date Title
EA200801996A1 (ru) 2-замещенные производные 4-бензилфталазинонов в качестве гистаминовых h1- и h3-антагонистов
ATE533762T1 (de) Chinolin- oder isochinolinsubstituierte p2x7- antagonisten
EA201390683A1 (ru) Пиперидинонкарбоксамидазаинданы - антагонисты рецептора cgrp
EA201001821A1 (ru) Производные триазола, полезные для лечения заболеваний
ATE489088T1 (de) N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration
UA108743C2 (uk) Похідні хіназолін-4(3н)-ону для застосування як інгібіторів рі3-кінази
ATE482210T1 (de) Oxadiazolderivate als s1p1-rezeptor-agonisten
EA201071169A1 (ru) ГИДРОКСИМЕТИЛПИРРОЛИДИНЫ В КАЧЕСТВЕ АГОНИСТОВ АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ β3
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
MA32898B1 (fr) Modulateurs allosteriques positifs du recepteur m1 d'arylmethylbenzoquinazolinone
EA201001683A1 (ru) Производные фенил- или пиридинилзамещенных индазолов
EA201100503A1 (ru) Глюкозидные производные и их применения
EA201070327A1 (ru) Катехоламиновые производные и их пролекарства
ATE542795T1 (de) Benzylpiperazinderivate als motilin- rezeptorantagonisten
EA200970065A1 (ru) Производные пиперазинила, предназначенные для лечения заболеваний, опосредованных рецептором gpr38
WO2009021965A3 (en) Substituted quinoline derivatives as h1 receptor antagonists
GEP20135744B (en) Quinuclidine carbonate derivatives and medicinal compositions containing the same
UA109290C2 (uk) Спільні кристали і солі інгібіторів ccr3
BR112014001908A2 (pt) derivados aza heterocíclicos substituídos
WO2008074803A8 (en) 4-benzyl-l ( 2h) -phthalazinones as h1 receptor antagonists
MX2011006006A (es) Compuestos, composicion farmaceutica y metodos para utilizarse en el tratamiento de trastornos metabolicos.
MX2011013869A (es) Agentes antihelminticos y su uso.
MA32945B1 (fr) Tétrahydropyrane spiro pyrrolidinone et pipéridinone substituées, leur préparation et leur utilisation thérapeutique
ATE440836T1 (de) Verbindungen
ATE548365T1 (de) 5-ht7-rezeptorantagonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties