ATE489088T1 - N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration - Google Patents
N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegenerationInfo
- Publication number
- ATE489088T1 ATE489088T1 AT07729898T AT07729898T ATE489088T1 AT E489088 T1 ATE489088 T1 AT E489088T1 AT 07729898 T AT07729898 T AT 07729898T AT 07729898 T AT07729898 T AT 07729898T AT E489088 T1 ATE489088 T1 AT E489088T1
- Authority
- AT
- Austria
- Prior art keywords
- neurodegeneration
- inflammation
- treatment
- pain
- phenylmethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0611155A GB0611155D0 (en) | 2006-06-06 | 2006-06-06 | Novel receptor antagonists and their methods of use |
GB0705802A GB0705802D0 (en) | 2007-03-26 | 2007-03-26 | Novel receptor antagonists and their methods of use |
PCT/EP2007/055518 WO2007141267A1 (en) | 2006-06-06 | 2007-06-05 | N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE489088T1 true ATE489088T1 (de) | 2010-12-15 |
Family
ID=38441613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07729898T ATE489088T1 (de) | 2006-06-06 | 2007-06-05 | N- (phenylmethyl) -2- (1h-pyrazol-4-yl) acetamid- derivate als p2x7-antagonisten zur behandlung von schmerzen, entzündungen und neurodegeneration |
Country Status (6)
Country | Link |
---|---|
US (1) | US20090149524A1 (de) |
EP (1) | EP2040700B1 (de) |
JP (1) | JP2009539795A (de) |
AT (1) | ATE489088T1 (de) |
DE (1) | DE602007010781D1 (de) |
WO (1) | WO2007141267A1 (de) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602008005582D1 (de) * | 2007-05-10 | 2011-04-28 | Glaxo Group Ltd | Pyrazolderivate als p2x7-modulatoren |
GB0724258D0 (en) * | 2007-12-12 | 2008-01-30 | Glaxo Group Ltd | Novel combinations |
GB0724625D0 (en) * | 2007-12-18 | 2008-01-30 | Glaxo Group Ltd | Novel compounds |
GB0803729D0 (en) * | 2008-02-29 | 2008-04-09 | Ge Healthcare Ltd | Imaging the central nervous system |
BRPI0910034B1 (pt) | 2008-03-25 | 2022-02-08 | Affectis Pharmaceuticals Ag | Antagonistas do p2x7r e composições farmacêuticas que os compreendem |
US8946231B2 (en) | 2009-03-23 | 2015-02-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
GB0906274D0 (en) * | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
EP2243772B1 (de) | 2009-04-14 | 2012-01-18 | Affectis Pharmaceuticals AG | Neuartige P2X7R-Antagonisten und ihre Verwendung |
WO2011072012A2 (en) | 2009-12-08 | 2011-06-16 | Vanderbilt University | Improved methods and compositions for vein harvest and autografting |
CN108383789A (zh) | 2010-01-27 | 2018-08-10 | 艾克提麦斯医药品有限公司 | 作为crth2拮抗剂的吡唑化合物 |
AU2011252351A1 (en) | 2010-05-14 | 2012-10-11 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of P2X7R antagonists |
TWI527809B (zh) | 2011-01-24 | 2016-04-01 | 百靈佳殷格翰國際股份有限公司 | 作為crth2拮抗劑之吡唑化合物 |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012130633A1 (en) | 2011-03-25 | 2012-10-04 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as crth2 antagonists |
EP2508511A1 (de) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitoren der Virenreplikation, Verfahren zu deren Herstellung und deren therapeutische Verwendung |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
AR087274A1 (es) | 2011-07-22 | 2014-03-12 | Actelion Pharmaceuticals Ltd | Derivados de amidas heterociclicas como antagonistas de receptores p2x7 |
SG11201403933UA (en) | 2012-01-20 | 2014-08-28 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
CA2890886C (en) | 2012-12-12 | 2020-10-27 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
WO2014097140A1 (en) | 2012-12-18 | 2014-06-26 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
JP6282016B2 (ja) | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | P2x7受容体アンタゴニストとしての複素環アミド誘導体 |
EP2956457B1 (de) | 2013-01-22 | 2016-11-23 | Actelion Pharmaceuticals Ltd | Heterocyclische amidderivate als p2x7-rezeptorantagonisten |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005019182A1 (en) * | 2003-08-20 | 2005-03-03 | Bayer Healthcare Ag | Pyrazolylmethylbenzamide derivatives as p2xt-receptor antagonists |
WO2008125600A2 (en) * | 2007-04-11 | 2008-10-23 | Glaxo Group Limited | Pyrazole derivatives as p2x7 modulators |
-
2007
- 2007-06-05 AT AT07729898T patent/ATE489088T1/de not_active IP Right Cessation
- 2007-06-05 DE DE602007010781T patent/DE602007010781D1/de active Active
- 2007-06-05 EP EP07729898A patent/EP2040700B1/de active Active
- 2007-06-05 WO PCT/EP2007/055518 patent/WO2007141267A1/en active Application Filing
- 2007-06-05 JP JP2009513674A patent/JP2009539795A/ja not_active Withdrawn
- 2007-06-05 US US12/303,260 patent/US20090149524A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2007141267A1 (en) | 2007-12-13 |
EP2040700B1 (de) | 2010-11-24 |
EP2040700A1 (de) | 2009-04-01 |
DE602007010781D1 (de) | 2011-01-05 |
US20090149524A1 (en) | 2009-06-11 |
JP2009539795A (ja) | 2009-11-19 |
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