AR073892A1 - Proceso de preparacion de inhibidores de sglt - Google Patents

Proceso de preparacion de inhibidores de sglt

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Publication number
AR073892A1
AR073892A1 ARP090103994A ARP090103994A AR073892A1 AR 073892 A1 AR073892 A1 AR 073892A1 AR P090103994 A ARP090103994 A AR P090103994A AR P090103994 A ARP090103994 A AR P090103994A AR 073892 A1 AR073892 A1 AR 073892A1
Authority
AR
Argentina
Prior art keywords
ring
optionally substituted
formula
compound
substituted unsaturated
Prior art date
Application number
ARP090103994A
Other languages
English (en)
Original Assignee
Mitsubishi Tanabe Pharma Corp
Janssen Pharmaceutica Nv
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Publication date
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Application filed by Mitsubishi Tanabe Pharma Corp, Janssen Pharmaceutica Nv filed Critical Mitsubishi Tanabe Pharma Corp
Publication of AR073892A1 publication Critical patent/AR073892A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/12Radicals substituted by halogen atoms or nitro or nitroso radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04Carbocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente está dirigida a un proceso para la preparacion de compuestos que tienen actividad inhibitoria contra el transportador de glucosa dependiente de sodio (SGLT) presente en el intestino o en el rinon. Reivindicacion 1: Un proceso para la preparacion de compuestos de formula (1), en donde el Anillo A y el Anillo B son uno de los siguientes: (1) el Anillo A es un anillo heterocíclico monocíclico insaturado opcionalmente sustituido y el Anillo B es un anillo heterocíclico monocíclico insaturado opcionalmente sustituido, anillo heterobicíclico fusionado insaturado opcionalmente sustituido, o un anillo de benceno opcionalmente sustituido; o (2) el Anillo A es un anillo de benceno opcionalmente sustituido, y el Anillo B es un anillo heterocíclico monocíclico insaturado opcionalmente sustituido o un anillo heterobicíclico fusionado insaturado opcionalmente sustituido, en donde Y está enlazado al anillo heterocíclico del anillo heterobicíclico fusionado; o (3) el Anillo A es un anillo heterobicíclico fusionado insaturado opcionalmente sustituido, en donde tanto la porcion azucar X-(azucar) como la porcion -Y-Anillo B) están en el mismo anillo heterocíclico del anillo heterobicíclico fusionado, y el Anillo B es un anillo heterocíclico monocíclico insaturado opcionalmente sustituido, un anillo heterobicíclico fusionado insaturado opcionalmente sustituido o un anillo de benceno opcionalmente sustituido; X es un átomo de carbono; Y es -(CH2)n-, en donde n es 1 o 2; siempre y cuando en el Anillo A, X sea parte de un enlace insaturado; o una sal o solvato farmacéuticamente aceptable de éste; el proceso comprende: hacer reaccionar un compuesto de formula (10), en donde Q0 es bromo o yodo, con un complejo de di(alquil C1-4) magnesio con cloruro de litio o un complejo de C1-4 cloruro de alquilmagnesio con cloruro de litio o un complejo de C1-4 bromuro de alquilmagnesio con cloruro de litio en un solvente orgánico o mezcla de éste a una temperatura que varía desde aproximadamente la temperatura ambiente hasta aproximadamente -78sC para obtener el compuesto de formula (11) correspondiente, en donde Q1 es el MgCl o MgBr correspondiente; o hacer reaccionar el compuesto de formula (11) con un compuesto de formula (12), en donde Z es un grupo protector de oxígeno, en un solvente orgánico o mezcla de éste a una temperatura que varía desde aproximadamente la temperatura ambiente hasta aproximadamente -78°C para obtener el compuesto de formula (13) correspondiente; hacer reaccionar el compuesto de formula (13) para obtener el compuesto de formula (1) correspondiente.
ARP090103994A 2008-10-17 2009-10-16 Proceso de preparacion de inhibidores de sglt AR073892A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10626008P 2008-10-17 2008-10-17
US10623108P 2008-10-17 2008-10-17
US12/578,934 US9056850B2 (en) 2008-10-17 2009-10-14 Process for the preparation of compounds useful as inhibitors of SGLT

Publications (1)

Publication Number Publication Date
AR073892A1 true AR073892A1 (es) 2010-12-09

Family

ID=42106967

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090103994A AR073892A1 (es) 2008-10-17 2009-10-16 Proceso de preparacion de inhibidores de sglt

Country Status (30)

Country Link
US (1) US9056850B2 (es)
EP (3) EP2457908B8 (es)
JP (3) JP6123111B2 (es)
KR (2) KR101724598B1 (es)
CN (3) CN102264714A (es)
AR (1) AR073892A1 (es)
AU (1) AU2009305413B2 (es)
BR (1) BRPI0920356B1 (es)
CA (2) CA2740853C (es)
CL (1) CL2011000849A1 (es)
CY (3) CY1113867T1 (es)
DK (3) DK2455374T3 (es)
EA (1) EA021373B1 (es)
ES (3) ES2854598T3 (es)
HK (1) HK1224289A1 (es)
HR (3) HRP20130254T1 (es)
HU (2) HUE052432T2 (es)
IL (2) IL212270A0 (es)
LT (2) LT2455374T (es)
MX (1) MX2011004054A (es)
NZ (1) NZ592204A (es)
PL (3) PL2346888T3 (es)
PT (3) PT2346888E (es)
RS (3) RS55577B1 (es)
SI (3) SI2455374T1 (es)
SM (2) SMT201300058B (es)
TW (3) TW201613905A (es)
UA (1) UA107450C2 (es)
WO (1) WO2010043682A2 (es)
ZA (1) ZA201103587B (es)

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JPWO2020050361A1 (ja) * 2018-09-06 2021-08-30 株式会社トクヤマ β−C−アリールグリコシド誘導体の製造方法
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