AR062570A1 - Proceso para la purificacion de las proteinas que contienen fc - Google Patents
Proceso para la purificacion de las proteinas que contienen fcInfo
- Publication number
- AR062570A1 AR062570A1 ARP070103817A ARP070103817A AR062570A1 AR 062570 A1 AR062570 A1 AR 062570A1 AR P070103817 A ARP070103817 A AR P070103817A AR P070103817 A ARP070103817 A AR P070103817A AR 062570 A1 AR062570 A1 AR 062570A1
- Authority
- AR
- Argentina
- Prior art keywords
- fluid
- purification
- proteins containing
- fractions
- concentration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 3
- 238000005277 cation exchange chromatography Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente solicitud se refiere a un proceso para reducir la concentracion de las fracciones Fc libres en un fluido que comprende una proteína que contiene Fc que comprende un paso de cromatografía de intercambio de cation. Reivindicacion 1: El método para reducir la concentracion de las fracciones de Fc libres en un fluido que comprende una proteína que contiene Fc, el método comprende someter dicho fluido a la cromatografía de intercambio de cation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06119611 | 2006-08-28 | ||
US84254206P | 2006-09-06 | 2006-09-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR062570A1 true AR062570A1 (es) | 2008-11-19 |
Family
ID=38610939
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070103817A AR062570A1 (es) | 2006-08-28 | 2007-08-28 | Proceso para la purificacion de las proteinas que contienen fc |
Country Status (21)
Country | Link |
---|---|
US (1) | US8513393B2 (es) |
EP (1) | EP2061803B2 (es) |
JP (1) | JP2010501623A (es) |
KR (1) | KR101770312B1 (es) |
AR (1) | AR062570A1 (es) |
AU (1) | AU2007291283B2 (es) |
CA (1) | CA2661748C (es) |
DK (1) | DK2061803T4 (es) |
EA (1) | EA017152B1 (es) |
ES (1) | ES2755386T5 (es) |
FI (1) | FI2061803T4 (es) |
HK (1) | HK1131400A1 (es) |
HU (1) | HUE045898T2 (es) |
IL (1) | IL197220A (es) |
LT (1) | LT2061803T (es) |
MX (1) | MX2009002014A (es) |
PL (1) | PL2061803T5 (es) |
PT (1) | PT2061803T (es) |
SI (1) | SI2061803T2 (es) |
UA (1) | UA99262C2 (es) |
WO (1) | WO2008025748A1 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101391457B1 (ko) | 2005-12-20 | 2014-05-19 | 브리스톨-마이어스 스큅 컴퍼니 | 조성물 및 조성물의 제조 방법 |
AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
US8513393B2 (en) † | 2006-08-28 | 2013-08-20 | Ares Trading S.A. | Process for the purification of Fc-containing proteins |
HUE037409T2 (hu) * | 2007-10-30 | 2018-08-28 | Genentech Inc | Antitest-tisztítás kationcserés kromatográfiával |
JP2012506384A (ja) * | 2008-10-20 | 2012-03-15 | アボット・ラボラトリーズ | Il−12に結合する抗体およびそれを精製する方法 |
SG195574A1 (en) * | 2008-10-20 | 2013-12-30 | Abbott Lab | Antibodies that bind to il-18 and methods of purifying the same |
CA2738499A1 (en) * | 2008-10-20 | 2010-04-29 | Abbott Laboratories | Viral inactivation during purification of antibodies |
AU2009347206C1 (en) | 2008-10-20 | 2016-12-08 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
WO2011017514A1 (en) | 2009-08-07 | 2011-02-10 | Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
PT3272764T (pt) | 2009-12-18 | 2024-04-24 | Novartis Ag | Método para cromatografia de afinidade |
US8951807B2 (en) | 2010-01-15 | 2015-02-10 | Bio-Rad Laboratories, Inc. | Surface neutralization of apatite |
US8895707B2 (en) * | 2010-08-18 | 2014-11-25 | Bio-Rad Laboratories, Inc. | Elution of proteins from hydroxyapatite resins without resin deterioration |
JP5798307B2 (ja) * | 2010-09-03 | 2015-10-21 | 国立大学法人名古屋大学 | グロボトリアオシルセラミドを特異的に認識するモノクローナル抗体及びその作製法 |
CA2820095C (en) * | 2010-12-21 | 2019-02-26 | F. Hoffmann-La Roche Ag | Isoform enriched antibody preparation and method for obtaining it |
EP2670704B1 (en) | 2011-02-02 | 2018-12-12 | Bio-Rad Laboratories, Inc. | Apatite surface neutralization with alkali solutions |
SG193545A1 (en) | 2011-03-29 | 2013-11-29 | Glaxosmithkline Llc | Buffer system for protein purification |
SG10201701224UA (en) * | 2012-03-12 | 2017-04-27 | Merck Patent Gmbh | Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode |
US9815695B2 (en) | 2012-05-30 | 2017-11-14 | Bio-Rad Laboratories, Inc. | In situ restoration of apatite-based chromatography resins |
EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
CN106536565A (zh) * | 2014-06-13 | 2017-03-22 | 鲁宾有限公司 | 一种用于纯化TNFR‑Fc融合蛋白的方法 |
WO2015200278A1 (en) | 2014-06-23 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Apatite in-situ restoration |
CN105392569B (zh) | 2014-06-23 | 2019-08-20 | 生物辐射实验室股份有限公司 | 磷灰石预处理 |
ES2733298T3 (es) * | 2014-07-18 | 2019-11-28 | Sandoz Ag | Cuantificación de TNFR2:Fc plegado erróneamente |
US10695693B2 (en) * | 2015-03-13 | 2020-06-30 | Bristol-Myers Squibb Company | Use of alkaline washes during chromatography to remove impurities |
PE20230494A1 (es) | 2020-05-08 | 2023-03-23 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras inhibidoras de april y baff y metodos de uso de las mismas |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
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AU630497B2 (en) | 1989-09-05 | 1992-10-29 | Immunex Corporation | Tumor necrosis factor-alpha and -beta receptors |
US5447851B1 (en) * | 1992-04-02 | 1999-07-06 | Univ Texas System Board Of | Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells |
EP0620739A4 (en) | 1992-09-15 | 1997-01-15 | Immunex Corp | Method of treating tnf-dependent inflammation using tumor necrosis factor antagonists. |
DE59309332D1 (de) * | 1993-12-27 | 1999-03-04 | Rotkreuzstiftung Zentratrallab | Verfahren zur Herstellung eines Konzentrates von Anti-D-Immunoglobulin G und pharmazeutische Zusammensetzung, die dieses enthält |
US6406901B1 (en) * | 1995-06-08 | 2002-06-18 | Immunex Corporation | TNF-a converting enzyme |
ES2227598T3 (es) * | 1995-06-08 | 2005-04-01 | Immunex Corporation | Enzima conversiva de tnf-alfa. |
US5969102A (en) | 1997-03-03 | 1999-10-19 | St. Jude Children's Research Hospital | Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof |
IL121900A (en) † | 1997-10-07 | 2001-12-23 | Omrix Biopharmaceuticals Ltd | A method for the purification of immunoglobulins |
ATE370961T1 (de) † | 1998-05-06 | 2007-09-15 | Genentech Inc | Reinigung von antikörpern durch ionenaustauschchromatographie |
EP1500661A1 (en) | 1998-06-01 | 2005-01-26 | Genetech, Inc. | Separation of protein monomers from aggregates by use of ion-exchange chromatography |
AU753468B2 (en) † | 1998-06-09 | 2002-10-17 | Csl Behring Ag | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
ATE453712T1 (de) | 1999-01-07 | 2010-01-15 | Zymogenetics Inc | Verfahren zur therapeutischen verwendung von löslichen rezeptoren br43x2 |
DE19955558C2 (de) | 1999-11-18 | 2003-03-20 | Stefan Kochanek | Permanente Amniozyten-Zelllinie, ihre Herstellung und Verwendung zur Herstellung von Gentransfervektoren |
AU2001261557B2 (en) * | 2000-05-12 | 2005-06-30 | Amgen Inc. | Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci |
KR101021124B1 (ko) * | 2001-05-24 | 2011-03-14 | 지모제넥틱스, 인코포레이티드 | Taci-면역글로불린 융합 단백질 |
MXPA04000134A (es) † | 2001-06-26 | 2005-06-06 | Abgenix Inc | Anticuerpos para ligandos de osteoprotegerina. |
MXPA04006053A (es) | 2001-12-21 | 2005-03-31 | Immunex Corp | Metodos para purificacion de proteina. |
WO2003102132A2 (en) † | 2002-04-26 | 2003-12-11 | Genetech, Inc. | Non-affinity purification of proteins |
HUE033623T2 (en) † | 2002-09-11 | 2017-12-28 | Genentech Inc | protein purification |
JP5525118B2 (ja) | 2002-09-11 | 2014-06-18 | 中外製薬株式会社 | タンパク質精製方法 |
AU2004215653B2 (en) * | 2003-02-28 | 2011-03-17 | Lonza Biologics Plc. | Antibody purification by protein A and ion exchange chromatography |
JPWO2004087761A1 (ja) | 2003-03-31 | 2006-07-27 | 麒麟麦酒株式会社 | ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製 |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
PT1678208E (pt) * | 2003-10-27 | 2013-07-10 | Wyeth Llc | Remoção de agregados de elevado peso molecular utilizando cromatografia de hidroxiapatite |
EP1682584B1 (en) | 2003-11-13 | 2013-04-17 | Hanmi Science Co., Ltd. | A pharmaceutical composition comprising an immunoglobulin fc region as a carrier |
EP1756155A2 (en) * | 2004-04-14 | 2007-02-28 | F.Hoffmann-La Roche Ag | PURIFIED INTERLEUKIN-15/Fc FUSION PROTEIN AND PREPARATION THEREOF |
DK1869065T3 (da) | 2005-03-11 | 2020-06-08 | Wyeth Llc | Fremgangsmåde til kromatografi med svag opdeling |
CA2604877A1 (en) * | 2005-04-11 | 2006-10-19 | J.P. Sercel Associates Inc. | Protein purification |
EA201100177A1 (ru) * | 2005-06-17 | 2011-06-30 | Элан Фарма Интернэшнл Лимитед | СПОСОБЫ ОЧИСТКИ АНТИТЕЛ К β-АМИЛОИДУ |
JP2010510963A (ja) † | 2006-06-14 | 2010-04-08 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | セラミックヒドロキシアパタイトを使用する抗体の精製方法 |
US8513393B2 (en) † | 2006-08-28 | 2013-08-20 | Ares Trading S.A. | Process for the purification of Fc-containing proteins |
AU2008206923A1 (en) * | 2007-01-17 | 2008-07-24 | Merck Serono S.A. | Process for the purification of Fc-containing proteins |
-
2007
- 2007-08-27 US US12/377,122 patent/US8513393B2/en active Active
- 2007-08-27 HU HUE07802925A patent/HUE045898T2/hu unknown
- 2007-08-27 EP EP07802925.3A patent/EP2061803B2/en active Active
- 2007-08-27 PT PT78029253T patent/PT2061803T/pt unknown
- 2007-08-27 CA CA2661748A patent/CA2661748C/en active Active
- 2007-08-27 SI SI200732135T patent/SI2061803T2/sl unknown
- 2007-08-27 DK DK07802925.3T patent/DK2061803T4/da active
- 2007-08-27 AU AU2007291283A patent/AU2007291283B2/en active Active
- 2007-08-27 EA EA200970231A patent/EA017152B1/ru not_active IP Right Cessation
- 2007-08-27 JP JP2009526068A patent/JP2010501623A/ja active Pending
- 2007-08-27 FI FIEP07802925.3T patent/FI2061803T4/fi active
- 2007-08-27 WO PCT/EP2007/058887 patent/WO2008025748A1/en active Application Filing
- 2007-08-27 KR KR1020097006443A patent/KR101770312B1/ko active IP Right Grant
- 2007-08-27 ES ES07802925T patent/ES2755386T5/es active Active
- 2007-08-27 UA UAA200902854A patent/UA99262C2/uk unknown
- 2007-08-27 MX MX2009002014A patent/MX2009002014A/es active IP Right Grant
- 2007-08-27 LT LT07802925T patent/LT2061803T/lt unknown
- 2007-08-27 PL PL07802925.3T patent/PL2061803T5/pl unknown
- 2007-08-28 AR ARP070103817A patent/AR062570A1/es not_active Application Discontinuation
-
2009
- 2009-02-24 IL IL197220A patent/IL197220A/en active IP Right Grant
- 2009-12-03 HK HK09111377.1A patent/HK1131400A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
UA99262C2 (uk) | 2012-08-10 |
IL197220A0 (en) | 2009-12-24 |
IL197220A (en) | 2013-06-27 |
ES2755386T3 (es) | 2020-04-22 |
AU2007291283A1 (en) | 2008-03-06 |
PL2061803T5 (pl) | 2023-03-27 |
DK2061803T3 (da) | 2019-11-18 |
AU2007291283B2 (en) | 2012-09-20 |
ES2755386T5 (es) | 2023-04-05 |
WO2008025748A1 (en) | 2008-03-06 |
EA200970231A1 (ru) | 2009-08-28 |
US8513393B2 (en) | 2013-08-20 |
CA2661748C (en) | 2016-02-09 |
FI2061803T4 (fi) | 2023-03-14 |
JP2010501623A (ja) | 2010-01-21 |
SI2061803T1 (sl) | 2019-12-31 |
SI2061803T2 (sl) | 2023-01-31 |
MX2009002014A (es) | 2009-03-09 |
EP2061803B2 (en) | 2022-11-16 |
LT2061803T (lt) | 2019-11-25 |
HK1131400A1 (en) | 2010-01-22 |
PT2061803T (pt) | 2019-11-21 |
DK2061803T4 (da) | 2022-12-05 |
EP2061803B1 (en) | 2019-08-14 |
EA017152B1 (ru) | 2012-10-30 |
EP2061803A1 (en) | 2009-05-27 |
US20100190961A1 (en) | 2010-07-29 |
CA2661748A1 (en) | 2008-03-06 |
KR101770312B1 (ko) | 2017-08-22 |
PL2061803T3 (pl) | 2020-02-28 |
HUE045898T2 (hu) | 2020-01-28 |
KR20090057296A (ko) | 2009-06-04 |
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