EA200701452A1 - Моноклональные антитела против подобного ангиопоэтину белка 4 (angptl 4) - Google Patents

Моноклональные антитела против подобного ангиопоэтину белка 4 (angptl 4)

Info

Publication number
EA200701452A1
EA200701452A1 EA200701452A EA200701452A EA200701452A1 EA 200701452 A1 EA200701452 A1 EA 200701452A1 EA 200701452 A EA200701452 A EA 200701452A EA 200701452 A EA200701452 A EA 200701452A EA 200701452 A1 EA200701452 A1 EA 200701452A1
Authority
EA
Eurasian Patent Office
Prior art keywords
monoclonal antibodies
angptl
angiopoetin
protein
antibodies against
Prior art date
Application number
EA200701452A
Other languages
English (en)
Other versions
EA016185B1 (ru
Inventor
Э-чиан Ли
Грегори М. Ландес
Киу Чунг
Лин Чэнь
Урви Десай
Дэвид Рид Поуэлл
Сеокдзоо Хонг
Original Assignee
Лексикон Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лексикон Фармасьютикалз, Инк. filed Critical Лексикон Фармасьютикалз, Инк.
Publication of EA200701452A1 publication Critical patent/EA200701452A1/ru
Publication of EA016185B1 publication Critical patent/EA016185B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Предоставлены моноклональные антитела, которые специфично связываются с ANGPTL4. Предоставлены моноклональные антитела, которые нейтрализуют по меньшей мере один вид активности ANGPTL4. Предоставлены способы лечения нарушения липидного метаболизма с использованием нейтрализующих моноклональных антител.
EA200701452A 2005-01-07 2006-01-06 Моноклональное антитело или его фрагмент к подобному ангиопоэтину белку 4 (angptl4) и их применение EA016185B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64202205P 2005-01-07 2005-01-07
PCT/US2006/000184 WO2006074228A1 (en) 2005-01-07 2006-01-06 Monoclonal antibodies against angiopoietin-like protein 4 (angptl4 )

Publications (2)

Publication Number Publication Date
EA200701452A1 true EA200701452A1 (ru) 2008-02-28
EA016185B1 EA016185B1 (ru) 2012-03-30

Family

ID=36177590

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701452A EA016185B1 (ru) 2005-01-07 2006-01-06 Моноклональное антитело или его фрагмент к подобному ангиопоэтину белку 4 (angptl4) и их применение

Country Status (14)

Country Link
US (3) US7655762B2 (ru)
EP (1) EP1846452B1 (ru)
JP (1) JP5366406B2 (ru)
KR (1) KR101387781B1 (ru)
CN (1) CN101128485B (ru)
AU (1) AU2006204001B2 (ru)
BR (1) BRPI0606432A2 (ru)
CA (1) CA2594233C (ru)
EA (1) EA016185B1 (ru)
IL (1) IL184235A (ru)
MX (1) MX2007008256A (ru)
NO (1) NO20073414L (ru)
WO (1) WO2006074228A1 (ru)
ZA (1) ZA200705980B (ru)

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* Cited by examiner, † Cited by third party
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US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
DK1781698T3 (en) * 2004-07-20 2016-10-03 Genentech Inc COMPOSITIONS AND METHODS FOR THE USE OF Angiopoietin-like-4-PROTEIN
US8604185B2 (en) 2004-07-20 2013-12-10 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
CN102641503A (zh) * 2004-07-20 2012-08-22 健泰科生物技术公司 血管生成素样4蛋白抑制剂，组合，以及其用途
PT2121751T (pt) 2006-12-08 2017-04-18 Lexicon Pharmaceuticals Inc Anticorpos monoclonais contra angptl3
WO2011046515A1 (en) * 2009-10-14 2011-04-21 Nanyang Technological University Antiproliferative agent
JO3274B1 (ar) * 2009-12-24 2018-09-16 Regeneron Pharma أجسام مضادة بشرية للبروتين 4 المشابه لأجيوبيوتين البشري
US9496081B2 (en) * 2011-04-08 2016-11-15 Access Business Group International Llc Counter wound inductive power supply
CN102242198A (zh) * 2011-05-25 2011-11-16 信阳师范学院 通过angptl4基因多态性进行牛育种方法
WO2013022406A1 (en) * 2011-08-08 2013-02-14 Nanyang Technological University Angiopoietin-like 4 and its use in modulating cell leakiness
AU2013243955B2 (en) * 2012-04-02 2018-02-22 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AU2013249577A1 (en) * 2012-04-16 2014-10-02 Regeneron Pharmaceuticals, Inc. Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor
GB201301313D0 (en) * 2013-01-25 2013-03-06 Univ Singapore Respiratory Tract Infections
WO2016020882A2 (en) * 2014-08-07 2016-02-11 Novartis Ag Angiopoetin-like 4 (angptl4) antibodies and methods of use
ES2906216T3 (es) * 2014-08-07 2022-04-13 Novartis Ag Anticuerpos de 4 similar a la angiopoyetina y métodos de uso
BR112018008867A8 (pt) * 2015-11-03 2019-02-26 Janssen Biotech Inc anticorpos que se ligam especificamente a pd-1 e seus usos
WO2020099478A2 (en) * 2018-11-13 2020-05-22 Lipigon Pharmaceuticals Ab Angptl4 oligonucleotides influencing the regulation of the fatty acid metabolism
US20220389088A1 (en) * 2019-10-29 2022-12-08 University Of Florida Research Foundation, Incorporated Anti-angiopoietin-like 4 (angptl4) antibodies and methods of use
CN115708872A (zh) * 2022-11-03 2023-02-24 中国科学院深圳先进技术研究院 抗血管生成素样蛋白4抗体在制备抑制炎症因子表达的药物中的应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
DE3785186T2 (de) 1986-09-02 1993-07-15 Enzon Lab Inc Bindungsmolekuele mit einzelpolypeptidkette.
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
AU4643699A (en) * 1998-06-24 2000-01-10 Compugen Ltd. Angiopoietin-like growth factor sequences
WO2001077151A2 (en) * 2000-04-07 2001-10-18 Millennium Pharmaceuticals, Inc. Fdrg proteins and nucleic acid molecules and uses therefor
NL1017421C2 (nl) 2001-02-21 2002-01-15 Synthon Bv Werkwijze voor het vervaardigen van paroxetine.
CN1141318C (zh) 2001-02-28 2004-03-10 中国医学科学院血液学研究所 人促血液血管细胞生成素及其制造方法
WO2003010205A1 (en) * 2001-07-26 2003-02-06 Duke University Medical Center Genes induced by hypoxia
CN102641503A (zh) * 2004-07-20 2012-08-22 健泰科生物技术公司 血管生成素样4蛋白抑制剂，组合，以及其用途
DK1781698T3 (en) * 2004-07-20 2016-10-03 Genentech Inc COMPOSITIONS AND METHODS FOR THE USE OF Angiopoietin-like-4-PROTEIN

Also Published As

Publication number Publication date
EA016185B1 (ru) 2012-03-30
AU2006204001A1 (en) 2006-07-13
AU2006204001B2 (en) 2011-06-16
US20120171217A1 (en) 2012-07-05
KR101387781B1 (ko) 2014-04-21
CA2594233A1 (en) 2006-07-13
US20060222645A1 (en) 2006-10-05
WO2006074228A1 (en) 2006-07-13
NO20073414L (no) 2007-10-02
MX2007008256A (es) 2007-12-06
EP1846452B1 (en) 2014-08-06
JP2008526857A (ja) 2008-07-24
CA2594233C (en) 2015-02-24
EP1846452A1 (en) 2007-10-24
IL184235A0 (en) 2007-10-31
JP5366406B2 (ja) 2013-12-11
US20110008359A1 (en) 2011-01-13
ZA200705980B (en) 2009-01-28
KR20070107696A (ko) 2007-11-07
BRPI0606432A2 (pt) 2009-06-30
US7655762B2 (en) 2010-02-02
US8092796B2 (en) 2012-01-10
CN101128485A (zh) 2008-02-20
IL184235A (en) 2012-10-31
CN101128485B (zh) 2012-09-26
US8591891B2 (en) 2013-11-26

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM