AR054157A1 - Medio de cultivo libre de suero para la produccion de las gonadotropinas recombinantes - Google Patents
Medio de cultivo libre de suero para la produccion de las gonadotropinas recombinantesInfo
- Publication number
- AR054157A1 AR054157A1 ARP060102879A ARP060102879A AR054157A1 AR 054157 A1 AR054157 A1 AR 054157A1 AR P060102879 A ARP060102879 A AR P060102879A AR P060102879 A ARP060102879 A AR P060102879A AR 054157 A1 AR054157 A1 AR 054157A1
- Authority
- AR
- Argentina
- Prior art keywords
- serum
- production
- recombinant gonadotropins
- recombinant
- free crop
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente está en el campo de la fabricacion de las proteínas recombinantes. Más específicamente, se refiere al uso de un medio de cultivo libre de suero que comprende un antioxidante para la produccion de las gonadotropinas recombinantes. El antioxidante se puede escoger del grupo que consiste en L-glutationa, 2-mercaptoetanol, L-metionina y una combinacion del ácido ascorbico y de (+)-alfa-tocoferol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05106060 | 2005-07-05 | ||
US69707705P | 2005-07-06 | 2005-07-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR054157A1 true AR054157A1 (es) | 2007-06-06 |
Family
ID=35134140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060102879A AR054157A1 (es) | 2005-07-05 | 2006-07-04 | Medio de cultivo libre de suero para la produccion de las gonadotropinas recombinantes |
Country Status (24)
Country | Link |
---|---|
US (1) | US8093052B2 (es) |
EP (1) | EP1899454B1 (es) |
JP (1) | JP5059757B2 (es) |
KR (1) | KR101346499B1 (es) |
CN (1) | CN101258236A (es) |
AR (1) | AR054157A1 (es) |
AU (1) | AU2006264917B2 (es) |
BR (1) | BRPI0612781B8 (es) |
CA (1) | CA2613867A1 (es) |
CY (1) | CY1112992T1 (es) |
DK (1) | DK1899454T3 (es) |
EA (1) | EA012840B1 (es) |
ES (1) | ES2388875T3 (es) |
HR (1) | HRP20120486T1 (es) |
IL (1) | IL188558A (es) |
MY (1) | MY149621A (es) |
NO (1) | NO341475B1 (es) |
PL (1) | PL1899454T3 (es) |
PT (1) | PT1899454E (es) |
RS (1) | RS52468B (es) |
SI (1) | SI1899454T1 (es) |
TW (1) | TWI369401B (es) |
UA (1) | UA91063C2 (es) |
WO (1) | WO2007003640A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101264096B (zh) * | 2007-03-12 | 2011-11-09 | 中国医学科学院药物研究所 | 人参皂苷Rg1在制备生精产品中的应用 |
PT2170942E (pt) * | 2007-06-28 | 2013-10-22 | Biogenerix Ag | Clone celular produtor de fsh |
AU2011246504B2 (en) | 2010-04-26 | 2013-09-26 | Novartis Ag | Improved cell culture medium |
CN102296047B (zh) * | 2011-08-13 | 2013-03-13 | 新疆农垦科学院 | 利用羔羊超排卵母细胞生产体外胚胎的方法 |
US10138467B2 (en) * | 2013-10-14 | 2018-11-27 | Ares Trading S.A. | Medium for high performance mammalian fed-batch cultures |
EP3383894B1 (en) * | 2015-12-02 | 2020-05-06 | CSL Behring Lengnau AG | Improved media for the expression of recombinant vitamin k-dependent proteins |
CN105462909B (zh) * | 2015-12-31 | 2019-09-27 | 哈药集团技术中心 | 一种高效表达人促卵泡激素的cho细胞的培养方法 |
CN108795841A (zh) * | 2017-05-03 | 2018-11-13 | 上海奥浦迈生物科技有限公司 | 一种st培养基及其应用 |
CN110042137B (zh) * | 2019-05-14 | 2023-02-28 | 上海赛迈生物科技有限公司 | 高密度灌注培养重组cho细胞生产人促卵泡激素的方法、培养基及其应用 |
US20220204920A1 (en) | 2019-05-16 | 2022-06-30 | Formycon Ag | Method for reducing methionine oxidation in recombinant proteins |
CN114836367A (zh) * | 2022-04-28 | 2022-08-02 | 上海东富龙生物试剂有限公司 | 用于hek293细胞培养及腺病毒、腺相关病毒复制扩增的化学成分限定培养基 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3110559C2 (de) | 1981-03-18 | 1985-05-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Vollsynthetisches Zellkulturmedium |
US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
FR2600076A1 (fr) * | 1986-06-12 | 1987-12-18 | Fond Ctre Nal Transfusion | Milieu de culture comportant de l'albumine humaine, procede de preparation d'un produit injectable a partir de ce milieu, produit obtenu et son utilisation, composition obtenue |
US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
USH1532H (en) * | 1993-11-03 | 1996-05-07 | Genetics Institute, Inc. | Adaption of mammalian cell lines to high cell densities |
WO1998004680A1 (en) * | 1996-07-26 | 1998-02-05 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
EP2221361A3 (en) * | 1996-08-30 | 2011-02-09 | Life Technologies Corporation | Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium |
DE69738806D1 (de) * | 1996-10-10 | 2008-08-14 | Invitrogen Corp | Tierzellkulturmedium mit pflanzlichen nährstoffen |
IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
WO1999050390A1 (en) * | 1998-03-30 | 1999-10-07 | Bionative Ab | Methionin containing animal cell culture medium and its use |
CA2468971A1 (en) * | 2001-12-04 | 2003-06-12 | Mitsubishi Pharma Corporation | Method of activating protein |
US6756431B2 (en) * | 2002-04-09 | 2004-06-29 | Crompton Corporation | Heterocyclic tin flame retardants/smoke suppressants and halogen-containing polymer composition containing same |
WO2004087213A1 (en) * | 2003-04-02 | 2004-10-14 | Ares Trading S.A. | Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant |
PT1638595E (pt) * | 2003-06-20 | 2013-04-26 | Ares Trading Sa | Fsh liofilizada / formulações de hl |
-
2006
- 2006-06-20 TW TW095121976A patent/TWI369401B/zh active
- 2006-07-03 MY MYPI20063160A patent/MY149621A/en unknown
- 2006-07-04 CA CA002613867A patent/CA2613867A1/en not_active Abandoned
- 2006-07-04 US US11/994,885 patent/US8093052B2/en active Active
- 2006-07-04 PT PT06764058T patent/PT1899454E/pt unknown
- 2006-07-04 KR KR1020087003007A patent/KR101346499B1/ko active IP Right Grant
- 2006-07-04 EP EP06764058A patent/EP1899454B1/en active Active
- 2006-07-04 UA UAA200801394A patent/UA91063C2/ru unknown
- 2006-07-04 ES ES06764058T patent/ES2388875T3/es active Active
- 2006-07-04 DK DK06764058.1T patent/DK1899454T3/da active
- 2006-07-04 EA EA200800253A patent/EA012840B1/ru not_active IP Right Cessation
- 2006-07-04 BR BRPI0612781A patent/BRPI0612781B8/pt active IP Right Grant
- 2006-07-04 CN CNA2006800322795A patent/CN101258236A/zh active Pending
- 2006-07-04 SI SI200631359T patent/SI1899454T1/sl unknown
- 2006-07-04 PL PL06764058T patent/PL1899454T3/pl unknown
- 2006-07-04 RS RS20120351A patent/RS52468B/en unknown
- 2006-07-04 WO PCT/EP2006/063862 patent/WO2007003640A1/en active Application Filing
- 2006-07-04 JP JP2008519930A patent/JP5059757B2/ja active Active
- 2006-07-04 AU AU2006264917A patent/AU2006264917B2/en active Active
- 2006-07-04 AR ARP060102879A patent/AR054157A1/es not_active Application Discontinuation
-
2008
- 2008-01-03 IL IL188558A patent/IL188558A/en active IP Right Grant
- 2008-01-31 NO NO20080580A patent/NO341475B1/no unknown
-
2012
- 2012-06-11 HR HRP20120486TT patent/HRP20120486T1/hr unknown
- 2012-07-09 CY CY20121100609T patent/CY1112992T1/el unknown
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Legal Events
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