BRPI0612781B8 - uso de um meio de cultura livre de soro para reduzir os níveis de formas oxidadas de uma gonadotrofina dimérica recombinante durante seu processo de fabricação - Google Patents
uso de um meio de cultura livre de soro para reduzir os níveis de formas oxidadas de uma gonadotrofina dimérica recombinante durante seu processo de fabricaçãoInfo
- Publication number
- BRPI0612781B8 BRPI0612781B8 BRPI0612781A BRPI0612781A BRPI0612781B8 BR PI0612781 B8 BRPI0612781 B8 BR PI0612781B8 BR PI0612781 A BRPI0612781 A BR PI0612781A BR PI0612781 A BRPI0612781 A BR PI0612781A BR PI0612781 B8 BRPI0612781 B8 BR PI0612781B8
- Authority
- BR
- Brazil
- Prior art keywords
- serum
- culture medium
- free culture
- manufacturing process
- oxidized forms
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 102000006771 Gonadotropins Human genes 0.000 title abstract 3
- 108010086677 Gonadotropins Proteins 0.000 title abstract 3
- 239000002622 gonadotropin Substances 0.000 title abstract 3
- 239000004017 serum-free culture medium Substances 0.000 title abstract 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- 235000006708 antioxidants Nutrition 0.000 abstract 2
- 229940094892 gonadotropins Drugs 0.000 abstract 2
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 abstract 2
- RWSXRVCMGQZWBV-PHDIDXHHSA-N L-Glutathione Natural products OC(=O)[C@H](N)CCC(=O)N[C@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-PHDIDXHHSA-N 0.000 abstract 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 1
- 239000002076 α-tocopherol Substances 0.000 abstract 1
- 235000004835 α-tocopherol Nutrition 0.000 abstract 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Reproductive Health (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05106060 | 2005-07-05 | ||
EP05106060.6 | 2005-07-05 | ||
US69707705P | 2005-07-06 | 2005-07-06 | |
US60/697,077 | 2005-07-06 | ||
PCT/EP2006/063862 WO2007003640A1 (en) | 2005-07-05 | 2006-07-04 | Serum-free culture medium for the production of recombinant gonadotropins |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0612781A2 BRPI0612781A2 (pt) | 2010-11-30 |
BRPI0612781B1 BRPI0612781B1 (pt) | 2020-09-15 |
BRPI0612781B8 true BRPI0612781B8 (pt) | 2021-05-25 |
Family
ID=35134140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0612781A BRPI0612781B8 (pt) | 2005-07-05 | 2006-07-04 | uso de um meio de cultura livre de soro para reduzir os níveis de formas oxidadas de uma gonadotrofina dimérica recombinante durante seu processo de fabricação |
Country Status (24)
Country | Link |
---|---|
US (1) | US8093052B2 (pt) |
EP (1) | EP1899454B1 (pt) |
JP (1) | JP5059757B2 (pt) |
KR (1) | KR101346499B1 (pt) |
CN (1) | CN101258236A (pt) |
AR (1) | AR054157A1 (pt) |
AU (1) | AU2006264917B2 (pt) |
BR (1) | BRPI0612781B8 (pt) |
CA (1) | CA2613867A1 (pt) |
CY (1) | CY1112992T1 (pt) |
DK (1) | DK1899454T3 (pt) |
EA (1) | EA012840B1 (pt) |
ES (1) | ES2388875T3 (pt) |
HR (1) | HRP20120486T1 (pt) |
IL (1) | IL188558A (pt) |
MY (1) | MY149621A (pt) |
NO (1) | NO341475B1 (pt) |
PL (1) | PL1899454T3 (pt) |
PT (1) | PT1899454E (pt) |
RS (1) | RS52468B (pt) |
SI (1) | SI1899454T1 (pt) |
TW (1) | TWI369401B (pt) |
UA (1) | UA91063C2 (pt) |
WO (1) | WO2007003640A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101264096B (zh) * | 2007-03-12 | 2011-11-09 | 中国医学科学院药物研究所 | 人参皂苷Rg1在制备生精产品中的应用 |
JP5570980B2 (ja) * | 2007-06-28 | 2014-08-13 | ラティオファーム ゲーエムベーハー | Fsh生産細胞クローン |
KR101848945B1 (ko) | 2010-04-26 | 2018-04-16 | 노파르티스 아게 | 개선된 세포 배양 배지 |
CN102296047B (zh) * | 2011-08-13 | 2013-03-13 | 新疆农垦科学院 | 利用羔羊超排卵母细胞生产体外胚胎的方法 |
KR102418824B1 (ko) * | 2013-10-14 | 2022-07-11 | 아레스 트레이딩 에스.아. | 포유동물의 고성능 유가식 배양을 위한 신규 배지 |
AU2016363789B2 (en) * | 2015-12-02 | 2022-06-02 | CSL Behring Lengnau AG | Improved media for the expression of recombinant vitamin K-dependent proteins |
CN105462909B (zh) * | 2015-12-31 | 2019-09-27 | 哈药集团技术中心 | 一种高效表达人促卵泡激素的cho细胞的培养方法 |
CN108795841A (zh) * | 2017-05-03 | 2018-11-13 | 上海奥浦迈生物科技有限公司 | 一种st培养基及其应用 |
CN110042137B (zh) * | 2019-05-14 | 2023-02-28 | 上海赛迈生物科技有限公司 | 高密度灌注培养重组cho细胞生产人促卵泡激素的方法、培养基及其应用 |
US20220204920A1 (en) | 2019-05-16 | 2022-06-30 | Formycon Ag | Method for reducing methionine oxidation in recombinant proteins |
CN114836367A (zh) * | 2022-04-28 | 2022-08-02 | 上海东富龙生物试剂有限公司 | 用于hek293细胞培养及腺病毒、腺相关病毒复制扩增的化学成分限定培养基 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3110559C2 (de) * | 1981-03-18 | 1985-05-09 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Vollsynthetisches Zellkulturmedium |
US4560655A (en) * | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) * | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
FR2600076A1 (fr) * | 1986-06-12 | 1987-12-18 | Fond Ctre Nal Transfusion | Milieu de culture comportant de l'albumine humaine, procede de preparation d'un produit injectable a partir de ce milieu, produit obtenu et son utilisation, composition obtenue |
US5122469A (en) * | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
USH1532H (en) * | 1993-11-03 | 1996-05-07 | Genetics Institute, Inc. | Adaption of mammalian cell lines to high cell densities |
WO1998004680A1 (en) | 1996-07-26 | 1998-02-05 | University Of Manitoba | Serum-free medium for growth of anchorage-dependant mammalian cells |
JP2000517188A (ja) * | 1996-08-30 | 2000-12-26 | ライフ テクノロジーズ,インコーポレイテッド | 無血清哺乳動物細胞培養培地およびその使用 |
DE69738806D1 (de) * | 1996-10-10 | 2008-08-14 | Invitrogen Corp | Tierzellkulturmedium mit pflanzlichen nährstoffen |
IL122732A0 (en) * | 1997-01-15 | 1998-08-16 | Akzo Nobel Nv | Liquid gonadotropin-containing formulation its preparation and a device containing same |
WO1999050390A1 (en) | 1998-03-30 | 1999-10-07 | Bionative Ab | Methionin containing animal cell culture medium and its use |
EP1452597A4 (en) * | 2001-12-04 | 2006-09-20 | Mitsubishi Pharma Corp | PROTEIN ACTIVATION METHOD |
US6756431B2 (en) * | 2002-04-09 | 2004-06-29 | Crompton Corporation | Heterocyclic tin flame retardants/smoke suppressants and halogen-containing polymer composition containing same |
DK1610822T4 (en) * | 2003-04-02 | 2019-01-14 | Ares Trading Sa | Liquid pharmaceutical FSH and LH formulations together with a nonionic surfactant |
CA2526099C (en) * | 2003-06-20 | 2013-02-05 | Ares Trading Sa | Freeze-dried fsh / lh formulations |
-
2006
- 2006-06-20 TW TW095121976A patent/TWI369401B/zh active
- 2006-07-03 MY MYPI20063160A patent/MY149621A/en unknown
- 2006-07-04 CA CA002613867A patent/CA2613867A1/en not_active Abandoned
- 2006-07-04 RS RS20120351A patent/RS52468B/en unknown
- 2006-07-04 ES ES06764058T patent/ES2388875T3/es active Active
- 2006-07-04 CN CNA2006800322795A patent/CN101258236A/zh active Pending
- 2006-07-04 SI SI200631359T patent/SI1899454T1/sl unknown
- 2006-07-04 JP JP2008519930A patent/JP5059757B2/ja active Active
- 2006-07-04 EA EA200800253A patent/EA012840B1/ru not_active IP Right Cessation
- 2006-07-04 WO PCT/EP2006/063862 patent/WO2007003640A1/en active Application Filing
- 2006-07-04 BR BRPI0612781A patent/BRPI0612781B8/pt active IP Right Grant
- 2006-07-04 PT PT06764058T patent/PT1899454E/pt unknown
- 2006-07-04 AR ARP060102879A patent/AR054157A1/es not_active Application Discontinuation
- 2006-07-04 US US11/994,885 patent/US8093052B2/en active Active
- 2006-07-04 EP EP06764058A patent/EP1899454B1/en active Active
- 2006-07-04 UA UAA200801394A patent/UA91063C2/ru unknown
- 2006-07-04 DK DK06764058.1T patent/DK1899454T3/da active
- 2006-07-04 KR KR1020087003007A patent/KR101346499B1/ko active IP Right Grant
- 2006-07-04 AU AU2006264917A patent/AU2006264917B2/en active Active
- 2006-07-04 PL PL06764058T patent/PL1899454T3/pl unknown
-
2008
- 2008-01-03 IL IL188558A patent/IL188558A/en active IP Right Grant
- 2008-01-31 NO NO20080580A patent/NO341475B1/no unknown
-
2012
- 2012-06-11 HR HRP20120486TT patent/HRP20120486T1/hr unknown
- 2012-07-09 CY CY20121100609T patent/CY1112992T1/el unknown
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
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Free format text: REF. A RPI NO 2153 DE 10/04/2012. ANULACAO DA EXIGENCIA 6.6 POR TER SIDO INDEVIDA. REQUERENTE NAO APRESENTOU RESPOSTA A EXIGENCIA CONFORME DISPOE A RESOLUCAO 207 DE 24/04/2009, ENTRETANTO, A RESPOSTA CONSTA NO FORMULARIO DE DEPOSITO. |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001 |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 15/09/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/07/2006 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |