ATE455752T1 - Herstellung von (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpent namin - Google Patents
Herstellung von (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpent naminInfo
- Publication number
- ATE455752T1 ATE455752T1 AT07787803T AT07787803T ATE455752T1 AT E455752 T1 ATE455752 T1 AT E455752T1 AT 07787803 T AT07787803 T AT 07787803T AT 07787803 T AT07787803 T AT 07787803T AT E455752 T1 ATE455752 T1 AT E455752T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- methoxyphenyl
- namin
- trimethylpent
- trimethylpentanamine
- Prior art date
Links
- JKVBTSJLQLSTHJ-SWLSCSKDSA-N (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentan-1-amine Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(OC)=C1 JKVBTSJLQLSTHJ-SWLSCSKDSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- KWTWDQCKEHXFFR-SMDDNHRTSA-N tapentadol Chemical compound CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 KWTWDQCKEHXFFR-SMDDNHRTSA-N 0.000 abstract 1
- 229960005126 tapentadol Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117708 | 2006-07-24 | ||
| PCT/EP2007/057559 WO2008012283A1 (en) | 2006-07-24 | 2007-07-23 | Preparation of (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpentanamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE455752T1 true ATE455752T1 (de) | 2010-02-15 |
Family
ID=37772663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07787803T ATE455752T1 (de) | 2006-07-24 | 2007-07-23 | Herstellung von (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpent namin |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8138376B2 (de) |
| EP (1) | EP2046726B1 (de) |
| JP (1) | JP5208933B2 (de) |
| KR (1) | KR101370398B1 (de) |
| CN (1) | CN101495447B (de) |
| AT (1) | ATE455752T1 (de) |
| AU (1) | AU2007278224C1 (de) |
| BR (1) | BRPI0714671B8 (de) |
| CA (1) | CA2656696C (de) |
| CY (1) | CY1110075T1 (de) |
| DE (1) | DE602007004494D1 (de) |
| DK (1) | DK2046726T3 (de) |
| EA (1) | EA015003B1 (de) |
| ES (1) | ES2339403T3 (de) |
| HR (1) | HRP20100197T1 (de) |
| IL (1) | IL196627A (de) |
| MX (1) | MX2009000911A (de) |
| PL (1) | PL2046726T3 (de) |
| PT (1) | PT2046726E (de) |
| SI (1) | SI2046726T1 (de) |
| WO (1) | WO2008012283A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI401237B (zh) * | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 | |
| CN102002065B (zh) * | 2009-09-02 | 2014-09-10 | 上海特化医药科技有限公司 | 他喷他多的制备方法及其中间体 |
| US8288592B2 (en) | 2009-09-22 | 2012-10-16 | Actavis Group Ptc Ehf | Solid state forms of tapentadol salts |
| IT1397189B1 (it) * | 2009-12-01 | 2013-01-04 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| AU2010337825A1 (en) | 2009-12-29 | 2012-07-05 | Mapi Pharma Limited | Intermediate compounds and processes for the preparation of tapentadol and related compounds |
| WO2011092719A2 (en) * | 2010-02-01 | 2011-08-04 | Ind-Swift Laboratories Limited | Process for the preparation of l-phenyl-3-dimethylaminopropane derivatives |
| US20130096346A1 (en) | 2010-03-05 | 2013-04-18 | Actavis Group Ptc Ehf | Resolution methods for isolating desired enantiomers of tapentadol intermediates and use thereof for the preparation of tapentadol |
| AU2011241897A1 (en) | 2010-04-05 | 2012-09-27 | Actavis Group Ptc Ehf | Novel process for preparing highly pure tapentadol or a pharmaceutically acceptable salt thereof |
| IT1401109B1 (it) * | 2010-07-02 | 2013-07-12 | Archimica Srl | Nuovo processo per la preparazione di tapentadol e suoi intermedi. |
| EP2595971A1 (de) * | 2010-07-23 | 2013-05-29 | Grünenthal GmbH | Salze oder kokristalle aus 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol |
| WO2012038974A1 (en) | 2010-09-20 | 2012-03-29 | Ind-Swift Laboratories Limited | Process for preparing l-phenyl-3-dimethylaminopropane derivative |
| CN102477016B (zh) * | 2010-11-26 | 2014-12-17 | 中国医学科学院药物研究所 | 他喷他多的中间体的合成与应用 |
| CZ303115B6 (cs) * | 2010-12-30 | 2012-04-11 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu |
| CZ302993B6 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
| CZ2010997A3 (cs) * | 2010-12-30 | 2012-02-08 | Zentiva, K.S. | Zpusob výroby (2R,3R)-N,N-dimethyl-3-(3-hydroxyfenyl)-2-methylpentylaminu (tapentadolu) |
| WO2012089181A1 (en) * | 2010-12-30 | 2012-07-05 | Zentiva, K.S. | O-substituted (2r,3r)-3-(3-hydroxyphenyl)-2-methyl-4-pentenoic acids and a method of obtaining the same |
| CN102617501A (zh) * | 2011-01-31 | 2012-08-01 | 中国科学院上海药物研究所 | 取代正戊酰胺类化合物、其制备方法及用途 |
| PL3287123T3 (pl) | 2011-03-04 | 2020-11-02 | Grünenthal GmbH | Wodny preparat farmaceutyczny tapentadolu do podawania doustnego |
| CA2828635C (en) * | 2011-03-04 | 2020-01-14 | Grunenthal Gmbh | Parenteral administration of tapentadol |
| LT2680834T (lt) | 2011-03-04 | 2018-01-10 | Grünenthal GmbH | Pusiau kieta vandeninė farmacinė kompozicija, turinti tapentadolio |
| CN102206164A (zh) * | 2011-04-11 | 2011-10-05 | 中国药科大学 | 一种他喷他多中间体的制备方法 |
| WO2012146978A2 (en) | 2011-04-28 | 2012-11-01 | Actavis Group Ptc Ehf | A novel process for the preparation of tapentadol or a pharmaceutically acceptable salt thereof |
| US20130150622A1 (en) | 2011-12-12 | 2013-06-13 | Boehringer Ingelheim International Gmbh | Stereoselective synthesis of tapentadol and its salts |
| WO2013120466A1 (en) | 2012-02-17 | 2013-08-22 | Zentiva, K.S. | A new solid form of tapentadol and a method of its preparation |
| EP2674414A1 (de) | 2012-06-15 | 2013-12-18 | Siegfried AG | Verfahren zur Herstellung von 1-aryl-1-alkyl-3-dialkylaminopropan-Verbindungen |
| CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
| IN2013MU03670A (de) | 2013-11-21 | 2015-07-31 | Unimark Remedies Ltd | |
| SI3083551T1 (en) | 2013-12-16 | 2018-04-30 | Farma Grs, D.O.O. | CRYSTAL FORM INTERMEDIATE TAPENTADOL |
| CN104725287A (zh) * | 2013-12-20 | 2015-06-24 | 北京蓝贝望生物医药科技股份有限公司 | 一种对甲苯磺酸酯的制备方法与应用 |
| CZ307492B6 (cs) | 2014-02-04 | 2018-10-17 | Zentiva, K.S. | Pevná forma maleátu tapentadolu a způsob její přípravy |
| HRP20190231T1 (hr) | 2015-03-27 | 2019-04-05 | Grünenthal GmbH | Stabilna formulacija za parenteralnu primjenu tapentadola |
| CN106278915A (zh) * | 2015-05-19 | 2017-01-04 | 重庆圣华曦药业股份有限公司 | 一种制备他喷他多中间体的方法 |
| HUE068166T2 (hu) | 2015-07-10 | 2024-12-28 | SpecGx LLC | Kétlépéses eljárás 3-szubsztituált fenil-alkilaminok elõállítására |
| CA3037810A1 (en) | 2016-09-23 | 2018-03-29 | Grunenthal Gmbh | Stable formulation for parenteral administration of tapentadol |
| SK812017A3 (sk) * | 2017-08-18 | 2019-03-01 | Saneca Pharmaceuticals A. S. | Spôsob prípravy tapentadolu a jeho medziproduktov |
| EP3807243B1 (de) | 2018-06-15 | 2024-05-22 | Pharmathen S.A. | Neuartiges verfahren zur herstellung von tapentadol |
| WO2020194326A1 (en) * | 2019-03-28 | 2020-10-01 | Council Of Scientific And Industrial Research | Process for the preparation of tapentadol and analogs thereof |
| EP4116288A1 (de) | 2021-07-08 | 2023-01-11 | KRKA, d.d., Novo mesto | Racemisierung von (s) und/oder (r)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-on und mischungen davon |
| EP4269384A1 (de) | 2022-04-26 | 2023-11-01 | KRKA, d.d., Novo mesto | Verfahren zur kristallisation eines tapentadolzwischenprodukts, tapentadolzwischenprodukt hoher reinheit, verfahren zur herstellung von tapentadol und tapentadol hoher reinheit |
| CN119176758B (zh) * | 2024-11-26 | 2025-05-09 | 苏州盛迪亚生物医药有限公司 | 一种固载催化制备他喷他多或其可药用盐的方法 |
| CN119192000B (zh) * | 2024-11-26 | 2025-07-15 | 苏州盛迪亚生物医药有限公司 | 连续流反应制备他喷他多或其可药用盐的方法 |
| CN119191999A (zh) * | 2024-11-26 | 2024-12-27 | 苏州盛迪亚生物医药有限公司 | 一种制备他喷他多或其可药用盐的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60188333A (ja) * | 1984-03-07 | 1985-09-25 | Ihara Chem Ind Co Ltd | ハロゲン化ベンゼン類の製造方法 |
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| DE19609847A1 (de) * | 1996-03-13 | 1997-09-18 | Gruenenthal Gmbh | Dimethyl-(3-aryl-but-3-enyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| EP1188433B1 (de) * | 2000-09-14 | 2007-01-03 | Firmenich Sa | Verwendung von ungesättigten Estern als Duftstoffe |
| DE10326097A1 (de) * | 2003-06-06 | 2005-01-05 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-butyl)-aminverbindungen |
| DE10328316A1 (de) * | 2003-06-23 | 2005-01-20 | Grünenthal GmbH | Verfahren zur Herstellung von Dimethyl-(3-aryl-buthyl)-aminverbindungen als pharmazeutische Wirkstoffe |
| TWI401237B (zh) * | 2006-07-24 | 2013-07-11 | ３-〔（１ｒ，２ｒ）-３-（二甲基氨基）-１-乙基-２-甲基丙基〕酚之製備 |
-
2007
- 2007-07-23 AT AT07787803T patent/ATE455752T1/de active
- 2007-07-23 JP JP2009521242A patent/JP5208933B2/ja active Active
- 2007-07-23 ES ES07787803T patent/ES2339403T3/es active Active
- 2007-07-23 PL PL07787803T patent/PL2046726T3/pl unknown
- 2007-07-23 US US12/374,894 patent/US8138376B2/en active Active
- 2007-07-23 HR HR20100197T patent/HRP20100197T1/hr unknown
- 2007-07-23 EA EA200970147A patent/EA015003B1/ru not_active IP Right Cessation
- 2007-07-23 SI SI200730205T patent/SI2046726T1/sl unknown
- 2007-07-23 DE DE602007004494T patent/DE602007004494D1/de active Active
- 2007-07-23 CA CA2656696A patent/CA2656696C/en active Active
- 2007-07-23 DK DK07787803.1T patent/DK2046726T3/da active
- 2007-07-23 KR KR1020097000899A patent/KR101370398B1/ko active Active
- 2007-07-23 EP EP07787803A patent/EP2046726B1/de active Active
- 2007-07-23 PT PT07787803T patent/PT2046726E/pt unknown
- 2007-07-23 MX MX2009000911A patent/MX2009000911A/es active IP Right Grant
- 2007-07-23 WO PCT/EP2007/057559 patent/WO2008012283A1/en not_active Ceased
- 2007-07-23 BR BRPI0714671A patent/BRPI0714671B8/pt active IP Right Grant
- 2007-07-23 AU AU2007278224A patent/AU2007278224C1/en active Active
- 2007-07-23 CN CN2007800284726A patent/CN101495447B/zh not_active Expired - Fee Related
-
2009
- 2009-01-21 IL IL196627A patent/IL196627A/en active IP Right Grant
-
2010
- 2010-04-20 CY CY20101100353T patent/CY1110075T1/el unknown
-
2012
- 2012-02-15 US US13/397,186 patent/US8440863B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE455752T1 (de) | Herstellung von (2r,3r)-3-(3-methoxyphenyl)-n,n,2-trimethylpent namin | |
| ATE515491T1 (de) | Herstellung von 3-ä(1r,2r)-3-(dimethylamino)- 1ethyl-2-methylpropylüphenol | |
| CY1124873T1 (el) | Διεργασια για την παρασκευη (1r,2r)-3-(3-διμεθυλαμινο-1-αιθυλο-2-μεθυλο-προπυλο)-φαινολης | |
| EA201100094A1 (ru) | Тиадиазолилоксифениламидины и их применение в качестве фунгицидов | |
| EA201100093A1 (ru) | Тиадиазолилоксифениламидины и применение их в качестве фунгицидов | |
| EA200900098A1 (ru) | Пептидные соединения для лечения расстройств, связанных с повышенной возбудимостью, и болезней, связанных с дисфункцией ионных каналов | |
| EA201100727A1 (ru) | Новый способ получения производных аминокислот | |
| BR112014012275A2 (pt) | purificação de proteína com a utilização de tampão bis-tris | |
| EA201190144A1 (ru) | Изотиазолилоксифениламидины и их применение в качестве фунгицидов | |
| EA200870514A1 (ru) | Ацетиленовые гетероарильные соединения | |
| EA200970247A1 (ru) | Способ получения оптического активного n-защищенного 3-аминопирролидина или оптически активного n-защищенного 3-аминопиперидина и соответствующих кетонов путем оптического разделения рацемических смесей аминов с использованием бактериальной омега-трансаминазы | |
| EA201070853A1 (ru) | Кристаллический (r)-2-(4-циклопропансульфонилфенил)-n-пиразин-2-ил-3-(тетрагидропиран-4-ил)пропионамид | |
| EA200801560A1 (ru) | Бифенилкарбоксамиды | |
| EA200900090A1 (ru) | Бензиламины, способ их получения и их применение в качестве противовоспалительных средств | |
| EA200970126A1 (ru) | Способ получения прегабалина и его энантиомера | |
| MX2007005936A (es) | Una sintesis asimetrica del acido (s)-(+)-3-(aminometil)-5- metilhexanoico. | |
| BRPI0507308A (pt) | nanossuspensões de agentes anti-retrovirais para entrega ao sistema nervoso central aumentada | |
| MX2010009931A (es) | Proceso para la preparacion de 2-amino-2-[2-(4-c3-c21-alquil-fenil )-etil]-propano-1,3-dioles. | |
| CO6390054A2 (es) | Formas cristalinas de un compuesto 3-carboxipropil-aminotetralina | |
| ITMI20050249A1 (it) | Procedimento per la preparazione di tolterodina | |
| EA201071164A1 (ru) | Жидкие и лиофилизованные композиции | |
| EA201170072A1 (ru) | Способ асимметричного синтеза замещенных 2-аминотиазолонов | |
| ATE546451T1 (de) | Cyclopropancarbonsäureester von acyclovir | |
| CL2011000932A1 (es) | Proceso para la preparacion de 9-diclorometilen-1,2,3,3-tetrahidro-1,4-metano-naftalen-5-ilamina; compuesto intermedio y proceso para preparar 6,6-diclorfulveno. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 2046726 Country of ref document: EP |