TWI369401B - Serum-free culture medium for the production of recombinant gonadotropins - Google Patents

Serum-free culture medium for the production of recombinant gonadotropins

Info

Publication number
TWI369401B
TWI369401B TW095121976A TW95121976A TWI369401B TW I369401 B TWI369401 B TW I369401B TW 095121976 A TW095121976 A TW 095121976A TW 95121976 A TW95121976 A TW 95121976A TW I369401 B TWI369401 B TW I369401B
Authority
TW
Taiwan
Prior art keywords
serum
production
culture medium
free culture
recombinant gonadotropins
Prior art date
Application number
TW095121976A
Other languages
English (en)
Other versions
TW200732473A (en
Inventor
Jean-Pierre Fonta
Paul Ducommun
Original Assignee
Ares Trading Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ares Trading Sa filed Critical Ares Trading Sa
Publication of TW200732473A publication Critical patent/TW200732473A/zh
Application granted granted Critical
Publication of TWI369401B publication Critical patent/TWI369401B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2511/00—Cells for large scale production
TW095121976A 2005-07-05 2006-06-20 Serum-free culture medium for the production of recombinant gonadotropins TWI369401B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05106060 2005-07-05
US69707705P 2005-07-06 2005-07-06

Publications (2)

Publication Number Publication Date
TW200732473A TW200732473A (en) 2007-09-01
TWI369401B true TWI369401B (en) 2012-08-01

Family

ID=35134140

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095121976A TWI369401B (en) 2005-07-05 2006-06-20 Serum-free culture medium for the production of recombinant gonadotropins

Country Status (24)

Country Link
US (1) US8093052B2 (zh)
EP (1) EP1899454B1 (zh)
JP (1) JP5059757B2 (zh)
KR (1) KR101346499B1 (zh)
CN (1) CN101258236A (zh)
AR (1) AR054157A1 (zh)
AU (1) AU2006264917B2 (zh)
BR (1) BRPI0612781B8 (zh)
CA (1) CA2613867A1 (zh)
CY (1) CY1112992T1 (zh)
DK (1) DK1899454T3 (zh)
EA (1) EA012840B1 (zh)
ES (1) ES2388875T3 (zh)
HR (1) HRP20120486T1 (zh)
IL (1) IL188558A (zh)
MY (1) MY149621A (zh)
NO (1) NO341475B1 (zh)
PL (1) PL1899454T3 (zh)
PT (1) PT1899454E (zh)
RS (1) RS52468B (zh)
SI (1) SI1899454T1 (zh)
TW (1) TWI369401B (zh)
UA (1) UA91063C2 (zh)
WO (1) WO2007003640A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264096B (zh) * 2007-03-12 2011-11-09 中国医学科学院药物研究所 人参皂苷Rg1在制备生精产品中的应用
PT2170942E (pt) * 2007-06-28 2013-10-22 Biogenerix Ag Clone celular produtor de fsh
AU2011246504B2 (en) 2010-04-26 2013-09-26 Novartis Ag Improved cell culture medium
CN102296047B (zh) * 2011-08-13 2013-03-13 新疆农垦科学院 利用羔羊超排卵母细胞生产体外胚胎的方法
US10138467B2 (en) * 2013-10-14 2018-11-27 Ares Trading S.A. Medium for high performance mammalian fed-batch cultures
EP3383894B1 (en) * 2015-12-02 2020-05-06 CSL Behring Lengnau AG Improved media for the expression of recombinant vitamin k-dependent proteins
CN105462909B (zh) * 2015-12-31 2019-09-27 哈药集团技术中心 一种高效表达人促卵泡激素的cho细胞的培养方法
CN108795841A (zh) * 2017-05-03 2018-11-13 上海奥浦迈生物科技有限公司 一种st培养基及其应用
CN110042137B (zh) * 2019-05-14 2023-02-28 上海赛迈生物科技有限公司 高密度灌注培养重组cho细胞生产人促卵泡激素的方法、培养基及其应用
US20220204920A1 (en) 2019-05-16 2022-06-30 Formycon Ag Method for reducing methionine oxidation in recombinant proteins
CN114836367A (zh) * 2022-04-28 2022-08-02 上海东富龙生物试剂有限公司 用于hek293细胞培养及腺病毒、腺相关病毒复制扩增的化学成分限定培养基

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3110559C2 (de) 1981-03-18 1985-05-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Vollsynthetisches Zellkulturmedium
US4560655A (en) * 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) * 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
FR2600076A1 (fr) * 1986-06-12 1987-12-18 Fond Ctre Nal Transfusion Milieu de culture comportant de l'albumine humaine, procede de preparation d'un produit injectable a partir de ce milieu, produit obtenu et son utilisation, composition obtenue
US5122469A (en) * 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
USH1532H (en) * 1993-11-03 1996-05-07 Genetics Institute, Inc. Adaption of mammalian cell lines to high cell densities
WO1998004680A1 (en) * 1996-07-26 1998-02-05 University Of Manitoba Serum-free medium for growth of anchorage-dependant mammalian cells
EP2221361A3 (en) * 1996-08-30 2011-02-09 Life Technologies Corporation Method for producing a polypeptide in vitro in mammalian cells in a protein-free and serum-free culture medium
DE69738806D1 (de) * 1996-10-10 2008-08-14 Invitrogen Corp Tierzellkulturmedium mit pflanzlichen nährstoffen
IL122732A0 (en) * 1997-01-15 1998-08-16 Akzo Nobel Nv Liquid gonadotropin-containing formulation its preparation and a device containing same
WO1999050390A1 (en) * 1998-03-30 1999-10-07 Bionative Ab Methionin containing animal cell culture medium and its use
CA2468971A1 (en) * 2001-12-04 2003-06-12 Mitsubishi Pharma Corporation Method of activating protein
US6756431B2 (en) * 2002-04-09 2004-06-29 Crompton Corporation Heterocyclic tin flame retardants/smoke suppressants and halogen-containing polymer composition containing same
WO2004087213A1 (en) * 2003-04-02 2004-10-14 Ares Trading S.A. Liquid pharmaceutical formulations of fsh and lh together with a non-ionic surfactant
PT1638595E (pt) * 2003-06-20 2013-04-26 Ares Trading Sa Fsh liofilizada / formulações de hl

Also Published As

Publication number Publication date
AU2006264917A1 (en) 2007-01-11
CN101258236A (zh) 2008-09-03
NO341475B1 (no) 2017-11-27
US8093052B2 (en) 2012-01-10
BRPI0612781A2 (pt) 2010-11-30
ES2388875T3 (es) 2012-10-19
CA2613867A1 (en) 2007-01-11
CY1112992T1 (el) 2016-04-13
BRPI0612781B1 (pt) 2020-09-15
US20090124006A1 (en) 2009-05-14
JP5059757B2 (ja) 2012-10-31
MY149621A (en) 2013-09-13
KR20080036599A (ko) 2008-04-28
PT1899454E (pt) 2012-06-25
KR101346499B1 (ko) 2013-12-31
JP2008544758A (ja) 2008-12-11
DK1899454T3 (da) 2012-07-09
RS52468B (en) 2013-02-28
IL188558A0 (en) 2008-04-13
EA200800253A1 (ru) 2008-06-30
EP1899454B1 (en) 2012-05-30
IL188558A (en) 2012-04-30
EA012840B1 (ru) 2009-12-30
AU2006264917B2 (en) 2011-04-28
HRP20120486T1 (hr) 2012-07-31
AR054157A1 (es) 2007-06-06
UA91063C2 (ru) 2010-06-25
NO20080580L (no) 2008-01-31
BRPI0612781B8 (pt) 2021-05-25
WO2007003640A1 (en) 2007-01-11
TW200732473A (en) 2007-09-01
EP1899454A1 (en) 2008-03-19
PL1899454T3 (pl) 2012-10-31
SI1899454T1 (sl) 2012-08-31

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