AR045238A1 - Compuestos utiles como inhibidores de canales ionicos regulados por voltaje - Google Patents
Compuestos utiles como inhibidores de canales ionicos regulados por voltajeInfo
- Publication number
- AR045238A1 AR045238A1 ARP040102855A ARP040102855A AR045238A1 AR 045238 A1 AR045238 A1 AR 045238A1 AR P040102855 A ARP040102855 A AR P040102855A AR P040102855 A ARP040102855 A AR P040102855A AR 045238 A1 AR045238 A1 AR 045238A1
- Authority
- AR
- Argentina
- Prior art keywords
- aliphatic
- nr6c
- nr5c
- optionally comprises
- independently selected
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 108090000862 Ion Channels Proteins 0.000 title 1
- 102000004310 Ion Channels Human genes 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 8
- 125000001931 aliphatic group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- -1 1,2-methylenedioxy Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
Classifications
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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Abstract
Reivindicación 1: Un compuesto de la fórmula (1), en donde: cada RN es independientemente hidrógeno o C1-4 alifático opcionalmente sustituido con hasta dos sustituyentes seleccionados de R1, R4, o R5; X1 es O, S o NRx; p es 0 o 1; Rx es H o R2; X2 es alifático C1-3, opcionalmente sustituido con hasta 2 sustituyentes seleccionados, de modo independiente, de R1, R4 o R5; Z se selecciona de un resto de grupo de fórmula (2), T es un anillo bicíclico o tricíclico aromático o no aromático de 8-14 miembros, que tiene 0-5 heteroátomos seleccionados de O, S, N, NH, S(O) o SO2; en donde el anillo T está unido al resto de la molécula a través de un átomo del anillo de carbono; en donde cada uno de Z y T comprende opcionalmente hasta 4 sustituyentes seleccionados, de modo independiente, de R1, R2, R3, R4 o R5; R1 es oxo, =NN(R6)2, =NN(R7)2, =NN(R6R7), R6 o (CH2)n-Y; n es 0, 1 ó 2; Y es halo, CN, NO2, CF3, OCF3, OH, SR6, S(O)R6, SO2R6, NH2, NHR6, N(R6)2, NR6R8, COOH, COOR6 u OR6; o dos R1 en átomos de anillo adyacentes, tomados juntos, forman 1,2-metilendioxi o 1,2-etilendioxi; R2 es alifático, en donde cada R2 comprende opcionalmente hasta 2 sustituyentes seleccionados, de modo independiente, de R1, R4 o R5; R3 es un anillo cicloalifático, arilo, heterocíclico o heteroarilo que opcionalmente comprende hasta 3 sustituyentes seleccionados, de modo independiente, de R1, R2, R4 o R5; R4 es OR5, OR6, OC(O)R6, OC(O)R5, OC(O)OR6, OC(O)OR5, OC(O)N(R6)2, OC(O)N(R5)2, OC(O)N(R6R5), OP(O)(OR6)2, OP(O)(OR5)2, OP(O)(OR6)(OR5), SR6, SR5, S(O)R6, S(O)R5, SO2R6, SO2R5, SO2N(R6)2, SO2N(R5)2, SO2NR5R6, SO3R6, SO3R5, C(O)R5, C(O)OR5, C(O)R6, C(O)OR6, C(O)N(R6)2, C(O)N(R5)2, C(O)N(R5R6), C(O)N(OR6)R6, C(O)N(OR5)R6, C(O)N(OR6)R5, C(O)N(OR5)R5, C(NOR6)R6, C(NOR6)R5, C(NOR5)R6, C(NOR5)R5, N(R6)2, N(R5)2, N(R5R6), NR5C(O)R5, NR6C(O)R6, NR6C(O)R5, NR6C(O)OR6, NR5C(O)OR6, NR6C(O)OR5, NR5C(O)OR5, NR6C(O)N(R6)2, NR6C(O)NR5R6, NR6C(O)N(R5)2, NR5C(O)N(R6)2, NR5C(O)NR5R6, NR5C(O)N(R5)2, NR6SO2R6, NR6SO2R5, NR5SO2R5, NR6SO2N(R6)2, NR6SO2NR5R6, NR6SO2N(R5)2, NR5SO2NR5R6, NR5SO2N(R5)2, N(OR6)R6, N(OR6)R5, N(OR5)R5, N(OR5)R6, P(O)(OR6)N(R6)2, P(O)(OR6)N(R5R6), P(O)(OR6)N(R5)2, P(O)(OR5)N(R5R6), P(O)(OR5)N(R6)2, P(O)(OR5)N(R5)2, P(O)(OR6)2, P(O)(OR5)2 o P(O)(OR6)(OR5); R5 es un anillo cicloalifático, arilo, heterocíclico o heteroarilo que opcionalmente comprende hasta 3 sustituyentes R1; R6 es H o alifático, en donde R6 comprende opcionalmente un sustituyente R7; R7 es un anillo cicloalifático, arilo, heterocíclico o heteroarilo y cada R7 comprende opcionalmente hasta 2 sustituyentes seleccionados, de modo independiente, de H, alifático o (CH2)n-Z'; Z' se selecciona de halo, CN, NO2, CF3, OCF3, OH, S-alifático, S(O)-alifático, SO2-alifático, NH2, N-alifático, N(alifático)2, N(alifático)R8, COOH, C(O)O(-alifático u O-alifático); y R8 es un grupo de protección amino; con la condición de que: i) cuando: X2, X1, q, y p son juntos -CH2-O-, entonces: T no sea ninguno de los restos de grupo de fórmula (3), ii) cuando: X2, X1, q y p son juntos -CH2-S-, entonces: T no sea ninguno de los restos de grupos de fórmula (4), en donde B es hidrógeno, metilo, n-propilo, isopropilo, alilo, bencilo o feniletilo.
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US8202861B2 (en) | 2012-06-19 |
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WO2005013914A8 (en) | 2006-09-28 |
JP2011032294A (ja) | 2011-02-17 |
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CA2539227A1 (en) | 2005-02-17 |
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KR20060073930A (ko) | 2006-06-29 |
EP2332912A1 (en) | 2011-06-15 |
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