HUE037637T2 - N-(3-fluorobenzil)-2-(5-(4-morfolinofenil)piridin-2-IL) acetamid, mint fehérje tirozin kináz modulátorok - Google Patents
N-(3-fluorobenzil)-2-(5-(4-morfolinofenil)piridin-2-IL) acetamid, mint fehérje tirozin kináz modulátorokInfo
- Publication number
- HUE037637T2 HUE037637T2 HUE13760222A HUE13760222A HUE037637T2 HU E037637 T2 HUE037637 T2 HU E037637T2 HU E13760222 A HUE13760222 A HU E13760222A HU E13760222 A HUE13760222 A HU E13760222A HU E037637 T2 HUE037637 T2 HU E037637T2
- Authority
- HU
- Hungary
- Prior art keywords
- morpholinophenyl
- fluorobenzyl
- pyridin
- acetamide
- tyrosine kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261695100P | 2012-08-30 | 2012-08-30 | |
US201361779868P | 2013-03-13 | 2013-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE037637T2 true HUE037637T2 (hu) | 2018-09-28 |
Family
ID=49162280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE13760222A HUE037637T2 (hu) | 2012-08-30 | 2013-08-30 | N-(3-fluorobenzil)-2-(5-(4-morfolinofenil)piridin-2-IL) acetamid, mint fehérje tirozin kináz modulátorok |
Country Status (13)
Country | Link |
---|---|
US (5) | US9926273B2 (hu) |
EP (1) | EP2890680B1 (hu) |
JP (3) | JP6499076B2 (hu) |
KR (1) | KR102346033B1 (hu) |
CN (2) | CN105263907B (hu) |
CA (1) | CA2883144C (hu) |
ES (1) | ES2664332T3 (hu) |
HK (2) | HK1212329A1 (hu) |
HU (1) | HUE037637T2 (hu) |
LT (1) | LT2890680T (hu) |
SI (1) | SI2890680T1 (hu) |
TW (1) | TWI664167B (hu) |
WO (1) | WO2014036426A1 (hu) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7968574B2 (en) * | 2004-12-28 | 2011-06-28 | Kinex Pharmaceuticals, Llc | Biaryl compositions and methods for modulating a kinase cascade |
US7935697B2 (en) | 2006-12-28 | 2011-05-03 | Kinex Pharmaceuticals, Llc | Compositions for modulating a kinase cascade and methods of use thereof |
CN105263907B (zh) | 2012-08-30 | 2018-11-20 | 阿西纳斯公司 | 作为蛋白质酪氨酸激酶调节剂的n-(3-氟苄基)-2-(5-(4-吗啉代苯基)吡啶-2-基)乙酰胺 |
CN106902357B (zh) * | 2015-12-21 | 2021-08-03 | 广州市香雪制药股份有限公司 | 药物组合物及其应用、药物包合物、静脉制剂及制备方法 |
CN106902358B (zh) * | 2015-12-21 | 2020-07-10 | 广州市香雪制药股份有限公司 | 口服制剂及其制备方法 |
CN114516832B (zh) * | 2020-11-20 | 2023-11-28 | 成都贝诺科成生物科技有限公司 | 一种微管蛋白抑制剂及其制备方法与应用 |
CN113354575B (zh) * | 2021-06-07 | 2022-09-27 | 河南应用技术职业学院 | 一种特班布林的合成方法 |
CN115477608B (zh) * | 2021-06-16 | 2023-12-12 | 成都贝诺科成生物科技有限公司 | 一种微管蛋白抑制剂及其制备方法与应用 |
CN116444425A (zh) * | 2022-01-14 | 2023-07-18 | 武汉人福创新药物研发中心有限公司 | 微管蛋白-src双靶点抑制剂 |
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US20100256147A1 (en) | 2007-04-13 | 2010-10-07 | Hangauer Jr David G | Biaryl acetamide derivatives as modulators of the kinase cascade for the treatment of hearing loss, osteoporosis and cell proliferation disorders |
EP2155681B1 (en) * | 2007-05-17 | 2018-05-02 | Athenex, Inc. | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof |
EP2558085B1 (en) * | 2010-04-16 | 2017-08-30 | Athenex, Inc. | Compositions and methods for the prevention and treatment of cancer |
CN105263907B (zh) | 2012-08-30 | 2018-11-20 | 阿西纳斯公司 | 作为蛋白质酪氨酸激酶调节剂的n-(3-氟苄基)-2-(5-(4-吗啉代苯基)吡啶-2-基)乙酰胺 |
-
2013
- 2013-08-30 CN CN201380056173.9A patent/CN105263907B/zh active Active
- 2013-08-30 ES ES13760222.3T patent/ES2664332T3/es active Active
- 2013-08-30 SI SI201330972T patent/SI2890680T1/en unknown
- 2013-08-30 JP JP2015530099A patent/JP6499076B2/ja active Active
- 2013-08-30 US US14/015,030 patent/US9926273B2/en active Active
- 2013-08-30 CA CA2883144A patent/CA2883144C/en active Active
- 2013-08-30 WO PCT/US2013/057565 patent/WO2014036426A1/en active Application Filing
- 2013-08-30 EP EP13760222.3A patent/EP2890680B1/en active Active
- 2013-08-30 TW TW102131239A patent/TWI664167B/zh active
- 2013-08-30 HU HUE13760222A patent/HUE037637T2/hu unknown
- 2013-08-30 LT LTEP13760222.3T patent/LT2890680T/lt unknown
- 2013-08-30 KR KR1020157008132A patent/KR102346033B1/ko active IP Right Grant
- 2013-08-30 CN CN201811229699.3A patent/CN109999040A/zh active Pending
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2016
- 2016-01-06 HK HK16100079.6A patent/HK1212329A1/xx unknown
- 2016-03-29 HK HK16103558.0A patent/HK1215544A1/zh unknown
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2018
- 2018-02-13 US US15/895,244 patent/US10106505B2/en active Active
- 2018-10-26 JP JP2018201398A patent/JP2019052153A/ja active Pending
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2019
- 2019-05-10 US US16/408,780 patent/US20190263755A1/en not_active Abandoned
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2020
- 2020-08-24 US US17/001,054 patent/US20210214305A1/en not_active Abandoned
- 2020-10-12 JP JP2020171651A patent/JP2021006580A/ja active Pending
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2022
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Also Published As
Publication number | Publication date |
---|---|
SI2890680T1 (en) | 2018-08-31 |
EP2890680B1 (en) | 2018-02-28 |
EP2890680A1 (en) | 2015-07-08 |
US20210214305A1 (en) | 2021-07-15 |
US9926273B2 (en) | 2018-03-27 |
TWI664167B (zh) | 2019-07-01 |
CA2883144A1 (en) | 2014-03-06 |
CN109999040A (zh) | 2019-07-12 |
US20180170875A1 (en) | 2018-06-21 |
JP2019052153A (ja) | 2019-04-04 |
WO2014036426A1 (en) | 2014-03-06 |
CN105263907B (zh) | 2018-11-20 |
CN105263907A (zh) | 2016-01-20 |
TW201422585A (zh) | 2014-06-16 |
HK1215544A1 (zh) | 2016-09-02 |
KR20150046329A (ko) | 2015-04-29 |
US10106505B2 (en) | 2018-10-23 |
CA2883144C (en) | 2023-01-17 |
JP2015526526A (ja) | 2015-09-10 |
HK1212329A1 (en) | 2016-06-10 |
US20230167060A1 (en) | 2023-06-01 |
LT2890680T (lt) | 2018-05-10 |
US20140066445A1 (en) | 2014-03-06 |
US20190263755A1 (en) | 2019-08-29 |
JP2021006580A (ja) | 2021-01-21 |
KR102346033B1 (ko) | 2021-12-30 |
ES2664332T3 (es) | 2018-04-19 |
JP6499076B2 (ja) | 2019-04-10 |
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