AR036029A1 - Derivados de fenilurea sustituidos con carbonamida, procedimiento para preparacion, medicamentos y su empleo para la preparacion de medicamentos para el tratamiento de la diabetes tipo ii - Google Patents
Derivados de fenilurea sustituidos con carbonamida, procedimiento para preparacion, medicamentos y su empleo para la preparacion de medicamentos para el tratamiento de la diabetes tipo iiInfo
- Publication number
- AR036029A1 AR036029A1 ARP020101919A ARP020101919A AR036029A1 AR 036029 A1 AR036029 A1 AR 036029A1 AR P020101919 A ARP020101919 A AR P020101919A AR P020101919 A ARP020101919 A AR P020101919A AR 036029 A1 AR036029 A1 AR 036029A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- coo
- alkenyl
- alkynyl
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
- C07C275/48—Y being a hydrogen or a carbon atom
- C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
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- C07D209/04—Indoles; Hydrogenated indoles
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Neurology (AREA)
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- Immunology (AREA)
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Abstract
Derivados de fenilurea sustituidos con carbonamida, caracterizados porque comprenden compuesto de la fórmula (1) en donde significan: A es fenilo, naftilo, pudiendo estar sustituido el radical fenilo o naftilo, hasta tres veces, con F, Cl, Br, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, O-alquenilo C2-6, O-alquinilo C2-6, S-alquilo C1-6, S-alquenilo C2-6, S-alquinilo C2-6, SO-alquilo C1-6, SO2-alquilo C1-6, SO2-NH2, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-4, alquilen C0-6-COOH, alquilen C0-6-COO-alquilo C1-7, alquilen C0-6-COO-alquenilo C2-7, CONH2, CONH-alquilo C1-6, CON-[alquilo C1-6]2, CONH-cicloalquilo C3-6, alquilen C0-6-NH2, alquilen C0-6-NH-alquilo C2-6, alquilen C0-6-N-[alquilo C1-6]2, NH-CO alquilo C1-6, NH-CO-fenilo, NH-SO2-fenilo, pudiendo estar sustituido el anillo de fenilo, hasta dos veces, con F, Cl, CN, OH, alquilo C1-6, O-alquilo C1-6, CF3, OCF3, COOH, COO-alquilo C1-6 o CONH2; R1 y R2, independientemente uno de otro, H, alquilo C1-6, O-alquilo C1-6, CO-alquilo C1-6, COO-alquilo C1-6; R3, R4, R5, R6, independientemente uno de otro, H, F, Cl, Br, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, O-alquenilo C2-6, O-alquinilo C2-6, S-alquilo C1-6, S-alquenilo C2-6, S-alquinilo C2-6, SO-alquilo C1-6, SO2-alquilo C1-6, SO2-NH2, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-7, cicloalquil C3-7-alquileno C1-4, COOH, COO-alquilo C1-6, CO-NH2, CO-NH-alquilo C1-6, CON-N-[alquilo C1-6]2, CO-NH-cicloalquilo C3-7, NH2, NH-alquilo C1-6, N-[alquilo C1-6]2, NH-CO-alquilo C1-6, NH-CO-fenilo, NH-SO2-fenilo, pudiendo estar sustituido el anillo de fenilo, hasta dos veces con F, Cl, CN, OH, alquilo C1-6, O-alquilo C1-6, CF3, OCF3, COOH, COO-alquilo C1-6 o CO-NH2; R7 es H, alquilo C1-6, CO-alquilo C1-6; R8 es H, alquilo C1-10, pudiendo estar sustituido alquilo, hasta 3 veces, con OH, CF3, CN, COOH, COO-alquilo C1-6, CO-NH2, NH2, NH-alquilo C1-6, N-[alquilo C1-6]2, NCO-alquilo C1-6, NCOO-alquilo C1-6, NCOO-alquenilo C1-6, NCOO-alquinilo C1-6, o NCOO-alquilen C1-4-arilo C6-10, (CH2)m- arilo, pudiendo ser m = 0-6 y pudiendo ser arilo igual fenilo, O-fenilo, CO- fenilo, benzo[1,3]dioxolilo, heterocicloalquilo, piridilo, indolilo, piperidinilo, tetrahidronaftilo, naftilo, 2,3-dihidrobenzo[1,4]dioxinilo, benzo[1,2,5]tiadiazolilo, pirrolidinilo, morfolinilo, y pudiendo estar sustituido el radical arilo, una o varias veces, con R9; R9 es F, Cl, Br, OH, NO2, CF3, OCF3, alquilo C1-6, alquil C1-6-OH, O-alquilo C1-6, S-alquilo C1-6, alquil C1-4-fenilo, COOH, COO-alquilo C1-6; así como sus sales fisiológicamente compatibles, así como procedimientos para su preparación, medicamentos y el uso de dichos compuestos para la preparación de medicamentos para el tratamiento de la diabetes tipo II.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10125567A DE10125567B4 (de) | 2001-05-25 | 2001-05-25 | Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE10207369A DE10207369A1 (de) | 2002-02-21 | 2002-02-21 | Carbonamid substituierte Phenylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
Publication Number | Publication Date |
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AR036029A1 true AR036029A1 (es) | 2004-08-04 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP020101919A AR036029A1 (es) | 2001-05-25 | 2002-05-23 | Derivados de fenilurea sustituidos con carbonamida, procedimiento para preparacion, medicamentos y su empleo para la preparacion de medicamentos para el tratamiento de la diabetes tipo ii |
Country Status (26)
Country | Link |
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US (2) | US6812250B2 (es) |
EP (1) | EP1404650B1 (es) |
JP (1) | JP4167592B2 (es) |
KR (1) | KR20040003007A (es) |
CN (1) | CN1218936C (es) |
AR (1) | AR036029A1 (es) |
AT (1) | ATE386017T1 (es) |
AU (1) | AU2002344151B2 (es) |
BG (1) | BG108318A (es) |
BR (1) | BR0210008A (es) |
CA (1) | CA2448023A1 (es) |
CZ (1) | CZ20033200A3 (es) |
DE (1) | DE50211685D1 (es) |
EE (1) | EE200300581A (es) |
HK (1) | HK1065027A1 (es) |
HR (1) | HRP20030971A2 (es) |
HU (1) | HUP0400052A3 (es) |
IL (1) | IL159031A0 (es) |
MX (1) | MXPA03009840A (es) |
NO (1) | NO20035220D0 (es) |
NZ (1) | NZ529697A (es) |
PE (1) | PE20021091A1 (es) |
PL (1) | PL363871A1 (es) |
RU (1) | RU2291858C2 (es) |
SK (1) | SK14442003A3 (es) |
WO (1) | WO2002096864A1 (es) |
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GB0205165D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205170D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205166D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
GB0205175D0 (en) | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
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DE102005026762A1 (de) | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen |
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US8375455B2 (en) | 2006-08-10 | 2013-02-12 | Wayne Odom | System, method, and device for storing and delivering data |
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US8634162B2 (en) * | 2007-03-08 | 2014-01-21 | HGST Netherlands B.V. | Perpendicular write head having a stepped flare structure and method of manufacture thereof |
DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
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DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
US9043934B2 (en) | 2012-04-06 | 2015-05-26 | Wayne Odom | System, method, and device for delivering communications and storing and delivering data |
US9378339B2 (en) | 2012-04-06 | 2016-06-28 | Wayne Odom | System, method, and device for delivering communications and storing and delivering data |
US8844054B2 (en) | 2012-04-06 | 2014-09-23 | Wayne Odom | System, method, and device for communicating and storing and delivering data |
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SK17252002A3 (sk) * | 2000-06-09 | 2003-05-02 | Aventis Pharma Deutschland Gmbh | Deriváty acylfenylmočoviny, spôsoby ich výroby a použitie ako liečivo |
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2002
- 2002-05-03 PE PE2002000376A patent/PE20021091A1/es not_active Application Discontinuation
- 2002-05-11 BR BR0210008-8A patent/BR0210008A/pt not_active IP Right Cessation
- 2002-05-11 SK SK1444-2003A patent/SK14442003A3/sk unknown
- 2002-05-11 EP EP02774016A patent/EP1404650B1/de not_active Expired - Lifetime
- 2002-05-11 MX MXPA03009840A patent/MXPA03009840A/es active IP Right Grant
- 2002-05-11 IL IL15903102A patent/IL159031A0/xx unknown
- 2002-05-11 EE EEP200300581A patent/EE200300581A/xx unknown
- 2002-05-11 HU HU0400052A patent/HUP0400052A3/hu unknown
- 2002-05-11 PL PL02363871A patent/PL363871A1/xx not_active Application Discontinuation
- 2002-05-11 CA CA002448023A patent/CA2448023A1/en not_active Abandoned
- 2002-05-11 CN CNB028105974A patent/CN1218936C/zh not_active Expired - Fee Related
- 2002-05-11 NZ NZ529697A patent/NZ529697A/en unknown
- 2002-05-11 JP JP2003500044A patent/JP4167592B2/ja not_active Expired - Fee Related
- 2002-05-11 AT AT02774016T patent/ATE386017T1/de not_active IP Right Cessation
- 2002-05-11 CZ CZ20033200A patent/CZ20033200A3/cs unknown
- 2002-05-11 AU AU2002344151A patent/AU2002344151B2/en not_active Ceased
- 2002-05-11 KR KR10-2003-7015334A patent/KR20040003007A/ko not_active Application Discontinuation
- 2002-05-11 WO PCT/EP2002/005205 patent/WO2002096864A1/de active IP Right Grant
- 2002-05-11 RU RU2003137222/04A patent/RU2291858C2/ru not_active IP Right Cessation
- 2002-05-11 DE DE50211685T patent/DE50211685D1/de not_active Expired - Lifetime
- 2002-05-23 AR ARP020101919A patent/AR036029A1/es unknown
- 2002-05-24 US US10/153,597 patent/US6812250B2/en not_active Expired - Lifetime
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2003
- 2003-11-05 BG BG108318A patent/BG108318A/xx unknown
- 2003-11-24 HR HR20030971A patent/HRP20030971A2/xx not_active Application Discontinuation
- 2003-11-24 NO NO20035220A patent/NO20035220D0/no not_active Application Discontinuation
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2004
- 2004-10-14 HK HK04107930A patent/HK1065027A1/xx not_active IP Right Cessation
- 2004-11-01 US US10/978,674 patent/US20050143456A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PE20021091A1 (es) | 2003-02-04 |
KR20040003007A (ko) | 2004-01-07 |
MXPA03009840A (es) | 2004-04-02 |
CA2448023A1 (en) | 2002-12-05 |
US20050143456A1 (en) | 2005-06-30 |
BR0210008A (pt) | 2004-08-10 |
RU2291858C2 (ru) | 2007-01-20 |
JP4167592B2 (ja) | 2008-10-15 |
CN1525955A (zh) | 2004-09-01 |
AU2002344151B2 (en) | 2007-01-18 |
HUP0400052A2 (hu) | 2004-04-28 |
PL363871A1 (en) | 2004-11-29 |
US6812250B2 (en) | 2004-11-02 |
WO2002096864A1 (de) | 2002-12-05 |
SK14442003A3 (sk) | 2004-05-04 |
RU2003137222A (ru) | 2005-05-20 |
BG108318A (en) | 2005-01-31 |
NZ529697A (en) | 2005-12-23 |
HK1065027A1 (en) | 2005-02-08 |
ATE386017T1 (de) | 2008-03-15 |
EP1404650B1 (de) | 2008-02-13 |
HRP20030971A2 (en) | 2005-08-31 |
JP2004529194A (ja) | 2004-09-24 |
CN1218936C (zh) | 2005-09-14 |
EE200300581A (et) | 2004-02-16 |
DE50211685D1 (de) | 2008-03-27 |
EP1404650A1 (de) | 2004-04-07 |
US20030176497A1 (en) | 2003-09-18 |
NO20035220D0 (no) | 2003-11-24 |
HUP0400052A3 (en) | 2008-12-29 |
IL159031A0 (en) | 2004-05-12 |
CZ20033200A3 (cs) | 2004-02-18 |
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