AR074604A1 - Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano. - Google Patents

Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano.

Info

Publication number
AR074604A1
AR074604A1 ARP090104821A ARP090104821A AR074604A1 AR 074604 A1 AR074604 A1 AR 074604A1 AR P090104821 A ARP090104821 A AR P090104821A AR P090104821 A ARP090104821 A AR P090104821A AR 074604 A1 AR074604 A1 AR 074604A1
Authority
AR
Argentina
Prior art keywords
tetrahydropirane
etil
hydroxi
derivatives
amino
Prior art date
Application number
ARP090104821A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR074604A1 publication Critical patent/AR074604A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Compuestos antibacterianos de la fórmula (1) en donde R1 representa alcoxi (notablemente metoxi); R2 representa H o F; o cada uno de R3, R4, R5 y R6 representa independientemente H o D; V representa CH y W representa CH o N o V representa N y W representa CH; Y representa CH o N; Z representa O, S o CH2; y A representa CH2, CH2CH2 o CD2CD2 y a sales de tales compuestos. Uso de los mismos para el tratamiento de una infección bacteriana y composiciones farmacéuticas que los contienen como principio activo.
ARP090104821A 2008-12-12 2009-12-11 Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano. AR074604A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2008055261 2008-12-12

Publications (1)

Publication Number Publication Date
AR074604A1 true AR074604A1 (es) 2011-01-26

Family

ID=41723046

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090104821A AR074604A1 (es) 2008-12-12 2009-12-11 Derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano.

Country Status (28)

Country Link
US (1) US8211890B2 (es)
EP (1) EP2376497B1 (es)
JP (1) JP4955835B2 (es)
KR (1) KR101297450B1 (es)
CN (1) CN102232078B (es)
AR (1) AR074604A1 (es)
AU (1) AU2009325902B2 (es)
BR (1) BRPI0924081A2 (es)
CA (1) CA2744456C (es)
CL (1) CL2011001413A1 (es)
CY (1) CY1114869T1 (es)
DK (1) DK2376497T3 (es)
ES (1) ES2435596T3 (es)
HK (1) HK1162478A1 (es)
HR (1) HRP20140010T1 (es)
IL (1) IL213432A (es)
MA (1) MA32956B1 (es)
MX (1) MX2011005905A (es)
MY (1) MY159183A (es)
NZ (1) NZ593891A (es)
PL (1) PL2376497T3 (es)
PT (1) PT2376497E (es)
RU (1) RU2525541C2 (es)
SG (1) SG172088A1 (es)
SI (1) SI2376497T1 (es)
TW (1) TWI426076B (es)
WO (1) WO2010067332A1 (es)
ZA (1) ZA201105095B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
WO2012164498A1 (en) 2011-05-31 2012-12-06 Actelion Pharmaceuticals Ltd New synthetic intermediates for manufacturing antibiotics
WO2013003383A1 (en) * 2011-06-27 2013-01-03 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
TW201313726A (zh) 2011-09-16 2013-04-01 Actelion Pharmaceuticals Ltd 製造合成之中間體之方法
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
AR090844A1 (es) * 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
TW201722965A (zh) * 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
EP3665156A4 (en) 2017-08-09 2021-04-28 Denali Therapeutics Inc. COMPOUNDS, COMPOSITIONS, AND PROCEDURES
EP4248965A3 (en) * 2017-09-01 2023-11-22 Denali Therapeutics Inc. Compounds, compositions and methods
CR20210426A (es) 2019-02-13 2021-09-30 Denali Therapeutics Inc Compuestos, composiciones y métodos
EP3924341A4 (en) 2019-02-13 2022-11-02 Denali Therapeutics Inc. COMPOUNDS, COMPOSITIONS AND METHODS

Family Cites Families (26)

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SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
ATE231505T1 (de) * 1991-03-28 2003-02-15 Eisai Co Ltd Neue heterocyclische/cyclische amine
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
EP2181996A1 (en) * 2002-01-29 2010-05-05 Glaxo Group Limited Aminopiperidine derivatives
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
DE10316081A1 (de) * 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
EP1773831A1 (en) 2004-07-08 2007-04-18 Glaxo Group Limited Antibacterial agents
WO2006032466A2 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
US20090131444A1 (en) 2005-05-24 2009-05-21 Astrazeneca Ab Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity
WO2007016610A2 (en) * 2005-08-02 2007-02-08 Glaxo Group Limited Antibacterial agents
PT1954697E (pt) 2005-10-21 2010-05-17 Glaxo Group Ltd Compostos tricíclicos peri-condensados úteis como agentes antibacterianos
JP2009520779A (ja) 2005-12-22 2009-05-28 グラクソ グループ リミテッド 複素環化合物、その製造およびその抗菌剤としての使用
DE102005062889A1 (de) 2005-12-29 2007-07-05 Robert Bosch Gmbh Elektrische Null-Kraft-Steckvorrichtung
EP1981881B1 (en) * 2006-01-26 2011-12-07 Actelion Pharmaceuticals Ltd. Tetrahydropyrane antibiotics
EP1996579A2 (en) * 2006-03-10 2008-12-03 Actelion Pharmaceuticals Ltd. Antibiotic compounds
DE602007009205D1 (de) 2006-04-06 2010-10-28 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
ES2370123T3 (es) * 2007-06-15 2011-12-12 Actelion Pharmaceuticals Ltd. Derivados de 3-amino-6-(1-aminoetil)-tetrahidropirano.
ES2426593T3 (es) 2007-11-26 2013-10-24 Toyama Chemical Co., Ltd. Derivado de naftiridina monohidrato y método para producir el mismo

Also Published As

Publication number Publication date
AU2009325902A1 (en) 2011-07-21
ZA201105095B (en) 2012-12-27
HK1162478A1 (es) 2012-08-31
US20110245259A1 (en) 2011-10-06
SI2376497T1 (sl) 2014-01-31
DK2376497T3 (da) 2013-11-18
MA32956B1 (fr) 2012-01-02
EP2376497B1 (en) 2013-09-18
TW201026699A (en) 2010-07-16
AU2009325902B2 (en) 2015-01-29
CL2011001413A1 (es) 2011-11-11
BRPI0924081A2 (pt) 2018-03-20
CA2744456A1 (en) 2010-06-17
CN102232078A (zh) 2011-11-02
JP4955835B2 (ja) 2012-06-20
WO2010067332A1 (en) 2010-06-17
MY159183A (en) 2016-12-30
MX2011005905A (es) 2011-06-20
PL2376497T3 (pl) 2014-03-31
SG172088A1 (en) 2011-07-28
ES2435596T3 (es) 2013-12-20
KR101297450B1 (ko) 2013-08-20
RU2525541C2 (ru) 2014-08-20
NZ593891A (en) 2013-05-31
HRP20140010T1 (hr) 2014-02-14
CY1114869T1 (el) 2016-12-14
CA2744456C (en) 2017-09-26
JP2012511566A (ja) 2012-05-24
IL213432A0 (en) 2011-07-31
EP2376497A1 (en) 2011-10-19
IL213432A (en) 2013-11-28
TWI426076B (zh) 2014-02-11
CN102232078B (zh) 2014-07-16
RU2011128550A (ru) 2013-01-20
PT2376497E (pt) 2013-11-21
US8211890B2 (en) 2012-07-03
KR20110086643A (ko) 2011-07-28

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