DK2376497T3 - 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran-derivater - Google Patents

5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran-derivater

Info

Publication number
DK2376497T3
DK2376497T3 DK09796819.2T DK09796819T DK2376497T3 DK 2376497 T3 DK2376497 T3 DK 2376497T3 DK 09796819 T DK09796819 T DK 09796819T DK 2376497 T3 DK2376497 T3 DK 2376497T3
Authority
DK
Denmark
Prior art keywords
tetrahydropyran
hydroxyethyl
derivatives
amino
Prior art date
Application number
DK09796819.2T
Other languages
English (en)
Inventor
Christian Hubschwerlen
Georg Rueedi
Jean-Philippe Surivet
Acklin Cornelia Zumbrunn
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Application granted granted Critical
Publication of DK2376497T3 publication Critical patent/DK2376497T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK09796819.2T 2008-12-12 2009-12-11 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran-derivater DK2376497T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008055261 2008-12-12
PCT/IB2009/055689 WO2010067332A1 (en) 2008-12-12 2009-12-11 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran derivatives

Publications (1)

Publication Number Publication Date
DK2376497T3 true DK2376497T3 (da) 2013-11-18

Family

ID=41723046

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09796819.2T DK2376497T3 (da) 2008-12-12 2009-12-11 5-amino-2-(1-hydroxy-ethyl)-tetrahydropyran-derivater

Country Status (28)

Country Link
US (1) US8211890B2 (da)
EP (1) EP2376497B1 (da)
JP (1) JP4955835B2 (da)
KR (1) KR101297450B1 (da)
CN (1) CN102232078B (da)
AR (1) AR074604A1 (da)
AU (1) AU2009325902B2 (da)
BR (1) BRPI0924081A2 (da)
CA (1) CA2744456C (da)
CL (1) CL2011001413A1 (da)
CY (1) CY1114869T1 (da)
DK (1) DK2376497T3 (da)
ES (1) ES2435596T3 (da)
HK (1) HK1162478A1 (da)
HR (1) HRP20140010T1 (da)
IL (1) IL213432A (da)
MA (1) MA32956B1 (da)
MX (1) MX2011005905A (da)
MY (1) MY159183A (da)
NZ (1) NZ593891A (da)
PL (1) PL2376497T3 (da)
PT (1) PT2376497E (da)
RU (1) RU2525541C2 (da)
SG (1) SG172088A1 (da)
SI (1) SI2376497T1 (da)
TW (1) TWI426076B (da)
WO (1) WO2010067332A1 (da)
ZA (1) ZA201105095B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR076222A1 (es) 2009-04-09 2011-05-26 Actelion Pharmaceuticals Ltd Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen
TW201300387A (zh) 2011-05-31 2013-01-01 Actelion Pharmaceuticals Ltd 供製備抗生素用之新合成中間物
EP2723737A1 (en) * 2011-06-27 2014-04-30 Kyorin Pharmaceutical Co., Ltd. Bridged bicyclic compounds for the treatment of bacterial infections
TW201313726A (zh) 2011-09-16 2013-04-01 Actelion Pharmaceuticals Ltd 製造合成之中間體之方法
AR089929A1 (es) 2012-02-10 2014-10-01 Actelion Pharmaceuticals Ltd Proceso para manufacturar un derivado de naftiridina
AR090844A1 (es) 2012-04-27 2014-12-10 Actelion Pharmaceuticals Ltd Proceso para elaborar derivados de naftiridina
UY36851A (es) * 2015-08-16 2017-03-31 Glaxosmithkline Ip Dev Ltd Compuestos para uso en aplicaciones antibacterianas
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
IL272089B2 (en) 2017-08-09 2023-09-01 Denali Therapeutics Inc Compounds, preparations and methods
MA50063A (fr) * 2017-09-01 2021-04-28 Denali Therapeutics Inc Composés, compositions et procédés
JP2022520236A (ja) 2019-02-13 2022-03-29 デナリ セラピューティクス インコーポレイテッド 化合物、組成物、及び、方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1095611A1 (ru) * 1982-09-10 2007-06-27 Краснодарский ордена Трудового Красного Знамени политехнический институт Хлорид 5-хлорметил-2-этил-8-метил-4Н-м-диоксино-(4,5-с)-пиридиния, обладающий антимикробной активностью
EP0646115B1 (en) * 1991-03-28 2003-01-22 Eisai Co., Ltd. Heterocyclic-cyclic amine derivatives
GB9822450D0 (en) 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
TW200406410A (en) * 2002-01-29 2004-05-01 Glaxo Group Ltd Compounds
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200427688A (en) 2002-12-18 2004-12-16 Glaxo Group Ltd Antibacterial agents
DE10316081A1 (de) 2003-04-08 2004-10-21 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
JP2008505920A (ja) 2004-07-08 2008-02-28 グラクソ　グループ　リミテッド 抗菌剤
JP4887297B2 (ja) * 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
CA2608072A1 (en) 2005-05-24 2006-11-30 Astrazeneca Ab Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity
WO2007016610A2 (en) * 2005-08-02 2007-02-08 Glaxo Group Limited Antibacterial agents
EP1954697B1 (en) 2005-10-21 2010-02-24 Glaxo Group Limited Peri condensed tricyclic compounds useful as antibacterial agents
DE602006013878D1 (de) 2005-12-22 2010-06-02 Glaxo Group Ltd Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
DE102005062889A1 (de) 2005-12-29 2007-07-05 Robert Bosch Gmbh Elektrische Null-Kraft-Steckvorrichtung
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
EP1996579A2 (en) * 2006-03-10 2008-12-03 Actelion Pharmaceuticals Ltd. Antibiotic compounds
US7709483B2 (en) 2006-04-06 2010-05-04 Glaxo Group Limited Pyrrolo-quinoxalinone derivatives as antibacterials
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
CL2008001003A1 (es) 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
ES2370123T3 (es) * 2007-06-15 2011-12-12 Actelion Pharmaceuticals Ltd. Derivados de 3-amino-6-(1-aminoetil)-tetrahidropirano.
CN101874032B (zh) 2007-11-26 2013-02-06 富山化学工业株式会社 二氮杂萘衍生物一水合物及其制备方法

Also Published As

Publication number Publication date
PL2376497T3 (pl) 2014-03-31
RU2011128550A (ru) 2013-01-20
CA2744456C (en) 2017-09-26
CN102232078A (zh) 2011-11-02
EP2376497A1 (en) 2011-10-19
PT2376497E (pt) 2013-11-21
IL213432A (en) 2013-11-28
SG172088A1 (en) 2011-07-28
SI2376497T1 (sl) 2014-01-31
US8211890B2 (en) 2012-07-03
HK1162478A1 (da) 2012-08-31
CN102232078B (zh) 2014-07-16
TWI426076B (zh) 2014-02-11
TW201026699A (en) 2010-07-16
AU2009325902B2 (en) 2015-01-29
RU2525541C2 (ru) 2014-08-20
IL213432A0 (en) 2011-07-31
EP2376497B1 (en) 2013-09-18
NZ593891A (en) 2013-05-31
MX2011005905A (es) 2011-06-20
MA32956B1 (fr) 2012-01-02
CL2011001413A1 (es) 2011-11-11
MY159183A (en) 2016-12-30
AR074604A1 (es) 2011-01-26
WO2010067332A1 (en) 2010-06-17
JP2012511566A (ja) 2012-05-24
KR101297450B1 (ko) 2013-08-20
HRP20140010T1 (hr) 2014-02-14
ES2435596T3 (es) 2013-12-20
CA2744456A1 (en) 2010-06-17
KR20110086643A (ko) 2011-07-28
JP4955835B2 (ja) 2012-06-20
ZA201105095B (en) 2012-12-27
US20110245259A1 (en) 2011-10-06
AU2009325902A1 (en) 2011-07-21
BRPI0924081A2 (pt) 2018-03-20
CY1114869T1 (el) 2016-12-14

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