AR064488A1 - DERIVADOS DE4-(1-AMINO-ETIL)-CICLOHEXILAMINA, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y EL USO DE LOS MISMOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO O PREVENCIoN DE UNA INFECCION BACTERIANA - Google Patents

DERIVADOS DE4-(1-AMINO-ETIL)-CICLOHEXILAMINA, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y EL USO DE LOS MISMOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO O PREVENCIoN DE UNA INFECCION BACTERIANA

Info

Publication number
AR064488A1
AR064488A1 ARP070105851A ARP070105851A AR064488A1 AR 064488 A1 AR064488 A1 AR 064488A1 AR P070105851 A ARP070105851 A AR P070105851A AR P070105851 A ARP070105851 A AR P070105851A AR 064488 A1 AR064488 A1 AR 064488A1
Authority
AR
Argentina
Prior art keywords
prevention
amino
preparation
pharmaceutical composition
treatment
Prior art date
Application number
ARP070105851A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39480472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR064488(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR064488A1 publication Critical patent/AR064488A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Compuestos de formula (1) en la cual R0 representa H o OH; R1 representa alcoxilo; U y W representan N, V representa CH y R2 representa H o F, o U y V representan CH, W representa N y R2 representa H o F, o U y V representan N, W representa CH y R2 representa H, o U representa N, V representa CH, W representa CRa y R2 representa H; Ra representa CH2OH o alcoxicarbonilo; A representa el grupo CH=CH-B o un sistema binuclear heterocíclico D, representando B un grupo fenilo mono- o di-substituido en el cual los substituyentes son átomos halogeno y D representa uno de entre los siguientes grupos (2) en donde Z representa CH o N, y Q representa O o S; y a las sales de tales compuestos. Estos compuestos son utiles como agentes antibacteriales, proveyendose además una composicion farmacéutica que los contiene. Estos derivados de 4-(1-amino-etil)-ciclohexillamina se utilizan en la preparacion de un medicamento para el tratamiento o prevencion de una infeccion bacteriana.
ARP070105851A 2006-12-22 2007-12-21 DERIVADOS DE4-(1-AMINO-ETIL)-CICLOHEXILAMINA, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y EL USO DE LOS MISMOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO O PREVENCIoN DE UNA INFECCION BACTERIANA AR064488A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2006055026 2006-12-22
IB2007052805 2007-07-13

Publications (1)

Publication Number Publication Date
AR064488A1 true AR064488A1 (es) 2009-04-08

Family

ID=39480472

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105851A AR064488A1 (es) 2006-12-22 2007-12-21 DERIVADOS DE4-(1-AMINO-ETIL)-CICLOHEXILAMINA, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y EL USO DE LOS MISMOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO O PREVENCIoN DE UNA INFECCION BACTERIANA

Country Status (15)

Country Link
US (1) US8044044B2 (es)
EP (1) EP2094267B1 (es)
JP (1) JP5755409B2 (es)
KR (1) KR101496894B1 (es)
CN (1) CN101563084B (es)
AR (1) AR064488A1 (es)
AU (1) AU2007337673B2 (es)
BR (1) BRPI0720684A8 (es)
CA (1) CA2670763C (es)
CL (1) CL2007003693A1 (es)
ES (1) ES2542148T3 (es)
MX (1) MX2009006552A (es)
RU (1) RU2460723C2 (es)
TW (1) TWI395584B (es)
WO (1) WO2008078305A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200940551A (en) 2008-02-20 2009-10-01 Actelion Pharmaceuticals Ltd Azatricyclic antibiotic compounds
PL2297107T3 (pl) * 2008-06-03 2014-04-30 Idorsia Pharmaceuticals Ltd Pochodne [4-(1-aminoetylo)cykloheksylo]metyloaminy i [6-(1-aminoetylo)tetrahydropiran-3-ylo]-metyloaminy jako środki przeciwbakteryjne
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
TW201022279A (en) * 2008-11-14 2010-06-16 Astrazeneca Ab Chemical compounds
MX2011005120A (es) 2008-11-17 2011-05-30 Hoffmann La Roche Acidos naftilaceticos.
JP6805232B2 (ja) 2015-07-24 2020-12-23 セルジーン コーポレイション （１ｒ，２ｒ，５ｒ）−５−アミノ−２−メチルシクロヘキサノール塩酸塩の合成方法及びそれに有用な中間体
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536725A (en) * 1993-08-25 1996-07-16 Fmc Corporation Insecticidal substituted-2,4-diamino-5,6,7,8-tetrahydroquinazolines
GB9821977D0 (en) 1998-10-08 1998-12-02 Smithkline Beecham Plc Compounds
GB0112834D0 (en) * 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
DE10161940A1 (de) 2001-12-17 2003-07-03 Nad Ag N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren
AR040335A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto
ATE463494T1 (de) * 2002-10-10 2010-04-15 Morphochem Ag Komb Chemie Neue verbindungen mit antibakterieller aktivität
AR042486A1 (es) * 2002-12-18 2005-06-22 Glaxo Group Ltd Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion .
DE102004041163A1 (de) 2004-08-25 2006-03-02 Morphochem Aktiengesellschaft für kombinatorische Chemie Neue Verbindungen mit antibakterieller Aktivität
WO2006032466A2 (en) * 2004-09-24 2006-03-30 Actelion Pharmaceuticals Ltd New bicyclic antibiotics
JP5314244B2 (ja) 2004-10-27 2013-10-16 富山化学工業株式会社 新規な含窒素複素環化合物およびその塩
ES2351613T3 (es) 2005-03-03 2011-02-08 Santen Pharmaceutical Co., Ltd. Nuevo compuesto cíclico que tiene un grupo quinolilalquiltio.
UA46692U (ru) * 2009-10-22 2009-12-25 Игорь Борисович Буркинский Способ предотвращения образования песочных пробок в нефтяных и газовых скважинах

Also Published As

Publication number Publication date
AU2007337673A1 (en) 2008-07-03
EP2094267A2 (en) 2009-09-02
KR101496894B1 (ko) 2015-03-03
ES2542148T3 (es) 2015-07-31
KR20090104024A (ko) 2009-10-05
JP5755409B2 (ja) 2015-07-29
BRPI0720684A8 (pt) 2017-12-26
BRPI0720684A2 (pt) 2016-03-15
CN101563084A (zh) 2009-10-21
JP2010513468A (ja) 2010-04-30
RU2460723C2 (ru) 2012-09-10
EP2094267B1 (en) 2015-04-22
MX2009006552A (es) 2009-06-26
CA2670763A1 (en) 2008-07-03
US20100029623A1 (en) 2010-02-04
TW200843754A (en) 2008-11-16
WO2008078305A3 (en) 2008-08-21
CA2670763C (en) 2015-02-17
CL2007003693A1 (es) 2008-06-27
WO2008078305A2 (en) 2008-07-03
TWI395584B (zh) 2013-05-11
RU2009127852A (ru) 2011-01-27
US8044044B2 (en) 2011-10-25
CN101563084B (zh) 2013-02-20
AU2007337673B2 (en) 2013-06-20

Similar Documents

Publication Publication Date Title
AR064488A1 (es) DERIVADOS DE4-(1-AMINO-ETIL)-CICLOHEXILAMINA, UNA COMPOSICION FARMACEUTICA QUE LO CONTIENE Y EL USO DE LOS MISMOS PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO O PREVENCIoN DE UNA INFECCION BACTERIANA
UY30759A1 (es) Compuestos quimicos
UY32158A (es) Derivados heterociclicos y metodos de uso de los mismos
UY28510A1 (es) Compuestos quimicos
ECSP066383A (es) Derivados de 5-fenil-4-metil-tiazol-2-il-amina como inhibidores de enzimas de cinasa fosfatidilinositol 3 (pi3) para el tratamiento de enfermedades inflamatorias de las vías respiratorias
CO6290656A2 (es) Derivados heterociclicos de urea y metodos de uso de los mismos -211
ECSP105253A (es) Derivados de 5-feniltiazol y uso como inhibidores de pi3 cinasa
UY32315A (es) Compuestos de piperidina y usos de los mismo-596
PE20160588A1 (es) Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos
UY31141A1 (es) Compuestos de piperidina y sus usos
MD3468974T2 (ro) Noi derivați de piperidinil, procedeu pentru prepararea lor și compoziții farmaceutice care ii conțin
DOP2012000310A (es) Morfolinopirimidinas y su uso en terapia
UY29384A1 (es) Derivados del ácido2-3s,4r)-4-(((3,4-dicloro-5-metil-1h-pirrol-2-il) carbonil)amino)-1,3-tiazol-5-carboxílico y sus sales, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciónes.
PA8592301A1 (es) Nuevos derivados de fluoroglicosidos heterociclicos, medicamentos que contienen estos compuestos, y el uso de los mismos
UY30544A1 (es) Compuestos de pirrolo-piperidina y sales farmacéuticametne aceptables de los mismos, procesos de fabricacion, composiciones y aplicaciones
CL2013002417A1 (es) Compuestos derivados de fluoropiridinona; composición farmacéutica que los comprende; y su uso en el tratamiento de infecciones bacterianas.
CL2011001413A1 (es) Compuestos derivados de 5-amino-2-(1-hidroxi-etil)-tetrahidropirano; composicion farmaceutica que comprende a uno de los compuestos; y su uso en la preparacion de medicamentos para la prevencion o el tratamiento de una infeccion bacteriana.
GT200600161A (es) Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de los trastornos psicoticos
CR11825A (es) Derivados de urea heterociclicos para el tratamiento de infecciones bacterianas
DOP2010000374A (es) Derivados heterociclicos de la urea y sus metodos de empleo
AR039601A1 (es) Derivados de nitrosodifenilamina y composiciones farmaceuticas que los comprenden como medicamentos que se pueden utilizar en el tratamiento de patologias que se caracterizan por estres oxidativo
UY32674A (es) Derivados heterociclicos de la urea y sus metodos de empleo
AR067008A1 (es) Derivados 3- amino-6-(1- amino - etil)-tetrahidropirano
UY32856A (es) Derivados heterocíclicos de urea y métodos de uso de los mismos
UY28356A1 (es) Derivados de benzimidazol, composiciones que los contienen, preparaciones de los mismos y sus usos

Legal Events

Date Code Title Description
FB Suspension of granting procedure