AR035817A1 - Compuestos de azabiciclico sustituidos que actuan sobre el receptor alfa7 nicotinico de la acetilcolina o donde existe un deficit en la formacion de ventanas sensoriales y su uso en la preparacion de medicamentos - Google Patents

Compuestos de azabiciclico sustituidos que actuan sobre el receptor alfa7 nicotinico de la acetilcolina o donde existe un deficit en la formacion de ventanas sensoriales y su uso en la preparacion de medicamentos

Info

Publication number
AR035817A1
AR035817A1 ARP020101299A ARP020101299A AR035817A1 AR 035817 A1 AR035817 A1 AR 035817A1 AR P020101299 A ARP020101299 A AR P020101299A AR P020101299 A ARP020101299 A AR P020101299A AR 035817 A1 AR035817 A1 AR 035817A1
Authority
AR
Argentina
Prior art keywords
compounds
substituted
deficit
alkyl
formation
Prior art date
Application number
ARP020101299A
Other languages
English (en)
Spanish (es)
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of AR035817A1 publication Critical patent/AR035817A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP020101299A 2001-04-19 2002-04-09 Compuestos de azabiciclico sustituidos que actuan sobre el receptor alfa7 nicotinico de la acetilcolina o donde existe un deficit en la formacion de ventanas sensoriales y su uso en la preparacion de medicamentos AR035817A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28495001P 2001-04-19 2001-04-19
US34890401P 2001-10-26 2001-10-26

Publications (1)

Publication Number Publication Date
AR035817A1 true AR035817A1 (es) 2004-07-14

Family

ID=26962909

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP020101299A AR035817A1 (es) 2001-04-19 2002-04-09 Compuestos de azabiciclico sustituidos que actuan sobre el receptor alfa7 nicotinico de la acetilcolina o donde existe un deficit en la formacion de ventanas sensoriales y su uso en la preparacion de medicamentos

Country Status (11)

Country Link
US (1) US6869946B2 (https=)
EP (1) EP1389208B1 (https=)
JP (1) JP2004526788A (https=)
AR (1) AR035817A1 (https=)
AT (1) ATE314367T1 (https=)
CA (1) CA2439960A1 (https=)
DE (1) DE60208366T2 (https=)
ES (1) ES2254723T3 (https=)
MX (1) MXPA03009644A (https=)
PE (1) PE20021019A1 (https=)
WO (1) WO2002085901A1 (https=)

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WO2004064836A2 (en) * 2003-01-22 2004-08-05 Pharmacia & Upjohn Company Llc Treatment of diseases with alpha-7 nach receptor full agonists
GB0310867D0 (en) 2003-05-12 2003-06-18 Novartis Ag Organic compounds
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NZ550534A (en) 2004-03-25 2009-07-31 Memory Pharm Corp Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
EP1736156A4 (en) * 2004-04-15 2010-06-16 Eisai R&D Man Co Ltd COMPOSITION CONTAINING 4-AMINO-5-CHLORO-N-¬ (1R, 3R, 5S) -8-METHYL-8-AZABICYCLO-3.2.1 OCT-3-YL-2-β-methyl-2-ynyloxy BENZAMIDE STABILIZED
WO2006001894A1 (en) * 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
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GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
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RU2418797C2 (ru) 2004-12-22 2011-05-20 Мемори Фармасьютиклз Корпорейшн Лиганды никотинового рецептора альфа-7, их получение и применение
BRPI0614874A2 (pt) * 2005-08-22 2011-04-19 Targacept Inc diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
JP5232374B2 (ja) * 2006-09-29 2013-07-10 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP5172124B2 (ja) * 2006-09-29 2013-03-27 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
WO2009146031A1 (en) 2008-03-31 2009-12-03 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
EP2300012A4 (en) * 2008-05-23 2011-07-06 Univ South Florida METHOD FOR TREATING PERIPHERAL SENSORY NERVE LOSS WITH COMPOUNDS WITH NICOTIC ACIDYLCHOLINE RECEPTOR EFFECT
TW201031664A (en) * 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
AR081402A1 (es) 2010-05-17 2012-08-29 Envivo Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
WO2012177263A1 (en) * 2011-06-24 2012-12-27 Intra-Cellular Therapies, Inc. Compounds and methods of prophylaxis and treatment regarding nictonic receptor antagonists
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
WO2016100184A1 (en) * 2014-12-16 2016-06-23 Forum Pharmaceuticals, Inc. Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
CN109320510B (zh) * 2018-11-27 2021-04-27 江苏慧聚药业有限公司 一种马罗匹坦游离碱的制备方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法

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Also Published As

Publication number Publication date
ES2254723T3 (es) 2006-06-16
DE60208366D1 (de) 2006-02-02
WO2002085901A8 (en) 2003-12-24
JP2004526788A (ja) 2004-09-02
US20030055043A1 (en) 2003-03-20
CA2439960A1 (en) 2002-10-31
EP1389208B1 (en) 2005-12-28
DE60208366T2 (de) 2006-07-06
ATE314367T1 (de) 2006-01-15
PE20021019A1 (es) 2002-11-13
WO2002085901A1 (en) 2002-10-31
MXPA03009644A (es) 2004-01-29
EP1389208A1 (en) 2004-02-18
US6869946B2 (en) 2005-03-22

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