DE60208366D1 - Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten) - Google Patents

Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten)

Info

Publication number
DE60208366D1
DE60208366D1 DE60208366T DE60208366T DE60208366D1 DE 60208366 D1 DE60208366 D1 DE 60208366D1 DE 60208366 T DE60208366 T DE 60208366T DE 60208366 T DE60208366 T DE 60208366T DE 60208366 D1 DE60208366 D1 DE 60208366D1
Authority
DE
Germany
Prior art keywords
nicotine
unit
receptor antagonists
disease treatment
substituted azabicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60208366T
Other languages
English (en)
Other versions
DE60208366T2 (de
Inventor
E Jon Jacobsen
P Walker
K Myers
W Piotrowski
E Groppi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Pharmacia and Upjohn Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co LLC filed Critical Pharmacia and Upjohn Co LLC
Application granted granted Critical
Publication of DE60208366D1 publication Critical patent/DE60208366D1/de
Publication of DE60208366T2 publication Critical patent/DE60208366T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60208366T 2001-04-19 2002-04-18 Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten) Expired - Fee Related DE60208366T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28495001P 2001-04-19 2001-04-19
US284950P 2001-04-19
US34890401P 2001-10-26 2001-10-26
US348904P 2001-10-26
PCT/US2002/008268 WO2002085901A1 (en) 2001-04-19 2002-04-18 Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists)

Publications (2)

Publication Number Publication Date
DE60208366D1 true DE60208366D1 (de) 2006-02-02
DE60208366T2 DE60208366T2 (de) 2006-07-06

Family

ID=26962909

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60208366T Expired - Fee Related DE60208366T2 (de) 2001-04-19 2002-04-18 Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten)

Country Status (11)

Country Link
US (1) US6869946B2 (de)
EP (1) EP1389208B1 (de)
JP (1) JP2004526788A (de)
AR (1) AR035817A1 (de)
AT (1) ATE314367T1 (de)
CA (1) CA2439960A1 (de)
DE (1) DE60208366T2 (de)
ES (1) ES2254723T3 (de)
MX (1) MXPA03009644A (de)
PE (1) PE20021019A1 (de)
WO (1) WO2002085901A1 (de)

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ES2405594T3 (es) 2002-09-25 2013-05-31 Memory Pharmaceuticals Corporation Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos
WO2004052889A1 (en) * 2002-12-06 2004-06-24 Pharmacia & Upjohn Company Llc Compounds as radioligands for the diagnosis of disease
EP1587511A2 (de) * 2003-01-22 2005-10-26 Pharmacia & Upjohn Company LLC Behandlung von krankheiten mit alpha-7 nach rezeptoragonisten
GB0310867D0 (en) * 2003-05-12 2003-06-18 Novartis Ag Organic compounds
DE602004010299T2 (de) 2003-12-22 2008-09-18 Memory Pharmaceuticals Corp. Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen
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ATE487716T1 (de) 2004-04-22 2010-11-15 Memory Pharm Corp Indole, 1h-indazole, 1,2-benzisoxazole, 1,2- benzoisothiazole, deren herstellung und verwendungen
JP2007538011A (ja) 2004-05-07 2007-12-27 メモリー・ファーマシューティカルズ・コーポレイション １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0424564D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
DE602005019094D1 (de) 2004-12-22 2010-03-11 Memory Pharmaceutical Corp Nikotinische alpha-7-rezeptorliganden gegen erkrankungen des zns
JP2009506037A (ja) * 2005-08-22 2009-02-12 ターガセプト，インコーポレイテッド ヘテロアリール置換ジアザトリシクロアルカン、その調製方法およびその使用方法
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
JP5172124B2 (ja) * 2006-09-29 2013-03-27 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP5232374B2 (ja) * 2006-09-29 2013-07-10 関東化学株式会社 ２位に置換基を有する光学活性キヌクリジノール類の製造方法
WO2009146031A1 (en) 2008-03-31 2009-12-03 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
EP2300012A4 (de) * 2008-05-23 2011-07-06 Univ South Florida Verfahren zur behandlung von peripherem sensorischem nervenverlust mit verbindungen mit nicotinsäure-acetylcholin-rezeptor-wirkung
TW201031664A (en) * 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
SI3029039T1 (en) 2010-05-17 2018-04-30 Forum Pharmaceuticals Inc. Pharmaceutical formulations containing crystalline forms of (R) -7-chloro-N- (quinuclidin-3-yl) benzo (b) thiophene-2-carboxamide hydrochloride monohydrate
WO2012177263A1 (en) * 2011-06-24 2012-12-27 Intra-Cellular Therapies, Inc. Compounds and methods of prophylaxis and treatment regarding nictonic receptor antagonists
AU2013259871A1 (en) 2012-05-08 2014-11-20 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
EP3233087B1 (de) * 2014-12-16 2019-10-02 Axovant Sciences GmbH Geminale substituierte chinuklidinamidverbindungen als agonisten von alpha-7-nikotinischen acetylcholinrezeptoren
CN109320510B (zh) * 2018-11-27 2021-04-27 江苏慧聚药业有限公司 一种马罗匹坦游离碱的制备方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法

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Also Published As

Publication number Publication date
PE20021019A1 (es) 2002-11-13
DE60208366T2 (de) 2006-07-06
US6869946B2 (en) 2005-03-22
CA2439960A1 (en) 2002-10-31
WO2002085901A8 (en) 2003-12-24
JP2004526788A (ja) 2004-09-02
AR035817A1 (es) 2004-07-14
ES2254723T3 (es) 2006-06-16
US20030055043A1 (en) 2003-03-20
WO2002085901A1 (en) 2002-10-31
ATE314367T1 (de) 2006-01-15
MXPA03009644A (es) 2004-01-29
EP1389208B1 (de) 2005-12-28
EP1389208A1 (de) 2004-02-18

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