MXPA03009644A - Grupos azabiciclicos sustituidos para el tratamiento de enfermedades. - Google Patents
Grupos azabiciclicos sustituidos para el tratamiento de enfermedades.Info
- Publication number
- MXPA03009644A MXPA03009644A MXPA03009644A MXPA03009644A MXPA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A MX PA03009644 A MXPA03009644 A MX PA03009644A
- Authority
- MX
- Mexico
- Prior art keywords
- disease
- treatment
- receptor antagonists
- substituted azabicyclic
- acethylcholine receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28495001P | 2001-04-19 | 2001-04-19 | |
US34890401P | 2001-10-26 | 2001-10-26 | |
PCT/US2002/008268 WO2002085901A1 (en) | 2001-04-19 | 2002-04-18 | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA03009644A true MXPA03009644A (es) | 2004-01-29 |
Family
ID=26962909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA03009644A MXPA03009644A (es) | 2001-04-19 | 2002-04-18 | Grupos azabiciclicos sustituidos para el tratamiento de enfermedades. |
Country Status (11)
Country | Link |
---|---|
US (1) | US6869946B2 (es) |
EP (1) | EP1389208B1 (es) |
JP (1) | JP2004526788A (es) |
AR (1) | AR035817A1 (es) |
AT (1) | ATE314367T1 (es) |
CA (1) | CA2439960A1 (es) |
DE (1) | DE60208366T2 (es) |
ES (1) | ES2254723T3 (es) |
MX (1) | MXPA03009644A (es) |
PE (1) | PE20021019A1 (es) |
WO (1) | WO2002085901A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
CA2476417A1 (en) * | 2002-02-15 | 2003-08-28 | Pharmacia & Upjohn Company | Azabicyclo-substituted benzoylamides and thioamides for treatment of cns-related disorders |
AU2003219690A1 (en) * | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
KR101129933B1 (ko) | 2002-09-25 | 2012-03-23 | 메모리 파마슈티칼스 코포레이션 | 인다졸, 벤조티아졸 및 벤조이소티아졸 및 그의 제조 및용도 |
AU2003283648A1 (en) * | 2002-12-06 | 2004-06-30 | Pharmacia & Upjohn Company Llc | Compounds as radioligands for the diagnosis of disease |
WO2004064836A2 (en) * | 2003-01-22 | 2004-08-05 | Pharmacia & Upjohn Company Llc | Treatment of diseases with alpha-7 nach receptor full agonists |
GB0310867D0 (en) * | 2003-05-12 | 2003-06-18 | Novartis Ag | Organic compounds |
BRPI0417323A (pt) | 2003-12-22 | 2007-03-27 | Memory Pharm Corp | indóis, 1h-indazóis, 1,2-benzisoxazóis, e 1,2-benzisotiazóis, composto, composição farmacêutica e usos dos mesmos |
NZ550534A (en) | 2004-03-25 | 2009-07-31 | Memory Pharm Corp | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
WO2005099698A1 (ja) * | 2004-04-15 | 2005-10-27 | Eisai R & D Management Co., Ltd. | 安定化された4-アミノ-5-クロロ-N-[(1R,3r,5S)-8-メチル-8-アザビシクロ[3.2.1]オクタ-3-イル]-2-[1-メチルブタ-2-インイルオキシ]ベンズアミド含有組成物 |
JP2007534692A (ja) * | 2004-04-22 | 2007-11-29 | メモリー・ファーマシューティカルズ・コーポレイション | インドール、1h−インダゾール、1,2−ベンズイソキサゾール、1,2−ベンゾイソチアゾール、ならびにその調製および使用 |
BRPI0510212A (pt) | 2004-05-07 | 2007-10-16 | Memory Pharm Corp | 1h-indazóis, benzotiazóis, 1,2 - benzoisoxazóis, 1,2-benzoisotiazóis, e cromonas e a preparação e usos dos mesmos |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
GB0424564D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
EP1828179B1 (en) | 2004-12-22 | 2010-01-20 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands against cns-related diseases |
CA2618700A1 (en) * | 2005-08-22 | 2007-03-01 | Targacept, Inc. | Heteroaryl-substituted diazatricycloalkanes, methods for its preparation and use thereof |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
JP5232374B2 (ja) * | 2006-09-29 | 2013-07-10 | 関東化学株式会社 | 2位に置換基を有する光学活性キヌクリジノール類の製造方法 |
JP5172124B2 (ja) * | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | 2位に置換基を有する光学活性キヌクリジノール類の製造方法 |
JP2011516489A (ja) | 2008-03-31 | 2011-05-26 | ユニバーシティ・オブ・サウス・フロリダ | 疾患誘発性運動失調症および非運動失調性平衡異常の治療法 |
US20110237597A1 (en) * | 2008-05-23 | 2011-09-29 | Zesiewicz Theresa A | Method of treating peripheral nerve sensory loss using compounds having nicotinic acetylcholine receptor activity |
TW201031664A (en) * | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
AR081402A1 (es) | 2010-05-17 | 2012-08-29 | Envivo Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato |
WO2012177263A1 (en) * | 2011-06-24 | 2012-12-27 | Intra-Cellular Therapies, Inc. | Compounds and methods of prophylaxis and treatment regarding nictonic receptor antagonists |
WO2013169646A1 (en) | 2012-05-08 | 2013-11-14 | Envivo Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
US10183938B2 (en) * | 2014-12-16 | 2019-01-22 | Axovant Sciences Gmbh | Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors |
CN109320510B (zh) * | 2018-11-27 | 2021-04-27 | 江苏慧聚药业有限公司 | 一种马罗匹坦游离碱的制备方法 |
CN111793017B (zh) * | 2019-04-04 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种内酰胺化合物的制备方法 |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3702324A (en) | 1970-06-24 | 1972-11-07 | Stanford Research Inst | 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines |
NL7611713A (nl) | 1975-11-03 | 1977-05-05 | Thomae Gmbh Dr K | Werkwijze voor de bereiding van verbindingen en preparaten met waardevolle farmacologische eigen- schappen. |
FR2529548A1 (fr) | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
US5175173A (en) | 1983-12-22 | 1992-12-29 | Sun Jung Hui | Carboxamides useful as antiemetic or antipsychotic agents |
US4593034A (en) | 1984-04-06 | 1986-06-03 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamides and thiobenzamides |
US4820715A (en) | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
US4870181A (en) | 1985-02-04 | 1989-09-26 | A. H. Robins Company, Incorporated | Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides |
US4605652A (en) | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
DE385517T1 (de) | 1985-03-14 | 1991-07-25 | Beecham Group P.L.C., Brentford, Middlesex, Gb | Arzneimittel zur behandlung von erbrechen. |
GB8520616D0 (en) | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
US4910193A (en) | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
EP0235878A3 (en) | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Novel compounds |
US4717563A (en) | 1986-03-05 | 1988-01-05 | A. H. Robins Company, Inc. | 2-alkoxy-N-(1-azabicyclo(2.2.2)oct-3-yl) benzamides and thiobenzamides in a method for alleviating emesis caused by non-platinum anticancer drugs |
HU895334D0 (en) | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
DE3780276T2 (de) | 1986-12-16 | 1993-02-25 | Robins Co Inc A H | Angstloesende n-(1-azabicyclo(2.2.2)oct-3-yl)benzamide und -thiobenzamide. |
US5237066A (en) | 1987-02-04 | 1993-08-17 | Delande S.A. | Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy |
US4835162A (en) | 1987-02-12 | 1989-05-30 | Abood Leo G | Agonists and antagonists to nicotine as smoking deterents |
DE3822792C2 (de) | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
GB8718345D0 (en) | 1987-08-03 | 1987-09-09 | Fordonal Sa | N-substituted benzamides |
US5206246A (en) | 1987-10-16 | 1993-04-27 | A. H. Robins Company, Incorporated | Anxiolytic-R-n(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides |
IE63474B1 (en) | 1987-12-24 | 1995-04-19 | Wyeth John & Brother Ltd | Heterocyclic compounds |
FR2625678B1 (fr) | 1988-01-13 | 1991-06-07 | Delalande Sa | Agents anorexigenes a base de n-(quinuclidin-3-yl)-benzamides ou thiobenzamides |
US4863919A (en) | 1988-02-01 | 1989-09-05 | A. H. Robins Company, Incorporated | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
DE3810552A1 (de) | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
DE3878235T2 (de) | 1988-08-04 | 1993-06-03 | Synthelabo | Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.)oct-3-yl)benzamide und thiobenzamide. |
EP0353371A1 (en) | 1988-08-04 | 1990-02-07 | Synthelabo | Memory enhancing-R-N-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and thiobenzamides |
US4920227A (en) | 1988-11-29 | 1990-04-24 | Rorer Pharmaceutical Corp. | Benzobicyclic carboxamide 5-HT3 antagonists |
US5290938A (en) | 1989-09-15 | 1994-03-01 | Chiron Laboratories A.S. | Preparation of S-(-)- and R-(+)-N-(quinuclidinyl-3)-amide |
GB8928837D0 (en) | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
US5057519A (en) | 1990-06-11 | 1991-10-15 | Bristol-Myers Squibb Company | 5-HT3 antagonists: use in reducing opiate tolerance |
US5070095A (en) | 1990-12-12 | 1991-12-03 | A. H. Robins Company, Incorporated | Substituted 4-(amidino)benzamides of 1-azabicyclo[2.2.2]octan-3- and -4-amine as gastric prokinetic, antiemetic, and anxiolytic agents |
GB9027487D0 (en) | 1990-12-19 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
US5084460A (en) | 1990-12-24 | 1992-01-28 | A. H. Robins Company, Incorporated | Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydroxybenzamides and thiobenzamides |
WO1992015579A1 (en) | 1991-03-08 | 1992-09-17 | Rhone-Poulenc Rorer International (Holdings) Inc. | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
US5273972A (en) | 1992-03-26 | 1993-12-28 | A. H. Robins Company, Incorporated | [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates |
US5236931A (en) | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
US5977144A (en) | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
EP1508614A1 (en) | 1993-03-08 | 2005-02-23 | MERCK & CO. INC. | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
IL109451A0 (en) | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
US5723103A (en) | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
DK0975327T3 (da) | 1997-04-18 | 2003-10-20 | Janssen Pharmaceutica Nv | Anvendelse af 5HT3-antagonister til befordring af tarmudskylning |
JP2003501022A (ja) | 1999-05-27 | 2003-01-14 | ファルマシア・アンド・アップジョン・カンパニー | イオンチャネルコンダクタンスを測定するための方法およびその組成物 |
SE9903760D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2002
- 2002-04-05 PE PE2002000274A patent/PE20021019A1/es not_active Application Discontinuation
- 2002-04-09 AR ARP020101299A patent/AR035817A1/es unknown
- 2002-04-17 US US10/124,145 patent/US6869946B2/en not_active Expired - Fee Related
- 2002-04-18 ES ES02764140T patent/ES2254723T3/es not_active Expired - Lifetime
- 2002-04-18 JP JP2002583428A patent/JP2004526788A/ja not_active Withdrawn
- 2002-04-18 EP EP02764140A patent/EP1389208B1/en not_active Expired - Lifetime
- 2002-04-18 MX MXPA03009644A patent/MXPA03009644A/es unknown
- 2002-04-18 AT AT02764140T patent/ATE314367T1/de not_active IP Right Cessation
- 2002-04-18 CA CA002439960A patent/CA2439960A1/en not_active Abandoned
- 2002-04-18 DE DE60208366T patent/DE60208366T2/de not_active Expired - Fee Related
- 2002-04-18 WO PCT/US2002/008268 patent/WO2002085901A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CA2439960A1 (en) | 2002-10-31 |
AR035817A1 (es) | 2004-07-14 |
ES2254723T3 (es) | 2006-06-16 |
PE20021019A1 (es) | 2002-11-13 |
DE60208366T2 (de) | 2006-07-06 |
WO2002085901A1 (en) | 2002-10-31 |
ATE314367T1 (de) | 2006-01-15 |
EP1389208B1 (en) | 2005-12-28 |
DE60208366D1 (de) | 2006-02-02 |
WO2002085901A8 (en) | 2003-12-24 |
US20030055043A1 (en) | 2003-03-20 |
JP2004526788A (ja) | 2004-09-02 |
EP1389208A1 (en) | 2004-02-18 |
US6869946B2 (en) | 2005-03-22 |
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