CA2439960A1 - Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor antagonists) - Google Patents
Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor antagonists) Download PDFInfo
- Publication number
- CA2439960A1 CA2439960A1 CA002439960A CA2439960A CA2439960A1 CA 2439960 A1 CA2439960 A1 CA 2439960A1 CA 002439960 A CA002439960 A CA 002439960A CA 2439960 A CA2439960 A CA 2439960A CA 2439960 A1 CA2439960 A1 CA 2439960A1
- Authority
- CA
- Canada
- Prior art keywords
- azabicyclo
- chlorobenzamide
- compound
- administered
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 24
- 201000010099 disease Diseases 0.000 title claims abstract description 23
- 229940044551 receptor antagonist Drugs 0.000 title description 2
- 239000002464 receptor antagonist Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 128
- 239000000203 mixture Substances 0.000 claims abstract description 125
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 56
- 241000124008 Mammalia Species 0.000 claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 45
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 34
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 31
- -1 cycloakyl Chemical group 0.000 claims abstract description 28
- 125000000547 substituted alkyl group Chemical group 0.000 claims abstract description 23
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims abstract description 14
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- 230000009151 sensory gating Effects 0.000 claims abstract description 11
- 230000006735 deficit Effects 0.000 claims abstract description 10
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- SAUBMRFYKTVXTL-UHFFFAOYSA-N 4-chloro-n-(2-methyl-1-azabicyclo[3.2.2]nonan-3-yl)benzamide Chemical compound C1C(CC2)CCN2C(C)C1NC(=O)C1=CC=C(Cl)C=C1 SAUBMRFYKTVXTL-UHFFFAOYSA-N 0.000 claims description 8
- NUKXVOISSGXHQT-UHFFFAOYSA-N 4-chloro-n-(4-ethyl-1-azabicyclo[3.2.2]nonan-3-yl)benzamide Chemical compound CCC1C(CC2)CCN2CC1NC(=O)C1=CC=C(Cl)C=C1 NUKXVOISSGXHQT-UHFFFAOYSA-N 0.000 claims description 8
- MEBUSTMEOOOFPF-UHFFFAOYSA-N 4-chloro-n-(4-methyl-1-azabicyclo[3.2.2]nonan-3-yl)benzamide Chemical compound CC1C(CC2)CCN2CC1NC(=O)C1=CC=C(Cl)C=C1 MEBUSTMEOOOFPF-UHFFFAOYSA-N 0.000 claims description 8
- KNJUGEIFWKPDKA-UHFFFAOYSA-N n-(1-azabicyclo[3.2.2]nonan-3-yl)-4-chlorobenzamide Chemical compound C1=CC(Cl)=CC=C1C(=O)NC1CN(CC2)CCC2C1 KNJUGEIFWKPDKA-UHFFFAOYSA-N 0.000 claims description 5
- XBGWFRGSMQHAAH-UHFFFAOYSA-N 4-chloro-n-(2-ethyl-1-azabicyclo[3.2.1]octan-3-yl)benzamide Chemical compound C1C(C2)CCN2C(CC)C1NC(=O)C1=CC=C(Cl)C=C1 XBGWFRGSMQHAAH-UHFFFAOYSA-N 0.000 claims description 2
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- DETWCCIEYHOSGZ-UHFFFAOYSA-N 4-chloro-n-(2-ethyl-1-azabicyclo[2.2.2]octan-3-yl)benzamide Chemical compound C1CC2CCN1C(CC)C2NC(=O)C1=CC=C(Cl)C=C1 DETWCCIEYHOSGZ-UHFFFAOYSA-N 0.000 claims 4
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- BMAIWQXUJRNDQG-UHFFFAOYSA-N n-(1-azabicyclo[2.2.1]heptan-3-yl)-4-chlorobenzamide Chemical compound C1=CC(Cl)=CC=C1C(=O)NC1C(C2)CCN2C1 BMAIWQXUJRNDQG-UHFFFAOYSA-N 0.000 claims 1
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- PRXNKYBFWAWBNZ-UHFFFAOYSA-N trimethylphenylammonium tribromide Chemical compound Br[Br-]Br.C[N+](C)(C)C1=CC=CC=C1 PRXNKYBFWAWBNZ-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 125000005500 uronium group Chemical group 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000004515 ventral tegmental area Anatomy 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28495001P | 2001-04-19 | 2001-04-19 | |
| US60/284,950 | 2001-04-19 | ||
| US34890401P | 2001-10-26 | 2001-10-26 | |
| US60/348,904 | 2001-10-26 | ||
| PCT/US2002/008268 WO2002085901A1 (en) | 2001-04-19 | 2002-04-18 | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2439960A1 true CA2439960A1 (en) | 2002-10-31 |
Family
ID=26962909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002439960A Abandoned CA2439960A1 (en) | 2001-04-19 | 2002-04-18 | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor antagonists) |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6869946B2 (https=) |
| EP (1) | EP1389208B1 (https=) |
| JP (1) | JP2004526788A (https=) |
| AR (1) | AR035817A1 (https=) |
| AT (1) | ATE314367T1 (https=) |
| CA (1) | CA2439960A1 (https=) |
| DE (1) | DE60208366T2 (https=) |
| ES (1) | ES2254723T3 (https=) |
| MX (1) | MXPA03009644A (https=) |
| PE (1) | PE20021019A1 (https=) |
| WO (1) | WO2002085901A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| EP1480977A2 (en) * | 2002-02-15 | 2004-12-01 | PHARMACIA & UPJOHN COMPANY | Substituted aryl compounds for treatment of disease |
| CA2476681A1 (en) | 2002-02-19 | 2003-08-28 | Bruce N. Rogers | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| MXPA05003317A (es) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
| WO2004052889A1 (en) * | 2002-12-06 | 2004-06-24 | Pharmacia & Upjohn Company Llc | Compounds as radioligands for the diagnosis of disease |
| EP1587511A2 (en) * | 2003-01-22 | 2005-10-26 | Pharmacia & Upjohn Company LLC | Treatment of diseases with alpha-7 nach receptor full agonists |
| GB0310867D0 (en) * | 2003-05-12 | 2003-06-18 | Novartis Ag | Organic compounds |
| RU2389729C2 (ru) | 2003-12-22 | 2010-05-20 | Мемори Фармасьютиклз Корпорейшн | 1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение |
| EP1735306A2 (en) | 2004-03-25 | 2006-12-27 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| US20070155780A1 (en) * | 2004-04-15 | 2007-07-05 | Hitoshi Nakata | Stabilized composition containing 4-amino-5-chloro-n-[(1r, 3r, 5s)-8-methyl-8-azabicyclo[3.2.1]oct-3-y1]-2-[1-methylbut-2-ynyloxy]benzamide |
| CA2567977A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| NZ551712A (en) | 2004-05-07 | 2010-07-30 | Memory Pharm Corp | 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof |
| AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0424564D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| CA2591817A1 (en) | 2004-12-22 | 2006-06-29 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| US7732607B2 (en) * | 2005-08-22 | 2010-06-08 | Anatoly Mazurov | Heteroaryl-substituted diazatricycloalkanes and methods of use thereof |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| JP5172124B2 (ja) * | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| JP5232374B2 (ja) * | 2006-09-29 | 2013-07-10 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| WO2009146031A1 (en) | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| JP2011520964A (ja) * | 2008-05-23 | 2011-07-21 | ユニバーシティ・オブ・サウス・フロリダ | ニコチン性アセチルコリン受容体活性を有する化合物を用いる末梢感覚神経喪失の治療方法 |
| TW201031664A (en) * | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| PE20170923A1 (es) | 2010-05-17 | 2017-07-12 | Forum Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado |
| WO2012177263A1 (en) * | 2011-06-24 | 2012-12-27 | Intra-Cellular Therapies, Inc. | Compounds and methods of prophylaxis and treatment regarding nictonic receptor antagonists |
| EP3461481A1 (en) | 2012-05-08 | 2019-04-03 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
| EP3623371A1 (en) * | 2014-12-16 | 2020-03-18 | Axovant Sciences GmbH | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| CN109320510B (zh) * | 2018-11-27 | 2021-04-27 | 江苏慧聚药业有限公司 | 一种马罗匹坦游离碱的制备方法 |
| CN111793017B (zh) * | 2019-04-04 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种内酰胺化合物的制备方法 |
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| US3702324A (en) | 1970-06-24 | 1972-11-07 | Stanford Research Inst | 3,4,5-trimethoxybenzamides of substituted anilines and of alkylpiperidines |
| NL7611713A (nl) | 1975-11-03 | 1977-05-05 | Thomae Gmbh Dr K | Werkwijze voor de bereiding van verbindingen en preparaten met waardevolle farmacologische eigen- schappen. |
| FR2529548A1 (fr) | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
| US5175173A (en) | 1983-12-22 | 1992-12-29 | Sun Jung Hui | Carboxamides useful as antiemetic or antipsychotic agents |
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| US4820715A (en) | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
| US4870181A (en) | 1985-02-04 | 1989-09-26 | A. H. Robins Company, Incorporated | Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides |
| US4605652A (en) | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| EP0201165B1 (en) | 1985-03-14 | 1994-07-20 | Beecham Group Plc | Medicaments for the treatment of emesis |
| GB8520616D0 (en) | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
| US4910193A (en) | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
| EP0235878A3 (en) | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Novel compounds |
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| HU895334D0 (en) | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
| DE3780276T2 (de) | 1986-12-16 | 1993-02-25 | Robins Co Inc A H | Angstloesende n-(1-azabicyclo(2.2.2)oct-3-yl)benzamide und -thiobenzamide. |
| US5237066A (en) | 1987-02-04 | 1993-08-17 | Delande S.A. | Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy |
| US4835162A (en) | 1987-02-12 | 1989-05-30 | Abood Leo G | Agonists and antagonists to nicotine as smoking deterents |
| DE3822792C2 (de) | 1987-07-11 | 1997-11-27 | Sandoz Ag | Neue Verwendung von 5HT¶3¶-Antagonisten |
| GB8718345D0 (en) | 1987-08-03 | 1987-09-09 | Fordonal Sa | N-substituted benzamides |
| US5206246A (en) | 1987-10-16 | 1993-04-27 | A. H. Robins Company, Incorporated | Anxiolytic-R-n(1-azabicyclo[2.2.2]oct-3-yl) benzamides and thiobenzamides |
| AU611976B2 (en) | 1987-12-24 | 1991-06-27 | John Wyeth & Brother Limited | Aroyl urea and carbamic acid derivatives of azabicyclo compounds |
| FR2625678B1 (fr) | 1988-01-13 | 1991-06-07 | Delalande Sa | Agents anorexigenes a base de n-(quinuclidin-3-yl)-benzamides ou thiobenzamides |
| US4863919A (en) | 1988-02-01 | 1989-09-05 | A. H. Robins Company, Incorporated | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
| DE3810552A1 (de) | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
| EP0353371A1 (en) | 1988-08-04 | 1990-02-07 | Synthelabo | Memory enhancing-R-N-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and thiobenzamides |
| DE3878235T2 (de) | 1988-08-04 | 1993-06-03 | Synthelabo | Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.)oct-3-yl)benzamide und thiobenzamide. |
| US4920227A (en) | 1988-11-29 | 1990-04-24 | Rorer Pharmaceutical Corp. | Benzobicyclic carboxamide 5-HT3 antagonists |
| US5290938A (en) | 1989-09-15 | 1994-03-01 | Chiron Laboratories A.S. | Preparation of S-(-)- and R-(+)-N-(quinuclidinyl-3)-amide |
| GB8928837D0 (en) | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
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| US5070095A (en) | 1990-12-12 | 1991-12-03 | A. H. Robins Company, Incorporated | Substituted 4-(amidino)benzamides of 1-azabicyclo[2.2.2]octan-3- and -4-amine as gastric prokinetic, antiemetic, and anxiolytic agents |
| GB9027487D0 (en) | 1990-12-19 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
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| US5236931A (en) | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
| US5273972A (en) | 1992-03-26 | 1993-12-28 | A. H. Robins Company, Incorporated | [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates |
| US5977144A (en) | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
| DE69434067T2 (de) | 1993-03-08 | 2006-03-02 | Merck & Co., Inc. | Menschliche neuronale nikotin-acetylcholin-rezeptor-verbindungen und methoden ihres einsatzes |
| IL109451A0 (en) | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
| US5723103A (en) | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
| US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| PT975327E (pt) | 1997-04-18 | 2003-11-28 | Janssen Pharmaceutica Nv | Uso de antagonistas de 5ht3 para estimular a lavagem intestinal |
| AU4980200A (en) | 1999-05-27 | 2000-12-18 | Pharmacia & Upjohn Company | Methods and compositions for measuring ion channel conductance |
| SE9903760D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
| SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2002
- 2002-04-05 PE PE2002000274A patent/PE20021019A1/es not_active Application Discontinuation
- 2002-04-09 AR ARP020101299A patent/AR035817A1/es unknown
- 2002-04-17 US US10/124,145 patent/US6869946B2/en not_active Expired - Fee Related
- 2002-04-18 JP JP2002583428A patent/JP2004526788A/ja not_active Withdrawn
- 2002-04-18 WO PCT/US2002/008268 patent/WO2002085901A1/en not_active Ceased
- 2002-04-18 AT AT02764140T patent/ATE314367T1/de not_active IP Right Cessation
- 2002-04-18 DE DE60208366T patent/DE60208366T2/de not_active Expired - Fee Related
- 2002-04-18 CA CA002439960A patent/CA2439960A1/en not_active Abandoned
- 2002-04-18 MX MXPA03009644A patent/MXPA03009644A/es unknown
- 2002-04-18 ES ES02764140T patent/ES2254723T3/es not_active Expired - Lifetime
- 2002-04-18 EP EP02764140A patent/EP1389208B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002085901A1 (en) | 2002-10-31 |
| US6869946B2 (en) | 2005-03-22 |
| ES2254723T3 (es) | 2006-06-16 |
| MXPA03009644A (es) | 2004-01-29 |
| US20030055043A1 (en) | 2003-03-20 |
| AR035817A1 (es) | 2004-07-14 |
| WO2002085901A8 (en) | 2003-12-24 |
| DE60208366T2 (de) | 2006-07-06 |
| EP1389208A1 (en) | 2004-02-18 |
| PE20021019A1 (es) | 2002-11-13 |
| JP2004526788A (ja) | 2004-09-02 |
| ATE314367T1 (de) | 2006-01-15 |
| EP1389208B1 (en) | 2005-12-28 |
| DE60208366D1 (de) | 2006-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |