DE60208366T2 - Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten) - Google Patents
Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten) Download PDFInfo
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- DE60208366T2 DE60208366T2 DE60208366T DE60208366T DE60208366T2 DE 60208366 T2 DE60208366 T2 DE 60208366T2 DE 60208366 T DE60208366 T DE 60208366T DE 60208366 T DE60208366 T DE 60208366T DE 60208366 T2 DE60208366 T2 DE 60208366T2
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- Prior art keywords
- azabicyclo
- chlorobenzamide
- mmol
- mixture
- int
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- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- PRXNKYBFWAWBNZ-UHFFFAOYSA-N trimethylphenylammonium tribromide Chemical compound Br[Br-]Br.C[N+](C)(C)C1=CC=CC=C1 PRXNKYBFWAWBNZ-UHFFFAOYSA-N 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- 125000005500 uronium group Chemical group 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229960000607 ziprasidone Drugs 0.000 description 1
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28495001P | 2001-04-19 | 2001-04-19 | |
| US284950P | 2001-04-19 | ||
| US34890401P | 2001-10-26 | 2001-10-26 | |
| US348904P | 2001-10-26 | ||
| PCT/US2002/008268 WO2002085901A1 (en) | 2001-04-19 | 2002-04-18 | Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60208366D1 DE60208366D1 (de) | 2006-02-02 |
| DE60208366T2 true DE60208366T2 (de) | 2006-07-06 |
Family
ID=26962909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60208366T Expired - Fee Related DE60208366T2 (de) | 2001-04-19 | 2002-04-18 | Substituierte azabicyclische einheiten zur krankheitsbehandlung (nikotinische acetylcholinrezeptor-antagonisten) |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6869946B2 (https=) |
| EP (1) | EP1389208B1 (https=) |
| JP (1) | JP2004526788A (https=) |
| AR (1) | AR035817A1 (https=) |
| AT (1) | ATE314367T1 (https=) |
| CA (1) | CA2439960A1 (https=) |
| DE (1) | DE60208366T2 (https=) |
| ES (1) | ES2254723T3 (https=) |
| MX (1) | MXPA03009644A (https=) |
| PE (1) | PE20021019A1 (https=) |
| WO (1) | WO2002085901A1 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| US6852716B2 (en) * | 2002-02-15 | 2005-02-08 | Pfizer Inc | Substituted-aryl compounds for treatment of disease |
| JP2005523288A (ja) | 2002-02-19 | 2005-08-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 疾病治療用の縮合した二環式−ｎ−架橋−複素環式芳香族カルボキサミド |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| MXPA05003317A (es) | 2002-09-25 | 2005-07-05 | Memory Pharm Corp | Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos. |
| WO2004052889A1 (en) * | 2002-12-06 | 2004-06-24 | Pharmacia & Upjohn Company Llc | Compounds as radioligands for the diagnosis of disease |
| WO2004064836A2 (en) * | 2003-01-22 | 2004-08-05 | Pharmacia & Upjohn Company Llc | Treatment of diseases with alpha-7 nach receptor full agonists |
| GB0310867D0 (en) | 2003-05-12 | 2003-06-18 | Novartis Ag | Organic compounds |
| DE602004010299T2 (de) | 2003-12-22 | 2008-09-18 | Memory Pharmaceuticals Corp. | Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen |
| NZ550534A (en) | 2004-03-25 | 2009-07-31 | Memory Pharm Corp | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| EP1736156A4 (en) * | 2004-04-15 | 2010-06-16 | Eisai R&D Man Co Ltd | COMPOSITION CONTAINING 4-AMINO-5-CHLORO-N-¬ (1R, 3R, 5S) -8-METHYL-8-AZABICYCLO-3.2.1 OCT-3-YL-2-β-methyl-2-ynyloxy BENZAMIDE STABILIZED |
| WO2006001894A1 (en) * | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
| JP2007538011A (ja) | 2004-05-07 | 2007-12-27 | メモリー・ファーマシューティカルズ・コーポレイション | １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用 |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| GB0424564D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
| RU2418797C2 (ru) | 2004-12-22 | 2011-05-20 | Мемори Фармасьютиклз Корпорейшн | Лиганды никотинового рецептора альфа-7, их получение и применение |
| BRPI0614874A2 (pt) * | 2005-08-22 | 2011-04-19 | Targacept Inc | diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos |
| US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| JP5232374B2 (ja) * | 2006-09-29 | 2013-07-10 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| JP5172124B2 (ja) * | 2006-09-29 | 2013-03-27 | 関東化学株式会社 | ２位に置換基を有する光学活性キヌクリジノール類の製造方法 |
| WO2009146031A1 (en) | 2008-03-31 | 2009-12-03 | University Of South Florida | Methods of treating disease-induced ataxia and non-ataxic imbalance |
| EP2300012A4 (en) * | 2008-05-23 | 2011-07-06 | Univ South Florida | METHOD FOR TREATING PERIPHERAL SENSORY NERVE LOSS WITH COMPOUNDS WITH NICOTIC ACIDYLCHOLINE RECEPTOR EFFECT |
| TW201031664A (en) * | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
| AR081402A1 (es) | 2010-05-17 | 2012-08-29 | Envivo Pharmaceuticals Inc | Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato |
| WO2012177263A1 (en) * | 2011-06-24 | 2012-12-27 | Intra-Cellular Therapies, Inc. | Compounds and methods of prophylaxis and treatment regarding nictonic receptor antagonists |
| CA2872005A1 (en) | 2012-05-08 | 2013-11-14 | Forum Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| WO2016100184A1 (en) * | 2014-12-16 | 2016-06-23 | Forum Pharmaceuticals, Inc. | Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors |
| CN109320510B (zh) * | 2018-11-27 | 2021-04-27 | 江苏慧聚药业有限公司 | 一种马罗匹坦游离碱的制备方法 |
| CN111793017B (zh) * | 2019-04-04 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种内酰胺化合物的制备方法 |
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| FI763021A7 (https=) | 1975-11-03 | 1977-05-04 | Thomae Gmbh Dr K | |
| FR2529548A1 (fr) | 1982-07-02 | 1984-01-06 | Delalande Sa | Nouveaux derives de l'amino-3 quinuclidine, leur procede et leur application en therapeutique |
| US5175173A (en) | 1983-12-22 | 1992-12-29 | Sun Jung Hui | Carboxamides useful as antiemetic or antipsychotic agents |
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| US4820715A (en) | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
| US4605652A (en) | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| US4870181A (en) | 1985-02-04 | 1989-09-26 | A. H. Robins Company, Incorporated | Process for the preparation of 2-alkoxy-N-(1-azabicyclo[2.2.2])octan-3-yl)aminobenzamides |
| DE201165T1 (de) | 1985-03-14 | 1989-04-20 | Beecham Group P.L.C., Brentford | Arzneimittel zur behandlung von emesis, anxietas und "irritable bowel syndrome". |
| GB8520616D0 (en) | 1985-08-16 | 1985-09-25 | Beecham Group Plc | Compounds |
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| EP0235878A3 (en) | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Novel compounds |
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| HU895334D0 (en) | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
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| IE62231B1 (en) | 1987-12-24 | 1995-01-11 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| FR2625678B1 (fr) | 1988-01-13 | 1991-06-07 | Delalande Sa | Agents anorexigenes a base de n-(quinuclidin-3-yl)-benzamides ou thiobenzamides |
| US4863919A (en) | 1988-02-01 | 1989-09-05 | A. H. Robins Company, Incorporated | Method of enhancing memory or correcting memory deficiency with arylamido(and arylthiomido)-azabicycloalkanes |
| DE3810552A1 (de) | 1988-03-29 | 1989-10-19 | Sandoz Ag | Ester und amide von indol-, benzo(b)thiopen-, benzo(b)furancarbonsaeuren oder 4-amino-2-methoxy-benzolsaeuren mit n-heterocyclischen oder n-heterobicyclischen alkoholen oder aminen, verfahren zu deren herstellung sie enthaltende pharmazeutische zusammensetzungen sowie applikator zur verabreichung derselben |
| DE3878235T2 (de) | 1988-08-04 | 1993-06-03 | Synthelabo | Antischizophren-wirksame s-n-(1-azabicyclo (2.2.2.)oct-3-yl)benzamide und thiobenzamide. |
| EP0353371A1 (en) | 1988-08-04 | 1990-02-07 | Synthelabo | Memory enhancing-R-N-(1-azabicyclo[2.2.2] oct-3-yl) benzamides and thiobenzamides |
| US4920227A (en) | 1988-11-29 | 1990-04-24 | Rorer Pharmaceutical Corp. | Benzobicyclic carboxamide 5-HT3 antagonists |
| US5290938A (en) | 1989-09-15 | 1994-03-01 | Chiron Laboratories A.S. | Preparation of S-(-)- and R-(+)-N-(quinuclidinyl-3)-amide |
| GB8928837D0 (en) | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
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| US5070095A (en) | 1990-12-12 | 1991-12-03 | A. H. Robins Company, Incorporated | Substituted 4-(amidino)benzamides of 1-azabicyclo[2.2.2]octan-3- and -4-amine as gastric prokinetic, antiemetic, and anxiolytic agents |
| GB9027487D0 (en) | 1990-12-19 | 1991-02-06 | Beecham Group Plc | Pharmaceuticals |
| US5084460A (en) | 1990-12-24 | 1992-01-28 | A. H. Robins Company, Incorporated | Methods of therapeutic treatment with N-(3-ouinuclidinyl)-2-hydroxybenzamides and thiobenzamides |
| CA2105655A1 (en) | 1991-03-08 | 1992-09-09 | Kent Neuenschwander | Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors |
| US5236931A (en) | 1992-03-26 | 1993-08-17 | A. H. Robins Company, Incorporated | 2-substituted benzamide and benzoate derivatives of 3-aminoquinuclidine and 3-quinuclidinol |
| US5273972A (en) | 1992-03-26 | 1993-12-28 | A. H. Robins Company, Incorporated | [(2-diakylaminomethyl)-3-quinuclidinyl]-benzamides and benzoates |
| US5977144A (en) | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
| CA2155330C (en) | 1993-03-08 | 2002-01-29 | Kathryn J. Elliott | Human neuronal nicotinic acetylcholine receptor compositions and methods employing same |
| IL109451A0 (en) | 1993-04-29 | 1994-07-31 | Zeneca Ltd | Heterocyclic derivatives |
| US5723103A (en) | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
| US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| CA2286076C (en) | 1997-04-18 | 2006-12-12 | Janssen Pharmaceutica N.V. | Use of 5ht3 antagonists for promoting intestinal lavage |
| WO2000073431A2 (en) | 1999-05-27 | 2000-12-07 | Pharmacia & Upjohn Company | Methods and compositions for measuring ion channel conductance |
| SE9903760D0 (sv) | 1999-10-18 | 1999-10-18 | Astra Ab | New compounds |
| SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| SE0000540D0 (sv) | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2002
- 2002-04-05 PE PE2002000274A patent/PE20021019A1/es not_active Application Discontinuation
- 2002-04-09 AR ARP020101299A patent/AR035817A1/es unknown
- 2002-04-17 US US10/124,145 patent/US6869946B2/en not_active Expired - Fee Related
- 2002-04-18 DE DE60208366T patent/DE60208366T2/de not_active Expired - Fee Related
- 2002-04-18 EP EP02764140A patent/EP1389208B1/en not_active Expired - Lifetime
- 2002-04-18 MX MXPA03009644A patent/MXPA03009644A/es unknown
- 2002-04-18 AT AT02764140T patent/ATE314367T1/de not_active IP Right Cessation
- 2002-04-18 JP JP2002583428A patent/JP2004526788A/ja not_active Withdrawn
- 2002-04-18 WO PCT/US2002/008268 patent/WO2002085901A1/en not_active Ceased
- 2002-04-18 ES ES02764140T patent/ES2254723T3/es not_active Expired - Lifetime
- 2002-04-18 CA CA002439960A patent/CA2439960A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2254723T3 (es) | 2006-06-16 |
| DE60208366D1 (de) | 2006-02-02 |
| AR035817A1 (es) | 2004-07-14 |
| WO2002085901A8 (en) | 2003-12-24 |
| JP2004526788A (ja) | 2004-09-02 |
| US20030055043A1 (en) | 2003-03-20 |
| CA2439960A1 (en) | 2002-10-31 |
| EP1389208B1 (en) | 2005-12-28 |
| ATE314367T1 (de) | 2006-01-15 |
| PE20021019A1 (es) | 2002-11-13 |
| WO2002085901A1 (en) | 2002-10-31 |
| MXPA03009644A (es) | 2004-01-29 |
| EP1389208A1 (en) | 2004-02-18 |
| US6869946B2 (en) | 2005-03-22 |
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Legal Events
| Date | Code | Title | Description |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |