JP2004526788A - 疾患治療用の置換型アザ二環式基（ニコチン性アセチルコリン受容体アンタゴニスト） - Google Patents

疾患治療用の置換型アザ二環式基（ニコチン性アセチルコリン受容体アンタゴニスト） Download PDF

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Publication number
JP2004526788A
JP2004526788A JP2002583428A JP2002583428A JP2004526788A JP 2004526788 A JP2004526788 A JP 2004526788A JP 2002583428 A JP2002583428 A JP 2002583428A JP 2002583428 A JP2002583428 A JP 2002583428A JP 2004526788 A JP2004526788 A JP 2004526788A
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Japan
Prior art keywords
azabicyclo
chlorobenzamide
oct
compound
administered
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Withdrawn
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JP2002583428A
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Japanese (ja)
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JP2004526788A5 (https=
Inventor
イー・ジョン・ジェイコブセン
ダニエル・ピー・ウォーカー
ジェイソン・ケイ・マイヤーズ
デイビッド・ダブリュー・ピオトロースキー
ビンセント・イー・グロッピ・ジュニア
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Pharmacia and Upjohn Co
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Pharmacia and Upjohn Co
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Publication of JP2004526788A publication Critical patent/JP2004526788A/ja
Publication of JP2004526788A5 publication Critical patent/JP2004526788A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2002583428A 2001-04-19 2002-04-18 疾患治療用の置換型アザ二環式基（ニコチン性アセチルコリン受容体アンタゴニスト） Withdrawn JP2004526788A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28495001P 2001-04-19 2001-04-19
US34890401P 2001-10-26 2001-10-26
PCT/US2002/008268 WO2002085901A1 (en) 2001-04-19 2002-04-18 Substituted azabicyclic moieties for the treatment of disease (nicotinic acethylcholine receptor agonists)

Publications (2)

Publication Number Publication Date
JP2004526788A true JP2004526788A (ja) 2004-09-02
JP2004526788A5 JP2004526788A5 (https=) 2005-12-22

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ID=26962909

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002583428A Withdrawn JP2004526788A (ja) 2001-04-19 2002-04-18 疾患治療用の置換型アザ二環式基（ニコチン性アセチルコリン受容体アンタゴニスト）

Country Status (11)

Country Link
US (1) US6869946B2 (https=)
EP (1) EP1389208B1 (https=)
JP (1) JP2004526788A (https=)
AR (1) AR035817A1 (https=)
AT (1) ATE314367T1 (https=)
CA (1) CA2439960A1 (https=)
DE (1) DE60208366T2 (https=)
ES (1) ES2254723T3 (https=)
MX (1) MXPA03009644A (https=)
PE (1) PE20021019A1 (https=)
WO (1) WO2002085901A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008088089A (ja) * 2006-09-29 2008-04-17 Kanto Chem Co Inc ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP2008088090A (ja) * 2006-09-29 2008-04-17 Kanto Chem Co Inc ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP2008518896A (ja) * 2004-11-05 2008-06-05 ノバルティス アクチエンゲゼルシャフト ニコチン性アセチルコリンα７受容体アンタゴニストの組合せ剤
JP2009506037A (ja) * 2005-08-22 2009-02-12 ターガセプト，インコーポレイテッド ヘテロアリール置換ジアザトリシクロアルカン、その調製方法およびその使用方法
JP2012515797A (ja) * 2009-01-26 2012-07-12 ターガセプト，インコーポレイテッド （２ｓ，３ｒ）−ｎ−２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）−３，５−ジフルオロベンズアミドの調製及び治療への適用
JP2014517078A (ja) * 2011-06-24 2014-07-17 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
JP2017538756A (ja) * 2014-12-16 2017-12-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物

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EP1480977A2 (en) * 2002-02-15 2004-12-01 PHARMACIA & UPJOHN COMPANY Substituted aryl compounds for treatment of disease
CA2476681A1 (en) 2002-02-19 2003-08-28 Bruce N. Rogers Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
MXPA05003317A (es) 2002-09-25 2005-07-05 Memory Pharm Corp Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
WO2004052889A1 (en) * 2002-12-06 2004-06-24 Pharmacia & Upjohn Company Llc Compounds as radioligands for the diagnosis of disease
EP1587511A2 (en) * 2003-01-22 2005-10-26 Pharmacia & Upjohn Company LLC Treatment of diseases with alpha-7 nach receptor full agonists
GB0310867D0 (en) * 2003-05-12 2003-06-18 Novartis Ag Organic compounds
RU2389729C2 (ru) 2003-12-22 2010-05-20 Мемори Фармасьютиклз Корпорейшн 1н-индазолы, 1, 2-бензизоксазолы и 1, 2-бензизотиазолы, их получение и применение
EP1735306A2 (en) 2004-03-25 2006-12-27 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US20070155780A1 (en) * 2004-04-15 2007-07-05 Hitoshi Nakata Stabilized composition containing 4-amino-5-chloro-n-[(1r, 3r, 5s)-8-methyl-8-azabicyclo[3.2.1]oct-3-y1]-2-[1-methylbut-2-ynyloxy]benzamide
CA2567977A1 (en) * 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
NZ551712A (en) 2004-05-07 2010-07-30 Memory Pharm Corp 1H-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparations and uses thereof
AR049401A1 (es) 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
CA2591817A1 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US8106066B2 (en) 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
WO2009146031A1 (en) 2008-03-31 2009-12-03 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
JP2011520964A (ja) * 2008-05-23 2011-07-21 ユニバーシティ・オブ・サウス・フロリダ ニコチン性アセチルコリン受容体活性を有する化合物を用いる末梢感覚神経喪失の治療方法
PE20170923A1 (es) 2010-05-17 2017-07-12 Forum Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado
EP3461481A1 (en) 2012-05-08 2019-04-03 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
CN109320510B (zh) * 2018-11-27 2021-04-27 江苏慧聚药业有限公司 一种马罗匹坦游离碱的制备方法
CN111793017B (zh) * 2019-04-04 2024-01-16 广东东阳光药业股份有限公司 一种内酰胺化合物的制备方法

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008518896A (ja) * 2004-11-05 2008-06-05 ノバルティス アクチエンゲゼルシャフト ニコチン性アセチルコリンα７受容体アンタゴニストの組合せ剤
JP2012255039A (ja) * 2004-11-05 2012-12-27 Novartis Ag ニコチン性アセチルコリンα７受容体アゴニストの組合せ剤
JP2009506037A (ja) * 2005-08-22 2009-02-12 ターガセプト，インコーポレイテッド ヘテロアリール置換ジアザトリシクロアルカン、その調製方法およびその使用方法
JP2008088089A (ja) * 2006-09-29 2008-04-17 Kanto Chem Co Inc ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP2008088090A (ja) * 2006-09-29 2008-04-17 Kanto Chem Co Inc ２位に置換基を有する光学活性キヌクリジノール類の製造方法
JP2012515797A (ja) * 2009-01-26 2012-07-12 ターガセプト，インコーポレイテッド （２ｓ，３ｒ）−ｎ−２−（（３−ピリジニル）メチル）−１−アザビシクロ［２．２．２］オクタ−３−イル）−３，５−ジフルオロベンズアミドの調製及び治療への適用
JP2014517078A (ja) * 2011-06-24 2014-07-17 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
JP2017538756A (ja) * 2014-12-16 2017-12-28 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物
JP2020033371A (ja) * 2014-12-16 2020-03-05 アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ α７−ニコチン性アセチルコリン受容体のアゴニストとしてのジェミナル置換キヌクリジンアミド化合物

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Publication number Publication date
WO2002085901A1 (en) 2002-10-31
US6869946B2 (en) 2005-03-22
CA2439960A1 (en) 2002-10-31
ES2254723T3 (es) 2006-06-16
MXPA03009644A (es) 2004-01-29
US20030055043A1 (en) 2003-03-20
AR035817A1 (es) 2004-07-14
WO2002085901A8 (en) 2003-12-24
DE60208366T2 (de) 2006-07-06
EP1389208A1 (en) 2004-02-18
PE20021019A1 (es) 2002-11-13
ATE314367T1 (de) 2006-01-15
EP1389208B1 (en) 2005-12-28
DE60208366D1 (de) 2006-02-02

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