AR035589A1 - Esteres de acido difenilmetilcarboxilico con efecto anticolinergico, un procedimiento para su preparacion, el uso de los mismos para la preparacion de un medicamento y los preparados farmaceuticos que los contienen - Google Patents
Esteres de acido difenilmetilcarboxilico con efecto anticolinergico, un procedimiento para su preparacion, el uso de los mismos para la preparacion de un medicamento y los preparados farmaceuticos que los contienenInfo
- Publication number
- AR035589A1 AR035589A1 ARP010104785A ARP010104785A AR035589A1 AR 035589 A1 AR035589 A1 AR 035589A1 AR P010104785 A ARP010104785 A AR P010104785A AR P010104785 A ARP010104785 A AR P010104785A AR 035589 A1 AR035589 A1 AR 035589A1
- Authority
- AR
- Argentina
- Prior art keywords
- effect
- preparation
- compounds
- fluorine
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Se describen ésteres de ácido difenilmetilcarboxílico de fórmula (1), en la que: A es un radical bivalente seleccionado entre el grupo que consta de fórmulas (2) y (3), X- significa un anión con carga negativa simple, preferentemente seleccionado entre el grupo formado por cloruro, bromuro, metilsulfato, 4-toluenosulfonato y metanosulfonato; R1 y R2 iguales o diferentes, significan un radical seleccionado entre el grupo que consta de metilo, etilo, n-propilo e isopropilo, que eventualmente puede estar sustituido con hidroxi o flúor; R3, R4, R5 y R6, iguales o diferentes, significan hidrógeno, metilo, etilo, metiloxi, etiloxi, hidroxi, flúor, cloro, bromo, CN, CF3 o NO2; R7 significa metilo, etilo, metiloxi, etiloxi, -CH2-F, -CH2-CH2-F, -O-CH2F, -O-CH2-CH2-F, -CH2-OH, -CH2-CH2-OH, CF3, -CH2-OMe, -CH2-CH2-OMe, -CH2-OEt, -CH2-CH2-OEt, -O-COMe, -O-COEt, -O-COCF3, -O-COCF3, flúor, cloro o bromo; eventualmente en forma de los isómeros ópticos individuales, de mezclas de los enantiómeros individuales o de racematos. Los compuestos de fórmula (1) son agentes anticolinérgicos que, por causa de su perfil de efecto, permiten la preparación de un medicamento que se puede aplicar una vez por día. Además, estos compuestos están caracterizados por una iniciación relativamente rápida del efecto y por presentar, después de dicha iniciación rápida del efecto, una actividad lo más constante posible a lo largo de un período de tiempo prolongado que le sigue. Además, la duración del efecto no sobrepasa esencialmente un período de tiempo de aproximadamente un día en dosificaciones que se pueden emplear de modo terapéuticamente conveniente. Finalmente, estos compuestos presentan un perfil de efecto que garantiza un buen control del efecto terapéutico. También se describe un procedimiento para preparar los compuestos de fórmula (1), los preparados farmacéuticos que los contienen y el uso de los mismos para preparar un medicamento destinado al tratamiento del asma, de la COPD, bradicardias sinusoidales causadas por el nervio vago, trastornos del ritmo cardíaco, espasmos en el tracto gastrointestinal, espasmos en las vías eferentes de orina y trastornos de la menstruación.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10050994A DE10050994A1 (de) | 2000-10-14 | 2000-10-14 | Neue als Arneimittel einsetzbare Anticholinergika sowie Verfahren zu deren Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
AR035589A1 true AR035589A1 (es) | 2004-06-16 |
Family
ID=7659808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010104785A Pending AR035589A1 (es) | 2000-10-14 | 2001-10-12 | Esteres de acido difenilmetilcarboxilico con efecto anticolinergico, un procedimiento para su preparacion, el uso de los mismos para la preparacion de un medicamento y los preparados farmaceuticos que los contienen |
Country Status (38)
Country | Link |
---|---|
EP (2) | EP1382606A3 (es) |
JP (2) | JP4109106B2 (es) |
KR (1) | KR100830359B1 (es) |
CN (1) | CN1275962C (es) |
AR (1) | AR035589A1 (es) |
AT (1) | ATE259805T1 (es) |
AU (2) | AU1397502A (es) |
BG (1) | BG66225B1 (es) |
BR (1) | BR0114635A (es) |
CA (1) | CA2425557C (es) |
DE (2) | DE10050994A1 (es) |
DK (1) | DK1325001T3 (es) |
EA (1) | EA005816B1 (es) |
EC (1) | ECSP034542A (es) |
EE (1) | EE05179B1 (es) |
ES (1) | ES2215147T3 (es) |
HK (1) | HK1060566A1 (es) |
HR (1) | HRP20030278B1 (es) |
HU (1) | HUP0301203A3 (es) |
IL (2) | IL155334A0 (es) |
ME (1) | MEP39908A (es) |
MX (1) | MXPA03003160A (es) |
MY (1) | MY127144A (es) |
NO (1) | NO328207B1 (es) |
NZ (1) | NZ525836A (es) |
PE (1) | PE20020433A1 (es) |
PL (1) | PL207311B1 (es) |
PT (1) | PT1325001E (es) |
RS (1) | RS50464B (es) |
SA (1) | SA01220414B1 (es) |
SI (1) | SI1325001T1 (es) |
SK (1) | SK287138B6 (es) |
TR (1) | TR200400376T4 (es) |
TW (1) | TWI306098B (es) |
UA (1) | UA73804C2 (es) |
UY (1) | UY26958A1 (es) |
WO (1) | WO2002032899A1 (es) |
ZA (1) | ZA200302914B (es) |
Families Citing this family (79)
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DE10200943A1 (de) * | 2002-01-12 | 2003-07-24 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Scopinestern |
US7405224B2 (en) | 2002-01-31 | 2008-07-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions |
DE10203753A1 (de) * | 2002-01-31 | 2003-08-14 | Boehringer Ingelheim Pharma | Neue Xanthencarbonsäureester, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7417051B2 (en) | 2002-04-12 | 2008-08-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising betamimetics and a novel anticholinergic |
US7084153B2 (en) | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
DE10256317A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittel enthaltend Betamimetika und ein neues Anticholinergikum |
DE10216429A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittel enthaltend Steroide und ein neues Anticholinergikum |
DK1497289T3 (da) * | 2002-04-12 | 2005-10-24 | Boehringer Ingelheim Pharma | Lægemiddel indeholdende betamimetika og et nyt anticholinergikum |
DE10224091A1 (de) * | 2002-05-31 | 2003-12-11 | Boehringer Ingelheim Pharma | Technisches Verfahren zur Herstellung von Tropenol |
DE10230750A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholonergika und NK1-Rezeptor-Antagonisten |
DE10230769A1 (de) * | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und PDE-IV-Inhibitoren |
ES2278170T3 (es) * | 2002-07-09 | 2007-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. |
DE10230751A1 (de) | 2002-07-09 | 2004-01-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern |
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US7244742B2 (en) | 2002-08-17 | 2007-07-17 | Boehringer Ingelheim Pharma Gmbh & Co Kg | Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic |
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EP2011538B1 (en) | 2007-07-06 | 2016-02-17 | Vectura Delivery Devices Limited | Inhaler |
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EP2077132A1 (en) | 2008-01-02 | 2009-07-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dispensing device, storage device and method for dispensing a formulation |
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UA121114C2 (uk) | 2014-05-07 | 2020-04-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Небулайзер, індикаторний пристрій і контейнер |
CA2952701C (en) | 2014-06-18 | 2023-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Muscarinic antagonists and combinations thereof for the treatment of airway disease in horses |
ES2809703T3 (es) * | 2015-09-04 | 2021-03-05 | Janssen Pharmaceutica Nv | Compuestos terapéuticos para el dolor y síntesis de los mismos |
CN113292574B (zh) * | 2020-02-21 | 2022-05-03 | 四川大学 | 一类手性多环的托品烷化合物及其制备方法和用途 |
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DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
DE4108393A1 (de) * | 1991-03-15 | 1992-09-17 | Boehringer Ingelheim Kg | Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln |
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2000
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2001
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- 2001-09-28 TR TR2004/00376T patent/TR200400376T4/xx unknown
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- 2001-09-28 MX MXPA03003160A patent/MXPA03003160A/es active IP Right Grant
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2003
- 2003-03-28 BG BG107688A patent/BG66225B1/bg active Active
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2004
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2008
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