CA2425557A1 - Anticholinergic agents that can be used as medicaments and method for the production thereof - Google Patents

Anticholinergic agents that can be used as medicaments and method for the production thereof Download PDF

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Publication number
CA2425557A1
CA2425557A1 CA002425557A CA2425557A CA2425557A1 CA 2425557 A1 CA2425557 A1 CA 2425557A1 CA 002425557 A CA002425557 A CA 002425557A CA 2425557 A CA2425557 A CA 2425557A CA 2425557 A1 CA2425557 A1 CA 2425557A1
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CA
Canada
Prior art keywords
medicaments
production
anticholinergic agents
preparing
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002425557A
Other languages
French (fr)
Other versions
CA2425557C (en
Inventor
Helmut Meissner
Gerd Morschhauser
Michael Paul Pieper
Gerald Pohl
Richard Reichl
Georg Speck
Rolf Banholzer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2425557A1 publication Critical patent/CA2425557A1/en
Application granted granted Critical
Publication of CA2425557C publication Critical patent/CA2425557C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

The present invention relates to new anticholinergics of general formula 1
CA002425557A 2000-10-14 2001-09-28 Anticholinergic agents that can be used as medicaments and method for the production thereof Expired - Lifetime CA2425557C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10050994.0 2000-10-14
DE10050994A DE10050994A1 (en) 2000-10-14 2000-10-14 New diphenylalkanoic acid azabicyclooctane ester quaternary salts useful as anticholinergic agents, especially in treatment of asthma and chronic obstructive pulmonary disease
PCT/EP2001/011226 WO2002032899A1 (en) 2000-10-14 2001-09-28 Novel anticholinergic agents that can be used as medicaments and method for the production thereof

Publications (2)

Publication Number Publication Date
CA2425557A1 true CA2425557A1 (en) 2003-04-11
CA2425557C CA2425557C (en) 2007-11-13

Family

ID=7659808

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425557A Expired - Lifetime CA2425557C (en) 2000-10-14 2001-09-28 Anticholinergic agents that can be used as medicaments and method for the production thereof

Country Status (38)

Country Link
EP (2) EP1382606A3 (en)
JP (2) JP4109106B2 (en)
KR (1) KR100830359B1 (en)
CN (1) CN1275962C (en)
AR (1) AR035589A1 (en)
AT (1) ATE259805T1 (en)
AU (2) AU2002213975B2 (en)
BG (1) BG66225B1 (en)
BR (1) BR0114635A (en)
CA (1) CA2425557C (en)
DE (2) DE10050994A1 (en)
DK (1) DK1325001T3 (en)
EA (1) EA005816B1 (en)
EC (1) ECSP034542A (en)
EE (1) EE05179B1 (en)
ES (1) ES2215147T3 (en)
HK (1) HK1060566A1 (en)
HR (1) HRP20030278B1 (en)
HU (1) HUP0301203A3 (en)
IL (2) IL155334A0 (en)
ME (1) MEP39908A (en)
MX (1) MXPA03003160A (en)
MY (1) MY127144A (en)
NO (1) NO328207B1 (en)
NZ (1) NZ525836A (en)
PE (1) PE20020433A1 (en)
PL (1) PL207311B1 (en)
PT (1) PT1325001E (en)
RS (1) RS50464B (en)
SA (1) SA01220414B1 (en)
SI (1) SI1325001T1 (en)
SK (1) SK287138B6 (en)
TR (1) TR200400376T4 (en)
TW (1) TWI306098B (en)
UA (1) UA73804C2 (en)
UY (1) UY26958A1 (en)
WO (1) WO2002032899A1 (en)
ZA (1) ZA200302914B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
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US7491719B2 (en) 2004-05-14 2009-02-17 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments
US7579358B2 (en) 2003-09-26 2009-08-25 Boehringer Ingelheim International Gmbh Aerosol formulation for inhalation comprising an anticholinergic
US7727984B2 (en) 2002-11-15 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co., Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US8420809B2 (en) 2005-08-15 2013-04-16 Boehringer Ingelheim International Gmbh Process for the manufacturing of betamimetics

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DE10203753A1 (en) * 2002-01-31 2003-08-14 Boehringer Ingelheim Pharma New xanthene carboxylic acid esters, processes for their preparation and their use as medicines
US7405224B2 (en) 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
DE10256317A1 (en) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Synergistic medicaments used for treating inflammaSynergistic medicaments used for treating inflammatory or obstructive respiratory tract diseases, cotory or obstructive respiratory tract diseases, contain quaternized scopine ester anticholinergic agntain quaternized scopine ester anticholinergic agent and beta-mimetic agent e.g. salmeterol salt ent and beta-mimetic agent e.g. salmeterol salt
DE10216429A1 (en) * 2002-04-12 2003-10-23 Boehringer Ingelheim Pharma Synergistic medicaments for treating inflammatory or obstructive respiratory tract diseases, containing quaternized scopine ester anticholinergic agent and steroid, e.g. budesonide
US7084153B2 (en) 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
BR0309185A (en) * 2002-04-12 2005-02-15 Boehringer Ingelheim Pharma Beta-mimetic drug and a new anticholinergic
DE10224091A1 (en) * 2002-05-31 2003-12-11 Boehringer Ingelheim Pharma Technical process for the production of tropenol
DE10230769A1 (en) * 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug compositions based on new anticholinergics and PDE-IV inhibitors
AU2003245989A1 (en) * 2002-07-09 2004-01-23 Boehringer Ingelheim Pharma Gmbh And Co. Kg Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
DE10230750A1 (en) * 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug compositions based on new anticholonergics and NK1 receptor antagonists
DE10230751A1 (en) * 2002-07-09 2004-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug compositions based on new anticholinergics and EGFR kinase inhibitors
MXPA05001595A (en) * 2002-08-14 2005-04-25 Boehringer Ingelheim Pharma Aerosol formulation for inhalation containing an anticholinergic agent.
DE10237739A1 (en) * 2002-08-17 2004-02-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Inhalable medicament for treating inflammatory or obstructive respiratory diseases, containing synergistic combination of tropane derivative anticholinergic agent, corticosteroid and beta-mimetic agent
US7244742B2 (en) 2002-08-17 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
DE10317461A1 (en) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Preparing microparticles labeled with technetium, useful as powders for inhalation, e.g. to study deposition of pharmaceuticals, such as anticholinergic agents, involves incubation with solution of technetium salt
DE10323966A1 (en) * 2003-05-27 2004-12-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg New long-acting drug combinations for the treatment of respiratory diseases
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US7462367B2 (en) 2003-07-11 2008-12-09 Boehringer Ingelheim International Gmbh Anticholinergic powder formulations for inhalation
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US7273603B2 (en) 2003-07-11 2007-09-25 Boehringer Ingelheim International Gmbh HFC solution formulations containing an anticholinergic
CA2533791C (en) * 2003-07-28 2012-05-22 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising betamimetics and an anticholinergic agent
DE602004021815D1 (en) * 2003-07-28 2009-08-13 Boehringer Ingelheim Pharma MEDICAMENTS FOR INHALATION WITH STEROIDS AND A NEW FLUORESCARBOXIC ACID ESTER
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Cited By (7)

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Publication number Priority date Publication date Assignee Title
US7727984B2 (en) 2002-11-15 2010-06-01 Boehringer Ingelheim Pharma Gmbh & Co., Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7786111B2 (en) 2002-11-15 2010-08-31 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US8044046B2 (en) 2002-11-15 2011-10-25 Boehringer Ingelheim Pharma Gmbh & Co Kg Medicaments for the treatment of chronic obstructive pulmonary disease
US7579358B2 (en) 2003-09-26 2009-08-25 Boehringer Ingelheim International Gmbh Aerosol formulation for inhalation comprising an anticholinergic
US7491719B2 (en) 2004-05-14 2009-02-17 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments
US8034809B2 (en) 2004-05-14 2011-10-11 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
US8420809B2 (en) 2005-08-15 2013-04-16 Boehringer Ingelheim International Gmbh Process for the manufacturing of betamimetics

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DK1325001T3 (en) 2004-06-21
CA2425557C (en) 2007-11-13
HUP0301203A3 (en) 2006-05-29
EA005816B1 (en) 2005-06-30
EP1325001A1 (en) 2003-07-09
KR100830359B1 (en) 2008-05-20
PT1325001E (en) 2004-07-30
EA200300459A1 (en) 2003-10-30
EE200300151A (en) 2003-06-16
AU1397502A (en) 2002-04-29
ZA200302914B (en) 2003-11-14
ECSP034542A (en) 2003-06-25
CN1275962C (en) 2006-09-20
ATE259805T1 (en) 2004-03-15
JP2004511557A (en) 2004-04-15
HRP20030278A2 (en) 2005-02-28
UA73804C2 (en) 2005-09-15
PE20020433A1 (en) 2002-06-28
JP2008120834A (en) 2008-05-29
IL155334A0 (en) 2003-11-23
SK4352003A3 (en) 2003-08-05
BG107688A (en) 2003-09-30
ES2215147T3 (en) 2004-10-01
HUP0301203A2 (en) 2003-10-28
YU29503A (en) 2006-03-03
UY26958A1 (en) 2002-06-20
PL207311B1 (en) 2010-11-30
HK1060566A1 (en) 2004-08-13
EE05179B1 (en) 2009-06-15
IL155334A (en) 2009-02-11
BG66225B1 (en) 2012-06-29
RS50464B (en) 2010-03-02
DE50101524D1 (en) 2004-03-25
HRP20030278B1 (en) 2006-02-28
EP1382606A3 (en) 2004-10-13
CN1468236A (en) 2004-01-14
KR20030041165A (en) 2003-05-23
AU2002213975B2 (en) 2006-11-09
WO2002032899A1 (en) 2002-04-25
SA01220414B1 (en) 2007-01-20
EP1325001B1 (en) 2004-02-18
PL360673A1 (en) 2004-09-20
JP4109106B2 (en) 2008-07-02
NO20031693L (en) 2003-05-28
MXPA03003160A (en) 2005-09-09
TWI306098B (en) 2009-02-11
MY127144A (en) 2006-11-30
SI1325001T1 (en) 2004-08-31
NO20031693D0 (en) 2003-04-11
NZ525836A (en) 2004-09-24
MEP39908A (en) 2011-02-10
BR0114635A (en) 2004-02-10
NO328207B1 (en) 2010-01-11
DE10050994A1 (en) 2002-04-18
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TR200400376T4 (en) 2004-03-22
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