AR031547A1 - Forma fisica de la sustancia 5-cloro-n-[2-[4-[[[(ciclohexilamino)-carbonil]amino]sulfonil]fenil]etil]-2-metoxibenzamida (gliburida), el uso de dicha sustancia en una tableta o capsula, las tabletas o capsulas que la contienen y las tabletas o capsulas que la contienen asociada con un farmaco para el - Google Patents

Forma fisica de la sustancia 5-cloro-n-[2-[4-[[[(ciclohexilamino)-carbonil]amino]sulfonil]fenil]etil]-2-metoxibenzamida (gliburida), el uso de dicha sustancia en una tableta o capsula, las tabletas o capsulas que la contienen y las tabletas o capsulas que la contienen asociada con un farmaco para el

Info

Publication number
AR031547A1
AR031547A1 ARP010100161A ARP010100161A AR031547A1 AR 031547 A1 AR031547 A1 AR 031547A1 AR P010100161 A ARP010100161 A AR P010100161A AR P010100161 A ARP010100161 A AR P010100161A AR 031547 A1 AR031547 A1 AR 031547A1
Authority
AR
Argentina
Prior art keywords
tablets
substance
capsules containing
physical form
phenyl
Prior art date
Application number
ARP010100161A
Other languages
English (en)
Inventor
Gillian Cave
Sarah J Nicholson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR031547A1 publication Critical patent/AR031547A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a una forma física del fármaco conocido como gliburida, también conocido como glibenclamida, y definido químicamente como 5-cloro-N-[2-[4-[[[(ciclohexilamino)-carbonil]amino]sulfonil]fenil]etil]-2-metoxibenzamida. Dicha forma física tiene las siguientes características de distribucion de tamano de partículas, un valor de 25% de subtamanos, entre 3 y 11 microm, un valor de 50% de subtamanos, entre 6 y 23 microm, y un valor de 75% de subtamanos, entre 15 y 46 microm. También se describe el uso de dicha forma física en tabletas o cápsulas, y las tabletas o cápsulas que las contienen eventualmente asociada con un fármaco.
ARP010100161A 2000-01-14 2001-01-12 Forma fisica de la sustancia 5-cloro-n-[2-[4-[[[(ciclohexilamino)-carbonil]amino]sulfonil]fenil]etil]-2-metoxibenzamida (gliburida), el uso de dicha sustancia en una tableta o capsula, las tabletas o capsulas que la contienen y las tabletas o capsulas que la contienen asociada con un farmaco para el AR031547A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48370300A 2000-01-14 2000-01-14

Publications (1)

Publication Number Publication Date
AR031547A1 true AR031547A1 (es) 2003-09-24

Family

ID=23921174

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010100161A AR031547A1 (es) 2000-01-14 2001-01-12 Forma fisica de la sustancia 5-cloro-n-[2-[4-[[[(ciclohexilamino)-carbonil]amino]sulfonil]fenil]etil]-2-metoxibenzamida (gliburida), el uso de dicha sustancia en una tableta o capsula, las tabletas o capsulas que la contienen y las tabletas o capsulas que la contienen asociada con un farmaco para el

Country Status (37)

Country Link
US (2) US20010036479A1 (es)
EP (1) EP1250321B1 (es)
JP (1) JP4787446B2 (es)
KR (1) KR100739906B1 (es)
CN (1) CN1210258C (es)
AR (1) AR031547A1 (es)
AT (1) ATE330937T1 (es)
AU (1) AU771705B2 (es)
BG (1) BG65782B1 (es)
BR (1) BR0107564A (es)
CA (1) CA2397294C (es)
CY (1) CY1106328T1 (es)
CZ (1) CZ20022429A3 (es)
DE (1) DE60120916T2 (es)
DK (1) DK1250321T3 (es)
EE (1) EE05020B1 (es)
ES (1) ES2264967T3 (es)
GE (1) GEP20043299B (es)
HU (1) HU228825B1 (es)
IL (2) IL150383A0 (es)
LT (1) LT5024B (es)
LV (1) LV12914B (es)
MX (1) MXPA02006835A (es)
MY (1) MY128577A (es)
NO (1) NO328152B1 (es)
NZ (1) NZ519920A (es)
PT (1) PT1250321E (es)
RO (1) RO121381B1 (es)
RU (1) RU2244707C2 (es)
SK (1) SK286925B6 (es)
TN (1) TNSN01005A1 (es)
TR (1) TR200201798T2 (es)
TW (1) TWI287989B (es)
UA (1) UA73968C2 (es)
UY (1) UY26529A1 (es)
WO (1) WO2001051463A1 (es)
ZA (1) ZA200205528B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767249B2 (en) * 2001-06-07 2010-08-03 Hewlett-Packard Development Company, L.P. Preparation of nanoparticles
US20050271737A1 (en) * 2001-06-07 2005-12-08 Chinea Vanessa I Application of a bioactive agent to a substrate
WO2003080056A2 (en) * 2002-03-21 2003-10-02 Teva Pharmaceutical Industries Ltd. Fine particle size pioglitazone
WO2003105809A1 (en) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
NZ546337A (en) 2003-10-31 2009-03-31 Takeda Pharmaceutical Solid preparation comprising an insulin sensitizer such as pioglitazone hydrochloride, an insulin secretagogue such as glimepiride and a polyoxyethylene sorbitan fatty acid ester such as Polysorbate 80
AU2004318976B2 (en) * 2004-04-29 2009-04-09 Lotus Pharmaceutical Co., Ltd. Oral modified-release lozenges and their preparation method
CN100455279C (zh) * 2004-04-29 2009-01-28 美时化学制药股份有限公司 口服延迟释放锭剂组成物及其制法
CN100341495C (zh) * 2004-12-29 2007-10-10 三九医药股份有限公司 格列本脲固体分散体、口服组合物及其制备方法
WO2006109175A2 (en) * 2005-04-11 2006-10-19 Aurobindo Pharma Limited Solid dosage form of an antidiabetic drug
US8529537B2 (en) * 2005-08-05 2013-09-10 Kimberly-Clark Worldwide, Inc. Absorbent article with enclosures
CN101287467B (zh) * 2005-08-22 2011-01-19 梅里奥尔医药I公司 用于调节Lyn激酶活性和治疗相关病症的方法和制剂
KR101577554B1 (ko) 2005-08-22 2015-12-14 멜리어 파마슈티칼스 아이, 인코포레이티드 Ｌｙｎ 키나제 활성의 조절 및 관련된 장애의 치료를 위한 방법 및 제제
EP2026787B1 (en) * 2006-05-13 2013-12-25 Novo Nordisk A/S Tablet formulation comprising repaglinide and metformin
WO2008026668A1 (fr) * 2006-08-31 2008-03-06 Daiichi Sankyo Company, Limited Composition médicale contenant un agent d'amélioration de la résistance à l'insuline
EP1967182A1 (en) * 2007-03-07 2008-09-10 KRKA, tovarna zdravil, d.d., Novo mesto Pharmaceutical composition comprising a salt of rosigliatazone
US8552184B2 (en) 2008-07-03 2013-10-08 Melior Pharmaceuticals I, Inc. Compounds and methods for treating disorders related to glucose metabolism
US8883852B2 (en) 2008-10-22 2014-11-11 University of Pittburgh—Of the Commonwealth System of Higher Education Radioprotective agents
US20130158055A1 (en) 2010-05-28 2013-06-20 Andrew G. Reaume Prevention Of Pancreatic Beta Cell Degeneration
EP2520298A1 (en) 2011-05-03 2012-11-07 Assistance Publique, Hopitaux De Paris Pharmaceutical composition comprising sulfonylureas (glibenclamide) or meglitinides for use for treating hyperglycaemia or for promoting growth of a premature infant
CN102743354A (zh) * 2012-07-31 2012-10-24 南京正科制药有限公司 瑞格列奈片及其制备方法
CN103142521B (zh) * 2013-03-21 2014-06-25 西南药业股份有限公司 格列本脲片及其制备方法
CN104127424A (zh) * 2014-07-30 2014-11-05 沈阳药科大学 格列本脲衍生物及其制备方法和应用
CN104127423A (zh) * 2014-07-30 2014-11-05 沈阳药科大学 格列喹酮衍生物及其制备方法和应用
CA3059432A1 (en) 2017-04-10 2018-10-18 Melior Pharmaceuticals I, Inc. Compositions comprising a lyn kinase activator and a trpms agonist
CN113143940A (zh) * 2020-12-30 2021-07-23 成都恒瑞制药有限公司 一种抗糖尿病药物组合物的制备方法
WO2023012610A1 (en) * 2021-08-03 2023-02-09 Avaca Pharma Private Limited Formulations, compositions and methods for the treatment of stroke

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3174901A (en) * 1963-01-31 1965-03-23 Jan Marcel Didier Aron Samuel Process for the oral treatment of diabetes
DE1185180B (de) 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
US3454635A (en) 1965-07-27 1969-07-08 Hoechst Ag Benzenesulfonyl-ureas and process for their manufacture
CA889876A (en) 1970-09-10 1972-01-04 Frank W. Horner Limited Purification of glyburide
DE2348334C2 (de) * 1973-09-26 1982-11-11 Boehringer Mannheim Gmbh, 6800 Mannheim Neue Zubereitungsform des N-4-[2-(5-Chlor-2-methoxybenzamido)äthyl]- phenyl-sulfonyl-N'-cyclohexylharnstoffs
US4060634A (en) * 1973-09-26 1977-11-29 Boehringer Mannheim G.M.B.H. Rapidly resorbable glibenclamide
US4916163A (en) * 1985-06-04 1990-04-10 The Upjohn Company Spray-dried lactose formulation of micronized glyburide
DE3833439A1 (de) 1988-10-01 1991-09-12 Hoechst Ag Verfahren zur mikronisierung von glibenclamid
RU2026670C1 (ru) 1988-10-05 1995-01-20 Дзе Апджон Компани Способ получения тонкодисперсного твердого фармацевтического вещества
US5258185A (en) 1989-08-23 1993-11-02 Bauer Kurt H Highly active, rapidly absorbable formulations of glibenclamide, processes for the production thereof and their use
DK0615445T3 (da) * 1991-12-05 1996-06-03 Alfatec Pharma Gmbh Farmaceutisk administrerbar nanosol og fremgangsmåde til fremstilling deraf
DK36392D0 (da) * 1992-03-19 1992-03-19 Novo Nordisk As Anvendelse af kemisk forbindelse
DE4323636A1 (de) * 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
IT1276130B1 (it) 1995-11-14 1997-10-27 Gentili Ist Spa Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo
US6153632A (en) * 1997-02-24 2000-11-28 Rieveley; Robert B. Method and composition for the treatment of diabetes
DE19721467A1 (de) * 1997-05-22 1998-11-26 Basf Ag Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe
DE122007000054I1 (de) 1997-06-18 2007-12-13 Smithkline Beecham Plc Behandlung der Diabetes mit Thiazolidindione und metformin
GB9715306D0 (en) 1997-07-18 1997-09-24 Smithkline Beecham Plc Novel method of treatment
ES2191977T3 (es) * 1997-10-27 2003-09-16 Merck Patent Gmbh Soluciones y dispersiones en estado solido de farmacos poco solubles en agua.
PT974356E (pt) 1998-07-15 2004-02-27 Merck Sante Sas Comprimidos compreendendo uma combinacao de metformina e de glibenclamida
US7374779B2 (en) * 1999-02-26 2008-05-20 Lipocine, Inc. Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
US6294192B1 (en) * 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents

Also Published As

Publication number Publication date
UA73968C2 (en) 2005-10-17
ATE330937T1 (de) 2006-07-15
RU2244707C2 (ru) 2005-01-20
WO2001051463A1 (en) 2001-07-19
PL356210A1 (en) 2004-06-14
MXPA02006835A (es) 2003-01-28
CZ20022429A3 (cs) 2003-06-18
HUP0203852A3 (en) 2005-05-30
NZ519920A (en) 2004-06-25
BG106870A (en) 2003-03-31
DE60120916D1 (de) 2006-08-03
KR20020073169A (ko) 2002-09-19
MY128577A (en) 2007-02-28
US6830760B2 (en) 2004-12-14
IL150383A (en) 2007-03-08
DK1250321T3 (da) 2006-07-31
EP1250321B1 (en) 2006-06-21
US20010036479A1 (en) 2001-11-01
LV12914B (en) 2003-01-20
BR0107564A (pt) 2002-10-01
AU771705B2 (en) 2004-04-01
HU228825B1 (en) 2013-05-28
IL150383A0 (en) 2002-12-01
NO20023367D0 (no) 2002-07-12
CA2397294C (en) 2011-03-22
GEP20043299B (en) 2004-03-10
CA2397294A1 (en) 2001-07-19
NO328152B1 (no) 2009-12-21
RO121381B1 (ro) 2007-04-30
EE05020B1 (et) 2008-06-16
CY1106328T1 (el) 2011-10-12
DE60120916T2 (de) 2007-02-15
KR100739906B1 (ko) 2007-07-16
RU2002121626A (ru) 2004-01-10
HUP0203852A2 (hu) 2003-04-28
JP2003519681A (ja) 2003-06-24
PT1250321E (pt) 2006-09-29
CN1395560A (zh) 2003-02-05
EE200200393A (et) 2003-10-15
ES2264967T3 (es) 2007-02-01
AU2474001A (en) 2001-07-24
CN1210258C (zh) 2005-07-13
TNSN01005A1 (en) 2005-11-10
UY26529A1 (es) 2001-08-27
TR200201798T2 (tr) 2002-11-21
SK286925B6 (sk) 2009-07-06
TWI287989B (en) 2007-10-11
SK9832002A3 (en) 2003-07-01
BG65782B1 (bg) 2009-11-30
LT2002085A (en) 2003-01-27
ZA200205528B (en) 2003-10-10
LT5024B (lt) 2003-06-25
US20030185880A1 (en) 2003-10-02
JP4787446B2 (ja) 2011-10-05
EP1250321A1 (en) 2002-10-23
NO20023367L (no) 2002-09-04

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