UA91852C2 - Фармацевтическая дозированная форма, которая содержит метформин и пиоглитазон как активные медикаменты - Google Patents

Фармацевтическая дозированная форма, которая содержит метформин и пиоглитазон как активные медикаменты

Info

Publication number
UA91852C2
UA91852C2 UAA200712007A UAA200712007A UA91852C2 UA 91852 C2 UA91852 C2 UA 91852C2 UA A200712007 A UAA200712007 A UA A200712007A UA A200712007 A UAA200712007 A UA A200712007A UA 91852 C2 UA91852 C2 UA 91852C2
Authority
UA
Ukraine
Prior art keywords
pioglitazone
metformin
pharmaceutical formulation
formulation containing
active medicaments
Prior art date
Application number
UAA200712007A
Other languages
English (en)
Ukrainian (uk)
Inventor
Казухиро Окохи
Авинаш Нангия
Анчали Лодин
Джек Р Кардинал
Original Assignee
Такеда Фармасьютикал Компани, Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37073782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA91852(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Такеда Фармасьютикал Компани, Лимитед filed Critical Такеда Фармасьютикал Компани, Лимитед
Publication of UA91852C2 publication Critical patent/UA91852C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Изобретение касается фармацевтической дозированной формы, которая состоит из: 1) ядра контролируемого высвобождения, которое состоит из метформина, окруженного оболочкой замедленного высвобождения, и 2) слоя немедленного высвобождения, который окружает ядро контролируемого высвобождения, содержащее пиоглитазона гидрохдорид и водорастворимое связующее вещество, которое имеет вязкость ниже 10 мПа.с, при испытании в форме 2 % водного раствора при 20 °С, в которой не менее, чем 90 % пиоглитазона гидрохдорида высвобождается на протяжении 30 минут, и в которой общее количество определенных примесей пиоглитазона гидрохдорида, присутствующих в дозированной форме, составляет не более, чем 0,6 % как определено с помощью высокоэффективной жидкостной хроматографии.
UAA200712007A 2005-03-30 2006-03-13 Фармацевтическая дозированная форма, которая содержит метформин и пиоглитазон как активные медикаменты UA91852C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/093,742 US9060941B2 (en) 2002-09-20 2005-03-30 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative

Publications (1)

Publication Number Publication Date
UA91852C2 true UA91852C2 (ru) 2010-09-10

Family

ID=37073782

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200712007A UA91852C2 (ru) 2005-03-30 2006-03-13 Фармацевтическая дозированная форма, которая содержит метформин и пиоглитазон как активные медикаменты

Country Status (25)

Country Link
US (1) US9060941B2 (ru)
EP (1) EP1863445B1 (ru)
JP (2) JP5827781B2 (ru)
KR (1) KR101401412B1 (ru)
CN (1) CN101222912B (ru)
AR (1) AR054238A1 (ru)
AU (1) AU2006232993B2 (ru)
BR (1) BRPI0609550A2 (ru)
CA (1) CA2601501C (ru)
CR (1) CR9355A (ru)
EA (1) EA015244B1 (ru)
ES (1) ES2573321T3 (ru)
GE (1) GEP20104936B (ru)
HK (1) HK1114337A1 (ru)
IL (1) IL186308A (ru)
MA (1) MA29675B1 (ru)
MX (1) MX2007011824A (ru)
NO (1) NO20075427L (ru)
NZ (1) NZ561124A (ru)
PE (1) PE20061389A1 (ru)
SG (1) SG160415A1 (ru)
TW (1) TWI344375B (ru)
UA (1) UA91852C2 (ru)
WO (1) WO2006107528A1 (ru)
ZA (1) ZA200707137B (ru)

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UA113858C2 (uk) 2011-10-21 2017-03-27 Такеда Фармасьютікал Компані Лімітед Лікарський засіб піоглітазону з уповільненим вивільненням
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CN101222912B (zh) 2012-10-03
GEP20104936B (en) 2010-03-25
MA29675B1 (fr) 2008-08-01
US20050226928A1 (en) 2005-10-13
TWI344375B (en) 2011-07-01
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BRPI0609550A2 (pt) 2010-04-13
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IL186308A (en) 2014-05-28
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