AR030080A1 - Levaduras modificadas y sus utilizaciones, especialmente para la produccion de derivados esteroides - Google Patents

Levaduras modificadas y sus utilizaciones, especialmente para la produccion de derivados esteroides

Info

Publication number
AR030080A1
AR030080A1 ARP010103640A ARP010103640A AR030080A1 AR 030080 A1 AR030080 A1 AR 030080A1 AR P010103640 A ARP010103640 A AR P010103640A AR P010103640 A ARP010103640 A AR P010103640A AR 030080 A1 AR030080 A1 AR 030080A1
Authority
AR
Argentina
Prior art keywords
strains
production
steroid derivatives
synthesis
modification
Prior art date
Application number
ARP010103640A
Other languages
English (en)
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of AR030080A1 publication Critical patent/AR030080A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • C12N9/0087—Steroid 21-monooxygenase (1.14.99.10)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente se refiere a nuevas cepas de levadura, a procedimientos y estructuras genéticas para su preparacion así como su utilizacion para la síntesis y la modificacion de compuestos esteroides. Más particularmente, el invento describe cepas que presentan una actividad disminuida del tipo de 20alfa-HSD, especialmente por modificacion de los genes CGY1 y/o YPR1. Las etapas de levadura de la presente permiten mejorar la eficacia de la síntesis o aumentar la selectividad o bien los rendimientos del procedimiento, así como la calidad del producto final. Las cepas, los procedimientos y los compuestos del invento son utiles en la investigacion, el desarrollo y la produccion de productos con actividad terapéutica y profiláctica, en seres humanos o en animales, especialmente de derivados esteroides.
ARP010103640A 2000-08-08 2001-07-30 Levaduras modificadas y sus utilizaciones, especialmente para la produccion de derivados esteroides AR030080A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0010437A FR2812884B1 (fr) 2000-08-08 2000-08-08 Levures modifiees et utilisations, notamment pour la production de derives steroidiens

Publications (1)

Publication Number Publication Date
AR030080A1 true AR030080A1 (es) 2003-08-13

Family

ID=8853403

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010103640A AR030080A1 (es) 2000-08-08 2001-07-30 Levaduras modificadas y sus utilizaciones, especialmente para la produccion de derivados esteroides

Country Status (22)

Country Link
US (2) US7879592B2 (es)
EP (1) EP1313873B1 (es)
JP (1) JP4864277B2 (es)
KR (1) KR100860702B1 (es)
AR (1) AR030080A1 (es)
AT (1) ATE390479T1 (es)
AU (2) AU7856201A (es)
BR (1) BRPI0113048B8 (es)
CA (1) CA2418370C (es)
CY (1) CY1108080T1 (es)
DE (1) DE60133396T2 (es)
DK (1) DK1313873T3 (es)
ES (1) ES2300347T3 (es)
FR (1) FR2812884B1 (es)
IL (2) IL154294A0 (es)
MX (1) MXPA03000702A (es)
NO (1) NO334484B1 (es)
NZ (1) NZ523612A (es)
PT (1) PT1313873E (es)
TW (1) TWI315739B (es)
WO (1) WO2002012536A1 (es)
ZA (1) ZA200300376B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2812884B1 (fr) 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
FR2820145B1 (fr) * 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome
FR2976949B1 (fr) 2011-06-21 2015-08-28 Sanofi Sa Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5571250A (en) 1978-11-22 1980-05-29 Hatano Kk Paper for paper box with lid and method of assembling paper box with lid by using same
BE889407A (fr) 1980-06-27 1981-10-16 Mallinckrodt Inc Amelioration du procede de preparation d'un lysat de limule
JPS62181571A (ja) 1986-08-11 1987-08-08 Canon Inc 画像処理装置
JPS63181571A (ja) 1987-01-22 1988-07-26 Matsushita Electric Ind Co Ltd 自動焦点整合装置
JPS6447380A (en) 1987-08-19 1989-02-21 Agency Ind Science Techn Steroid-oxidizing yeast strain
JPS6471250A (en) 1987-09-11 1989-03-16 Nec Corp Multi-function telephone set
EP0340878B1 (en) 1988-05-06 2001-05-16 Aventis Pharma S.A. Process for the biochemical oxidation of steroids and genetically engineered cells to be used therefor
JPH0231680A (ja) * 1988-07-22 1990-02-01 Agency Of Ind Science & Technol チトクロムＰ４５０ｃ↓２↓１産生酵母菌株
CN1042567A (zh) 1988-09-23 1990-05-30 吉斯特-布罗卡迪斯公司 类固醇多步氧化方法和所用的遗传工程细胞
JPH02249488A (ja) * 1989-03-22 1990-10-05 Sumitomo Chem Co Ltd チトクロムＰ４５０↓ｃ↓２↓１と酵母ＮＡＤＰＨ‐チトクロムＰ４５０還元酵素の融合酸化酵素、該酵素をコードする遺伝子および該酵素の製造方法
JP2645130B2 (ja) 1989-03-31 1997-08-25 日清製粉株式会社 ステロイド誘導体
FR2678611B1 (fr) 1991-07-04 1995-01-20 Roussel Uclaf Nouveaux esters pyrethrinouides de l'alcool 1,3,4,5,6,7-hexahydro 1,3-dioxo-2h-isoindol-2-yl-methylique, leur procede de preparation et leur application comme pesticides.
JP3363197B2 (ja) 1992-06-18 2003-01-08 麒麟麦酒株式会社 アルコールアセチルトランスフェラーゼ遺伝子およびその利用
US5547868A (en) 1993-06-09 1996-08-20 Regents Of The University Of California Cholesterol disposal fusion enzymes
IL162476A (en) 1995-02-15 2005-12-18 Aventis Pharma Sa Arabidopsis thaliana proteins having delta -5,7- sterol - delta -7- reductase activity
JP4093598B2 (ja) 1995-03-14 2008-06-04 大関株式会社 新規なアルコールアセチルトランスフェラーゼ遺伝子
DE19744212B4 (de) 1997-09-30 2006-01-19 Schering Ag Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen
US6303302B1 (en) * 1997-11-19 2001-10-16 The Whitehead Institute For Biomedical Research Regulation of fungal gene expression
FR2774393B1 (fr) 1998-02-05 2000-03-24 Hoechst Marion Roussel Inc Souches de levure ayant le gene atf2 interrompu et leurs applications
FR2799206A1 (fr) 1999-10-05 2001-04-06 Transgene Sa Procede de production de steroides modifies par fermentation de levures
FR2812884B1 (fr) 2000-08-08 2002-11-08 Aventis Pharma Sa Levures modifiees et utilisations, notamment pour la production de derives steroidiens
FR2820145B1 (fr) 2001-01-31 2004-01-23 Aventis Pharma Sa Souche de levure produisant des steroides de facon autonome

Also Published As

Publication number Publication date
AU2001278562B2 (en) 2006-07-20
KR100860702B1 (ko) 2008-09-26
NO20030606L (no) 2003-02-07
JP2004505634A (ja) 2004-02-26
DE60133396D1 (de) 2008-05-08
CA2418370C (fr) 2014-03-11
MXPA03000702A (es) 2003-06-04
DK1313873T3 (da) 2008-07-14
JP4864277B2 (ja) 2012-02-01
DE60133396T2 (de) 2009-07-09
WO2002012536A1 (fr) 2002-02-14
AU7856201A (en) 2002-02-18
EP1313873A1 (fr) 2003-05-28
US7879592B2 (en) 2011-02-01
FR2812884B1 (fr) 2002-11-08
FR2812884A1 (fr) 2002-02-15
NO20030606D0 (no) 2003-02-07
EP1313873B1 (fr) 2008-03-26
ZA200300376B (en) 2004-01-22
NZ523612A (en) 2004-11-26
IL154294A (en) 2010-05-31
TWI315739B (en) 2009-10-11
ATE390479T1 (de) 2008-04-15
US8173402B2 (en) 2012-05-08
IL154294A0 (en) 2003-09-17
CY1108080T1 (el) 2014-02-12
ES2300347T3 (es) 2008-06-16
US20040082025A1 (en) 2004-04-29
NO334484B1 (no) 2014-03-17
BRPI0113048B1 (pt) 2015-12-22
KR20030024842A (ko) 2003-03-26
US20110104749A1 (en) 2011-05-05
BR0113048A (pt) 2003-07-01
PT1313873E (pt) 2008-05-27
CA2418370A1 (fr) 2002-02-14
BRPI0113048B8 (pt) 2021-05-25

Similar Documents

Publication Publication Date Title
PE20050255A1 (es) Nuevas cianotiazolidas y procedimiento para su preparacion como medicamentos
MX356086B (es) Produccion de acidos grasos y derivados de los mismos.
WO2007120811A3 (en) Hemangio-colony forming cells
NO20050598L (no) Fremsgangmate for fremstilling av zeaxantin og/eller biosyntetiske mellomprodukter og/eller folgeprodukter derav
CY1117683T1 (el) Ρετινοειδες-λιποσωματα για ενισχυση ρυθμισης εκφρασης hsp47
ATE517895T1 (de) Harminderivate, bei deren herstellung verwendete zwischenprodukte, herstellungsverfahren und verwendung davon
PT1928882E (pt) (s)-n-metilnaltrexona, processo para a sua síntese e sua utilização farmacêutica
EP3623465A3 (en) Production of fatty acids and derivatives thereof
ECSP055524A (es) Derivados de indolin-fenilsufonamida
HK1118577A1 (en) Rnai expression constructs rnai
CY1113112T1 (el) Παραγωγα θειενοπυριδονης ως ενεργοποιητες της πρωτεϊνικης κινασης (αμρκ) που ενεργοποιουνται απο το amρ
UY29639A1 (es) Amidas sustituidas con heteroarilo que comprenden un grupo enlazador insaturado o cíclico, y su uso como productos farmacéuticos
WO2006029081A3 (en) Nucleoside-lipid conjugates, their method of preparation and uses thereof
MX2012001786A (es) Derivados de sulfuro sustituidos con 3-triazolilfenilo como acaricidas e insecticidas.
MX2009007436A (es) Derivados espirociclicos de acido tetronico.
CR10092A (es) Nuevos derivados de furopirimidina aciclicos sustituidos y su uso
CL2021001209A1 (es) Constructos de suministro para transcitosis y métodos relacionados
DOP2002000481A (es) Derivados de acido acetico
TW200621703A (en) Alkylidene-tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents
AR030080A1 (es) Levaduras modificadas y sus utilizaciones, especialmente para la produccion de derivados esteroides
UY29769A1 (es) Proceso para preparar acidos y lactonas sacarinicos
TW200510308A (en) Isophthalic acid derivatives
CU24011B1 (es) Piperidinas 2-fenil-5-(1,2,4-oxadiazol-5-il) sustituidas
WO2009108898A3 (en) Production and uses of type 1 ribosome inactivating proteins
BRPI0509028A (pt) processo para produção de derivados de c-glicosìdeo de flavona

Legal Events

Date Code Title Description
FG Grant, registration