ATE517895T1 - Harminderivate, bei deren herstellung verwendete zwischenprodukte, herstellungsverfahren und verwendung davon - Google Patents

Harminderivate, bei deren herstellung verwendete zwischenprodukte, herstellungsverfahren und verwendung davon

Info

Publication number
ATE517895T1
ATE517895T1 AT04735720T AT04735720T ATE517895T1 AT E517895 T1 ATE517895 T1 AT E517895T1 AT 04735720 T AT04735720 T AT 04735720T AT 04735720 T AT04735720 T AT 04735720T AT E517895 T1 ATE517895 T1 AT E517895T1
Authority
AT
Austria
Prior art keywords
production
intermediate products
products used
compounds
medicines
Prior art date
Application number
AT04735720T
Other languages
English (en)
Inventor
Jialin Wu
Qi Chen
Rihui Cao
F Yu
Zihou Wang
Wenlie Peng
Original Assignee
Xinjiang Huashidan Pharmaceutical Res Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xinjiang Huashidan Pharmaceutical Res Co Ltd filed Critical Xinjiang Huashidan Pharmaceutical Res Co Ltd
Application granted granted Critical
Publication of ATE517895T1 publication Critical patent/ATE517895T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04735720T 2003-06-02 2004-06-02 Harminderivate, bei deren herstellung verwendete zwischenprodukte, herstellungsverfahren und verwendung davon ATE517895T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB031364063A CN100503607C (zh) 2003-06-02 2003-06-02 去氢骆驼蓬碱衍生物类化合物及其应用
PCT/CN2004/000591 WO2004106335A1 (fr) 2003-06-02 2004-06-02 Derives harminiques, intermediaires utilises pour leur elaboration, procedes d'elaboration, et utilisation de ces derives

Publications (1)

Publication Number Publication Date
ATE517895T1 true ATE517895T1 (de) 2011-08-15

Family

ID=33480390

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04735720T ATE517895T1 (de) 2003-06-02 2004-06-02 Harminderivate, bei deren herstellung verwendete zwischenprodukte, herstellungsverfahren und verwendung davon

Country Status (6)

Country Link
US (1) US8772311B2 (de)
EP (1) EP1634881B1 (de)
JP (1) JP5128812B2 (de)
CN (1) CN100503607C (de)
AT (1) ATE517895T1 (de)
WO (1) WO2004106335A1 (de)

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CN101429198B (zh) * 2007-11-09 2013-10-23 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物及其应用
BRPI0918122A8 (pt) 2008-12-19 2017-01-24 Macrogenics Inc molécula de diabody, diabody, e mólecula dart
US8362277B2 (en) 2009-01-09 2013-01-29 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
US9162980B2 (en) 2009-01-09 2015-10-20 Board Of Regents Of The University Of Texas System Anti-depression compounds
EP2385829B1 (de) 2009-01-09 2018-08-01 Board of Regents of the University of Texas System Proneurogene verbindungen
US9962368B2 (en) 2009-01-09 2018-05-08 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN102146080B (zh) * 2010-02-10 2013-01-30 新疆华世丹药业股份有限公司 β-咔啉碱衍生物类化合物及其应用
US20130231360A1 (en) * 2010-04-22 2013-09-05 The Brigham And Women S Hospital, Inc. Beta-Carbolines as Inhibitors of Haspin and DYRK Kinases
CA2803697A1 (en) 2010-06-25 2011-12-29 Facultes Universitaires Notre Dame De La Paix Beta carboline derivatives useful in the treatment of proliferative disorders
AU2011274787B2 (en) 2010-07-07 2016-06-16 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
WO2012024433A2 (en) * 2010-08-17 2012-02-23 Translational Genomics Research Institute Compounds that inhibit tau phosphorylation
CN102952151B (zh) * 2011-08-31 2017-07-28 新疆华世丹药物研究有限责任公司 3位双β‑咔啉碱类化合物、其制法和其药物组合物与用途
CN111012779A (zh) * 2011-10-25 2020-04-17 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物在制备抗菌药物中的应用
US9701676B2 (en) 2012-08-24 2017-07-11 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
CN104812761B (zh) * 2012-11-26 2018-12-04 新疆华世丹药物研究有限责任公司 双β-咔啉碱类化合物、其制法和其药物组合物与用途
CN102977096B (zh) * 2012-12-07 2014-12-17 中国药科大学 具有靶向特性的去氢骆驼蓬碱衍生物的抗肿瘤前药
EP3068388A4 (de) 2013-11-11 2017-04-12 Board of Regents of the University of Texas System Nervenschützende verbindungen und verwendung davon
WO2015070237A1 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective chemicals and methods for identifying and using same
CN104744460B (zh) * 2013-12-30 2017-06-16 南开大学 β‑咔啉，二氢‑β‑咔啉和四氢‑β‑咔啉生物碱衍生物及其制备方法和在防治植物病毒、杀菌、杀虫方面的应用
CN103864787B (zh) * 2014-03-21 2015-11-18 河南师范大学 一种β-咔啉化合物的绿色合成方法
MX2017002489A (es) * 2014-10-21 2017-09-13 Ions Pharmaceutical S À R L Agentes terapeuticos humanos.
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US20160106687A1 (en) 2014-10-21 2016-04-21 Life Plus, LLC Human therapeutic agents
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
CN104530043B (zh) * 2014-12-03 2017-06-06 西北农林科技大学 9‑取代β‑咔啉类化合物及其用于制备预防或治疗肿瘤药物的应用
CN104557916B (zh) * 2014-12-03 2017-02-22 西北农林科技大学 2‑取代β‑咔啉类化合物及其用于制备预防或治疗肿瘤药物的应用
EP3321264A1 (de) 2016-11-14 2018-05-16 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Selektive inhibitoren der genotoxischen stressinduzierten ikk/nf-kb-pfade
CN106588918B (zh) * 2016-12-08 2019-02-19 广东省测试分析研究所（中国广州分析测试中心） 一种3-氨基-β-咔啉的制备方法及其应用
CN106977515A (zh) * 2017-04-13 2017-07-25 河北科技大学 β‑咔啉、γ‑咔啉衍生物、其制备方法及用途
US20200354327A1 (en) * 2017-10-31 2020-11-12 Cytus H&B Co., Ltd. Compound having stat3 inhibitory activity and use thereof
US10947253B2 (en) 2019-08-05 2021-03-16 Ankh Life Sciences Limited Fused polycyclic dimers
CN111362937B (zh) * 2020-03-06 2021-06-22 贵州医科大学 N-芳基-β-卡波林类衍生物及其用途
MX2023000332A (es) * 2020-07-23 2023-02-09 Merck Patent Gmbh Heterociclos triciclicos.
CN113248498A (zh) * 2021-06-03 2021-08-13 河南沁朋科技有限公司 9H-吡啶[3,4-b]吲哚的合成新方法
CN114621225A (zh) * 2022-04-06 2022-06-14 石河子大学 一种咪唑并吡啶并吲哚类化合物及其制备方法、应用
CN115487184A (zh) * 2022-09-06 2022-12-20 南昌大学 去氢骆驼蓬碱在制备治疗结肠癌药物中的应用
US11897881B1 (en) 2023-07-31 2024-02-13 King Faisal University Substituted pyrido[3,4-b]indole-3-carboxylic acids as CK2 inhibitors

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FR2555988A1 (fr) 1983-12-06 1985-06-07 Centre Nat Rech Scient Derive de b-carbolines, procede pour leurs preparations et medicament les contenant
WO1997037658A1 (en) 1996-04-04 1997-10-16 F.Hoffmann-La Roche Ag Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents
DE19807993A1 (de) 1998-02-26 1999-09-02 Bayer Ag Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten
PT1137413E (pt) * 1998-12-10 2005-05-31 Agouron Pharma Antagonistas nao-peptidicos do receptor de glp-1 e metodos de utilizacao
EP1209158A1 (de) * 2000-11-18 2002-05-29 Aventis Pharma Deutschland GmbH Substitutierte beta-Carboline
GB0121941D0 (en) * 2001-09-11 2001-10-31 Astrazeneca Ab Chemical compounds
CN1160352C (zh) 2001-12-19 2004-08-04 北京大学 具有抗HIV和抗癌活性的3-位取代的β-咔啉化合物，制备方法及其组合物和用途
BRPI0407052A (pt) * 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização

Also Published As

Publication number Publication date
WO2004106335A8 (fr) 2006-03-09
US8772311B2 (en) 2014-07-08
EP1634881A4 (de) 2008-04-16
EP1634881B1 (de) 2011-07-27
US20090227619A1 (en) 2009-09-10
CN1552711A (zh) 2004-12-08
EP1634881A1 (de) 2006-03-15
JP2006526580A (ja) 2006-11-24
JP5128812B2 (ja) 2013-01-23
WO2004106335A1 (fr) 2004-12-09
CN100503607C (zh) 2009-06-24

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