CY1117683T1 - Ρετινοειδες-λιποσωματα για ενισχυση ρυθμισης εκφρασης hsp47 - Google Patents
Ρετινοειδες-λιποσωματα για ενισχυση ρυθμισης εκφρασης hsp47Info
- Publication number
- CY1117683T1 CY1117683T1 CY20161100543T CY161100543T CY1117683T1 CY 1117683 T1 CY1117683 T1 CY 1117683T1 CY 20161100543 T CY20161100543 T CY 20161100543T CY 161100543 T CY161100543 T CY 161100543T CY 1117683 T1 CY1117683 T1 CY 1117683T1
- Authority
- CY
- Cyprus
- Prior art keywords
- retina
- liposomes
- boost
- hsp47 expression
- expression regulation
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2320/00—Applications; Uses
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Diabetes (AREA)
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Abstract
Αυτό που περιγράφεται είναι φαρμακευτικές συνθέσεις που περιλαμβάνουν μόριο διπλόκλωνου νουκλεϊνικού οξέος που περιλαμβάνει κλώνο με νόημα και αντινοηματικό κλώνο όπου οι με νόημα και αντινοηματικοί κλώνοι επιλέγονται από ολιγονουκλεοτίδια που περιγράφονται ως SERPINH1_2 (SEQ ID NOS: 60 και 127), SERPTNHI_45a (SEQ ID NOS: 98 και 165), και SERPTNH1_51 (SEQ ID NOS: 101 και 168), και φορέα φαρμάκου που περιέχει μίγμα ενός ρετινοειδούς και μίας φλύκταινας λιπιδίου, και μεθόδους χρήσης αυτών των φαρμακευτικών συνθέσεων για να θεραπεύεται ασθένεια που συνδυάζεται με έκφραση hsp47, συμπεριλαμβανομένης ίνωσης.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161494832P | 2011-06-08 | 2011-06-08 | |
US201161497447P | 2011-06-15 | 2011-06-15 | |
PCT/US2012/041761 WO2012170957A2 (en) | 2011-06-08 | 2012-06-08 | Retinoid-liposomes for enhancing modulation of hsp47 expression |
Publications (1)
Publication Number | Publication Date |
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CY1117683T1 true CY1117683T1 (el) | 2017-05-17 |
Family
ID=46395700
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20161100543T CY1117683T1 (el) | 2011-06-08 | 2016-06-17 | Ρετινοειδες-λιποσωματα για ενισχυση ρυθμισης εκφρασης hsp47 |
CY20181100947T CY1120685T1 (el) | 2011-06-08 | 2018-09-11 | Ρετινοειδες-λιποσωματα για ενισχυση ρυθμισης εκφρασης hsp47 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100947T CY1120685T1 (el) | 2011-06-08 | 2018-09-11 | Ρετινοειδες-λιποσωματα για ενισχυση ρυθμισης εκφρασης hsp47 |
Country Status (20)
Country | Link |
---|---|
US (4) | US8741867B2 (el) |
EP (2) | EP3075855B1 (el) |
JP (1) | JP5873168B2 (el) |
KR (1) | KR102002771B1 (el) |
CN (1) | CN103781909B (el) |
AU (1) | AU2012267472B2 (el) |
CA (1) | CA2836925C (el) |
CY (2) | CY1117683T1 (el) |
DK (2) | DK2717921T3 (el) |
ES (2) | ES2586593T3 (el) |
HR (1) | HRP20181440T8 (el) |
HU (1) | HUE039379T2 (el) |
LT (1) | LT3075855T (el) |
PL (2) | PL2717921T3 (el) |
PT (2) | PT3075855T (el) |
RS (1) | RS57824B1 (el) |
RU (1) | RU2628694C2 (el) |
SI (1) | SI3075855T1 (el) |
TW (1) | TWI658830B (el) |
WO (1) | WO2012170957A2 (el) |
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JP5950428B2 (ja) * | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
RU2769872C2 (ru) * | 2011-06-08 | 2022-04-07 | Нитто Денко Корпорейшн | СОЕДИНЕНИЯ ДЛЯ НАЦЕЛЕННОЙ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА И УСИЛЕНИЯ АКТИВНОСТИ siPHK |
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US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
TWI658830B (zh) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Hsp47表現調控強化用類視色素脂質體 |
EP2781225B1 (en) * | 2011-11-18 | 2019-10-09 | Nitto Denko Corporation | Intestinal fibrosis treatment agent |
HUE056014T2 (hu) | 2012-06-08 | 2022-01-28 | Nitto Denko Corp | Lipidek gyógyszerszállító készítményekhez |
EP3116512B1 (en) * | 2014-03-11 | 2020-06-10 | Dai Niann-tzyy | Pharmaceutical composition and method for reducing scar formation |
CN104174034A (zh) * | 2014-08-20 | 2014-12-03 | 南京大学 | 肝星状细胞靶向的基因药物输送载体及其制备方法和应用 |
US20180002702A1 (en) | 2014-12-26 | 2018-01-04 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
US10792299B2 (en) | 2014-12-26 | 2020-10-06 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
BR112018008344A2 (pt) | 2015-12-13 | 2018-10-30 | Nitto Denko Corp | molécula de ácido nucleico, composição farmacêutica, vetor ou célula, método para prevenir, tratar ou melhorar uma doença, e, uso de uma composição |
US10562849B2 (en) | 2016-05-16 | 2020-02-18 | The Board Of Regents Of The University Of Texas System | Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids |
JP6833456B2 (ja) * | 2016-11-02 | 2021-02-24 | 日東電工株式会社 | 皮膚線維症処置剤 |
EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
WO2018170464A1 (en) * | 2017-03-17 | 2018-09-20 | The Johns Hopkins University | Targeted epigenetic therapy against distal regulatory element of tgfb2 expression |
WO2020181130A2 (en) * | 2019-03-05 | 2020-09-10 | MiRagen Therapeutics, Inc. | Polynucleotide conjugates and uses thereof |
TWI740533B (zh) | 2020-06-11 | 2021-09-21 | 國立中央大學 | 評估個體罹患腹膜硬化症之風險的方法、其分析器及其套組 |
JP2023532011A (ja) * | 2020-06-24 | 2023-07-26 | ブリストル-マイヤーズ スクイブ カンパニー | 標的分子の合成方法 |
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