BR0113048A - Lêvedo modificados e utilizações, principalmente para a produção de derivados esteroidianos - Google Patents
Lêvedo modificados e utilizações, principalmente para a produção de derivados esteroidianosInfo
- Publication number
- BR0113048A BR0113048A BR0113048-0A BR0113048A BR0113048A BR 0113048 A BR0113048 A BR 0113048A BR 0113048 A BR0113048 A BR 0113048A BR 0113048 A BR0113048 A BR 0113048A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- strains
- steroid derivatives
- mainly
- steroid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
- C12N9/0087—Steroid 21-monooxygenase (1.14.99.10)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Abstract
"LêVEDOS MODIFICADOS E UTILIZAçõES, PRINCIPALMENTE PARA A PRODUçãO DE DERIVADOS ESTEROIDIANOS". A presente invenção refere-se a novas cepas de lêvedo, processos e construções genéticas para seu preparo, assim como sua utilização para a síntese ou a modificação de compostos esteroidianos. Mais particularmente, a invenção descreve cepas que apresentam uma atividade de tipo 20<244>-HSD diminuída, notadamente por modificação dos genes GCY1 e/ou YPR1. As cepas de lêvedo da invenção permitem melhorar a eficácia da síntese ou aumentar a seletividade ou os rendimentos do processo, assim como a qualidade do produto final. As cepas, processos e compostos da invenção são úteis na pesquisa, no desenvolvimento e na produção de produtos com atividade terapêutica ou profilática, no homem ou no animal, notadamente de derivados esteroidianos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0010437A FR2812884B1 (fr) | 2000-08-08 | 2000-08-08 | Levures modifiees et utilisations, notamment pour la production de derives steroidiens |
| PCT/FR2001/002417 WO2002012536A1 (fr) | 2000-08-08 | 2001-07-24 | Levures modifiees et utilisations, notamment pour la production de derives steroidiens |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR0113048A true BR0113048A (pt) | 2003-07-01 |
| BRPI0113048B1 BRPI0113048B1 (pt) | 2015-12-22 |
| BRPI0113048B8 BRPI0113048B8 (pt) | 2021-05-25 |
Family
ID=8853403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0113048A BRPI0113048B8 (pt) | 2000-08-08 | 2001-07-24 | cepas saccharomyces cerevisiae com genes ypr1 e gcy1 modificados e tendo atividade 20 alfa-hidroxiesteróide dehidrogenase (20 alfa-hsd) reduzida, seus usos na preparação de compostos esteroidais, bem como processos de modificação de hidroxiprogesterona e 11-deoxicortisol |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7879592B2 (pt) |
| EP (1) | EP1313873B1 (pt) |
| JP (1) | JP4864277B2 (pt) |
| KR (1) | KR100860702B1 (pt) |
| AR (1) | AR030080A1 (pt) |
| AT (1) | ATE390479T1 (pt) |
| AU (2) | AU2001278562B2 (pt) |
| BR (1) | BRPI0113048B8 (pt) |
| CA (1) | CA2418370C (pt) |
| CY (1) | CY1108080T1 (pt) |
| DE (1) | DE60133396T2 (pt) |
| DK (1) | DK1313873T3 (pt) |
| ES (1) | ES2300347T3 (pt) |
| FR (1) | FR2812884B1 (pt) |
| IL (2) | IL154294A0 (pt) |
| MX (1) | MXPA03000702A (pt) |
| NO (1) | NO334484B1 (pt) |
| NZ (1) | NZ523612A (pt) |
| PT (1) | PT1313873E (pt) |
| TW (1) | TWI315739B (pt) |
| WO (1) | WO2002012536A1 (pt) |
| ZA (1) | ZA200300376B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2812884B1 (fr) | 2000-08-08 | 2002-11-08 | Aventis Pharma Sa | Levures modifiees et utilisations, notamment pour la production de derives steroidiens |
| FR2820145B1 (fr) | 2001-01-31 | 2004-01-23 | Aventis Pharma Sa | Souche de levure produisant des steroides de facon autonome |
| FR2976949B1 (fr) * | 2011-06-21 | 2015-08-28 | Sanofi Sa | Procede de preparation de levures genetiquement transformees capables de produire une molecule d'interet a haut titre |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5571250A (en) | 1978-11-22 | 1980-05-29 | Hatano Kk | Paper for paper box with lid and method of assembling paper box with lid by using same |
| BE889407A (fr) | 1980-06-27 | 1981-10-16 | Mallinckrodt Inc | Amelioration du procede de preparation d'un lysat de limule |
| JPS62181571A (ja) | 1986-08-11 | 1987-08-08 | Canon Inc | 画像処理装置 |
| JPS63181571A (ja) | 1987-01-22 | 1988-07-26 | Matsushita Electric Ind Co Ltd | 自動焦点整合装置 |
| JPS6447380A (en) | 1987-08-19 | 1989-02-21 | Agency Ind Science Techn | Steroid-oxidizing yeast strain |
| JPS6471250A (en) | 1987-09-11 | 1989-03-16 | Nec Corp | Multi-function telephone set |
| EP0340878B1 (en) | 1988-05-06 | 2001-05-16 | Aventis Pharma S.A. | Process for the biochemical oxidation of steroids and genetically engineered cells to be used therefor |
| JPH0231680A (ja) * | 1988-07-22 | 1990-02-01 | Agency Of Ind Science & Technol | チトクロムＰ４５０ｃ↓２↓１産生酵母菌株 |
| CN1042567A (zh) | 1988-09-23 | 1990-05-30 | 吉斯特-布罗卡迪斯公司 | 类固醇多步氧化方法和所用的遗传工程细胞 |
| JPH02249488A (ja) * | 1989-03-22 | 1990-10-05 | Sumitomo Chem Co Ltd | チトクロムＰ４５０↓ｃ↓２↓１と酵母ＮＡＤＰＨ‐チトクロムＰ４５０還元酵素の融合酸化酵素、該酵素をコードする遺伝子および該酵素の製造方法 |
| JP2645130B2 (ja) | 1989-03-31 | 1997-08-25 | 日清製粉株式会社 | ステロイド誘導体 |
| FR2678611B1 (fr) | 1991-07-04 | 1995-01-20 | Roussel Uclaf | Nouveaux esters pyrethrinouides de l'alcool 1,3,4,5,6,7-hexahydro 1,3-dioxo-2h-isoindol-2-yl-methylique, leur procede de preparation et leur application comme pesticides. |
| JP3363197B2 (ja) | 1992-06-18 | 2003-01-08 | 麒麟麦酒株式会社 | アルコールアセチルトランスフェラーゼ遺伝子およびその利用 |
| US5547868A (en) | 1993-06-09 | 1996-08-20 | Regents Of The University Of California | Cholesterol disposal fusion enzymes |
| IL116872A (en) | 1995-02-15 | 2004-12-15 | Aventis Pharma Sa | Delta 5,7-Strol Reductase from Arbidopsis Thaliana |
| JP4093598B2 (ja) | 1995-03-14 | 2008-06-04 | 大関株式会社 | 新規なアルコールアセチルトランスフェラーゼ遺伝子 |
| DE19744212B4 (de) | 1997-09-30 | 2006-01-19 | Schering Ag | Verfahren zur Herstellung von Ergosterol und dessen Zwischenprodukten mittels rekombinanter Hefen |
| US6303302B1 (en) * | 1997-11-19 | 2001-10-16 | The Whitehead Institute For Biomedical Research | Regulation of fungal gene expression |
| FR2774393B1 (fr) | 1998-02-05 | 2000-03-24 | Hoechst Marion Roussel Inc | Souches de levure ayant le gene atf2 interrompu et leurs applications |
| FR2799206A1 (fr) | 1999-10-05 | 2001-04-06 | Transgene Sa | Procede de production de steroides modifies par fermentation de levures |
| FR2812884B1 (fr) | 2000-08-08 | 2002-11-08 | Aventis Pharma Sa | Levures modifiees et utilisations, notamment pour la production de derives steroidiens |
| FR2820145B1 (fr) | 2001-01-31 | 2004-01-23 | Aventis Pharma Sa | Souche de levure produisant des steroides de facon autonome |
-
2000
- 2000-08-08 FR FR0010437A patent/FR2812884B1/fr not_active Expired - Lifetime
-
2001
- 2001-07-24 AU AU2001278562A patent/AU2001278562B2/en not_active Expired
- 2001-07-24 JP JP2002517820A patent/JP4864277B2/ja not_active Expired - Lifetime
- 2001-07-24 US US10/343,993 patent/US7879592B2/en not_active Expired - Lifetime
- 2001-07-24 PT PT01956637T patent/PT1313873E/pt unknown
- 2001-07-24 MX MXPA03000702A patent/MXPA03000702A/es active IP Right Grant
- 2001-07-24 AT AT01956637T patent/ATE390479T1/de active
- 2001-07-24 WO PCT/FR2001/002417 patent/WO2002012536A1/fr active IP Right Grant
- 2001-07-24 ES ES01956637T patent/ES2300347T3/es not_active Expired - Lifetime
- 2001-07-24 AU AU7856201A patent/AU7856201A/xx active Pending
- 2001-07-24 KR KR1020037001820A patent/KR100860702B1/ko active IP Right Grant
- 2001-07-24 BR BRPI0113048A patent/BRPI0113048B8/pt not_active IP Right Cessation
- 2001-07-24 EP EP01956637A patent/EP1313873B1/fr not_active Expired - Lifetime
- 2001-07-24 DK DK01956637T patent/DK1313873T3/da active
- 2001-07-24 NZ NZ523612A patent/NZ523612A/en not_active IP Right Cessation
- 2001-07-24 IL IL15429401A patent/IL154294A0/xx unknown
- 2001-07-24 DE DE60133396T patent/DE60133396T2/de not_active Expired - Lifetime
- 2001-07-24 CA CA2418370A patent/CA2418370C/fr not_active Expired - Lifetime
- 2001-07-30 AR ARP010103640A patent/AR030080A1/es active IP Right Grant
- 2001-08-08 TW TW090119307A patent/TWI315739B/zh not_active IP Right Cessation
-
2003
- 2003-01-14 ZA ZA200300376A patent/ZA200300376B/en unknown
- 2003-02-04 IL IL154294A patent/IL154294A/en active IP Right Grant
- 2003-02-07 NO NO20030606A patent/NO334484B1/no not_active IP Right Cessation
-
2008
- 2008-05-20 CY CY20081100524T patent/CY1108080T1/el unknown
-
2011
- 2011-01-14 US US13/006,607 patent/US8173402B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: AS CLASSIFICACOES ANTERIORES ERAM: C12P 33/06 , C12N 15/53 , C12N 1/16 Ipc: C12P 33/06 (2006.01), C12N 15/53 (2006.01), C12N 1 |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 22/12/2015, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/07/2001 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 24/07/2021 |