DOP2002000481A - Derivados de acido acetico - Google Patents
Derivados de acido aceticoInfo
- Publication number
- DOP2002000481A DOP2002000481A DO2002000481A DO2002000481A DOP2002000481A DO P2002000481 A DOP2002000481 A DO P2002000481A DO 2002000481 A DO2002000481 A DO 2002000481A DO 2002000481 A DO2002000481 A DO 2002000481A DO P2002000481 A DOP2002000481 A DO P2002000481A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- acetic acid
- acid derivatives
- dyslipidemias
- ppar
- computations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Abstract
La presente solicitud se refiere a nuevos derivados acido acético sustituidos, procedimientos para su preparación, así como a su uso en medicamentos, especialmente como cómputos Potentes activadores de PPAR-delta para la profilaxis y/o el tratamiento de enfermedades cardiovasculares pulmonares, especialmente de dislipidemias y enfermedades cardiacas coronarias.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10151390A DE10151390A1 (de) | 2001-10-18 | 2001-10-18 | Essigsäurederivate |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2002000481A true DOP2002000481A (es) | 2003-04-30 |
Family
ID=7702887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2002000481A DOP2002000481A (es) | 2001-10-18 | 2002-10-08 | Derivados de acido acetico |
Country Status (12)
Country | Link |
---|---|
US (1) | US20050154061A1 (es) |
EP (1) | EP1438285A1 (es) |
JP (1) | JP2005506379A (es) |
AR (1) | AR037507A1 (es) |
CA (1) | CA2463226A1 (es) |
DE (1) | DE10151390A1 (es) |
DO (1) | DOP2002000481A (es) |
GT (1) | GT200300003A (es) |
PE (1) | PE20030609A1 (es) |
SV (1) | SV2004001294A (es) |
UY (1) | UY27491A1 (es) |
WO (1) | WO2003035603A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10337839A1 (de) * | 2003-08-18 | 2005-03-17 | Bayer Healthcare Ag | Indolin-Derivate |
EP1661890B1 (en) * | 2003-09-03 | 2011-01-05 | Kowa Co., Ltd. | Ppar-activating compound and pharmaceutical composition containing same |
JP2007536343A (ja) | 2004-05-05 | 2007-12-13 | ノボ ノルディスク アクティーゼルスカブ | Pparアゴニストとしてのフェノキシ酢酸誘導体 |
JP4981662B2 (ja) | 2004-05-05 | 2012-07-25 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規の化合物、その製法と使用 |
EP1899302B1 (en) | 2005-06-30 | 2011-10-19 | High Point Pharmaceuticals, LLC | Phenoxy acetic acids as ppar delta activators |
JP5054028B2 (ja) | 2005-12-22 | 2012-10-24 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 新規化合物、それらの製造および使用 |
EP1999098A2 (en) | 2006-03-09 | 2008-12-10 | High Point Pharmaceuticals, LLC | Compounds that modulate ppar activity, their preparation and use |
US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
EP2538784B1 (en) | 2010-02-25 | 2015-09-09 | Merck Sharp & Dohme Corp. | Benzimidazole derivatives useful anti-diabetic agents |
JP5728099B2 (ja) | 2011-02-25 | 2015-06-03 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗糖尿病剤として有用な新規環状アザベンゾイミダゾール誘導体 |
AU2013296470B2 (en) | 2012-08-02 | 2016-03-17 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
ES2811087T3 (es) | 2013-09-09 | 2021-03-10 | Vtv Therapeutics Llc | Uso de agonistas de PPAR-delta para tratar la atrofia muscular |
WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9822473D0 (en) * | 1998-10-16 | 1998-12-09 | Glaxo Group Ltd | Chemical compounds |
IL155125A0 (en) * | 2000-10-05 | 2003-10-31 | Bayer Ag | Propionic acid derivatives with ppar-alpha activating properties |
-
2001
- 2001-10-18 DE DE10151390A patent/DE10151390A1/de not_active Withdrawn
-
2002
- 2002-10-08 DO DO2002000481A patent/DOP2002000481A/es unknown
- 2002-10-09 WO PCT/EP2002/011275 patent/WO2003035603A1/de not_active Application Discontinuation
- 2002-10-09 JP JP2003538119A patent/JP2005506379A/ja active Pending
- 2002-10-09 CA CA002463226A patent/CA2463226A1/en not_active Abandoned
- 2002-10-09 US US10/492,761 patent/US20050154061A1/en not_active Abandoned
- 2002-10-09 EP EP02777295A patent/EP1438285A1/de not_active Withdrawn
- 2002-10-15 UY UY27491A patent/UY27491A1/es not_active Application Discontinuation
- 2002-10-17 SV SV2002001294A patent/SV2004001294A/es not_active Application Discontinuation
- 2002-10-17 PE PE2002001026A patent/PE20030609A1/es not_active Application Discontinuation
- 2002-10-18 AR ARP020103941A patent/AR037507A1/es unknown
-
2003
- 2003-01-10 GT GT200300003A patent/GT200300003A/es unknown
Also Published As
Publication number | Publication date |
---|---|
SV2004001294A (es) | 2004-02-24 |
US20050154061A1 (en) | 2005-07-14 |
CA2463226A1 (en) | 2003-05-01 |
EP1438285A1 (de) | 2004-07-21 |
DE10151390A1 (de) | 2003-05-08 |
PE20030609A1 (es) | 2003-09-07 |
GT200300003A (es) | 2004-09-21 |
WO2003035603A1 (de) | 2003-05-01 |
JP2005506379A (ja) | 2005-03-03 |
AR037507A1 (es) | 2004-11-17 |
UY27491A1 (es) | 2003-05-30 |
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