WO2006029081A3 - Nucleoside-lipid conjugates, their method of preparation and uses thereof - Google Patents
Nucleoside-lipid conjugates, their method of preparation and uses thereof Download PDFInfo
- Publication number
- WO2006029081A3 WO2006029081A3 PCT/US2005/031543 US2005031543W WO2006029081A3 WO 2006029081 A3 WO2006029081 A3 WO 2006029081A3 US 2005031543 W US2005031543 W US 2005031543W WO 2006029081 A3 WO2006029081 A3 WO 2006029081A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- conjugates
- nucleoside
- cardiolipin
- analogues
- lipid conjugates
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60661004P | 2004-09-02 | 2004-09-02 | |
US60/606,610 | 2004-09-02 | ||
US63232804P | 2004-12-01 | 2004-12-01 | |
US60/632,328 | 2004-12-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006029081A2 WO2006029081A2 (en) | 2006-03-16 |
WO2006029081A3 true WO2006029081A3 (en) | 2009-04-23 |
Family
ID=36036926
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/031543 WO2006029081A2 (en) | 2004-09-02 | 2005-09-02 | Nucleoside-lipid conjugates, their method of preparation and uses thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006029081A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9393256B2 (en) | 2011-09-16 | 2016-07-19 | Gilead Pharmasset Llc | Methods for treating HCV |
Families Citing this family (20)
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---|---|---|---|---|
EP4032897A1 (en) | 2003-05-30 | 2022-07-27 | Gilead Pharmasset LLC | Modified fluorinated nucleoside analogues |
WO2006031725A2 (en) | 2004-09-14 | 2006-03-23 | Pharmasset, Inc. | Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
AU2009329872B2 (en) | 2008-12-23 | 2016-07-07 | Gilead Pharmasset Llc | Synthesis of purine nucleosides |
NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
PA8855701A1 (en) | 2008-12-23 | 2010-07-27 | NUCLEOSID ANALOGS | |
TWI598358B (en) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | Nucleoside phosphoramidates |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
EP2552931B1 (en) | 2010-03-31 | 2014-07-23 | Gilead Pharmasset LLC | Stereoselective synthesis of phosphorus containing actives |
WO2012075140A1 (en) | 2010-11-30 | 2012-06-07 | Pharmasset, Inc. | Compounds |
JP6006292B2 (en) * | 2011-04-08 | 2016-10-12 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル)Inserm(Institut National Dela Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for inhibiting influenza virus replication |
WO2013043529A1 (en) * | 2011-09-19 | 2013-03-28 | Emory University | Bone morphogenetic protein pathway activation, compositions for ossification, and methods related thereto |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
JP6420247B2 (en) | 2012-11-13 | 2018-11-07 | ボーイエン セラピューティクス,インコーポレイティド | Gemcitabine prodrug and use thereof |
ES2771458T3 (en) | 2013-01-31 | 2020-07-06 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
WO2015030853A1 (en) | 2013-08-27 | 2015-03-05 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
US10463684B2 (en) | 2014-01-29 | 2019-11-05 | Board Of Regents, The Uneversety Of Texas System | Nucleobase analogue derivatives and their applications |
US10071112B2 (en) | 2014-10-08 | 2018-09-11 | Epigenetics Pharma Llc | Vitamin E-nucleoside prodrugs |
WO2021050629A1 (en) * | 2019-09-10 | 2021-03-18 | Virginia Commonwealth University | Polymer drugs for cancer therapies |
EP4248949A1 (en) | 2022-03-21 | 2023-09-27 | R.G.C.C. Holdings AG | Liposomal compositions |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3564089A (en) * | 1966-09-29 | 1971-02-16 | Sandra Jean Kiddy | Diagnostic reagent for syphilis |
US6384019B1 (en) * | 1997-01-24 | 2002-05-07 | Norsk Hydro Asa | Gemcitabine derivatives |
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2005
- 2005-09-02 WO PCT/US2005/031543 patent/WO2006029081A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3564089A (en) * | 1966-09-29 | 1971-02-16 | Sandra Jean Kiddy | Diagnostic reagent for syphilis |
US6384019B1 (en) * | 1997-01-24 | 2002-05-07 | Norsk Hydro Asa | Gemcitabine derivatives |
Non-Patent Citations (3)
Title |
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EARLY ET AL.: "Lake Michigan Sponge Phosphatic Metabolite Variations with Habitat: a 31P Nuclear Magnetic Resonance Study", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, PART B: BIOCHEMISTRY & MOLECULAR BIOLOGY, vol. 123B, no. 4, 1999, pages 329 - 343 * |
HONG ET AL.: "Nucleoside Conjugates. 15. Synthesis and Biological Activity of Anti-HIV Nucleoside Conjugates of Ether and Thioether Phospholipidsl", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1996, pages 1771 - 1777 * |
SCHNEIDER ET AL.: "Oligonucleotides containing flexible nucleoside analogs", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 112, no. 1, 1990, pages 453 - 455 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9393256B2 (en) | 2011-09-16 | 2016-07-19 | Gilead Pharmasset Llc | Methods for treating HCV |
Also Published As
Publication number | Publication date |
---|---|
WO2006029081A2 (en) | 2006-03-16 |
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