AR016196A1 - Suspension de principio activo peroral - Google Patents
Suspension de principio activo peroralInfo
- Publication number
- AR016196A1 AR016196A1 ARP990101338A ARP990101338A AR016196A1 AR 016196 A1 AR016196 A1 AR 016196A1 AR P990101338 A ARP990101338 A AR P990101338A AR P990101338 A ARP990101338 A AR P990101338A AR 016196 A1 AR016196 A1 AR 016196A1
- Authority
- AR
- Argentina
- Prior art keywords
- dispersion medium
- suspension
- less
- microm
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased/Invalidation/Refusal/Rejection/Nullification
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
Una suspension, aplicable por vía oral, de un principio activo farmacéutico del tipo FNEAI con un espectro del tamano de granos suspendible en un medio dedispersion fisiologicamente indiferente, en la que la solubilidad del principio activo es muyes casa, preferiblemente menor que 500 microg/ml, de modo que lasuspension no presenta ningun sabor específico perceptible, suspension que contiene una pequena cantidad de dioxido de silicio muy disperso para laestabilizacion mediante formacion deuna e structura siloide tridimensional, creándose la estructura siloide tridimensional mediante la incorporacion deldioxido de silicio en el medio de dispersion bajo la accion de elevadas fuerzas de cizallamiento, y que contiene adicionalmente unapequena cantidad depolímeros hidrofilos solubles en el medio de dispersion. Un procedimiento para la produccion de un preparado líquido, aplicable p.o., de un principio activofarmacéutico del tipo FNEAI en forma de una suspension estabilizada,procedimiento en el cual: (i) se muele el principio activo solido, de modo que se crea unespectro del tamano de granos en el que al menos el 90% de las partículas es menor que 50 microm, pero preferiblemente al menos el 50% de las partículas esmenorque 10 microm, pero en particular, aproximadamente el 90% de las partículas es menor que 10 microm; (ii) el principio activo molido se suspende en unmedio de dispersion fisiologicamente indiferente en el que la solubilidad del principio activo esmuy escasa; (iii) en el medio de dispersion se incorporan,con empleo de elevadas fuerzas de cizallamiento, pequenas cantidades de dioxido de silicio muy disperso; (iv) al medio de dispersion se anaden pequenascantidades de polímeros hidrofilossolubles en el medio de dispersion y (v) al medio de dispersion se pueden anadir, opcionalmente independientes una de otra,una o varias sustancias aromáticas, uno o varios edulcorantes, coadyuvantes ususales o uno o varios agentes conservantes,efectuándose la adicion de l assustancias aromáticas en virtud de sus propiedades disgregantes de la espuma preferiblemente en la ultima etapa de la preparacion. La utilizacion de un
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98105568A EP0945131A1 (de) | 1998-03-27 | 1998-03-27 | Perorale Wirkstoff-Suspension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR016196A1 true AR016196A1 (es) | 2001-06-20 |
Family
ID=8231651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990101338A Ceased/Invalidation/Refusal/Rejection/Nullification AR016196A1 (es) | 1998-03-27 | 1999-03-26 | Suspension de principio activo peroral |
Country Status (26)
| Country | Link |
|---|---|
| EP (2) | EP0945131A1 (es) |
| JP (1) | JP3323189B2 (es) |
| KR (1) | KR100587208B1 (es) |
| CN (1) | CN1150888C (es) |
| AR (1) | AR016196A1 (es) |
| AT (1) | ATE225648T1 (es) |
| AU (1) | AU762464B2 (es) |
| BR (1) | BR9909189A (es) |
| CA (1) | CA2326048C (es) |
| CO (1) | CO5070601A1 (es) |
| DE (1) | DE59903023D1 (es) |
| DK (1) | DK1066029T3 (es) |
| ES (1) | ES2184428T3 (es) |
| HK (1) | HK1034184A1 (es) |
| HU (1) | HU228474B1 (es) |
| IL (1) | IL137479A (es) |
| MY (1) | MY124599A (es) |
| NO (1) | NO321401B1 (es) |
| NZ (1) | NZ507610A (es) |
| PL (1) | PL192969B1 (es) |
| PT (1) | PT1066029E (es) |
| TR (1) | TR200002772T2 (es) |
| TW (1) | TWI232759B (es) |
| UY (1) | UY25443A1 (es) |
| WO (1) | WO1999049845A1 (es) |
| ZA (1) | ZA200003951B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8231899B2 (en) | 1998-09-10 | 2012-07-31 | Nycomed Danmark Aps | Quick release pharmaceutical compositions of drug substances |
| US20020035107A1 (en) | 2000-06-20 | 2002-03-21 | Stefan Henke | Highly concentrated stable meloxicam solutions |
| DE10161077A1 (de) | 2001-12-12 | 2003-06-18 | Boehringer Ingelheim Vetmed | Hochkonzentrierte stabile Meloxicamlösungen zur nadellosen Injektion |
| US8992980B2 (en) | 2002-10-25 | 2015-03-31 | Boehringer Ingelheim Vetmedica Gmbh | Water-soluble meloxicam granules |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US8512727B2 (en) * | 2003-03-03 | 2013-08-20 | Alkermes Pharma Ireland Limited | Nanoparticulate meloxicam formulations |
| EP1938803A3 (en) * | 2003-03-03 | 2010-10-27 | Elan Pharma International Limited | Formulations comprising nanoparticulate meloxican |
| AU2003100262B4 (en) * | 2003-04-07 | 2003-09-18 | Jurox Pty Ltd | Stable carprofen composition |
| US20050158367A1 (en) * | 2004-01-16 | 2005-07-21 | The Procter & Gamble Company | Liquid compositions comprising one or more medicaments |
| EP1568369A1 (en) | 2004-02-23 | 2005-08-31 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the treatment of respiratory diseases in pigs |
| WO2006042381A1 (en) * | 2004-10-21 | 2006-04-27 | Parnell Laboratories (Aust) Pty Limited | Anti-inflammatory preparation |
| DK1824493T3 (da) * | 2004-12-06 | 2008-12-08 | Janssen Pharmaceutica Nv | Oral suspension, der omfatter meloxicam |
| GB2438287A (en) * | 2006-05-19 | 2007-11-21 | Norbrook Lab Ltd | Stable aqueous suspension |
| JP5559339B2 (ja) * | 2009-10-12 | 2014-07-23 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | メロキシカムを含む組成物のための容器 |
| CA2791805A1 (en) | 2010-03-03 | 2011-09-09 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the long-term treatment of musculoskeletal disorders in cats |
| US20110218191A1 (en) * | 2010-03-03 | 2011-09-08 | Boehringer Ingelheim Vetmedica Gmbh | Use of meloxicam for the long term-treatment of kidney disorders in cats |
| JP6092629B2 (ja) * | 2010-03-10 | 2017-03-08 | ルピン・リミテッドＬｕｐｉｎ Ｌｉｍｉｔｅｄ | リファキシミン使用準備済懸濁液 |
| CA2993363A1 (en) * | 2010-03-19 | 2011-09-22 | Boston Biomedical, Inc. | Naphthofuran compounds and compositions for targeting cancer stem cells |
| US9795568B2 (en) | 2010-05-05 | 2017-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Low concentration meloxicam tablets |
| GB201117858D0 (en) | 2011-10-17 | 2011-11-30 | Norbrook Lab Ltd | Paste |
| US20150192322A1 (en) * | 2012-12-19 | 2015-07-09 | Mitsubishi Electric Corporation | Air conditioner |
| MX2017013715A (es) | 2015-04-28 | 2018-03-02 | Mars Inc | Proceso de preparacion de un producto de alimento para mascotas humedo esterilizado. |
| KR102145022B1 (ko) * | 2018-08-14 | 2020-08-14 | 동아제약 주식회사 | 이부프로펜의 현탁액 조성물 및 투여 제형 |
| CN112044605B (zh) * | 2019-06-06 | 2022-06-21 | 钟志勇 | 选钛药剂及选钛方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1196307B (it) * | 1984-10-22 | 1988-11-16 | Chiesi Farma Spa | Formulazioni farmaceutiche acquose di piroxicam monoidrato |
| US4835187A (en) * | 1987-06-15 | 1989-05-30 | American Home Products Corporation | Spray dried ibuprofen |
| JP2860729B2 (ja) * | 1992-03-10 | 1999-02-24 | エスエス製薬株式会社 | プラノプロフェン懸濁シロップ剤 |
| GB2318511A (en) * | 1996-10-23 | 1998-04-29 | Eurand Int | Process for the preparation of a pharmaceutical composition for rapid suspension in water |
-
1998
- 1998-03-27 EP EP98105568A patent/EP0945131A1/de not_active Withdrawn
-
1999
- 1999-03-04 TW TW088103315A patent/TWI232759B/zh not_active IP Right Cessation
- 1999-03-23 DE DE59903023T patent/DE59903023D1/de not_active Expired - Lifetime
- 1999-03-23 NZ NZ507610A patent/NZ507610A/en not_active IP Right Cessation
- 1999-03-23 HU HU0102036A patent/HU228474B1/hu unknown
- 1999-03-23 CN CNB998044695A patent/CN1150888C/zh not_active Expired - Lifetime
- 1999-03-23 EP EP99913291A patent/EP1066029B1/de not_active Expired - Lifetime
- 1999-03-23 DK DK99913291T patent/DK1066029T3/da active
- 1999-03-23 PL PL342345A patent/PL192969B1/pl unknown
- 1999-03-23 AT AT99913291T patent/ATE225648T1/de active
- 1999-03-23 AU AU31470/99A patent/AU762464B2/en not_active Expired
- 1999-03-23 KR KR1020007010684A patent/KR100587208B1/ko not_active IP Right Cessation
- 1999-03-23 IL IL13747999A patent/IL137479A/xx not_active IP Right Cessation
- 1999-03-23 JP JP2000540811A patent/JP3323189B2/ja not_active Expired - Lifetime
- 1999-03-23 TR TR2000/02772T patent/TR200002772T2/xx unknown
- 1999-03-23 PT PT99913291T patent/PT1066029E/pt unknown
- 1999-03-23 CA CA002326048A patent/CA2326048C/en not_active Expired - Lifetime
- 1999-03-23 ES ES99913291T patent/ES2184428T3/es not_active Expired - Lifetime
- 1999-03-23 BR BR9909189-5A patent/BR9909189A/pt not_active Application Discontinuation
- 1999-03-23 WO PCT/EP1999/001948 patent/WO1999049845A1/de active IP Right Grant
- 1999-03-24 UY UY25443A patent/UY25443A1/es not_active IP Right Cessation
- 1999-03-25 MY MYPI99001139A patent/MY124599A/en unknown
- 1999-03-26 CO CO99018550A patent/CO5070601A1/es unknown
- 1999-03-26 AR ARP990101338A patent/AR016196A1/es not_active Ceased/Invalidation/Refusal/Rejection/Nullification
-
2000
- 2000-08-03 ZA ZA200003951A patent/ZA200003951B/xx unknown
- 2000-09-26 NO NO20004822A patent/NO321401B1/no not_active IP Right Cessation
-
2001
- 2001-07-04 HK HK01104589A patent/HK1034184A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |