JP6799126B2 - 口腔ケア組成物 - Google Patents
口腔ケア組成物 Download PDFInfo
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- JP6799126B2 JP6799126B2 JP2019183004A JP2019183004A JP6799126B2 JP 6799126 B2 JP6799126 B2 JP 6799126B2 JP 2019183004 A JP2019183004 A JP 2019183004A JP 2019183004 A JP2019183004 A JP 2019183004A JP 6799126 B2 JP6799126 B2 JP 6799126B2
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- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
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- 239000010634 clove oil Substances 0.000 description 1
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- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
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- 150000002460 imidazoles Chemical class 0.000 description 1
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- 235000012738 indigotine Nutrition 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
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- 239000000787 lecithin Substances 0.000 description 1
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
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- 239000001627 myristica fragrans houtt. fruit oil Substances 0.000 description 1
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- 235000015097 nutrients Nutrition 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000008601 oleoresin Substances 0.000 description 1
- 235000013808 oxidized starch Nutrition 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
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- 150000004291 polyenes Chemical class 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 235000019512 sardine Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009967 tasteless effect Effects 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 150000003557 thiazoles Chemical class 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/594—Mixtures of polymers
Description
本出願は、2013年9月27日出願の米国仮出願第61/883,810号の優先権を主張するものであり、その開示は、参照によりその全体が本明細書に組み込まれる。
水性条件下でペイロードを送達するために使用される歯磨き粉等の組成物は、典型的には、単一組成物中で1つ以上のポリマーを使用する。ある場合には、本組成物は、これらのポリマーのうちの1つが水溶性であり、1つが不溶性であることを必要とする。また、以前に開示された多くのポリマー組成物は、わずかに水性の条件下で溶解し、それ故に歯磨き粉等の配合物中で安定していない。したがって、ペイロードを組み込み、水性条件下で安定しており、高度に水性の条件下で溶解して、ペイロードを送達することのできるポリマー組成物が必要とされている。
セルロースポリマー、デンプン、保湿剤、及びペイロードを有する組成物を提供し、 セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
歯磨き粉基剤及びセルロースポリマー組成物を有する歯磨き粉配合物を更に提供し、 この歯磨き粉基剤は、約35重量%未満の水を有し、この組成物は、
セルロースポリマー、デンプン、保湿剤、及びペイロードを含み、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
セルロースポリマー、デンプン、保湿剤、及びペイロードを有する膜組成物を作製するための方法も提供し、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
この歯磨き粉基剤は、約35重量%未満の水を有し、この組成物は、
セルロースポリマー、デンプン、保湿剤、及びペイロードを含み、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
セルロースポリマー:デンプンの重量比が約3:1〜約0.75:1である、組成物から、または
歯磨き粉基剤及びセルロースポリマー組成物を有する歯磨き粉配合物からペイロードを放出するための方法も提供され、
この歯磨き粉基剤は、約35重量%未満の水を有し、この組成物は、
セルロースポリマー、デンプン、保湿剤、及びペイロードを含み、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
セルロースポリマー、デンプン、保湿剤、及びペイロードを有する組成物を提供し、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
約35重量%未満の水を有する歯磨き粉基剤と、
セルロースポリマー、デンプン、保湿剤、及びペイロードを含む組成物と、を含む歯磨き粉配合物を更に提供し、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1である。
水中でセルロースポリマー混合物を形成することと、
1つ以上の保湿剤をこの混合物に添加することと、
デンプンをこの混合物に添加することと、
この混合物を冷却させることと、
水を冷却された混合物から除去して、約5重量%未満の水を有する組成物を提供することと、を含む。
水中でセルロースポリマー混合物を形成することと、
1つ以上の保湿剤をこの混合物に添加することと、
デンプンをこの混合物に添加することと、
この混合物を冷却させることと、
水を冷却された混合物から除去して、固体組成物を提供することと、
この固体組成物を歯磨き粉基剤に添加することと、を含む。
組成物を機械的作用または湿潤環境に供することを含み、
この組成物は、セルロースポリマー、デンプン、保湿剤、及びペイロードを含み、
セルロースポリマー:デンプンの重量比は、約3:1〜約0.75:1であり、
この湿潤環境は、約35重量%を超える水を含む。
実施例1で形成された膜を正方形(1.5mm×1.5mm)に切断し、33重量%未満の水含有量を有する歯磨き粉基剤と合わせ、結果として生じる歯磨き粉をオーバーヘッドミキサー内で100〜120rpmで混合する。
歯磨き粉配合物を、実施例1の膜組成物を33重量%未満の水含有量を有する歯磨き粉基剤と合わせることによって形成し、分割し、A)室温で撹拌、B)40℃で撹拌した。1ヶ月後、この膜組成物は、A)室温及びB)40℃の両方の温度で撹拌された歯磨き粉配合物中で安定している。巻き上がりも膨張も観察されなかった。磨きを伴う機械的作用に供したとき、この膜組成物は容易に溶解した。
Claims (7)
- 35重量%未満の水を有する歯磨き粉基剤と、
膜の重量に対し5重量パーセント以下の水、ヒドロキシプロピルメチルセルロースサブユニットを有するセルロースポリマー、デンプン、保湿剤、及びペイロードを含む膜と、を含み、
前記膜内に含まれる前記セルロースポリマーは、2%水溶液として45mPa・s〜60mPa・sの粘度を有し、
前記セルロースポリマーは、前記膜の重量に対し15重量%〜40重量%であり、
前記保湿剤は、ジオール、トリオール、ポリソルベート、またはそれらの混合物から選択され、
前記ペイロードは、甘味剤、香味剤、口臭清涼剤、抗微生物剤、薬草剤、植物剤、ビタミン、抗酸化剤、またはそれらの混合物のうちの1つ以上であり、前記甘味剤は、単糖、二糖、可溶性サッカリン塩、及びサイクラメート塩ジペプチド系甘味料からなる群から選択され、
前記セルロースポリマー: 前記デンプンの重量比は、3:1〜0.75:1であり、
前記膜は、100〜250ミクロンの厚さである、歯磨き粉配合物。 - 前記保湿剤の量が、重量基準で、前記セルロースポリマーの量を超える、請求項1に記載の配合物。
- 前記膜が前記歯磨き粉配合物の10重量%〜30重量%である、請求項1または2に記載の配合物。
- 前記セルロースポリマー:前記デンプンの前記重量比が、2:1である、請求項1〜3のいずれか1項に記載の配合物。
- 前記膜が5重量パーセント以下の水含有量を有する、請求項1〜4のいずれか1項に記載の配合物。
- 前記保湿剤が、グリセリン、ポリソルベート、またはそれらの混合物から選択される、請求項1〜5のいずれか1項に記載の配合物。
- 前記ペイロードが、甘味剤、香味剤、薬草剤、植物剤、ビタミン、抗酸化剤、またはそれらの混合物のうちの1つ以上である、請求項1〜6のいずれか1項に記載の配合物。
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JP2016516856A Pending JP2016531856A (ja) | 2013-09-27 | 2014-09-26 | 口腔ケア組成物 |
JP2019183004A Active JP6799126B2 (ja) | 2013-09-27 | 2019-10-03 | 口腔ケア組成物 |
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JP2016516856A Pending JP2016531856A (ja) | 2013-09-27 | 2014-09-26 | 口腔ケア組成物 |
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CN (1) | CN105722555A (ja) |
BR (1) | BR112016006624B8 (ja) |
WO (1) | WO2015048417A1 (ja) |
Families Citing this family (5)
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MX2019006351A (es) * | 2016-12-19 | 2019-08-22 | Colgate Palmolive Co | Composiciones de cuidado bucal que incluyen carbon vegetal. |
CN113116747A (zh) * | 2020-01-14 | 2021-07-16 | 罗盖特公司 | 天然和多孔淀粉在牙膏中作为白色颜料 |
CN114432162A (zh) * | 2020-10-30 | 2022-05-06 | 高露洁-棕榄公司 | 膜和包含所述膜的口腔护理组合物 |
CN113384471B (zh) * | 2021-06-10 | 2023-03-17 | 好维股份有限公司 | 一种包含薄膜的口腔护理产品 |
WO2022261879A1 (en) * | 2021-06-17 | 2022-12-22 | The Procter & Gamble Company | Dentifrice compositions with striated appearance |
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US6419903B1 (en) * | 2001-08-20 | 2002-07-16 | Colgate Palmolive Company | Breath freshening film |
ITMI20022343A1 (it) * | 2002-11-05 | 2004-05-06 | Biofarm Srl | Pellicola a rapida dissoluzione in acqua, contenente sistanze cosmetiche, aromatiche, farmaceutiche o alimentari. |
US6669929B1 (en) * | 2002-12-30 | 2003-12-30 | Colgate Palmolive Company | Dentifrice containing functional film flakes |
PL209744B1 (pl) * | 2002-12-30 | 2011-10-31 | Colgate Palmolive Co | Kompozycje do pielęgnacji jamy ustnej lub pielęgnacji osobistej |
US20070148213A1 (en) * | 2005-12-22 | 2007-06-28 | Sayed Ibrahim | Film containing compositions |
US9682256B2 (en) * | 2006-07-14 | 2017-06-20 | Colgate-Palmolive Company | Methods of making compositions comprising films |
WO2009045022A2 (en) * | 2007-10-03 | 2009-04-09 | C.L. Pharm | Edible film |
TWI396554B (zh) * | 2009-05-26 | 2013-05-21 | Colgate Palmolive Co | 增進可溶性鋅的量之口腔保健調配物 |
KR101074271B1 (ko) * | 2009-06-25 | 2011-10-17 | (주)차바이오앤디오스텍 | 불쾌한 맛을 효과적으로 은폐한 경구용 속용 필름 |
TWI435733B (zh) * | 2010-01-29 | 2014-05-01 | Colgate Palmolive Co | 用於口臭控制之口腔保健調配物 |
AU2011383264B2 (en) * | 2011-12-16 | 2014-09-18 | Colgate-Palmolive Company | Color changing oral compositions containing film |
CN104470378A (zh) * | 2012-06-28 | 2015-03-25 | 奥普蒂迈格斯齐默尔曼博士有限公司 | 制造用于可食用薄膜的薄膜制剂的方法及其用途 |
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BR112016006624B8 (pt) | 2020-08-11 |
EP3049158A1 (en) | 2016-08-03 |
BR112016006624B1 (pt) | 2020-07-21 |
BR112016006624A2 (pt) | 2017-08-01 |
EP3049158B1 (en) | 2019-10-23 |
US20160243017A1 (en) | 2016-08-25 |
JP2020023524A (ja) | 2020-02-13 |
JP2016531856A (ja) | 2016-10-13 |
CN105722555A (zh) | 2016-06-29 |
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