AR013838A1 - Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos - Google Patents

Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos

Info

Publication number
AR013838A1
AR013838A1 ARP970104362A ARP970104362A AR013838A1 AR 013838 A1 AR013838 A1 AR 013838A1 AR P970104362 A ARP970104362 A AR P970104362A AR P970104362 A ARP970104362 A AR P970104362A AR 013838 A1 AR013838 A1 AR 013838A1
Authority
AR
Argentina
Prior art keywords
olanzapine
dihydrates
methyl
substantially pure
piperazinyl
Prior art date
Application number
ARP970104362A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21832120&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR013838(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR013838A1 publication Critical patent/AR013838A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP970104362A 1996-09-23 1997-09-23 Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos AR013838A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2648796P 1996-09-23 1996-09-23

Publications (1)

Publication Number Publication Date
AR013838A1 true AR013838A1 (es) 2001-01-31

Family

ID=21832120

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970104362A AR013838A1 (es) 1996-09-23 1997-09-23 Compuestos de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b]benzodiazepina-dihidratos; los dihidratos b,d y e de dicho compuesto y proceso para preparar la forma ii sustancialmente pura de la olanzapina a partir de dichos dihidratos

Country Status (35)

Country Link
US (1) US6020487A (esLanguage)
EP (1) EP0831098B1 (esLanguage)
JP (2) JP2001500877A (esLanguage)
KR (1) KR100560015B1 (esLanguage)
CN (1) CN1122036C (esLanguage)
AR (1) AR013838A1 (esLanguage)
AT (1) ATE209208T1 (esLanguage)
AU (1) AU719441B2 (esLanguage)
BR (1) BR9712100A (esLanguage)
CA (1) CA2265712C (esLanguage)
CO (1) CO4910140A1 (esLanguage)
CZ (1) CZ299248B6 (esLanguage)
DE (1) DE69708428T2 (esLanguage)
DK (1) DK0831098T3 (esLanguage)
EA (1) EA001642B1 (esLanguage)
EG (1) EG23861A (esLanguage)
ES (1) ES2166051T3 (esLanguage)
HU (1) HU226484B1 (esLanguage)
ID (1) ID27275A (esLanguage)
IL (1) IL128962A (esLanguage)
IN (1) IN187156B (esLanguage)
MY (1) MY125565A (esLanguage)
NO (1) NO323980B1 (esLanguage)
NZ (1) NZ334448A (esLanguage)
PE (1) PE110398A1 (esLanguage)
PL (3) PL196069B1 (esLanguage)
PT (1) PT831098E (esLanguage)
RS (1) RS49598B (esLanguage)
SI (1) SI0831098T1 (esLanguage)
SV (1) SV1997000081A (esLanguage)
TR (1) TR199900640T2 (esLanguage)
TW (1) TW470746B (esLanguage)
UA (1) UA59371C2 (esLanguage)
WO (1) WO1998012199A1 (esLanguage)
ZA (1) ZA978515B (esLanguage)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ2003566A3 (cs) * 2000-08-31 2004-01-14 Dr. Reddy's Laboratories Ltd. Způsob přípravy hydrátů olanzapinu a jejich konverze na krystalické formy olanzapinu
US6740753B2 (en) * 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
CA2464306A1 (en) * 2001-10-29 2003-05-08 Dr. Reddy's Laboratories Ltd. Olanzapine dihydrate-ii a process for its preparation and use thereof
AU2002367119A1 (en) 2001-12-24 2003-07-15 Sun Pharmaceutical Industries Limited Crystalline form I of 2-methyl-4-(4-methyl-1-piperazinyl) 10H thieno [2,3-b][1,5]benzodiazepine
AU2003243153A1 (en) * 2002-04-23 2003-11-10 Dr. Reddy's Laboratories Limited Novel crystalline polymorph form-vi of olanzapine and a process for preparation thereof
WO2003101997A1 (en) * 2002-05-31 2003-12-11 Geneva Pharmaceuticals, Inc. Process of preparation of olanzapine form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
WO2004058773A1 (en) * 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
AU2004291043A1 (en) * 2003-11-18 2005-06-02 3M Innovative Properties Company Olanzapine containing transdermal drug delivery compositions
EP1611139B1 (en) * 2003-12-22 2008-06-04 Teva Pharmaceutical Industries Ltd. Methods of preparing olanzapine
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
EP1716154A1 (en) * 2004-02-19 2006-11-02 Neuland Laboratories Ltd Process for the preparation of olanzapine form 1 useful as antipsychotic drug
WO2006006185A1 (en) * 2004-07-14 2006-01-19 Shasun Chemicals And Drugs Limited Improved process for making form i of olanzapine.
ES2253091B1 (es) 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
ES2303462B1 (es) 2004-09-06 2009-06-05 Shasun Chemicals And Drugs Limited Nuevo procedimiento para la preparacion de una forma polimorfica i de olanzapina farmaceuticamente pura.
CN101106972A (zh) * 2004-11-16 2008-01-16 伊兰制药国际有限公司 注射用纳米微粒奥氮平制剂
US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
CA2591644A1 (en) * 2007-06-14 2008-12-14 Apotex Pharmachem Inc. Novel processes to form-i of olanzapine
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin
JP6008734B2 (ja) * 2012-12-20 2016-10-19 株式会社トクヤマ オランザピンｉｉ型結晶の製造方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
ES2153373T3 (es) * 1992-05-29 2001-03-01 Lilly Co Eli Derivados de tienobenzodiazepina para el tratamiento de trastornos del sistema nervioso central.
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5602124A (en) * 1994-12-12 1997-02-11 Allelix Biopharmaceuticals, Inc. 5-HT2 receptor ligands
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5631250A (en) * 1995-03-24 1997-05-20 Eli Lilly And Company Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) * 1995-03-24 1997-06-10 Eli Lilly And Company Solvate of olanzapine
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
BR9711541A (pt) * 1996-09-23 1999-08-24 Lilly Co Eli Dihidrato d de olanzapina

Also Published As

Publication number Publication date
NO991382D0 (no) 1999-03-22
ATE209208T1 (de) 2001-12-15
PL196069B1 (pl) 2007-12-31
NZ334448A (en) 2000-08-25
WO1998012199A1 (en) 1998-03-26
AU719441B2 (en) 2000-05-11
IL128962A0 (en) 2000-02-17
IL128962A (en) 2003-01-12
CA2265712C (en) 2006-10-31
EP0831098A3 (en) 1998-04-29
AU4484197A (en) 1998-04-14
CZ299248B6 (cs) 2008-05-28
HUP0000066A2 (hu) 2000-06-28
SV1997000081A (es) 1999-01-14
JP2009242407A (ja) 2009-10-22
CN1122036C (zh) 2003-09-24
ES2166051T3 (es) 2002-04-01
TR199900640T2 (xx) 1999-06-21
ZA978515B (en) 1999-03-23
YU15599A (sh) 2001-12-26
KR100560015B1 (ko) 2006-03-15
CO4910140A1 (es) 2000-04-24
PL196068B1 (pl) 2007-12-31
PL332482A1 (en) 1999-09-13
EP0831098B1 (en) 2001-11-21
ID27275A (id) 2001-03-22
UA59371C2 (uk) 2003-09-15
TW470746B (en) 2002-01-01
EP0831098A2 (en) 1998-03-25
HUP0000066A3 (en) 2000-11-28
IN187156B (esLanguage) 2002-02-16
MY125565A (en) 2006-08-30
CZ99099A3 (cs) 1999-11-17
CA2265712A1 (en) 1998-03-26
PE110398A1 (es) 1999-01-14
JP2001500877A (ja) 2001-01-23
NO323980B1 (no) 2007-07-30
EA001642B1 (ru) 2001-06-25
EG23861A (en) 2007-11-18
PL194565B1 (pl) 2007-06-29
DE69708428T2 (de) 2002-07-04
SI0831098T1 (en) 2002-04-30
EA199900326A1 (ru) 1999-08-26
KR20000048520A (ko) 2000-07-25
CN1234802A (zh) 1999-11-10
US6020487A (en) 2000-02-01
HK1009807A1 (en) 1999-06-11
BR9712100A (pt) 1999-08-31
DE69708428D1 (de) 2002-01-03
RS49598B (sr) 2007-06-04
HU226484B1 (en) 2009-03-02
NO991382L (no) 1999-03-22
DK0831098T3 (da) 2002-05-21
PT831098E (pt) 2002-04-29

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