AR013803A1 - Forma cristalina del acido (r)-3-[[(4-fluorfenil)sulfonil]amino]-1,2,3,4- tetrahidro-9h-carbazol-9-propanoico (ramatroban), proceso para su preparacion,su uso para la manufactura de un medicamento y medicamento que la contiene - Google Patents
Forma cristalina del acido (r)-3-[[(4-fluorfenil)sulfonil]amino]-1,2,3,4- tetrahidro-9h-carbazol-9-propanoico (ramatroban), proceso para su preparacion,su uso para la manufactura de un medicamento y medicamento que la contieneInfo
- Publication number
- AR013803A1 AR013803A1 ARP980106318A ARP980106318A AR013803A1 AR 013803 A1 AR013803 A1 AR 013803A1 AR P980106318 A ARP980106318 A AR P980106318A AR P980106318 A ARP980106318 A AR P980106318A AR 013803 A1 AR013803 A1 AR 013803A1
- Authority
- AR
- Argentina
- Prior art keywords
- medicinal product
- thermodynamically stable
- ramatroban
- manufacture
- preparation
- Prior art date
Links
- LDXDSHIEDAPSSA-OAHLLOKOSA-N Ramatroban Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CCC(=O)O)S(=O)(=O)C1=CC=C(F)C=C1 LDXDSHIEDAPSSA-OAHLLOKOSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229950004496 ramatroban Drugs 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 2
- 239000002253 acid Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 238000009331 sowing Methods 0.000 abstract 2
- 238000001228 spectrum Methods 0.000 abstract 2
- 238000001237 Raman spectrum Methods 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000011521 glass Substances 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19757983A DE19757983A1 (de) | 1997-12-24 | 1997-12-24 | Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013803A1 true AR013803A1 (es) | 2001-01-10 |
Family
ID=7853457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980106318A AR013803A1 (es) | 1997-12-24 | 1998-12-11 | Forma cristalina del acido (r)-3-[[(4-fluorfenil)sulfonil]amino]-1,2,3,4- tetrahidro-9h-carbazol-9-propanoico (ramatroban), proceso para su preparacion,su uso para la manufactura de un medicamento y medicamento que la contiene |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6362214B1 (h) |
| EP (1) | EP1051398B1 (h) |
| JP (2) | JP3817668B2 (h) |
| KR (1) | KR100586350B1 (h) |
| CN (1) | CN1140510C (h) |
| AR (1) | AR013803A1 (h) |
| AT (1) | ATE263152T1 (h) |
| AU (1) | AU744242B2 (h) |
| BG (1) | BG65024B1 (h) |
| BR (1) | BR9814496A (h) |
| CA (1) | CA2313230A1 (h) |
| CO (1) | CO4970800A1 (h) |
| DE (2) | DE19757983A1 (h) |
| DK (1) | DK1051398T3 (h) |
| ES (1) | ES2218874T3 (h) |
| GT (1) | GT199800198A (h) |
| HN (1) | HN1998000186A (h) |
| HU (1) | HUP0004432A3 (h) |
| ID (1) | ID25446A (h) |
| IL (1) | IL136278A (h) |
| IN (1) | IN192932B (h) |
| MY (1) | MY116312A (h) |
| NO (1) | NO316618B1 (h) |
| NZ (1) | NZ504741A (h) |
| PE (1) | PE20000115A1 (h) |
| PL (1) | PL341359A1 (h) |
| PT (1) | PT1051398E (h) |
| RU (1) | RU2220137C2 (h) |
| SI (1) | SI1051398T1 (h) |
| SK (1) | SK285109B6 (h) |
| TR (1) | TR200001936T2 (h) |
| TW (1) | TW552258B (h) |
| UA (1) | UA66832C2 (h) |
| UY (2) | UY25324A1 (h) |
| WO (1) | WO1999033803A1 (h) |
| ZA (1) | ZA9811817B (h) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2395120T3 (es) * | 2006-12-20 | 2013-02-08 | Cardoz Ab | Combinación de pemirolast y ramotrobán para su uso en el tratamiento de transtornos inflamatorios |
| US20100099693A1 (en) * | 2007-01-16 | 2010-04-22 | Johan Raud | New combination for use in the treatment of inflammatory disorders |
| WO2009007674A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast |
| WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
| CN103054857A (zh) * | 2012-12-30 | 2013-04-24 | 北京阜康仁生物制药科技有限公司 | 一种以雷马曲班为活性成分的固体制剂 |
| WO2016128565A1 (en) | 2015-02-13 | 2016-08-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1557665A (en) * | 1975-12-10 | 1979-12-12 | Ici Ltd | Process for the manufacture of a carboxyalkylamino anthraquinone compounds |
| US4616028A (en) * | 1985-04-22 | 1986-10-07 | American Home Products Corporation | Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, compositions and use |
| CN1015711B (zh) | 1986-02-21 | 1992-03-04 | 拜尔公司 | 制备环烷并[1，2-b]吲哚-磺酰胺类化合物的方法 |
| DE3631824A1 (de) | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
| GB8924392D0 (en) * | 1989-10-30 | 1989-12-20 | Bayer Ag | Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides |
| DE19506739A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino]-tetrahydrocarbazol-propansäureester |
-
1997
- 1997-12-24 DE DE19757983A patent/DE19757983A1/de not_active Withdrawn
-
1998
- 1998-12-09 HN HN1998000186A patent/HN1998000186A/es unknown
- 1998-12-11 AR ARP980106318A patent/AR013803A1/es unknown
- 1998-12-15 GT GT199800198A patent/GT199800198A/es unknown
- 1998-12-22 MY MYPI98005837A patent/MY116312A/en unknown
- 1998-12-22 PE PE1998001272A patent/PE20000115A1/es not_active Application Discontinuation
- 1998-12-23 CO CO98076459A patent/CO4970800A1/es unknown
- 1998-12-23 UY UY25324A patent/UY25324A1/es not_active IP Right Cessation
- 1998-12-23 ZA ZA9811817A patent/ZA9811817B/xx unknown
- 1998-12-23 TW TW087121479A patent/TW552258B/zh not_active IP Right Cessation
- 1998-12-24 CN CNB98812405XA patent/CN1140510C/zh not_active Expired - Fee Related
- 1998-12-24 PL PL98341359A patent/PL341359A1/xx not_active Application Discontinuation
- 1998-12-24 ID IDW20001226A patent/ID25446A/id unknown
- 1998-12-24 IL IL13627898A patent/IL136278A/xx not_active IP Right Cessation
- 1998-12-24 SI SI9830656T patent/SI1051398T1/xx unknown
- 1998-12-24 WO PCT/JP1998/005844 patent/WO1999033803A1/en not_active Application Discontinuation
- 1998-12-24 BR BR9814496-0A patent/BR9814496A/pt not_active Application Discontinuation
- 1998-12-24 ES ES98961506T patent/ES2218874T3/es not_active Expired - Lifetime
- 1998-12-24 UA UA2000074335A patent/UA66832C2/uk unknown
- 1998-12-24 PT PT98961506T patent/PT1051398E/pt unknown
- 1998-12-24 JP JP2000526487A patent/JP3817668B2/ja not_active Expired - Lifetime
- 1998-12-24 CA CA002313230A patent/CA2313230A1/en not_active Abandoned
- 1998-12-24 SK SK975-2000A patent/SK285109B6/sk unknown
- 1998-12-24 TR TR2000/01936T patent/TR200001936T2/xx unknown
- 1998-12-24 NZ NZ504741A patent/NZ504741A/xx unknown
- 1998-12-24 AU AU16874/99A patent/AU744242B2/en not_active Ceased
- 1998-12-24 HU HU0004432A patent/HUP0004432A3/hu unknown
- 1998-12-24 EP EP98961506A patent/EP1051398B1/en not_active Expired - Lifetime
- 1998-12-24 AT AT98961506T patent/ATE263152T1/de not_active IP Right Cessation
- 1998-12-24 IN IN43MU2000 patent/IN192932B/en unknown
- 1998-12-24 KR KR1020007007031A patent/KR100586350B1/ko not_active Expired - Fee Related
- 1998-12-24 DE DE69822882T patent/DE69822882T2/de not_active Expired - Fee Related
- 1998-12-24 RU RU2000119741/04A patent/RU2220137C2/ru not_active IP Right Cessation
- 1998-12-24 DK DK98961506T patent/DK1051398T3/da active
- 1998-12-24 US US09/582,250 patent/US6362214B1/en not_active Expired - Fee Related
-
1999
- 1999-06-18 UY UY25575A patent/UY25575A1/es unknown
-
2000
- 2000-06-21 NO NO20003217A patent/NO316618B1/no unknown
- 2000-06-23 BG BG104554A patent/BG65024B1/bg unknown
-
2005
- 2005-11-25 JP JP2005340586A patent/JP4411269B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |