AR012827A1 - Complejo de bis-platino, metodo para su preparacion y uso del mismo en la preparacion de una composicion farmaceutica - Google Patents

Complejo de bis-platino, metodo para su preparacion y uso del mismo en la preparacion de una composicion farmaceutica

Info

Publication number
AR012827A1
AR012827A1 ARP970103280A ARP970103280A AR012827A1 AR 012827 A1 AR012827 A1 AR 012827A1 AR P970103280 A ARP970103280 A AR P970103280A AR P970103280 A ARP970103280 A AR P970103280A AR 012827 A1 AR012827 A1 AR 012827A1
Authority
AR
Argentina
Prior art keywords
group
preparation
bis
platinum
4alkyl
Prior art date
Application number
ARP970103280A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Univ Virginia Commonwealth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Univ Virginia Commonwealth filed Critical Hoffmann La Roche
Publication of AR012827A1 publication Critical patent/AR012827A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe dicho complejo de bis-platino (II) con ligandos de poliamina de formula (I), en donde: dos de los ligandos X, Y y Z unidos a cada nucleo deplatino son amoníaco y el otro ligando se selecciona del grupo que consta de cloruro,bromuro , ioduro y un grupo aciloxi C1-4; n y m son independientementeentre sí un numero entero del 2 al 8; p es un numero entero que puede ser 1 o 2; A se selecciona del grupo que consiste de -B-, -B-(CH2)r-B-, -B-(CH2)r-B-(CH2)z -B-, en donde ry z son n umeros enteros que varían en un rango de 2 a 8 y B es un grupo -NR1- o -N(R2)2+ . 1/pQ-p, en donde R1 se selecciona del grupoque consta de hidrogeno, alquilo C1-4, acilo C1-4, ter-butiloxicarbonilo y R2 se selecciona del grupo queconsta de hidrog eno,alquilo C1-4;y Q(-P)es un anionque se selecciona entre cloruro, bromuro, ioduro, nitrato, sulfato, sulfato ácido y perclorato. El método para elaborar complejos bis platino (II) y eluso de los mismos para el tratamiento detumores en mamífero s. También se describe el método para elaborar los ligandos de poliamina y el uso delcompuesto nuevo (VIIc) como un intermediario en la síntesis de ligandos de poliamina.
ARP970103280A 1996-07-22 1997-07-22 Complejo de bis-platino, metodo para su preparacion y uso del mismo en la preparacion de una composicion farmaceutica AR012827A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2230696P 1996-07-22 1996-07-22

Publications (1)

Publication Number Publication Date
AR012827A1 true AR012827A1 (es) 2000-11-22

Family

ID=21808912

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970103280A AR012827A1 (es) 1996-07-22 1997-07-22 Complejo de bis-platino, metodo para su preparacion y uso del mismo en la preparacion de una composicion farmaceutica

Country Status (13)

Country Link
US (1) US6022892A (es)
EP (1) EP0912584B1 (es)
JP (2) JP4181636B2 (es)
AR (1) AR012827A1 (es)
AT (1) ATE229966T1 (es)
AU (1) AU731729B2 (es)
CA (1) CA2260971C (es)
DE (1) DE69717999T2 (es)
DK (1) DK0912584T3 (es)
ES (1) ES2190801T3 (es)
TW (1) TW483897B (es)
WO (1) WO1998003519A2 (es)
ZA (1) ZA976421B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.
ZA976422B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity.
KR100314720B1 (ko) * 1999-03-26 2001-11-26 박호군 포스파젠 삼합체에 도입된 백금 착물, 그의 제조방법 및 그를 유효성분으로 하는 항암제
ITMI991508A1 (it) 1999-07-09 2001-01-09 Novuspharma Spa Nitrati di bis-platino complessi con ligandi poliamminici
IT1313594B1 (it) * 1999-08-03 2002-09-09 Novuspharma Spa Bisplatino complessi attivi per via orale.
WO2003018594A1 (en) * 2001-08-22 2003-03-06 Virginia Commonwealth University Targeted bisplatinum polyamines as pro-drugs: selective release of platinum
US6904310B2 (en) 2002-05-07 2005-06-07 Scimed Life Systems, Inc. Customized material for improved radiopacity
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2005092298A1 (en) * 2004-03-26 2005-10-06 Cell Therapeutics Europe S.R.L. Nanoparticle formulations of platinum compounds
ITMI20052449A1 (it) 2005-12-22 2007-06-23 Cell Therapeutics Europe Srl Nuovi bis-platino complessi ad attivita' antitumorale
ITMI20081660A1 (it) * 2008-09-18 2010-03-19 Cell Therapeutics Inc Sede Secon Daria Complesso di platino ad attivita' antitumorale
CN109293702B (zh) * 2018-08-27 2020-05-29 河南大学 一种四价铂多胺配合物、其制备方法及应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805411C3 (de) * 1968-10-26 1980-06-19 Chemische Werke Huels Ag, 4370 Marl Verfahren zur Hersteilung von N- ( w -Am'inoalkanoyl)-diaminen
DE2220016C3 (de) * 1972-04-24 1980-06-12 Henkel Kgaa, 4000 Duesseldorf Umsetzungsprodukte von e - Caprolactam mit 13-Propandiaminen, Verfahren zu deren Herstellung und deren Verwendung
US4493794A (en) * 1980-12-31 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Peptide, process for preparation thereof and use thereof
DE3204168A1 (de) * 1982-02-06 1983-08-11 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von sulfonamiden
GB8325494D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
JPS6117542A (ja) * 1984-07-03 1986-01-25 Takeda Chem Ind Ltd スペルミン誘導体
JPS6153250A (ja) * 1984-08-21 1986-03-17 Fujisawa Pharmaceut Co Ltd スペルミジン誘導体
US4871729A (en) * 1986-07-25 1989-10-03 University Of Vermont And State Agricultural College Bisplatinum complexes as chemotherapeutic agents
US4797393A (en) * 1986-07-25 1989-01-10 University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US5107007A (en) * 1989-09-01 1992-04-21 The University Of Vermont And State Agricultural College Bis-platinum complexes as chemotherapeutic agents
US4895840A (en) * 1987-06-10 1990-01-23 A. H. Robins Company, Incorporated N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
AU2817589A (en) * 1987-12-18 1989-07-19 Boehringer Biochemia Robin S.P.A Amino anthracenediones-bis platinum complexes, useful as antitumoral agents
JPH04193853A (ja) * 1990-11-26 1992-07-13 Fujisawa Pharmaceut Co Ltd 置換アセトアミド化合物の製造法
JPH0782225A (ja) * 1993-09-14 1995-03-28 Fuji Photo Film Co Ltd アミノ酸誘導体及びその用途
JPH07206811A (ja) * 1994-01-18 1995-08-08 Wakunaga Pharmaceut Co Ltd チオウレア誘導体、その製造法及びその利用
IT1273391B (it) * 1994-03-31 1997-07-08 Boehringer Mannheim Italia Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono
JP3503993B2 (ja) * 1994-08-24 2004-03-08 田岡化学工業株式会社 Ｎ−モノ−ｔ−ブチルオキシカルボニルアルキレンジアミンの製造法
JPH0859588A (ja) * 1994-08-24 1996-03-05 Microbial Chem Res Found Ｄ−β−リジルメタンジアミン誘導体、およびそれらの製法
JPH07165740A (ja) * 1994-11-07 1995-06-27 Banyu Pharmaceut Co Ltd ２−（２−アミノチアゾリル）−２−（１−カルボキシ−１−ビニルオキシイミノ）酢酸及びその製法
ZA976421B (en) * 1996-07-22 1998-01-22 Boehringer Mannheim Italia New bis-platinum complexes with polyamine ligands as antitumor agents.

Also Published As

Publication number Publication date
WO1998003519A3 (en) 2003-04-17
DE69717999D1 (de) 2003-01-30
JP4181636B2 (ja) 2008-11-19
WO1998003519A2 (en) 1998-01-29
CA2260971C (en) 2008-09-09
US6022892A (en) 2000-02-08
ES2190801T3 (es) 2003-08-16
JP5052420B2 (ja) 2012-10-17
EP0912584B1 (en) 2002-12-18
JP2009007357A (ja) 2009-01-15
ZA976421B (en) 1998-01-22
JP2002512589A (ja) 2002-04-23
EP0912584A2 (en) 1999-05-06
DK0912584T3 (da) 2003-04-14
DE69717999T2 (de) 2003-11-13
TW483897B (en) 2002-04-21
AU3671097A (en) 1998-02-10
ATE229966T1 (de) 2003-01-15
CA2260971A1 (en) 1998-01-29
AU731729B2 (en) 2001-04-05

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