ATE229966T1 - Bis-platin komplexe mit polyamin-liganden als antitumorales mittel - Google Patents
Bis-platin komplexe mit polyamin-liganden als antitumorales mittelInfo
- Publication number
- ATE229966T1 ATE229966T1 AT97933548T AT97933548T ATE229966T1 AT E229966 T1 ATE229966 T1 AT E229966T1 AT 97933548 T AT97933548 T AT 97933548T AT 97933548 T AT97933548 T AT 97933548T AT E229966 T1 ATE229966 T1 AT E229966T1
- Authority
- AT
- Austria
- Prior art keywords
- bis
- platinum complexes
- antitumoral agent
- polyamine ligands
- polyamine
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 229920000768 polyamine Polymers 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
- C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2230696P | 1996-07-22 | 1996-07-22 | |
PCT/US1997/012553 WO1998003519A2 (en) | 1996-07-22 | 1997-07-22 | New bis-platinum complexes with polyamine ligands as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE229966T1 true ATE229966T1 (de) | 2003-01-15 |
Family
ID=21808912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97933548T ATE229966T1 (de) | 1996-07-22 | 1997-07-22 | Bis-platin komplexe mit polyamin-liganden als antitumorales mittel |
Country Status (13)
Country | Link |
---|---|
US (1) | US6022892A (de) |
EP (1) | EP0912584B1 (de) |
JP (2) | JP4181636B2 (de) |
AR (1) | AR012827A1 (de) |
AT (1) | ATE229966T1 (de) |
AU (1) | AU731729B2 (de) |
CA (1) | CA2260971C (de) |
DE (1) | DE69717999T2 (de) |
DK (1) | DK0912584T3 (de) |
ES (1) | ES2190801T3 (de) |
TW (1) | TW483897B (de) |
WO (1) | WO1998003519A2 (de) |
ZA (1) | ZA976421B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA976422B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity. |
ZA976421B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polyamine ligands as antitumor agents. |
KR100314720B1 (ko) * | 1999-03-26 | 2001-11-26 | 박호군 | 포스파젠 삼합체에 도입된 백금 착물, 그의 제조방법 및 그를 유효성분으로 하는 항암제 |
ITMI991508A1 (it) | 1999-07-09 | 2001-01-09 | Novuspharma Spa | Nitrati di bis-platino complessi con ligandi poliamminici |
IT1313594B1 (it) * | 1999-08-03 | 2002-09-09 | Novuspharma Spa | Bisplatino complessi attivi per via orale. |
JP2005501123A (ja) * | 2001-08-22 | 2005-01-13 | ヴァージニア コモンウェルス ユニバーシティ | プロドラッグとしての標的ビス白金ポリアミド:白金の選択的放出 |
US6904310B2 (en) | 2002-05-07 | 2005-06-07 | Scimed Life Systems, Inc. | Customized material for improved radiopacity |
US7138520B2 (en) * | 2003-01-13 | 2006-11-21 | Massachusetts Institute Of Technology | Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same |
EP1734937A1 (de) * | 2004-03-26 | 2006-12-27 | Cell Therapeutics Europe S.R.L. | Nanoteilchen-formulierungen von platinverbindungen |
ITMI20052449A1 (it) * | 2005-12-22 | 2007-06-23 | Cell Therapeutics Europe Srl | Nuovi bis-platino complessi ad attivita' antitumorale |
ITMI20081660A1 (it) * | 2008-09-18 | 2010-03-19 | Cell Therapeutics Inc Sede Secon Daria | Complesso di platino ad attivita' antitumorale |
CN109293702B (zh) * | 2018-08-27 | 2020-05-29 | 河南大学 | 一种四价铂多胺配合物、其制备方法及应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1805411C3 (de) * | 1968-10-26 | 1980-06-19 | Chemische Werke Huels Ag, 4370 Marl | Verfahren zur Hersteilung von N- ( w -Am'inoalkanoyl)-diaminen |
DE2220016C3 (de) * | 1972-04-24 | 1980-06-12 | Henkel Kgaa, 4000 Duesseldorf | Umsetzungsprodukte von e - Caprolactam mit 13-Propandiaminen, Verfahren zu deren Herstellung und deren Verwendung |
US4493794A (en) * | 1980-12-31 | 1985-01-15 | Fujisawa Pharmaceutical Co., Ltd. | Peptide, process for preparation thereof and use thereof |
DE3204168A1 (de) * | 1982-02-06 | 1983-08-11 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von sulfonamiden |
GB8325494D0 (en) * | 1983-09-23 | 1983-10-26 | Hider R C | Pharmaceutical compositions |
JPS6117542A (ja) * | 1984-07-03 | 1986-01-25 | Takeda Chem Ind Ltd | スペルミン誘導体 |
JPS6153250A (ja) * | 1984-08-21 | 1986-03-17 | Fujisawa Pharmaceut Co Ltd | スペルミジン誘導体 |
US5107007A (en) * | 1989-09-01 | 1992-04-21 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US4871729A (en) * | 1986-07-25 | 1989-10-03 | University Of Vermont And State Agricultural College | Bisplatinum complexes as chemotherapeutic agents |
US4797393A (en) * | 1986-07-25 | 1989-01-10 | University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
US4895840A (en) * | 1987-06-10 | 1990-01-23 | A. H. Robins Company, Incorporated | N-(aryl-,aryloxy-,arylthio-arylsulfinyl-and arylsulfonyl-)alkyl-N,N'-(or n'n')alkylaminoalkyl ureas and cyanoguanidines |
DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
WO1989005815A1 (en) * | 1987-12-18 | 1989-06-29 | Boehringer Biochemia Robin S.P.A. | Amino anthracenediones-bis platinum complexes, useful as antitumoral agents |
JPH04193853A (ja) * | 1990-11-26 | 1992-07-13 | Fujisawa Pharmaceut Co Ltd | 置換アセトアミド化合物の製造法 |
JPH0782225A (ja) * | 1993-09-14 | 1995-03-28 | Fuji Photo Film Co Ltd | アミノ酸誘導体及びその用途 |
JPH07206811A (ja) * | 1994-01-18 | 1995-08-08 | Wakunaga Pharmaceut Co Ltd | チオウレア誘導体、その製造法及びその利用 |
IT1273391B (it) * | 1994-03-31 | 1997-07-08 | Boehringer Mannheim Italia | Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono |
JPH0859588A (ja) * | 1994-08-24 | 1996-03-05 | Microbial Chem Res Found | D−β−リジルメタンジアミン誘導体、およびそれらの製法 |
JP3503993B2 (ja) * | 1994-08-24 | 2004-03-08 | 田岡化学工業株式会社 | N−モノ−t−ブチルオキシカルボニルアルキレンジアミンの製造法 |
JPH07165740A (ja) * | 1994-11-07 | 1995-06-27 | Banyu Pharmaceut Co Ltd | 2−(2−アミノチアゾリル)−2−(1−カルボキシ−1−ビニルオキシイミノ)酢酸及びその製法 |
ZA976421B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polyamine ligands as antitumor agents. |
-
1997
- 1997-07-21 ZA ZA9706421A patent/ZA976421B/xx unknown
- 1997-07-22 ES ES97933548T patent/ES2190801T3/es not_active Expired - Lifetime
- 1997-07-22 JP JP50631398A patent/JP4181636B2/ja not_active Expired - Lifetime
- 1997-07-22 AU AU36710/97A patent/AU731729B2/en not_active Expired
- 1997-07-22 WO PCT/US1997/012553 patent/WO1998003519A2/en active IP Right Grant
- 1997-07-22 DK DK97933548T patent/DK0912584T3/da active
- 1997-07-22 EP EP97933548A patent/EP0912584B1/de not_active Expired - Lifetime
- 1997-07-22 CA CA002260971A patent/CA2260971C/en not_active Expired - Lifetime
- 1997-07-22 AT AT97933548T patent/ATE229966T1/de active
- 1997-07-22 AR ARP970103280A patent/AR012827A1/es active IP Right Grant
- 1997-07-22 DE DE69717999T patent/DE69717999T2/de not_active Expired - Lifetime
- 1997-07-22 US US09/147,089 patent/US6022892A/en not_active Expired - Lifetime
- 1997-07-24 TW TW086110530A patent/TW483897B/zh not_active IP Right Cessation
-
2008
- 2008-06-16 JP JP2008156473A patent/JP5052420B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
WO1998003519A3 (en) | 2003-04-17 |
CA2260971C (en) | 2008-09-09 |
DK0912584T3 (da) | 2003-04-14 |
AU3671097A (en) | 1998-02-10 |
JP2002512589A (ja) | 2002-04-23 |
WO1998003519A2 (en) | 1998-01-29 |
US6022892A (en) | 2000-02-08 |
AR012827A1 (es) | 2000-11-22 |
DE69717999T2 (de) | 2003-11-13 |
CA2260971A1 (en) | 1998-01-29 |
DE69717999D1 (de) | 2003-01-30 |
ES2190801T3 (es) | 2003-08-16 |
EP0912584A2 (de) | 1999-05-06 |
JP5052420B2 (ja) | 2012-10-17 |
EP0912584B1 (de) | 2002-12-18 |
JP4181636B2 (ja) | 2008-11-19 |
ZA976421B (en) | 1998-01-22 |
JP2009007357A (ja) | 2009-01-15 |
AU731729B2 (en) | 2001-04-05 |
TW483897B (en) | 2002-04-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69809739D1 (de) | Organometallische komplexe | |
DE69726729D1 (de) | Fungizide mittel mit verbesserter bioverfügbarkeit | |
HUP0400256A2 (hu) | Új, módosított ligandumok | |
DE69732669D1 (de) | Drehendes Reibungschweissverfahren | |
DE69709897T2 (de) | Phosphin-liganden | |
ATE219490T1 (de) | Indazoleamid-verbindungen als serotoninergene mittel | |
ATE229966T1 (de) | Bis-platin komplexe mit polyamin-liganden als antitumorales mittel | |
DE69015393T2 (de) | Immunosuppressives Mittel. | |
HK1057044A1 (en) | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as d4 ligands | |
DE69714504D1 (de) | Benzothiopene, diese enthaltende Zubereitungen und Verfahren | |
ATE226211T1 (de) | Antitumor-wirksame bis-platin komplexe mit polymethylen-derivaten als liganden | |
NO20002159D0 (no) | Piperazin-cyklodekstrin-komplekser | |
FR2715150B1 (fr) | Chariot élévateur. | |
DK0926953T3 (da) | Halogenpropargylinkonklusionskomplekser | |
ATE240963T1 (de) | Salze von anionischen komplexen ru(iii), als antimetastatische und antineoplastische mittel | |
NO20000422D0 (no) | Katalysatorer basert på fulven-metallkomplekser | |
DE59809348D1 (de) | Algizide mittel | |
FR2778915B1 (fr) | Nouvelles furylphosphines et complexes organometalliques les comprenant | |
DE29620785U1 (de) | Mittel zum Zusammenhalten von Möbelseiten mit den dazugehörigen Möbelböden | |
TR199700529A3 (tr) | Elektrik kenetleri. | |
DE59710282D1 (de) | Cis-verbrückte metallkomplexe | |
DE69717366D1 (de) | Ruthenium-Phospin Komplex | |
DE69407616T2 (de) | Verträglichmachende mittel | |
KR980000948U (ko) | 블록 놀이 기구 | |
ES1037964Y (es) | Perfeccionamientos en trenes con ruedas poleas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0912584 Country of ref document: EP |