AR011072A1 - Intermediarios para la preparacion cefixima, un proceso para su produccion y su uso en la preparacion de cefixima - Google Patents
Intermediarios para la preparacion cefixima, un proceso para su produccion y su uso en la preparacion de cefiximaInfo
- Publication number
- AR011072A1 AR011072A1 ARP980100163A ARP980100163A AR011072A1 AR 011072 A1 AR011072 A1 AR 011072A1 AR P980100163 A ARP980100163 A AR P980100163A AR P980100163 A ARP980100163 A AR P980100163A AR 011072 A1 AR011072 A1 AR 011072A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- defined above
- carboxymethoxyimino
- aminothiazol
- vinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un proceso para la produccion de cefixima de la formula (II), que comprende: a. hacer reaccionar un ácido 7-amino-3-vinil-3-cefem-4-carboxílicode la formula (III A) en donde R5 y R6 son hidrogeno o un grupo de salida, y R7 es hidrogeno, alquilo, cicloalquilo, alquilarilo, arilo, arilalquilo sililo;con un ácido 2-(aminotiazol-4-il)-2-carboximetoxiimino)acético de la formula (IV A), en donde R9 es alquilo, cicloalquilo, alquilarilo, arilo, oarilalquilo, R10 es hidrogeno, y R11 es hidrogeno, sililo, o acilo, para dar un ácido 7-[2-(aminotiazol-4-il)-2-(carboximetoxiimino)acetamido]-3-vinil-3-cefem-4-carboxílico de la formula (I A), en donde R7, R9, R10 y R11 son como se definieron anteriormente; b. hacer reaccionar un ácido7-[2-(aminotiazol-4-il)-2-(carboximetoxiimino)-acetamido]-3-vinil-3-cefem-4-carboxílico de la formula (I A), en donde R7, R9, R10 y R11 son como se definieron anteriormente, con unaamina de la formula (VI), en donde R1, R2 y R3 independientemente unos de otras, son hidrogeno, alquilo, cicloalquilo, alquilarilo, arilo, o aralquilo,para dar una sal cristalina de un compuesto de la formula (I A), en donde R7, R9, R10, y R11 son como se definieron anteriormente, con una amina de laformula(VI), en donde R1, R2, y R3 son como se definieron anteriormente; c. hacer reaccionar un ácido 7-[2-(aminotiazol-4-il)-2-(carboximetoxiimino)-acetamido]-3-vinil-3-cefem-4-carboxílico de la formua (I A), en donde R7, R8, R10 y R11 son como se definieron anteriormente, con ácido sulfurico, paraobtener un compuesto de la formula (II A), en donde R7, R10 y R11 son como se definieron anteriormente, en la forma de una sal de adicion de ácido sulfuricocristalina, y si se desea, d. convertir unasal de adicion de ácido sulfurico de ácido 7-[2-(aminotiazol-4-il)-2-(carboximetoxiimino)acetamido]-3-vinil-3-
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT6197A AT404726B (de) | 1997-01-16 | 1997-01-16 | Kristalline salze von derivaten der 3-vinyl-3-cephem-4-carbonsäure und verfahren zu deren herstellung |
AT0006297A AT404727B (de) | 1997-01-16 | 1997-01-16 | Kristallines salz von cefixim und verfahren zu dessen herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
AR011072A1 true AR011072A1 (es) | 2000-08-02 |
Family
ID=25591299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980100163A AR011072A1 (es) | 1997-01-16 | 1998-01-14 | Intermediarios para la preparacion cefixima, un proceso para su produccion y su uso en la preparacion de cefixima |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0968214B1 (es) |
JP (2) | JP2000514090A (es) |
KR (1) | KR20000070275A (es) |
AR (1) | AR011072A1 (es) |
AU (1) | AU6614198A (es) |
DE (1) | DE69823012T2 (es) |
ES (1) | ES2219874T3 (es) |
HK (1) | HK1024698A1 (es) |
TW (1) | TW538045B (es) |
WO (1) | WO1998031685A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT102061B (pt) * | 1997-10-08 | 2000-06-30 | J K Ind Ltd | Processo de preparacao de um antibiotico cefalosporina geralmente activo-cefixime |
AT406773B (de) * | 1998-04-02 | 2000-08-25 | Biochemie Gmbh | Neues salz von 7-(2-(aminothiazol-4yl)-2- |
KR100377556B1 (ko) * | 1999-01-27 | 2003-03-26 | 주식회사 엘지생명과학 | 세픽심 제조에 유용한 중간체의 제조방법 |
WO2000068234A2 (en) | 1999-05-07 | 2000-11-16 | Ranbaxy Laboratories Limited | Process for the preparation of cefpodoxime acid |
KR100342600B1 (ko) | 2000-03-06 | 2002-07-04 | 한미정밀화학주식회사 | 신규한 티아졸 화합물 및 그의 제조 방법 |
KR100392409B1 (ko) | 2000-03-20 | 2003-07-22 | 한미정밀화학주식회사 | 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법 |
KR100451672B1 (ko) * | 2001-06-05 | 2004-10-08 | 한미약품 주식회사 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
ITMI20012364A1 (it) * | 2001-11-09 | 2003-05-09 | Antibioticos Spa | Processo di sintesi della cefixima via alchil-o arilsolfonati |
ITMI20022076A1 (it) * | 2002-10-01 | 2004-04-02 | Antibioticos Spa | Sali di intermedi del cefdinir. |
CN100506811C (zh) * | 2003-04-25 | 2009-07-01 | 日本化学医药株式会社 | (2s,3s)-3-[[(1s)-1-异丁氧基甲基-3-甲基丁基]氨基甲酰基]环氧乙烷-2-甲酸盐 |
EP1863822B1 (en) | 2005-03-29 | 2009-10-14 | Hetero Drugs Limited | An improved process for the preparation of cefixime |
CN102311452B (zh) * | 2011-09-22 | 2013-07-03 | 山东罗欣药业股份有限公司 | 头孢克肟晶体、其制备方法及含有该晶体的片剂组合物 |
CN103087080B (zh) * | 2011-11-03 | 2016-08-31 | 石药集团中奇制药技术(石家庄)有限公司 | 一种盐酸头孢卡品酯的制备方法及其合成中间体 |
CN107056815B (zh) * | 2017-06-16 | 2019-06-25 | 成都倍特药业有限公司 | 一种头孢克肟及精制方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
-
1998
- 1998-01-07 TW TW087100131A patent/TW538045B/zh not_active IP Right Cessation
- 1998-01-14 ES ES98907945T patent/ES2219874T3/es not_active Expired - Lifetime
- 1998-01-14 JP JP10533299A patent/JP2000514090A/ja active Pending
- 1998-01-14 EP EP98907945A patent/EP0968214B1/en not_active Expired - Lifetime
- 1998-01-14 KR KR1019997006503A patent/KR20000070275A/ko not_active Application Discontinuation
- 1998-01-14 AU AU66141/98A patent/AU6614198A/en not_active Abandoned
- 1998-01-14 WO PCT/EP1998/000190 patent/WO1998031685A1/en not_active Application Discontinuation
- 1998-01-14 DE DE69823012T patent/DE69823012T2/de not_active Expired - Fee Related
- 1998-01-14 AR ARP980100163A patent/AR011072A1/es unknown
-
2000
- 2000-07-04 HK HK00104089A patent/HK1024698A1/xx not_active IP Right Cessation
-
2004
- 2004-01-19 JP JP2004010146A patent/JP2004155793A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU6614198A (en) | 1998-08-07 |
WO1998031685A1 (en) | 1998-07-23 |
JP2004155793A (ja) | 2004-06-03 |
TW538045B (en) | 2003-06-21 |
DE69823012D1 (de) | 2004-05-13 |
JP2000514090A (ja) | 2000-10-24 |
KR20000070275A (ko) | 2000-11-25 |
DE69823012T2 (de) | 2005-03-24 |
ES2219874T3 (es) | 2004-12-01 |
HK1024698A1 (en) | 2001-01-12 |
EP0968214A1 (en) | 2000-01-05 |
EP0968214B1 (en) | 2004-04-07 |
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Legal Events
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FB | Suspension of granting procedure |