GB1073299A - Improvements in or relating to the manufacture of barbituric acid derivatives - Google Patents

Improvements in or relating to the manufacture of barbituric acid derivatives

Info

Publication number
GB1073299A
GB1073299A GB3442664A GB3442664A GB1073299A GB 1073299 A GB1073299 A GB 1073299A GB 3442664 A GB3442664 A GB 3442664A GB 3442664 A GB3442664 A GB 3442664A GB 1073299 A GB1073299 A GB 1073299A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
barbituric acid
products
relating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3442664A
Inventor
John William James
James Albert Baker
Brian Alfred Gore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aspro Nicholas Ltd
Original Assignee
Aspro Nicholas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aspro Nicholas Ltd filed Critical Aspro Nicholas Ltd
Priority to GB3442664A priority Critical patent/GB1073299A/en
Priority to DE19651545553 priority patent/DE1545553A1/en
Priority to SE10952/65A priority patent/SE319480B/xx
Priority to DK426865A priority patent/DK118289B/en
Publication of GB1073299A publication Critical patent/GB1073299A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises new compounds of Formula I wherein X is NH and the preparation of compounds I <FORM:1073299/C2/1> wherein X is O or NH, R1 is R3-pyridyl-CH2 -(R3 being hydrogen or C1- 4 alkyl), and R2\t is phenyl optionally substituted by one or more halogen, hydroxy or C1- 4 alkyl or alkoxy substituents, C5- 4 cycloalkyl, aralkyl or C3- 7 alkyl, and their pharmaceutically acceptable salts, by reacting with R1Y or an acid addition salt thereof (Y being Cl, Br, I or alkyl or aryl sulphonate) an adsorbate on a strongly basic anion exchange material of a corresponding 5-R2-barbituric acid, and optionally hydro lysing products wherein X is NH to the keto compounds, an optional further step comprising reducing 5 - pyridylmethyl - 5 - R2 - oxobar bituric acid products to 5-piperidinylmethyl -5-R2-oxobarturic acids which can then be N-methylated.
GB3442664A 1964-08-21 1964-08-21 Improvements in or relating to the manufacture of barbituric acid derivatives Expired GB1073299A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB3442664A GB1073299A (en) 1964-08-21 1964-08-21 Improvements in or relating to the manufacture of barbituric acid derivatives
DE19651545553 DE1545553A1 (en) 1964-08-21 1965-08-17 5,5-disubstituted barbituric acid derivatives and process for the preparation of 5,5-disubstituted barbituric acid derivatives
SE10952/65A SE319480B (en) 1964-08-21 1965-08-20
DK426865A DK118289B (en) 1964-08-21 1965-08-20 Process for the preparation of a 5,5-disubstituted barbituric acid or a salt thereof.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3442664A GB1073299A (en) 1964-08-21 1964-08-21 Improvements in or relating to the manufacture of barbituric acid derivatives

Publications (1)

Publication Number Publication Date
GB1073299A true GB1073299A (en) 1967-06-21

Family

ID=10365496

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3442664A Expired GB1073299A (en) 1964-08-21 1964-08-21 Improvements in or relating to the manufacture of barbituric acid derivatives

Country Status (4)

Country Link
DE (1) DE1545553A1 (en)
DK (1) DK118289B (en)
GB (1) GB1073299A (en)
SE (1) SE319480B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013038153A1 (en) 2011-09-14 2013-03-21 The University Court Of The University Of Aberdeen 18f-labelled barbiturate compounds for use as positron emission imaging agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013038153A1 (en) 2011-09-14 2013-03-21 The University Court Of The University Of Aberdeen 18f-labelled barbiturate compounds for use as positron emission imaging agents

Also Published As

Publication number Publication date
DE1545553A1 (en) 1969-06-19
DK118289B (en) 1970-08-03
SE319480B (en) 1970-01-19

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